GenBank-Updates@genbank.bio.net (09/05/90)
LOCUS HUMAMYB01 1152 bp ds-DNA PRI 05-SEP-1990
DEFINITION Human amyloid-beta protein gene, exon 1.
ACCESSION M34862
KEYWORDS amyloid-beta protein.
SEGMENT 1 of 19
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites; intron/exon boundaries)
AUTHORS Yoshikai,S.-i., Sasaki,H., Doh-ura,K., Furuya,H. and Sakaki,Y.
TITLE Genomic organization of the human amyloid beta-protein precursor
gene
JOURNAL Gene 87, 257-263 (1990)
STANDARD full staff_entry
REFERENCE 2 (bases 1 to 1152)
AUTHORS Yoshikai,S.-i., Sasaki,H., Doh-ura,K., Furuya,H. and Sakaki,Y.
JOURNAL Unpublished (1990)
STANDARD full staff_entry
COMMENT Computer-readable sequence for [1] kindly submitted by Y.Sakaki,
27-AUG-1990.
FEATURES from to/span description
pept 980 + 1036 amyloid-beta protein, exon 1
pep$ 980 + 1036 amyloid-beta protein (alt), exon 1
pre-msg 834 > 1152 amyloid-beta protein mRNA and introns
IVS 1037 > 1152 amyloid-beta protein intron A
binding 484 490 API- binding site
binding 789 795 API- binding site
site 517 530 heat shock element
BASE COUNT 237 a 366 c 340 g 209 t
ORIGIN
1 gatctctcct aatttttcct tcttccccaa ctcagatgga tgttacatcc ctgcttaaca
61 acaaaaaaag accccccgcc ccgcaaaatc cacactgacc acccccttta acaaaacaaa
121 accaaaaaca aacaaaaata taagaaagaa acaaaaccca agcccagaac cctgctttca
181 agaagaagta aatgggttgg ccgcttcttt gccaggtcct gcgccttgct cctttggttc
241 gttctaaaga tagaaattcc aggttgctcg tgcctgcttt tgacgttggg ggttaaaaaa
301 tgaggttttg ctgtctcaac aagcaaagaa aatcctattt cctttaagct tcactcgttc
361 tcattctctt ccagaaacgc ctgccccacc tctccaaacc gagagaaaaa acgaaatgcg
421 gataaaaacg caccctagca gcagtccttt atacgacacc cccgggaggc ctgcggggtc
481 ggatgattca agctcacggg gacgagcagg agcgctctcg acttttctag agcctcagcg
541 tcctaggact cacctttccc tgatcctgca ccgtccctct cctggcccca gactctccct
601 cccactgttc acgaagccca ggtggccgtc ggccggggag cggagggggc gcgtggggtg
661 caggcggcgc caaggcgctg cacctgtggg cgcggggcga gggcccctcc cggcgcgagc
721 gggcgcagtt ccccggcggc gccgctaggg gtctctctcg ggtgccgagc ggggtgggcc
781 ggatcagctg actcgcctgg ctctgagccc cgccgccgcg ctcgggctcc gtcagtttcc
841 tcggcagcgg taggcgagag cacgcggagg agcgtgcgcg gggccccggg agacggcggc
901 ggtggcggcg cgggcagagc aaggacgcgg cggatcccac tcgcacagca gcgcactcgg
961 tgccccgcgc agggtcgcga tgctgcccgg tttggcactg ctcctgctgg ccgcctggac
1021 ggctcgggcg ctggaggtgg gtgccgcgcc tcggaagggg ggggaggctg cacggtgggg
1081 acgcgatacc ccccaagacc ttaacccaag tctttaatgc agagaagccg ggggtccgtc
1141 aatgggaccc ct
//