werner@aecom.UUCP (Craig Werner) (11/08/86)
<> ! An Early Event in the Interferon-Induced ! Transmembrane Signalling Process. ! Yap WH, Teo TS, Tan YH ! Science 234:355 (17 Oct 1986) Human interferon stimulates a transient two- to threefold increase in the concentration of diacylglycerol and inositol tris-phosphate within 15 to 30 seconds of cell exposure to interferon. Antibodies to interferon inhibit this effect. The stimulation was measurable in isolated cell membranes exposed to interfereon. Human alpha and beta, but not gamma interferon stimulate this increase in cells containing the appropriate interferon receptor. The effect was proportional to the number of interferon receptors. Both the diacylglycerol increase and antiviral effects induced by interferon could correlated in terms of dose dependence. Thus a transient diacylglerol increase is an early event in the interferon-induced transmembrane signalling process. -- Craig Werner (MD/PhD '91) !philabs!aecom!werner (1935-14E Eastchester Rd., Bronx NY 10461, 212-931-2517) "Trust me. I'm almost a doctor."