GenBank-Updates@genbank.bio.net (08/18/90)
LOCUS HUMMHDRB4A 942 bp ds-DNA PRI 18-AUG-1990
DEFINITION Human MHC class II HLA-DRB4-null beta chain pseudogene (DQw9,DR7,
DRB4-null,Bw57), exons 2a and 2b.
ACCESSION M30694
KEYWORDS cell surface glycoprotein; class II gene;
integral membrane protein; major histocompatibility complex;
pseudogene.
SOURCE Human (individual DB, haplotype DQw9,DR7,DRB4-null,Bw57) B cell
line DBB 10W#9052 DNA, clones D[62,118].
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 942)
AUTHORS Sutton,V.R. and Knowles,R.W.
TITLE An aberrant DRB4 null gene transcript is found that could encode a
novel HLA-DR beta chain
JOURNAL Immunogenetics 31, 112-117 (1990)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [1] kindly submitted
by R.W.Knowles, 13-DEC-1989.
FEATURES from to/span description
pept.ps / 45 199 MHC HLA-DRB4-null beta chain, exon 2a (AA at
47) /nomgen="HLA-DRB4" /map="6p21.3"
/hgml_locus_uid="LZ0076Z"
650 / 902 MHC HLA-DRB4-null beta chain, exon 2b
pre-msg < 1 > 942 HLA-DRB4 mRNA and introns
IVS < 1 44 HLA-DRB4 intron 1
IVS 200 649 HLA-DRB4 intron 2a
IVS 903 > 942 HLA-DRB4 intron 2b
site 631 632 MHC HLA-DRB4-null beta chain mutant splice
site
BASE COUNT 181 a 240 c 321 g 200 t
ORIGIN Chromosome 6p21.3.
1 gcaccctaat gtaattgaga tcatcctttt attctctgtt ccagaactcc acacttctga
61 cgtttctcat tcctgtctaa gctcttgtgt gtttggtttt tggccatcac gttcactgct
121 ctttaagctc ccccagcgga gtggagaggt ctgttttcct ttgtttggat tcctagaggc
181 agcgcagacc aggcacaagg tcagcactaa ggaagggttc acgggatgaa cacggtgggt
241 gctgttgaag gaaccggtaa agcgtgtggg atgagaggag cagagagtgt ctttcaggtg
301 aagactccca gaaggaggcc gcgtgggccg cggtgctggg cggatcctcc tccagctcct
361 gcctggagtt ctccagaaca ggctggaggc agggaggggg tccccaaaag cctgaggatc
421 agaaggggtt ttcccgcctg gtcccccaga ccccggttcg cctcaggaag actgaggacg
481 agcccctggg ctgctggtgg tgggcgttgc gggtggggcc ggttaaggtt cccagcgccc
541 gcaccccgcc cagggagtcc gggttggtgg cgtcgctgtc agtgtcttct caggaggccg
601 cccgtgtgac cggatcgttc gtgtccccac aacacgtttc ttggagcagg ctaagtgtga
661 gtgtcatttc ctcaatggga cggagcgagt gtggaacctg atcagataca tctataacca
721 agaggagtac gcgcgctaca acagtgacct gggggagtac caggcggtga cggagctggg
781 gcggcctgac gctgagtact ggaacagcca gaaggacctc ctggagcgga ggcgggccga
841 ggtggacacc tactgcagat acaactacgg ggttgtggag agcttcacag tgcagcggcg
901 aggtgagcat ggtggagggc ggggcctggg tccctgtgag cg
//