GenBank-Updates@genbank.bio.net (09/02/90)
LOCUS HUMTNFAB 7112 bp ds-DNA PRI 02-SEP-1990
DEFINITION Human tumor necrosis factor and lymphotoxin genes, complete cds.
ACCESSION M16441
KEYWORDS lymphotoxin; tumor necrosis factor.
SOURCE Human placenta DNA, clone pTNF186.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 7112)
AUTHORS Nedospasov,S.A., Shakhov,A.N., Turetskaya,R.L., Mett,V.A.,
Azizov,M.M., Georgiev,G.P., Korobko,V.G., Dobrynin,V.N.,
Filippov,S.A., Bystrov,N.S., Boldyreva,E.F., Chuvpilo,S.A.,
Chumakov,A.M., Shingarova,L.N. and Ovchinnikov,Y.A.
TITLE Tandem arrangement of genes coding for tumor necrosis factor
(TNF-alpha) and lymphotoxin (TNF-beta) in the human genome
JOURNAL Cold Spring Harb. Symp. Quant. Biol. 51, 611-624 (1986)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [1] kindly submitted
by C.V.Jongeneel, 02-OCT-1988.
FEATURES from to/span description
pept 1276 1374 lymphotoxin, exon 2 (first expressed exon)
/nomgen="TNFB" /map="6p21.3"
/hgml_locus_uid="LA0068H"
1461 1566 lymphotoxin, exon 3
1814 2226 lymphotoxin, exon 4
pept 4275 4460 tumor necrosis factor, exon 1 /nomgen="TNFA"
/map="6p21.3" /hgml_locus_uid="LE0142E"
5067 5112 tumor necrosis factor, exon 2
5300 5347 tumor necrosis factor, exon 3
5649 6070 tumor necrosis factor, exon 4
pre-msg 819 2855 lymphotoxin mRNA and introns
IVS 980 1266 lymphotoxin intron A
IVS 1375 1460 lymphotoxin intron B
IVS 1567 1813 lymphotoxin intron C
pre-msg 4095 6859 TNF mRNA and introns
IVS 4461 5066 TNF intron A
IVS 5113 5299 TNF intron B
IVS 5348 5648 TNF intron C
BASE COUNT 1676 a 2005 c 1865 g 1566 t
ORIGIN 1 bp upstream of EcoRI site; chromosome 6p21.3.
1 gaattctcga aacttccttt gtagaaaact ttggaaggtg tctgccacat tgatcctgga
61 atgtgtgttt atttggggtt atataaatct gttctgtgga agccacctga agtcaggaag
121 agatggaggg catccttcag gagtgagatg agacctcatc atacttgact gtccagcatc
181 atctctgagt gaggggacca aaaaatttat cttccaaact aggacacttt caagagtgga
241 agggggatcc attaatattt tcacctggac aagaggcaaa caccagaatg tccccgatga
301 aggggatata taatggacct tcttgatgtg aaacctgcca gatgggctgg aaagtccgta
361 tactgggaca agtatgattt gagttgtttg ggacaaggac aggggtacaa gagaaggaaa
421 tgggcaaaga gagaagcctg tactcagcca agggtgcaga gatgttatat atgattgctc
481 ttcagggaac cgggcctcca gctcacaccc cagctgctca accacctcct ctctgaattg
541 actgtccctt ctttggaact ctaggcctga ccccactccc tggccctccc agcccacgat
601 tcccctgacc cgactccctt tcccagaact cagtcgcctg aacccccagc ctgtggttct
661 ctcctaggcc tcagcctttc ctgcctttga ctgaaacagc agtatcttct aagccctggg
721 ggcttccccg ggccccagcc ccgacctaga acccgcccgc tgcctgccac gctgccactg
781 ccgcttcctc tataaaggga cctgagcgtc cgggcccagg ggctccgcac agcaggtgag
841 gctctcctgc cccatctcct tgggctgccc gtgcttcgtg ctttggacta ccgcccagca
901 gtgtcctgcc ctctgcctgg gcctcggtcc ctcctgcacc tgctgcctgg atccccggcc
961 tgcctgggcc tgggccttgg tgggtttggt tttggtttcc ttctctgtct ctgactctcc
1021 atctgtcagt ctcattgtct ctgtcacaca ttctctgttt ctgccatgat tcctctctgt
1081 tcccttcctg tctctctctg tctccctctg ctcaccttgg ggtttctctg actgcatctt
1141 gtccccttct ctgtcgatct ctctctcggg ggtcgggggg tgctgtctcc cagggcggga
1201 ggtctgtctt ccgccgcgtg ccccgccccg ctcactgtct ctctctctct ctctctttct
1261 ctgcaggttc tccccatgac accacctgaa cgtctcttcc tcccaagggt gtgtggcacc
1321 accctacacc tcctccttct ggggctgctg ctggttctgc tgcctggggc ccaggtgagg
1381 cagcaggaga atgggggctg ctggggtggc tcagccaaac cttgagccct agagcccccc
