GenBank-Updates@genbank.bio.net (08/17/90)
LOCUS HUMPDHBET 8872 bp ds-DNA PRI 17-AUG-1990
DEFINITION Human pyruvate dehydrogenase beta subunit gene, complete cds.
ACCESSION D90086
KEYWORDS pyruvate dehydrogenase beta subunit.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 2010 to 2639; sites)
AUTHORS Koike,K., Urata,Y. and Koike,M.
TITLE Molecular cloning and characterization of human pyruvate
dehydrogenase beta subunit gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87, 5594-5597 (1990)
STANDARD full staff_entry
REFERENCE 2 (bases 1 to 8872; for [1])
AUTHORS Koike,K., Urata,Y. and Koike,M.
JOURNAL Unpublished (1990)
STANDARD full staff_entry
COMMENT These data kindly submitted in computer readable form, for release
after publication, by:
Kichiko Koike
Department of Pathological Biochemistry
Atomic Disease Institute
Nagasaki University School of Medicine
12-4, Sakamoto-machi
Nagasaki 852
Japan
Phone: 0958-47-2111 x2347
Fax: 0958-47-8514
FEATURES from to/span description
pept 2447 2488 pyruvate dehydrogenase beta subunit, exon 1
(EC 1.2.4.1) /hgml_locus_uid="LU0223C"
/nomgen="PDHB" /map="unassigned"
2571 2624 pyruvate dehydrogenase beta subunit, exon 2
4270 4377 pyruvate dehydrogenase beta subunit, exon 3
4461 4523 pyruvate dehydrogenase beta subunit, exon 4
4625 4660 pyruvate dehydrogenase beta subunit, exon 5
5314 5599 pyruvate dehydrogenase beta subunit, exon 6
6019 6129 pyruvate dehydrogenase beta subunit, exon 7
6456 6547 pyruvate dehydrogenase beta subunit, exon 8
7642 7783 pyruvate dehydrogenase beta subunit, exon 9
8077 8222 pyruvate dehydrogenase beta subunit, exon 10
pre-msg 2315 8626 PDHB mRNA and introns
IVS 2489 2570 PDHB intron A
IVS 2625 4269 PDHB intron B
IVS 4378 4460 PDHB intron C
IVS 4524 4624 PDHB intron D
IVS 4661 5313 PDHB intron E
IVS 5600 6018 PDHB intron F
IVS 6130 6455 PDHB intron G
IVS 6548 7641 PDHB intron H
IVS 7784 8076 PDHB intron I
rpt 475 753 Alu repeat 1
rpt 3546 3839 Alu repeat 2
rpt 7100 7388 Alu repeat 3
signal 2233 2237 CAAT box
signal 8605 8610 polyadenylation signal
BASE COUNT 2293 a 2042 c 1997 g 2540 t
ORIGIN
1 gaattctttc ttgtgtgaga tccaagaact ctctcttggg atctcgatcg ggactgcttt
61 cctgtaacat ctccttttgc ttggcaaatc tgatcctgaa atcttttggt gctaggttgt
121 gggaaaggtg ggaaggactg attcactttt tcattctgag caccacccac aaacttttgg
181 gggctgaaat ctcaagttca ggagtttctc agggatgctg tggcagtcta ggaagtgctg
241 gccattcctg aggccctggc agggacagtt gggactagac gatggtggca ggtgagggag
301 actcagaagg tgttgattcc atatcttgaa gatcttctat ccattttaca gatgaaacag
361 tcccagagag taaatgtcat ctctatgcag ctgtccccaa atttctacct ttagccctga
421 ctaggcccta ggctccaggc aacctgggta tgtcccagtc atctaaagaa taaaggctgg
481 ctgcagtgct catgcctgta atcccagcac tttgggaggc tgaggcgggt ggatcacttg
541 aggtcaagag ttcaacatca gcctggtcaa catagtgaaa actcatctct actaaaaata
601 aaaaaaatta gccgggcatg gtggcaggtg cctgtaatcc cagctactcg ggaggctgaa
661 gcaggggaat agcttgaacc tgggaggcag aggttgcagt gaggcccact gcacttcagc
721 ctgggtgaca gagtgaaact ccatctcaaa aaataaacaa aaatacactc ttacttcccc
781 agctcctggc acttacactg ccccaggtcc tcccttcccc cactatccat ccagcaatga
841 caaaaatcca aaattttcct ctgctcttcc ctagcactta cagcattcct attgattcta
