GenBank-Updates@genbank.bio.net (09/05/90)
LOCUS HUMIFNG 5961 bp ds-DNA PRI 05-SEP-1990
DEFINITION Human immune interferon (IFN-gamma) gene and flanks.
ACCESSION J00219 M37265
KEYWORDS gamma-interferon; interferon.
SOURCE Human DNA and cDNA to mRNA (see comment).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 366 to 588; 1828 to 1896; 1992 to 2174; 4600 to 5318)
AUTHORS Gray,P.W., Leung,D.W., Pennica,D., Yelverton,E., Najarian,R.,
Simonsen,C.C., Derynck,R., Sherwood,P.J., Wallace,D.M.,
Berger,S.L., Levinson,A.D. and Goeddel,D.V.
TITLE Expression of human immune interferon cDNA in E.coli and monkey
cells
JOURNAL Nature 295, 503-508 (1982)
STANDARD full staff_review
REFERENCE 2 (bases 384 to 588; 1828 to 1897; 4598 to 5312)
AUTHORS Devos,R., Cheroutre,H., Taya,Y., Degrave,W., van Heuverswyn,H. and
Fiers,W.
TITLE Molecular cloning of human immune interferon cDNA and its
expression in eukaryotic cells
JOURNAL Nucleic Acids Res. 10, 2487-2501 (1982)
STANDARD full staff_review
REFERENCE 3 (bases 167 to 708; 1779 to 2259; 4592 to 5396)
AUTHORS Taya,Y., Devos,R., Tavernier,J., Cheroutre,H., Engler,G. and
Fiers,W.
TITLE Cloning and structure of the human immune interferon-gamma
chromosomal gene
JOURNAL EMBO J. 1, 953-958 (1982)
STANDARD full staff_review
REFERENCE 4 (bases 347 to 483)
AUTHORS Derynck,R., Leung,D.W., Gray,P.W. and Goeddel,D.V.
TITLE Human interferon gamma is encoded by a single class of mRNA
JOURNAL Nucleic Acids Res. 10, 3605-3615 (1982)
STANDARD full staff_review
REFERENCE 5 (bases 1 to 5961)
AUTHORS Gray,P.W. and Goeddel,D.V.
TITLE Structure of the human immune interferon gene
JOURNAL Nature 298, 859-863 (1982)
STANDARD full staff_review
REFERENCE 6 (bases 4720 to 5319)
AUTHORS Derynck,R., Singh,A. and Goeddel,D.V.
TITLE Expression of the human interferon-gamma cDNA in yeast
JOURNAL Nucleic Acids Res. 11, 1819-1837 (1983)
STANDARD full staff_review
REFERENCE 7 (bases 1 to 5961)
AUTHORS Gray,P.W. and Goeddel,D.V.
TITLE Human immune interferon (IFN-gamma) gene sequence and structure
JOURNAL Basic Life Sci. 25, 35-61 (1983)
STANDARD simple staff_entry
COMMENT Immune interferon (IFN-gamma) shows little homology with leukocyte
(IFN-alpha) and fibroblast (IFN-beta) interferons. See other loci
beginning <HUMIFN>. IFN-gamma protein (35,000 to 70,000 mw as
presently estimated) has both antiviral and antitumorigenic
capabilities. Unlike the other interferons, its gene has three
intervening sequences, the first of which contains a repetitive
element. [4],[5] argue that there is only one IFN-gamma gene per
haploid genome. [3] analyzes the promoter region and reports two
sequences homologous to sequences in the promoter regions of
chicken albumin and the human IFN-beta genes(bases 234-241;
276-289). [6] studies the IFN-gamma sequence recombined to the pgk
promoter segment of yeast (see <HUMIFNGYST>).
Complete source information: Human DNA ([3],[4],[5],[7]) and cDNA
to mRNA ([1],[2],[4],[6]).
