GenBank-Updates@genbank.bio.net (08/25/90)
LOCUS MUSBFIGE 3305 bp ss-mRNA ROD 25-AUG-1990
DEFINITION Mouse IgE-binding factor mRNA, complete cds.
ACCESSION M10062 M36709 M36710
KEYWORDS IgE binding factor; glycoprotein.
SOURCE Mouse cell line 23B6, cDNA to mRNA, clone 8.3.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 1770)
AUTHORS Martens,C.L., Huff,T.F., Jardieu,P., Trounstine,M.L., Coffman,R.L.,
Ishizaka,K. and Moore,K.W.
TITLE cDNA clones encoding IgE-binding factors from a rat-mouse T-cell
hybridoma
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 2460-2464 (1985)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 3305)
AUTHORS Moore,K.W., Trounstine,M.L. and Martens,C.
JOURNAL Unpublished (1985) DNAX Res Inst, 901 California Ave, Palo Alto, CA
STANDARD full staff_review
REFERENCE 3 (sites)
AUTHORS Toh,H., Ono,M. and Miyata,T.
TITLE Retroviral gag and DNA endonuclease coding sequences in IgE-binding
factor gene
JOURNAL Nature 318, 388-389 (1985)
STANDARD simple staff_entry
COMMENT Draft entry and computer-readable sequence for [1] kindly submitted
by C.Martens, 10-OCT-1985.
[3] notes that:
The 3' two-thirds of the IgE-BF coding sequence shows a
surprising homology (72%) at the DNA level with coding
sequences of the gag and pol (DNA endonuclease) genes of
the Syrian hamster intracisternal A particle (IAP H18),
an endogenous retrovirus. This marked homology demonstrates
that the rodent gene encoding IgE-BF is a hybrid gene which
evolved very recently by integrating genes of viral origin,
and that the encoded polypeptide comprises three separate
domains: an IgE-BF domain and retrovirus-derived gag and
DNA endonuclease-like domains.
FEATURES from to/span description
pept 94 1767 IgE-binding factor
mRNA < 94 3305 IgE-BF mRNA
site 700 1402 IAP gag-like domain
site 1358 1770 IAP pol-like domain
BASE COUNT 919 a 723 c 837 g 826 t
ORIGIN 18 bp upstream of RsaI site.
1 gctagagtac cagtgagtac agctttacga ggtaagtctg atcttgaact ttctaaggaa
61 attcaagaca gtctatcaga agtaaagtgg aaaatggctt tacaagttat gtttggcctt
121 gaattttttc tagtgttaga agcccttttg ttccttttca catgttatca agtggttaag
181 gcagggcgga ttctagatga aattcaggac aagctatcag aagtaaagcg gggagagaga
241 gtaggaacaa agaggaaata tggtacacaa aataagtata caggcctttc caagggtctt
301 gaacccgagg aaaagttaag gttaggtagg aatacctgga gagagattag aagaaaaaga
361 ggaaaaaggg aaaagaagaa agatcaatta gcggaggtct ctaggaaaag gagcctgtgc
421 tcatcgctgg atgggctcgg gaagccagct cttagtagct ctgaagcagg tgaagaatcc
481 tcctctgagg aaacagactg ggaggaagaa gcagcccatt accagccagc taattggtca
541 agaaaaaagc caaaagcggc tggcgaaggc cagtttgctg attggcctca gggcagtcgg
601 cttcaaggtc cgccctatgc ggagtccccg ccctgcgtag tgcgtcagca atgcgcagag
661 agatgcgcag agaggcagtg cgcagagagg cagtgcgcag actcattcat tcccagagag
721 gaacaaagga aaatacaaca ggcatttccg gtctttgaag gagccgaggg tgggcgtgtc
781 cacgctccgg tagaatactt acaaattaaa gaaattgccg agtcggttcg taaatatgga
841 accaatgcta attttacctt ggtgcagtta gacaggctcg ccggcatggc actaactcct