1441 tcaactctgt tctcccctag gggctccctg gtgttggcct cacaccttca gctgcccaga
1501 ctgcccgtca gcaccccaag atgcatcttg cccacagcac cctcaaacct gctgctcacc
1561 tcattggtaa acatccacct gacctcccag acatgtcccc accagctctc ctcctacccc
1621 tgcctcagga acccaagcat ccacccctct cccccaactt cccccacgct aaaaaaaaca
1681 gagggagccc actcctatgc ctccccctgc catcccccag gaactcagtt gttcagtgcc
1741 cacttcctca gggattgaga cctctgatcc agacccctga tctcccaccc ccatccccta
1801 tggctcttcc taggagaccc cagcaagcag aactcactgc tctggagagc aaacacggac
1861 cgtgccttcc tccaggatgg tttctccttg agcaacaatt ctctcctggt ccccaccagt
1921 ggcatctact tcgtctactc ccaggtggtc ttctctggga aagcctactc tcccaaggcc
1981 acctcctccc cactctacct ggcccatgag gtccagctct tctcctccca gtaccccttc
2041 catgtgcctc tcctcagctc ccagaagatg gtgtatccag ggctgcagga accctggctg
2101 cactcgatgt accacggggc tgcgttccag ctcacccagg gagaccagct atccacccac
2161 acagatggca tcccccacct agtcctcagc cctagtactg tcttctttgg agccttcgct
2221 ctgtagaact tggaaaaatc cagaaagaaa aaataattga tttcaagacc ttctccccat
2281 tctgcctcca ttctgaccat ttcaggggtc gtcaccacct ctcctttggc cattccaaca
2341 gctcaagtct tccctgatca agtcaccgga gctttcaaag aaggaattct aggcatccca
2401 ggggaccaca cctccctgaa ccatccctga tgtctgtctg gctgaggatt tcaagcctgc
2461 ctaggaattc ccagcccaaa gctgttggtc ttgtccacca gctaggtggg gcctagatcc
2521 acacacagag gaagagcagg cacatggagg agcttggggg atgactagag gcagggaggg
2581 gactatttat gaaggcaaaa aaattaaatt atttatttat ggaggatgga gagaggggaa
2641 taatagaaga acatccaagg agaaacagag acaggcccaa gagatgaaga gtgagagggc
2701 atgcgcacaa ggctgaccaa gagagaaaga agtaggcatg agggatcaca gggccccaga
2761 aggcagggaa aggctctgaa agccagctgc cgaccagagc cccacacgga ggcatctgca
2821 ccctcgatga agcccaataa acctcttttc tctgaaatgc tgtctgcttg tgtgtgtgtg
2881 tctgggagtg agaacttccc agtctatcta aggaatggag ggagggacag agggctcaaa
2941 gggagcaaga gctgtgggga gaacaaaagg ataagggctc agagagcttc agggatatgt
3001 gatggactca ccaggtgagg ccgccagact gctgcagggg aagcaaagga gaagctgaga
3061 agatgaagga aaagtcaggg tctggagggg cgggggtcag ggagctcctg ggagatatgg
3121 ccacatgtag cggctctgag gaatgggtta caggagacct ctggggagat gtgaccacag
3181 caatgggtag gagaatgtcc agggctatga aagtcgagta tggggacccc cccttaacga
3241 agacagggcc atgtagaggg ccccagggag tgaaagagcc tccaggacct ccaggtatgg
3301 aatacagggg acgtttaaga agatatggcc acacactggg gccctgagaa gtgagagctt
3361 catgaaaaaa atcagggacc ccagagttcc ttggaagcca agactgaaac cagcattatg
3421 agtctccggg tcagaatgaa agaagagggc ctgccccagt ggggtctgtg aattcccggg
3481 ggtgatttca ctccccgggg ctgtcccagg cttgtccctg ctacccgcac ccagcctttc
3541 ctgaggcctc aagcctgcca ccaagccccc agctccttct ccccgcaggg cccaaacaca
3601 ggcctcagga ctcaacacag cttttccctc caaccccgtt ttctctccct caacggactc
3661 agctttctga agcccctccc agttctagtt ctatcttttt cctgcatcct gtctggaagt
3721 tagaaggaaa cagaccacag acctggtccc caaaagaaat ggaggcaata ggttttgagg
3781 ggcatgggga cggggttcag cctccagggt cctacacaca aatcagtcag tggcccagaa
3841 gacccccctc ggaatcggag cagggaggat ggggagtgtg aggggtatcc ttgatgcttg
3901 tgtgtcccca actttccaaa tccccgcccc cgcgatggag aagaaaccga gacagaaggt
3961 gcagggccca ctaccgcttc ctccagatga gctcatgggt ttctccacca aggaagtttt
4021 ccgctggttg aatgattctt tccccgccct cctctcgccc cagggacata taaaggcagt
4081 tgttggcaca cccagccagc agacgctccc tcagcaagga cagcagagga ccagctaaga
4141 gggagagaag caactacaga ccccccctga aaacaaccct cagacgccac atcccctgac
4201 aagctgccag gcaggttctc ttcctctcac atactgaccc acggcttcac cctctctccc
4261 ctggaaagga caccatgagc actgaaagca tgatccggga cgtggagctg gccgaggagg
