GenBank-Updates@genbank.bio.net (09/05/90)
LOCUS HUMIFNG 5961 bp ds-DNA PRI 05-SEP-1990 DEFINITION Human immune interferon (IFN-gamma) gene and flanks. ACCESSION J00219 M37265 KEYWORDS gamma-interferon; interferon. SOURCE Human DNA and cDNA to mRNA (see comment). ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 366 to 588; 1828 to 1896; 1992 to 2174; 4600 to 5318) AUTHORS Gray,P.W., Leung,D.W., Pennica,D., Yelverton,E., Najarian,R., Simonsen,C.C., Derynck,R., Sherwood,P.J., Wallace,D.M., Berger,S.L., Levinson,A.D. and Goeddel,D.V. TITLE Expression of human immune interferon cDNA in E.coli and monkey cells JOURNAL Nature 295, 503-508 (1982) STANDARD full staff_review REFERENCE 2 (bases 384 to 588; 1828 to 1897; 4598 to 5312) AUTHORS Devos,R., Cheroutre,H., Taya,Y., Degrave,W., van Heuverswyn,H. and Fiers,W. TITLE Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells JOURNAL Nucleic Acids Res. 10, 2487-2501 (1982) STANDARD full staff_review REFERENCE 3 (bases 167 to 708; 1779 to 2259; 4592 to 5396) AUTHORS Taya,Y., Devos,R., Tavernier,J., Cheroutre,H., Engler,G. and Fiers,W. TITLE Cloning and structure of the human immune interferon-gamma chromosomal gene JOURNAL EMBO J. 1, 953-958 (1982) STANDARD full staff_review REFERENCE 4 (bases 347 to 483) AUTHORS Derynck,R., Leung,D.W., Gray,P.W. and Goeddel,D.V. TITLE Human interferon gamma is encoded by a single class of mRNA JOURNAL Nucleic Acids Res. 10, 3605-3615 (1982) STANDARD full staff_review REFERENCE 5 (bases 1 to 5961) AUTHORS Gray,P.W. and Goeddel,D.V. TITLE Structure of the human immune interferon gene JOURNAL Nature 298, 859-863 (1982) STANDARD full staff_review REFERENCE 6 (bases 4720 to 5319) AUTHORS Derynck,R., Singh,A. and Goeddel,D.V. TITLE Expression of the human interferon-gamma cDNA in yeast JOURNAL Nucleic Acids Res. 11, 1819-1837 (1983) STANDARD full staff_review REFERENCE 7 (bases 1 to 5961) AUTHORS Gray,P.W. and Goeddel,D.V. TITLE Human immune interferon (IFN-gamma) gene sequence and structure JOURNAL Basic Life Sci. 25, 35-61 (1983) STANDARD simple staff_entry COMMENT Immune interferon (IFN-gamma) shows little homology with leukocyte (IFN-alpha) and fibroblast (IFN-beta) interferons. See other loci beginning <HUMIFN>. IFN-gamma protein (35,000 to 70,000 mw as presently estimated) has both antiviral and antitumorigenic capabilities. Unlike the other interferons, its gene has three intervening sequences, the first of which contains a repetitive element. [4],[5] argue that there is only one IFN-gamma gene per haploid genome. [3] analyzes the promoter region and reports two sequences homologous to sequences in the promoter regions of chicken albumin