FEATURES from to/span description
pept 475 588 interferon-gamma, exon 1
/hgml_locus_uid="LV0085W" /nomgen="IFNG"
/map="12q24.1"
1828 1896 interferon-gamma, exon 2
1992 2174 interferon-gamma, exon 3
4600 4734 interferon-gamma, exon 4
sigp 478 534 signal peptide
pre-msg 347 4919 IFN-gamma mRNA (alt.) [5],[6]
pre-msg 347 5319 IFN-gamma mRNA (alt.) [1],[2],[4],[5]
pre-msg 350 4919 IFN-gamma mRNA (alt.) [3],[6]
pre-msg 350 5319 IFN-gamma mRNA (alt.) [1],[2],[3],[4]
IVS 589 1827 IFN-gamma intron A
IVS 1897 1991 IFN-gamma intron B
IVS 2175 4599 IFN-gamma intron C
variant 4712 4712 a in [1]; g in [2],[3],[5]
BASE COUNT 1829 a 1012 c 1170 g 1950 t
ORIGIN 300bp upstream from mst-ii site, on 8.6kb bamh-i fragment.
1 agcaaatgat caatgtgctt tgtgaatgaa gagtcaacat tttaccaggg cgaagtgggg
61 aggtacaaaa aaatttccag tccttgaatg gtgtgaagta aaagtgcctc aaagaatccc
121 accagaatgg cacaggtggg cataatgggt ctgtctcatc gtcaaaggac ccaaggagtc
181 taaaggaaac tctaactaca acacccaaat gccacaaaac cttagttatt aatacaaact
241 atcatccctg cctatctgtc accatctcat cttaaaaaac ttgtgaaaat acgtaatcct
301 caggagactt caattaggta taaataccag cagccagagg aggtgcagca cattgttctg
361 atcatctgaa gatcagctat tagaagagaa agatcagtta agtcctttgg acctgatcag
421 cttgatacaa gaactactga tttcaacttc tttggcttaa ttctctcgga aacgatgaaa
481 tatacaagtt atatcttggc ttttcagctc tgcatcgttt tgggttctct tggctgttac
541 tgccaggacc catatgtaaa agaagcagaa aaccttaaga aatattttgt aagtatgact
601 ttttaatagt acttgtttgt ggttgaaaat gactgaatat cgacttgctg tagcatctct
661 gataggctgt catctcttgt aggcagtcat tttgagattt ggtgttattt tgttaattat
721 tgactagatg agttccttga ctaaataatc tagatattgt tttaaccttc tgctcagttt
781 gtatagagac ttaaaaggga tttatgaatt ttccaaaaga tgggcataat atgggtatga
841 agcataatga tgttaataat tttgtggtgg gaactcattc agttgtgata gtcaaggagt
901 atgcagattg aaaaaaatga ttggttatta gtttttgact tctcagactc taaggtcaag
961 attagcatta aaaaggtaat aggaaatgtt tacaaattaa agtcaaaaag gtccttaaag
1021 ctttggctta aaaaaataac tgataggtga ttttctccaa aaagtgattt caacattctg
1081 cttctctatc tatattactt gtgaagtatt ccggaacttc gttgctcact gggattttgg
1141 aagaattatg attctggcta aggaatgttt aaaaatttta agtgaatttt ttgagtttct
1201 tttaaaattt tattgatggt taatgaaaag tttttacatt ttaaatattt cattatttgt
1261 ttaaaactta gctgttataa ttatagctgt cataataata ttcagacatt cacaattgat
1321 tttattctta caacacaaaa tcaaatctca cacacacaca cacacacaca cactcgcaca
1381 tgtttggaac tatcttttaa agctcgtata ataataccct acaggaaggc acagtagatg
1441 taatagaaac ctgtaccatt ggggggcagt attttatagt ggggtggctt tgctgttttt
1501 tgtttttgta ttttttagcc tagcttgaaa atactttctt tagcttacta tagtttttgg
1561 gacctttgga gtatcagctt tgttgagctc atttgtgaca ttgcaattta atggttatat