4321 cgctccccaa gaagacaggg gggccccagg gctccaggcg gtgcttgttc ctcagcctct
4381 tctccttcct gatcgtggca ggcgccacca cgctcttctg cctgctgcac tttggagtga
4441 tcggccccca gagggaagag gtgagtgcct ggccagcctt catccactct cccacccaag
4501 gggaaatgga gacgcaagag agggagagag atgggatggg tgaaagatgt gcgctgatag
4561 ggagggatgg agagaaaaaa acgtggagaa agacggggat gcagaaagag atgtggcaag
4621 agatggggaa gagagagaga gaaagatgga gagacaggat gtctggcaca tggaaggtgc
4681 tcactaagtg tgtatggagt gaatgaatga atgaatgaat gaacaagcag atatataaat
4741 aagatatgga gacagatgtg gggtgtgaga agagagatgg gggaagaaac aagtgatatg
4801 aataaagatg gtgagacaga aagagcggga aatatgacag ctaaggagag agatggggga
4861 gataaggaga gaagaagata gggtgtctgg cacacagaag acactcaggg aaagagctgt
4921 tgaatgcctg gaaggtgaat acacagatga atggagagag aaaaccagac acctcagggc
4981 taagagcgca ggccagacag gcagccagct gttcctcctt taagggtgac tccctcgatg
5041 ttaaccattc tccttctccc caacagttcc ccagggacct ctctctaatc agccctctgg
5101 cccaggcagt cagtaagtgt ctccaaacct ctttcctaat tctgggtttg ggtttggggg
5161 tagggttagt accggtatgg aagcagtggg ggaaatttaa agttttggtc ttgggggagg
5221 atggatggag gtgaaagtag gggggtattt tctaggaagt ttaagggtct cagctttttc
5281 ttttctctct cctcttcagg atcatcttct cgaaccccga gtgacaagcc tgtagcccat
5341 gttgtaggta agagctctga ggatgtgtct tggaacttgg agggctagga tttggggatt
5401 gaagcccggc tgatggtagg cagaacttgg agacaatgtg agaaggactc gctgagctca
5461 agggaagggt ggaggaacag cacaggcctt agtgggatac tcagaacgtc atggccaggt
5521 gggatgtggg atgacagaca gagaggacag gaaccggatg tggggtgggc agagctcgag
5581 ggccaggatg tggagagtga accgacatgg ccacactgac tctcctctcc ctctctccct
5641 ccctccagca aaccctcaag ctgaggggca gctccagtgg ctgaaccgcc gggccaatgc
5701 cctcctggcc aatggcgtgg agctgagaga taaccagctg gtggtgccat cagagggcct
5761 gtacctcatc tactcccagg tcctcttcaa gggccaaggc tgcccctcca cccatgtgct
5821 cctcacccac accatcagcc gcatcgccgt ctcctaccag accaaggtca acctcctctc
5881 tgccatcaag agcccctgcc agagggagac cccagagggg gctgaggcca agccctggta
5941 tgagcccatc tatctgggag gggtcttcca gctggagaag ggtgaccgac tcagcgctga
6001 gatcaatcgg cccgactatc tcgactttgc cgagtctggg caggtctact ttgggatcat
6061 tgccctgtga ggaggacgaa catccaacct tcccaaacgc ctcccctgcc ccaatccctt
6121 tattaccccc tccttcagac accctcaacc tcttctggct caaaaagaga attgggggct
6181 tagggtcgga acccaagctt agaactttaa gcaacaagac caccacttcg aaacctggga
6241 ttcaggaatg tgtggcctgc acagtgaagt gctggcaacc actaagaatt caaactgggg
6301 cctccagaac tcactggggc ctacagcttt gatccctgac atctggaatc tggagaccag
6361 ggagcctttg gttctggcca gaatgctgca ggacttgaga agacctcacc tagaaattga
6421 cacaagtgga ccttaggcct tcctctctcc agatgtttcc agacttcctt gagacacgga
6481 gcccagccct ccccatggag ccagctccct ctatttatgt ttgcacttgt gattatttat
6541 tatttattta ttatttattt atttacagat gaatgtattt atttgggaga ccggggtatc
6601 ctgggggacc caatgtagga gctgccttgg ctcagacatg ttttccgtga aaacggagct
6661 gaacaatagg ctgttcccat gtagccccct ggcctctgtg ccttcttttg attatgtttt
6721 ttaaaatatt tatctgatta agttgtctaa acaatgctga tttggtgacc aactgtcact
6781 cattgctgag cctctgctcc ccaggggagt tgtgtctgta atcgccctac tattcagtgg
6841 cgagaaataa agtttgctta gaaaagaaac atggtctcct tcttggaatt aattctgcat
6901 ctgcctcttc ttgtgggtgg gaagaagctc cctaagtcct ctctccacag gctttaagat
6961 ccctcggacc cagtcccatc cttagactcc tagggccctg gagaccctac ataaacaaag
7021 cccaacagaa tattccccat cccccaggaa acaagagcct gaacctaatt acctctccct
7081 cagggcatgg gaatttccaa ctctgggaat tc
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