901 gcccaaatag atctaaaact gttcccctcc ctctccatct ggaagttgcc tcctagtctg
961 cctctgttgc tgccacagac ttcccagcat ccgcctgttc tgcctttgcc tccaccccct
1021 cccattccca gtcagcaacc tactggaagt tgcaaattcc taatttggca gcctgcagcg
1081 ggtgatccat agaagggaat gtttggaatg tcttggggat gggtggagac tgggtgctca
1141 attgtcccat ctgaccccca aggccaaatt aagactaatg agcttccaga ggttgtccct
1201 atggccaagt gtttggcacc tccccataag ggaggagacc acccctcata ttgtcttatg
1261 cccaatttct gcctccaaag aaagaaaaag taaaaactaa aaggcaggaa atgaaatcca
1321 caaacagaga tcctggtgcc acaccctggg ccttggtaaa gatcgccccg acctaatcgg
1381 ttatgttaac tatagattac agacattgta tagaaaagca ctgtgaaaat ccctatcctg
1441 ttccggtcta attaccggtg cttgcagccc ctagtcacat accccctgct tgctcaatca
1501 atcatgaccc tctcacgcac acctccttag agctgtgagc ccttaaaagg gacaggaatt
1561 gccattcggg gagctcggtc ttgagacaag agtcttgccc atcccctggc cgaataaacc
1621 ccttccttct ttaactcggt gtctgaggag tttcgtctgc ggcttgtcct gctacatcca
1681 tagggccgcc cttctctaaa gttgttgtaa ccttccccca agcaggaatc cacttctgct
1741 ttaggaagca gtgggaaaaa gaccatgctt tagagtcaag acagtcctaa attaaaatat
1801 cggctcattt aatcaatttc tgcttcagtt taaccgtctt caaaatggag ataataataa
1861 cactaattac ccaagtgggg tactgtgaga atgagctata cagcaatatc tcaatgcttg
1921 gctcacagta ggtgcttaat acaatcaatg aaagctatga tgtgcattat aaggaatcaa
1981 cagacagcac tgtccaggga agactagact cactcatgaa gtgttaagtt ccccatcaat
2041 agagcgtgtg caagcacttc ttggtgccca aaggattcca gcacccacaa caggttggcc
2101 taactcttaa ggtctctcca gcttccagag atcatgctcc tcagggtctg acttctagtc
2161 cccacgcttc aagtaacacc gaccaggcac gtgtccgcag cgtgcacccc gcctgtcggt
2221 caccgcctac tgtcaataaa gttgatttga ggcggctcca ggcagagggg cacggccacc
2281 cacacgccac ctcagcccgg ccccgcggcc cctcaccggt gggcgggtgg gcgggtcacg
2341 cagccggctc agcgccttgc cattgcccgc gccggtggag gcgggcgtgc tcacgtctgc
2401 cggcccctct ggggtcgttt ggcagcggat agaggacacg accaagatgg cggcggtgtc
2461 tggcttggtg cggagacccc ttcgggaggt aggcagcagc gcgcggcctg tattcccacg
2521 cgacccctgc ccacccctgt cccgccgtca tcttcctctc tccctgccag gtctccgggc
2581 tgctgaagag gcgctttcac tggaccgcgc cggctgcgct gcaggtaaca ggcgcgggtg
2641 ctcgtcggac gagggcgggg aggtcccccc ttctctcggg aaggaggccg gagtccggcc
2701 tgcgctgtcg gttccggccg cgtgggcctt gggtttgcgg agccagcatc ctccgtggag
2761 ctcctgctgc ctctgtcgcc gcctggcaat tacacaccgg cgagtcacca cctcacagct
2821 ggctgggcaa tgggggaaaa ctaagactag gcgtttcctc cctcactcca tgtttttttc
2881 tttaaattgc agcaaaatag acctaactta aaatgtactt tttagaagtg tataattcag
2941 tggcattaag tacattcacc atgttgtaca accattaacc accatccatt tccagaactt
3001 tttaatcatc ccaagcagaa actgtccatt actcggtaac tcctcatttc ccttccccaa
3061 acccctggta acccctgttg tacttttctg tctttatgag gttgcctatt ctagaacttc
3121 ttataagtgg catcatttgt ccttttgtgt ctggcttatc tcagcataat gtcctcaagg
3181 ttcatccatg ttgtagcatg cgtcagagtt tgattctttc ctaaggctga ataatatata
3241 tatgtatatt tttttgagat agtctccctc tgtcacccag gttggagtgc agtggcgcga
3301 tctcagctca ctgcaacctc cacctcctgg gctcaaggga ttctcgcgcc tcacactcct
3361 gagtagctgt gattagatgc cggtgccacc acaccgggct aatttttgta tttttagtac
3421 agacagggtc tcaccatatt gcccaggctg gtcttgaact cctggcctca agtgatctgc
3481 ctgccttggc ctcccaaagt gctaggatta caggcatgag ccacctcgct cagcccgaca
3541 ttttcttttt tttttttgag acggagtttt gctcttgctg cccaggctag agtgcagtgg