and the human IFN-beta genes(bases 234-241; 276-289). [6] studies the IFN-gamma sequence recombined to the pgk promoter segment of yeast (see <HUMIFNGYST>). Complete source information: Human DNA ([3],[4],[5],[7]) and cDNA to mRNA ([1],[2],[4],[6]). FEATURES from to/span description pept 475 588 interferon-gamma, exon 1 /hgml_locus_uid="LV0085W" /nomgen="IFNG" /map="12q24.1" 1828 1896 interferon-gamma, exon 2 1992 2174 interferon-gamma, exon 3 4600 4734 interferon-gamma, exon 4 sigp 478 534 signal peptide pre-msg 347 4919 IFN-gamma mRNA (alt.) [5],[6] pre-msg 347 5319 IFN-gamma mRNA (alt.) [1],[2],[4],[5] pre-msg 350 4919 IFN-gamma mRNA (alt.) [3],[6] pre-msg 350 5319 IFN-gamma mRNA (alt.) [1],[2],[3],[4] IVS 589 1827 IFN-gamma intron A IVS 1897 1991 IFN-gamma intron B IVS 2175 4599 IFN-gamma intron C variant 4712 4712 a in [1]; g in [2],[3],[5] BASE COUNT 1829 a 1012 c 1170 g 1950 t ORIGIN 300bp upstream from mst-ii site, on 8.6kb bamh-i fragment. 1 agcaaatgat caatgtgctt tgtgaatgaa gagtcaacat tttaccaggg cgaagtgggg 61 aggtacaaaa aaatttccag tccttgaatg gtgtgaagta aaagtgcctc aaagaatccc 121 accagaatgg cacaggtggg cataatgggt ctgtctcatc gtcaaaggac ccaaggagtc 181 taaaggaaac tctaactaca acacccaaat gccacaaaac cttagttatt aatacaaact 241 atcatccctg cctatctgtc accatctcat cttaaaaaac ttgtgaaaat acgtaatcct 301 caggagactt caattaggta taaataccag cagccagagg aggtgcagca cattgttctg 361 atcatctgaa gatcagctat tagaagagaa agatcagtta agtcctttgg acctgatcag 421 cttgatacaa gaactactga tttcaacttc tttggcttaa ttctctcgga aacgatgaaa 481 tatacaagtt atatcttggc ttttcagctc tgcatcgttt tgggttctct tggctgttac 541 tgccaggacc catatgtaaa agaagcagaa aaccttaaga aatattttgt aagtatgact 601 ttttaatagt acttgtttgt ggttgaaaat gactgaatat cgacttgctg tagcatctct 661 gataggctgt catctcttgt aggcagtcat tttgagattt ggtgttattt tgttaattat 721 tgactagatg agttccttga ctaaataatc tagatattgt tttaaccttc tgctcagttt 781 gtatagagac ttaaaaggga tttatgaatt ttccaaaaga tgggcataat atgggtatga 841 agcataatga tgttaataat tttgtggtgg gaactcattc agttgtgata gtcaaggagt 901 atgcagattg aaaaaaatga ttggttatta gtttttgact tctcagactc taaggtcaag 961 attagcatta aaaaggtaat aggaaatgtt tacaaattaa agtcaaaaag gtccttaaag 1021 ctttggctta aaaaaataac tgataggtga ttttctccaa aaagtgattt caacattctg 1081 cttctctatc tatattactt gtgaagtatt ccggaacttc gttgctcact gggattttgg 1141 aagaattatg attctggcta aggaatgttt aaaaatttta agtgaatttt ttgagtttct 1201 tttaaaattt tattgatggt taatgaaaag tttttacatt ttaaatattt cattatttgt 1261 ttaaaactta gctgttataa ttatagctgt cataataata ttcagacatt cacaattgat 1321 tttattctta caacacaaaa tcaaatctca cacacacaca cacacacaca cactcgcaca 1381 tgtttggaac tatcttttaa agctcgtata ataataccct acaggaaggc acagtagatg 1441 taatagaaac