werner@aecom.UUCP (Craig Werner) (11/08/86)
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! An Early Event in the Interferon-Induced
! Transmembrane Signalling Process.
! Yap WH, Teo TS, Tan YH
! Science 234:355 (17 Oct 1986)
Human interferon stimulates a transient two- to threefold increase
in the concentration of diacylglycerol and inositol tris-phosphate within
15 to 30 seconds of cell exposure to interferon. Antibodies to
interferon inhibit this effect. The stimulation was measurable in
isolated cell membranes exposed to interfereon. Human alpha and beta,
but not gamma interferon stimulate this increase in cells containing the
appropriate interferon receptor. The effect was proportional to the
number of interferon receptors. Both the diacylglycerol increase and
antiviral effects induced by interferon could correlated in terms of dose
dependence. Thus a transient diacylglerol increase is an early event in
the interferon-induced transmembrane signalling process.
--
Craig Werner (MD/PhD '91)
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(1935-14E Eastchester Rd., Bronx NY 10461, 212-931-2517)
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