3601 cactatctct caggctcact gcaatctctg cctcctgggt tcaagcaatt ctgcctcagc
3661 ctcccgagta gctgggatta cagcacccgc caccacaccc ggccaatttt tgtattttta
3721 gtagagaatg ggtttcacca tgttggccag ggtggtctcg aactcctgac ctcaagtgat
3781 ccacctgcct tggcctccca gagtgctgga attacaggtg tgagccaccg tgcctggcct
3841 tgttttgtct attgtgagta atgctgctgt gaacattgat gtgcaagtat atgcttgaat
3901 ccctgctttc aattatttgg ggcatataca tagaagtgga attgatggat tgtatgttaa
3961 ttctcctctc cttccttttt ttaactagat tttaccattc attatattaa aagagcaact
4021 cctacattct ggatgcaaag tatttggcat ggcgtggcac ctagtgagca ctcagtacat
4081 taacacatgc aaagaccaac tatgtgtaat agaaatgtta cttttagaat tctttgagtt
4141 tttagagaga agcttgttct agtgttttta tattgtatgc tgtgggcagc ctaggtaaat
4201 ataaaggaag aaaatcttag ttgaatccca aacaattctg tattgactgt ttttgcatac
4261 ctgtgacagg tgacagttcg tgatgctata aatcagggta tggatgagga gctggaaaga
4321 gatgagaagg tatttctgct tggagaagaa gttgcccagt atgatggggc atacaaggta
4381 actaaaatat atgaaagtta tacaaaattg aggtcactgt tacccccaga tacacttaag
4441 ggatcaactc ttaattgtag gttagtcgag ggctgtggaa gaaatatgga gacaagagga
4501 ttattgacac tcccatatca gaggtaagcc ttccagtggg aagcagaccc tggaggcatg
4561 tctattagtg tccattatcc tcatttttat ggattttcac ttatgtttat attttacttt
4621 atagatgggc tttgctggaa ttgctgtagg tgcagctatg gtatgtaata ctcctttatg
4681 aaacttatcc aaagacattc ttgttttctt ttttttttct tttgagacag agtctcactc
4741 tgttgtccag cctggagtgc actggcacca tctccccttc caggttcaag caattctcct
4801 gcctccagcc tccatagtgg ctggggttac aggtggccac tgtgcctagc caattttttg
4861 tgtttttagt agagatgggg tttaccatgt tggccaggct ggtcttgaac tcctggcctc
4921 aagtgatccg accgccttgg cctcccaaag tgctgggatt acaggcgtga gccactgtgc
4981 ccatccccaa agagatttaa catcaccttt taaaaacatc atttgggaaa aaaaaaaaat
5041 accaagtagg tagatgtggt ggtgcttgcc tgcagtccca gctactcggg atgctgagga
5101 aggattactt gagcctagga gttagaggct gcagtgagct atgatgttgg ccactgcact
5161 ccagcatggg tgacagtgag accctgtcca taaaaaataa aaataaaaat aaataaaaac
5221 attatttgaa tgttggaaga cttggagtga tttgtttgct actgtttgtt gctgtttcta
5281 gtctttttaa catccacgtt tttgatttta caggctgggt tgcggcccat ttgtgaattt
5341 atgaccttca atttctccat gcaagccatt gaccaggtta taaactcagc tgccaagacc
5401 tactacatgt ctggtggcct tcagcctgtg cctatagtct tcaggggacc caatggtgcc
5461 tcagcaggtg tagctgccca gcactcacag tgctttgctg cctggtatgg gcactgccca
5521 ggcttaaagg tggtcagtcc ctggaattca gaggatgcta aaggacttat taaatcagcc
5581 attcgggata acaatccagg tcagcacagg gaccctttgg ttttttttga agattgaaaa
5641 actaaaatga tatatttgca cagaggaaac cattaaagtc ttttagttag gcttagatat
5701 atcgtataga atgttaatac tttatatagt aaagagtagt aaagaatgtg cttgcttttc
5761 ctatttccga atataagggg gccagctagg taaaggggac atttactgca cacccacaat
5821 actggtttga tagataaaat tatattgacc actacaaatt taagtaccta aactgctctc
5881 aaggctgctg gtcatggtag agataaggct aatcagcaca atgaaacttc tcacaagatg
5941 aatgatattg ctttctatgc agttttagtc attctggatg tgattaatta cttttgttta
6001 aatatttatg tttttcagtg gtggtgctag agaatgaatt gatgtatggg gttccttttg
6061 aatttctccc ggaagctcag tcaaaagatt ttctgattcc tattggaaaa gccaaaatag
6121 aaaggcaagg taagaaaact aagatatata aacagtattt ttaatccagc ccctcaattt
6181 tggtaaaatt taatctagag ttactgcatt tactttgact gaaaaattat aggatgagct