ctgtaccatt ggggggcagt attttatagt ggggtggctt tgctgttttt 1501 tgtttttgta ttttttagcc tagcttgaaa atactttctt tagcttacta tagtttttgg 1561 gacctttgga gtatcagctt tgttgagctc atttgtgaca ttgcaattta atggttatat 1621 tgggaaataa aaaagctaaa agaacataat agtctttgtc tatatctcac ataagccttt 1681 tgggaatact tattgttaga actaagcaga agagttgaaa aggaaatcag tgaatattgt 1741 cacatctgag ttcaatgaaa cttgaaatat atttttaagg caatttatgg gctaattgta 1801 aaccaatttt ttcttttttt tttttagaat gcaggtcatt cagatgtagc ggataatgga 1861 actcttttct taggcatttt gaagaattgg aaagaggtaa gctgaatatt cccatttggc 1921 taattttcct gttgcttgct ttctgatgga taaattcaca tcatcctctg tttgtgctct 1981 ttccttccaa ggagagtgac agaaaaataa tgcagagcca aattgtctcc ttttacttca 2041 aactttttaa aaactttaaa gatgaccaga gcatccaaaa gagtgtggag accatcaagg 2101 aagacatgaa tgtcaagttt ttcaatagca acaaaaagaa acgagatgac ttcgaaaagc 2161 tgactaatta ttcggtgagg ctatttaaat tctttctttg gtttcattgc cgagggtctt 2221 gcaaagcatt tattctccag aaagtagaca ttagctattt aacagttgct aaagctatga 2281 actcaactca tggctgaaac tctaccttac tatttccatt cgtgtttggg tgactttgca 2341 aagccagtaa gagaatcgct gaagtatgta atgtagagaa atgctggcat tgtaactatt 2401 gcgtaaagac aggtgagttg acaaattcca gtgaagagga agtaggtgag gaagaagcag 2461 ggagtactga gaagcagttc tctcattgtc ccttgctcat atgatggaaa ttctcttact 2521 ttgaatgaga ggctgtctgt cttaatggaa agagcagtgg gaggagctga gaagatgtgt 2581 gttctcctcc caactcagcc accaaggaac tgtgatgaat cacatggctg gctgggctca 2641 gtttcctcat cttaaaagga aactgttagg ttcactgtat aagtttgatg accttctttg 2701 ctccaaaact ctacaatgca aagaatagaa aatgagaatg agatagaaga aagctacagt 2761 ctttgaatag gtaccaggga caccccactg caagtctcta gccaacctat cagattgtac 2821 tgcccaatta gaagcaagaa tggttgctgt ttgtttgttt ttagggaaaa atagatagaa 2881 tttatacctt atgaaaagat tgttctatca actctctatc aactttcaga atatctcagc 2941 tggagaactc cttagactcc taagtcttac ctcatgaact tgtatcttta agttatggct 3001 tctataaaca gaaagataac gttgaggcat aaagacaaat catgtttttc agaatgtttt 3061 ctagaagaca aaggcctcta gattcctttg gggttgactt tgatataaat gggctcaaat 3121 gagagggacc agggtcttca agctagcatt tgtgttctta ggatatgtgc tcagctttca 3181 ctattgctgg gcctgcctct cactcctctc atgtaagccc ccagaaacag aaaggagaga 3241 catggcaaca ggtctccttt ggttataaac tagacactca gcacttgttt ctaatccagt 3301 ggtgcccctg gcttactgtt cagtcctgga taagtctctt agtttcttgg tgatgatttg 3361 aacattggaa agtaaaatct gtcacttgca aacacacagc ttgtcgaaaa ttttttctac 3421 tctgcaggaa ctgggcctta aaaaaatgaa aaaaaatctg tggtttcttc cttctggaag 3481 ctacaaacct cctgtttctt gatgggcaat cttgagtgag ctctattaat tattattctc 3541 tttggctcag ttgctaagct attttatgca tgttatgccc tttgacaatt agtctttagc 3601 tgtaatcccc cagccatcct cagaaatgtg gtgaggtagc catagtgttc ccaagattag 3661 aaaaatgtaa tggcagagcc aagaggaagg taaatggtcc acatcttatg