1621 tgggaaataa aaaagctaaa agaacataat agtctttgtc tatatctcac ataagccttt
1681 tgggaatact tattgttaga actaagcaga agagttgaaa aggaaatcag tgaatattgt
1741 cacatctgag ttcaatgaaa cttgaaatat atttttaagg caatttatgg gctaattgta
1801 aaccaatttt ttcttttttt tttttagaat gcaggtcatt cagatgtagc ggataatgga
1861 actcttttct taggcatttt gaagaattgg aaagaggtaa gctgaatatt cccatttggc
1921 taattttcct gttgcttgct ttctgatgga taaattcaca tcatcctctg tttgtgctct
1981 ttccttccaa ggagagtgac agaaaaataa tgcagagcca aattgtctcc ttttacttca
2041 aactttttaa aaactttaaa gatgaccaga gcatccaaaa gagtgtggag accatcaagg
2101 aagacatgaa tgtcaagttt ttcaatagca acaaaaagaa acgagatgac ttcgaaaagc
2161 tgactaatta ttcggtgagg ctatttaaat tctttctttg gtttcattgc cgagggtctt
2221 gcaaagcatt tattctccag aaagtagaca ttagctattt aacagttgct aaagctatga
2281 actcaactca tggctgaaac tctaccttac tatttccatt cgtgtttggg tgactttgca
2341 aagccagtaa gagaatcgct gaagtatgta atgtagagaa atgctggcat tgtaactatt
2401 gcgtaaagac aggtgagttg acaaattcca gtgaagagga agtaggtgag gaagaagcag
2461 ggagtactga gaagcagttc tctcattgtc ccttgctcat atgatggaaa ttctcttact
2521 ttgaatgaga ggctgtctgt cttaatggaa agagcagtgg gaggagctga gaagatgtgt
2581 gttctcctcc caactcagcc accaaggaac tgtgatgaat cacatggctg gctgggctca
2641 gtttcctcat cttaaaagga aactgttagg ttcactgtat aagtttgatg accttctttg
2701 ctccaaaact ctacaatgca aagaatagaa aatgagaatg agatagaaga aagctacagt
2761 ctttgaatag gtaccaggga caccccactg caagtctcta gccaacctat cagattgtac
2821 tgcccaatta gaagcaagaa tggttgctgt ttgtttgttt ttagggaaaa atagatagaa
2881 tttatacctt atgaaaagat tgttctatca actctctatc aactttcaga atatctcagc
2941 tggagaactc cttagactcc taagtcttac ctcatgaact tgtatcttta agttatggct
3001 tctataaaca gaaagataac gttgaggcat aaagacaaat catgtttttc agaatgtttt
3061 ctagaagaca aaggcctcta gattcctttg gggttgactt tgatataaat gggctcaaat
3121 gagagggacc agggtcttca agctagcatt tgtgttctta ggatatgtgc tcagctttca
3181 ctattgctgg gcctgcctct cactcctctc atgtaagccc ccagaaacag aaaggagaga
3241 catggcaaca ggtctccttt ggttataaac tagacactca gcacttgttt ctaatccagt
3301 ggtgcccctg gcttactgtt cagtcctgga taagtctctt agtttcttgg tgatgatttg
3361 aacattggaa agtaaaatct gtcacttgca aacacacagc ttgtcgaaaa ttttttctac
3421 tctgcaggaa ctgggcctta aaaaaatgaa aaaaaatctg tggtttcttc cttctggaag
3481 ctacaaacct cctgtttctt gatgggcaat cttgagtgag ctctattaat tattattctc
3541 tttggctcag ttgctaagct attttatgca tgttatgccc tttgacaatt agtctttagc
3601 tgtaatcccc cagccatcct cagaaatgtg gtgaggtagc catagtgttc ccaagattag
3661 aaaaatgtaa tggcagagcc aagaggaagg taaatggtcc acatcttatg aagcatcatc
3721 taaatggccc tattggttag agtgaggaga tgcaagtagt tcaatttgct tgcctagaag