6241 caagatgccc caatttctca ttcagttgtg cttttctaga tctcagtctg gtaggtttgt
6301 gtttcatttc taggaaggct gccacattcc tcagctcact ggaatgaagt tgaattgaag
6361 actttatgaa tgaacaagag ccacagctgg ctgcacagtg gtgtagcatc ttcagtttca
6421 acctgatctc tgatctgtga ccactctgtt ttcaggaaca catataactg tggtttccca
6481 ttcaagacct gtgggccact gcttagaagc tgcagcagtg ctatctaaag aaggagttga
6541 atgtgaggtg agtggacatt tacttgttct taaagaatta gaagggctcc ttttagattt
6601 aagacccaga agagttctgt aacaggttaa ttagatgtaa aaccttgctt tgtcactcat
6661 ttctgtcttc ttgcttaaag ctgggaacct gcctgcagtt cacatactta gcttttacct
6721 cttcaggtca cttaggtctg gacttttttg agagacagtg ggagctctct gaacctcttc
6781 tggttctctc agtgataccc cccgagagag aaaaaaacag gcttttgttc tgttgcccag
6841 gctgaagtgc agtggctgga tcatggctca ctgtaaccgt gaactcctgg gcccaagtga
6901 tgctcccacc tcacccttct gaggttctgg atcttttaga aactcaccat gtgctagtta
6961 tacttgggca agttatatac tctaaatctg tttcatcagc tataaaacag ggataatata
7021 aatactgtcc cgtcataggg ctgttgtgag aattacactt agtgtagtgc ttggtacatg
7081 atgggcactc agctgttaac tgttaactta ttttgatgag ggaatttaaa gtgaagggag
7141 gattggctgg gcgtggtgga tcacctgagg tcaggagttc aagaccagtc tggccaacat
7201 gttgaaaccc catctctact aaaatacaaa attagctagg cgcggtggtc tatagcctgt
7261 aatccagcta ctccagagct gaggcaggta cgaatgactt gaactggaag gccgggggtg
7321 gcagtgagcc gagatcacgc cactgcactc cagcctggac aaccaagagc aaaactccat
7381 cccaaaaaga aataaaaaag tgaaggaaga taaatgaatc ctataactgc acagagctgc
7441 ttgtggtaga catacagatc tttgttttaa ttaaaatttt tccttttaca gtttgtacat
7501 tcatgaatag gtattcatag gcagattaga ttttcctaga tacaaagatt aacaggaaac
7561 aaaaaaggaa atggtattat ggggataagg ctctatttgt gctgcaatag ctctgtaaac
7621 ttgattatat tacctgttta ggtgataaat atgcgtacca ttagaccaat ggacatggaa
7681 accatagaag ccagtgtcat gaagacaaat catcttgtaa ctgtggaagg aggctggcca
7741 cagtttggag taggagctga aatctgtgcc aggatcatgg aaggtatttc aaagaaactg
7801 gttctagaat acagtcaagc tatagtaaac atcatgtacc tgaatacgta caggataaag
7861 agattgaaag ctaggagtgg ccaaacgact tcaactttaa acttgtaagt ttggcatttc
7921 tcttcaggca gatattttta aaagcaaatc cagaaagcgg ttccccataa ttagcattcc
7981 ttacattttc tcttcctggt cagccacacc tctgtgccaa ggtggtagtg cccagctggc
8041 atttgcactc tctcagttga gccttccttc tcctaggtcc tgcgttcaat ttcctggatg
8101 ctcctgctgt tcgtgtcaca ggtgctgatg tccctatgcc ttatgcaaag attctagagg
8161 acaactctat acctcaggtc aaagacatca tatttgcaat aaagaaaaca ttaaatattt
8221 agtttggact tgaatatcaa gtcgttgaaa tttatttgaa atacttgctg gcactgcacc
8281 tggatttgta ctgcaagacc tgactattca taaaggaaaa cgatttctaa agcaacagca
8341 ggtatttttg tacagggaag tttaaatgtg tttgtgtatg gaaaactctc cactctcctc
8401 ccctagatgc catgcttcct tttgtctgtt acggttgcca tgttctttga ataacaaatt
8461 atatcacatt ttatcctctc tcaccacaag gacaaagtat ggatgtggca gagtcctgat
8521 gaaagatgta tccaaacaag ataacttata tgtataaaat taaagcatat aatacacatt
8581 tactgttagt ttgttttgat aaggaataaa ggaatttcta acatgactaa tttttttttt
8641 ttttgagaca atgtttggct ctgttcccca agctggagtg tgatggcaca atcttggcct
8701 cactgcagcc tccacctccc aggttcaagt gattctcctg cctcagcctc agtaggaaat
8761 tagccaccac atccggctaa ttttggtgtt tttagtagag gtggggtttc accatgttgg
8821 ccaggctggt cttgaacacc tgacctcagg tgatccgttg accgaggtcg ac
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