901 gctgactggc aaacggttgt aaaagccgct ctccctagta tgggcaaata tatggaatgg
961 agagcgcttt ggcacgaagc tgcacaagcg caggcccgag caaacgcagc tgctttgact
1021 ccagagcaga gagattggac ttttgacttg ttaacgggtc agggagctta ttctgctgat
1081 cagacaaact accattgggg agcttatgcc cagatttctt ccacggctat taggcctgga
1141 aggcgctctc gagcaggtga aaccactggt cagttaacaa agataatcca gggacctcag
1201 gaatccttct cagattttgt ggccagaatg acagaggcag cagagcgtat ttttggagag
1261 tcagagcaag ctgcgcctct gatagaacag ctaatctatg agcaagccac aaaggagtgc
1321 cgagcggtcc atagccccaa gaaagaacaa aggcttacaa gactggctca gggtctgtcg
1381 agagcttggg ggaaacccag actccttaag actgataatg gaccagctta tacgtctcaa
1441 aaattccaac agttctgccg tcagatggac gtgacccacc tgactggact tccatacaac
1501 cctcaaggac agggtattgt tgagcgtgcg catcgcaccc tcaaagccta tcttataaaa
1561 cagaagaggg gaacttttga ggagactgta ccccgagcac caagagtgtc ggtgtctttg
1621 gcactcttta cactcaattt tttaaatatt gatgctcatg gccatactgc ggctgaacgt
1681 catgttcaga gccagatagg cccaatgaga tggttaaatg gaaaaatgtc cttgataata
1741 aatggtatgg cccggatcct atcttgataa gatccagggg agctatctgt gtttccccac
1801 agaatgaaga caacccattt tgggtaccag aaagactcac ccgaaaaatc cagactgacc
1861 aagggaatac taatgtccct cgtcttggtg atgtccaggg cgtcaataat aaagagagag
1921 cagcgttggg ggataatgtc gacatttcca ctcccaatga cggtgatgta taatgctcaa
1981 gtattctcct gcttttttac cactaactag gaactgggtt tagccttgat tcagacagcc
2041 ttggctctgt ctggacaggt ccagatgact gacaccatta acactttgtc agcctcagtg
2101 actacagtca tagatgaaca ggcctcagct aatgtcaaga tacagagagg tctcatgctg
2161 gttaatcaac tcatagatct tgtccagata caactagatg tattatgaca aataactcag
2221 cagggatgtg aacaaaagtt tccgggattg tgtgttattt ccattcagta tgttaaattt
2281 actagggcag ctaatttgtc aaaaagtctt tttcagtata tgttacagaa ttggatggct
2341 gaatttgaac agacccttcg aggcttgcca tcattcaggt caactccacg cgcttggacc
2401 tgtccctgac caaaggatta cccaattgga tctcctcagc attttctttc tttaaaaaat
2461 gggtgggatt aatattattt ggagatacac tttgctgtgg attagtgttg cttctttgat
2521 tggtctgtaa gcttaaggcc taaactagga gagacaaggt ggttattgcc caggcgcttg
2581 caggactaga acatggagct tcccctgata tatctatgct taggcaatag gtcgctggcc
2641 actcagctct tatatctcac gaggctagtc tcattgcacg ggatagagtg agtgtgcttc
2701 agcagcccga gagagttgca aggctaagca ctgcaatgga aaggctctgc ggcatatatg
2761 agcctattct agggaaacat gtcatctttc atgaaggttc agtgtcctag ttcccttccc
2821 ccaggcaaaa cgacacggga gcaggtcagg gttgctctgg gtaaaagcct gtaagcctaa
2881 gagctaatcc tgtacatggc tcctttacct acacactggg gatttgacct ctatctccac
2941 tctcattaat atgggtggcc tatttgctct tattaaaaga aaaaggggga gatgttggga
3001 gccgccccca cattcgccgt tacaagatgg cgctgacatc ctgtgttcta agtggtaaac
3061 aaataatctg cgcatgtgcc aagggtatct tatgactact tgtgctctgc cttccccgtg
3121 acgtcaactc ggccgatggg ctgcagccaa tcaaggagtg atacgtccga ggcgaaggag
3181 aatgctcctt aagagggacg gggttttcgt tttctctctc tcttgcttct tgctctcttg
3241 cttcttgctc tcttgcttcc tgcaccctgg ctcctgaaga tgtaagaaat aaagctttgc
3301 cgcag
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