3781 gcagggtact ggaaaagttg ttgcaattct taattttaaa ctttatatat cagtaagcca
3841 tatataaata tgattggggg tgtttatttt aaaatctatt atggaaattg agagactgac
3901 ctaatctggg agaaattaaa aattacagtt ttcactcgtt ttggatttgg tgttttctag
3961 ggtacctaac ctagatcagt ggttctcaaa cttaggtgga tgtcagaatc acctggggag
4021 cttagtgaat gcacagggca cagtccttcc acttcatgca cctggatctc tgaggtcttt
4081 gacaggtttc cggattaatc tgctatgcac aacagtgaga atcattgacc tatagttact
4141 catttgatgc atacaggaaa gactgaagta taaagtgata taattggtag attgatgata
4201 gagaggtcat agaaacagtc tcatcctcct ttagatgaga aaatagaagt tcagagaggt
4261 taagtagctg gctcaaggtc agaattattg catgcatgag attcaaaccc acctttttat
4321 gctgactcca caaccaggag tcttttcact atataatttc aagaattcta tagaagtaga
4381 tttaaagata tgtgatggac tccaccacat tatagcacaa ctagaaatgt aattgtaatt
4441 tttagcttca actgctgaag aagtaaatat tgtatattaa ggtaatacgg tccatttttt
4501 aaaggaatac ttttattttc actgaccatc atgacattag cagaatatcc tgatggctta
4561 tatgcctgaa attaattttg ctcttttctt tcccgatagg taactgactt gaatgtccaa
4621 cgcaaagcaa tacatgaact catccaagtg atggctgaac tgtcgccagc agctaaaaca
4681 gggaagcgaa aaaggagtca gatgctgttt cgaggtcgaa gagcatccca gtaatggttg
4741 tcctgcctgc aatatttgaa ttttaaatct aaatctattt attaatattt aacattattt
4801 atatggggaa tatattttta gactcatcaa tcaaataagt atttataata gcaacttttg
4861 tgtaatgaaa atgaatatct attaatatat gtattattta taattcctat atcctgtgac
4921 tgtctcactt aatcctttgt tttctgacta attaggcaag gctatgtgat tacaaggctt
4981 tatctcaggg gccaactagg cagccaacct aagcaagatc ccatgggttg tgtgtttatt
5041 tcacttgatg atacaatgaa cacttataag tgaagtgata ctatccagtt actgccggtt
5101 tgaaaatatg cctgcaatct gagccagtgc tttaatggca tgtcagacag aacttgaatg
5161 tgtcaggtga ccctgatgaa aacatagcat ctcaggagat ttcatgcctg gtgcttccaa
5221 atattgttga caactgtgac tgtacccaaa tggaaagtaa ctcatttgtt aaaattatca
5281 atatctaata tatatgaata aagtgtaagt tcacaactac ttatgctgtg ttggactttt
5341 tctaagtgag acctggagtg aaagaactac ctattaatga attagtaggg aggggagtct
5401 tcttagctgt gaaaatttta gagttgcatt tggttccatt aaatgtggta tttctttcca
5461 ctagcatttt gttggctttc gcttttccag ttagcagctc tttgaattat ctttctaaga
5521 tacagattta attatgtcac tattcaattc agaggttctg ctatggaatg tagtttaaac
5581 tgcttagctt ggcacacaga gatttatttc tagccccttc tccaccttcc tatttcctcc
5641 ttcgtttcag aatcttcctc tccctcatcc aatgctggca aacaccagtg ggggtggagt
5701 agtgggtgta agctctaggg agaaggcttg gattggaatc caagttattc cattacaagt
5761 agtgtgacct ttaatacatt atgtatattg tctaagtttc agctttattg tctgaaaaag
5821 aaaaataatt gtgtgttcct cataatattg tggtacgaat tgattctttc actcaagaaa
5881 tatttactgg agtacctact acatgcctgg tgctgttgta gaccttgaga taccttactc
5941 aagcaaaaca gccaaggatc c
//