aagcatcatc 3721 taaatggccc tattggttag agtgaggaga tgcaagtagt tcaatttgct tgcctagaag 3781 gcagggtact ggaaaagttg ttgcaattct taattttaaa ctttatatat cagtaagcca 3841 tatataaata tgattggggg tgtttatttt aaaatctatt atggaaattg agagactgac 3901 ctaatctggg agaaattaaa aattacagtt ttcactcgtt ttggatttgg tgttttctag 3961 ggtacctaac ctagatcagt ggttctcaaa cttaggtgga tgtcagaatc acctggggag 4021 cttagtgaat gcacagggca cagtccttcc acttcatgca cctggatctc tgaggtcttt 4081 gacaggtttc cggattaatc tgctatgcac aacagtgaga atcattgacc tatagttact 4141 catttgatgc atacaggaaa gactgaagta taaagtgata taattggtag attgatgata 4201 gagaggtcat agaaacagtc tcatcctcct ttagatgaga aaatagaagt tcagagaggt 4261 taagtagctg gctcaaggtc agaattattg catgcatgag attcaaaccc acctttttat 4321 gctgactcca caaccaggag tcttttcact atataatttc aagaattcta tagaagtaga 4381 tttaaagata tgtgatggac tccaccacat tatagcacaa ctagaaatgt aattgtaatt 4441 tttagcttca actgctgaag aagtaaatat tgtatattaa ggtaatacgg tccatttttt 4501 aaaggaatac ttttattttc actgaccatc atgacattag cagaatatcc tgatggctta 4561 tatgcctgaa attaattttg ctcttttctt tcccgatagg taactgactt gaatgtccaa 4621 cgcaaagcaa tacatgaact catccaagtg atggctgaac tgtcgccagc agctaaaaca 4681 gggaagcgaa aaaggagtca gatgctgttt cgaggtcgaa gagcatccca gtaatggttg 4741 tcctgcctgc aatatttgaa ttttaaatct aaatctattt attaatattt aacattattt 4801 atatggggaa tatattttta gactcatcaa tcaaataagt atttataata gcaacttttg 4861 tgtaatgaaa atgaatatct attaatatat gtattattta taattcctat atcctgtgac 4921 tgtctcactt aatcctttgt tttctgacta attaggcaag gctatgtgat tacaaggctt 4981 tatctcaggg gccaactagg cagccaacct aagcaagatc ccatgggttg tgtgtttatt 5041 tcacttgatg atacaatgaa cacttataag tgaagtgata ctatccagtt actgccggtt 5101 tgaaaatatg cctgcaatct gagccagtgc tttaatggca tgtcagacag aacttgaatg 5161 tgtcaggtga ccctgatgaa aacatagcat ctcaggagat ttcatgcctg gtgcttccaa 5221 atattgttga caactgtgac tgtacccaaa tggaaagtaa ctcatttgtt aaaattatca 5281 atatctaata tatatgaata aagtgtaagt tcacaactac ttatgctgtg ttggactttt 5341 tctaagtgag acctggagtg aaagaactac ctattaatga attagtaggg aggggagtct 5401 tcttagctgt gaaaatttta gagttgcatt tggttccatt aaatgtggta tttctttcca 5461 ctagcatttt gttggctttc gcttttccag ttagcagctc tttgaattat ctttctaaga 5521 tacagattta attatgtcac tattcaattc agaggttctg ctatggaatg tagtttaaac 5581 tgcttagctt ggcacacaga gatttatttc tagccccttc tccaccttcc tatttcctcc 5641 ttcgtttcag aatcttcctc tccctcatcc aatgctggca aacaccagtg ggggtggagt 5701 agtgggtgta agctctaggg agaaggcttg gattggaatc caagttattc cattacaagt 5761 agtgtgacct ttaatacatt atgtatattg tctaagtttc agctttattg tctgaaaaag 5821 aaaaataatt gtgtgttcct cataatattg tggtacgaat tgattctttc actcaagaaa 5881 tatttactgg agtacctact acatgcctgg tgctgttgta gaccttgaga taccttactc 5941 aagcaaaaca gccaaggatc c //