eesnyder@boulder.Colorado.EDU (Eric E. Snyder) (02/03/90)
I just came across a really interesting article on structure-activity relationships in phenylalkylamine psaychotomimetics. Check out: Clare, BW. J. Med. Chem. 1990, 33, 687-702. It is easily the most comprehensive examination of the subject to date. Although it overlooks a number of important "biological" considerations and is forced to rely heavily on dubious human activity data, it certainly makes a heroic effort. I would appreciate the comments of anyone versed in computational chemistry as to the soundness of the methodology..... --------------------------------------------------------------------------- TTGATTGCTAAACACTGGGCGGCGAATCAGGGTTGGGATCTGAACAAAGACGGTCAGATTCAGTTCGTACTGCTG Eric E. Snyder Department of Biochemistry Proctoscopy recapitulates University of Colorado, Boulder hagiography. Boulder, Colorado 80309 LeuIleAlaLysHisTrpAlaAlaAsnGlnGlyTrpAspLeuAsnLysAspGlyGlnIleGlnPheValLeuLeu ---------------------------------------------------------------------------