GenBank-Updates@genbank.bio.net (08/22/90)
LOCUS BOVMHDRA 2631 bp ds-DNA MAM 22-AUG-1990
DEFINITION Bovine MHC class II BoLA-DR-alpha gene, 3' end.
ACCESSION M30120
KEYWORDS cell surface glycoprotein; class II gene;
integral membrane protein; major histocompatibility complex.
SOURCE Bovine (Holstein; individual 2042) DNA, clone W3.
ORGANISM Bos taurus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovidae.
REFERENCE 1 (bases 1 to 2631)
AUTHORS van der Poel,J.J., Groenen,M.A.M., Dijkhof,R.J.M., Ruyter,D. and
Giphart,M.J.
TITLE The nucleotide sequence of the bovine MHC class II alpha genes:
DRA, DQA and DYA
JOURNAL Immunogenetics 31, 29-36 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [1] kindly submitted
by J.J.van der Poel, 21-NOV-1989.
FEATURES from to/span description
pept / 263 508 MHC BoLA-DR-alpha chain, exon 2 (AA at 265)
938 1219 MHC BoLA-DR-alpha chain, exon 3
1510 1664 MHC BoLA-DR-alpha chain, exon 4
pre-msg < 1 > 2359 MHC BoLA-DR-alpha chain mRNA and introns
IVS < 1 262 MHC BoLA-DR-alpha chain intron A
IVS 509 937 MHC BoLA-DR-alpha chain intron B
IVS 1220 1509 MHC BoLA-DR-alpha chain intron C
IVS 1676 > 2358 MHC BoLA-DR-alpha chain intron D (no splice
consensus)
BASE COUNT 648 a 677 c 540 g 766 t
ORIGIN Chromosome 23.
1 aagcttatga aactccgggt tttgagccct catttccttc agctctcaca ctgtcccttt
61 gcttctccac ccctagctct gctcaacacg aatgtcctcc acgcaggcct tgtcttccaa
121 cttatcccta ctctccatca ctccttccca catggccctc tctttctacc accccggccc
181 acatatgtgc atctcacatc ctgggttctt ctccatcttc ctctcctggt tcccaccctg
241 accccctttc ttgtcttttc agagaatcat gtgatcatcc aagctgagtt ctatctgaaa
301 cctgaggaat cagccgagtt tatgtttgac tttgatggtg atgagatttt ccacgtggat
361 atggggaaga aggagacggt gtggcggctt ccagaatttg gacattttgc cagctttgag
421 gctcagggtg ccctggccaa tatggctgtg atgaaagcca acctggacat catgataaag
481 cgctccaaca acaccccaaa caccaatggt acctctgctc cagtcctcct agacttggga
541 attgtagctt taaacagatg cttgagctct ttgtgttttg ttatgagatt tcccctcagg
601 cctattattg tcgtatgcca aaccccacat tcttatgcca ccagcccaag aacttcagga
661 gttttctcct ttcttgatgt gctaagatct tgtctttggc aaccacagtc tgtcataaag
721 cctttgccct gagtccatgc tgggggagcc aggaatgagg tccttgaata tgttatgccc
781 agtaccgttc ccttttcatg ggggagggaa taacagctgg gtatctgaga ccatggcata
841 tattcccaag acagttttag ctgctatgtc agcctcgatg ggacgaagag gggcagggct
901 aagcagggaa ggctaatttc tgttgcttgt ctcccagttc ctccagaagt gactctgctc
961 ccaaacaagc ctgtggaact gggagagccc aacacactca tctgcttcat tgacaagttc
1021 tccccacccg tgatcagtgt cacatggctt cgaaatggca aacctgtcac tgatggagtg
1081 tcacagacgg tcttcctgcc caggaatgac caccttttcc gcaagttcca ctacctcccc
1141 ttcctgccca caacagagga tgtctatgac tgcaaggtgg agcacttggg tttgaatgag
1201 cctcttctca agcactgggg tgagtaccgt ccttcagtct cctttacttc attgttcctc
1261 ctgtgatgcg tgtgtctggt ccttagggac ccgaggatct gcttcacgac tgctccagtt
1321 ctggtttcta gtcttctccc attgctctga cttccgctct tctcgtctat aattccctga
1381 catcgtcctc tcttcctctc atttaattga tgaaaaaaaa aatcttttga ctaagtatca
1441 tatattttgt gctaagtgct gctccctacc acatgcattt cttatgtact ctgacttatt
1501 tttccccaga gtatgaagct ccagcccccc tcccagagac cacagagaat gcagtgtgtg
1561 ccctgggcct gattgtggct ctggtgggca tcattgcagg gaccatcttc atcatcaagg
1621 gcgtgcgcaa agccaacacc gttgaacgcc gagggcctct gtgaggcgcc tgcaggtgag
1681 tctgctgtgg tcagaggatg acatctctgg aatgattcaa gcggaggaaa agagtgagga
1741 aaaggacatg cgatgccttt aaaggaaaac cattccaaaa gtcatggctc ctgatttatc
1801 acaatggaca gaatcagaca ttgtcatcat ctgatattcc aaagccctgc attcctacac
1861 cccattccat acatgtcacc aaagatcatg ccttcagtct tggaaactat ctccagtacc
1921 aaaatagttg tttcacatta aaatagtgag tccaatgatc tgggaaagcc aacctcaaga
1981 ttacaacact tcctggcttt atatttcctg agataagaca tcagctttga agcatttcca
2041 gagatcgtca ctttttgggg gtttagggta actgtatgaa gtggaaatgt cttggagacc
2101 catgcctgct tttgcccctc cattctggaa aaaaaaaaaa tggtgtcaga agatctaaga
2161 gaaaatgaaa atgctgcttc attctttcac ggaaggtagg aaatagcagt tcatgttgaa
2221 aaggttgcat ttatgagagg tcacacaaat attaagagac ttttccaaag tcagaggtta
2281 aggagtaaga gtaaggaatc tgaagataag agctcaaaat attcatttta aactctatag
2341 taactatgtg tgttctgcta caggtaatgg actttgttac agagaagatc aatgaagata
2401 tttctgcctt aatagcttta caaacccggc aattctccaa ttgttcacct cactgaagac
2461 caccatgctt cagcacttcc cagtccttta cttaccctaa gagtaagatg ccttccacaa
2521 tctccagatt ctaatctcta gttattccct gtctactgct ccttcttgta ttggttttcc
2581 ctccattttc cactgtcttc ttattatcac catgtaatgc ctttggaatg g
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