werner@aecom.UUCP (Craig Werner) (11/13/86)
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! Isolation of a New Virus, HBLV, in Patients with
! Lymphoproliferative Disorders.
! SZ Salahuddin, DV Ablashi, PD Markham, SF Josephs, S Sturzenegger,
! M Kaplan, G Halligan, P Biberfeld, Flossie Wong-Stall, B Kramarsky,
! Robert C Gallo.
! Science 234:596 (31 Oct. 1986)
A novel human B-lymphotropic virus (HBLV) was isolated from the
peripheral blood leukocytes of six individuals: two HTLV-III seropositive
patients from the United States (one with AIDS-related lymphoma and one
with dermatopathic lymphadenopathy), three HTLV-III seronegative patients
from the United States (one with angioimmunoblastic lymphadenopathy, one
with cutaneous T-cell lymphoma, and with with immunoblastic lymphoma),
and one HTLV-III seronegative patient with acute lymphocytic leukemia
from Jamaica. All six isolates were closely related by antigenic
analysis, and sera from all six virus-positive patients reacted
immunologically with each virus isolate. In contrast, only four sera
from 220 randomly selected healthy donors and none from 12 AIDS patients
without associated lymphoma were seropositive. The virus selectively
infected freshly isolated human B cells and converted them into large
refractile mono- or binucleated cells with nuclear and cytoplasmic
inclusion bodies. HBLV is morphologically similar to viruses of the
herpesvirus family but is readily distinguishable from the known human
and nonhuman primate herpesviruses by host range, in vitro biological
effects, and antigenic features.
--
Craig Werner (MD/PhD '91)
!philabs!aecom!werner
(1935-14E Eastchester Rd., Bronx NY 10461, 212-931-2517)
"When I was your age, I always did it for half an hour a day."