GenBank-Updates@genbank.bio.net (09/02/90)
LOCUS YSCPAHMA 5798 bp ds-DNA PLN 02-SEP-1990
DEFINITION S.cerevisiae.
ACCESSION M36822
KEYWORDS negative regulator; paired amphipathic helix motifs.
SOURCE S.cerevisiae (strain GRF88) DNA.
ORGANISM Saccharomyces cerevisiae
Eukaryota; Plantae; Thallobionta; Eumycota; Hemiascomycetes;
Endomycetales; Saccharomycetaceae.
REFERENCE 1 (bases 1 to 5798)
AUTHORS Wang,H., Clark,I., Nicholson,P.R., Herskowitz,I. and Stillman,D.J.
TITLE the saccharomyces cerevisiae sin3 gene, a negative regulator of ho,
contains four paired amphipathic helix motifs
JOURNAL Unpublished (1990)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [1] kindly submitted
by D.J.Stillman, 20-JUL-1990.
Author address:
University of Utah, School of Medicine,
Dept. of Cellular, Viral and Molecular Biology,
Salt Lake City, Utah 84132
Stillman@bioscience.biology.utah.edu
SIN3 is a negative regulator of HO expression. sin3- was isolated
as a suppressor of SWI5, permitting HO expression in a swi5-
mutant. The normal asymmetric pattern of of HO expression is
altered in sin3- mutants. Homozygous sin3- diploids are
sporulation defective. The SIN3 protein is nuclear localized.
The predicted SIN3 protein contains four copies of a paired
amphipathic helix motif similar to those seen in the TPR proteins
(SSN6, CDC16, CDC23, SKI3, and nuc2) and the HLH proteins
(myc, myoD, etc).
FEATURES from to/span description
pept 1057 5673 SIN3 open reading frame
pre-msg 836 > 5673 SIN3 mRNA and introns
pre-msg 850 > 5673 SIN3 mRNA and introns
pre-msg 852 > 5673 SIN3 mRNA and introns
pre-msg 855 > 5673 SIN3 mRNA and introns
pre-msg 858 > 5673 SIN3 mRNA and introns
pre-msg 859 > 5673 SIN3 mRNA and introns
pre-msg 861 > 5673 SIN3 mRNA and introns
signal 422 433 REB1 protein binding site
signal 448 457 REB1 protein binding site
signal 685 694 REB1 protein binding site
signal 711 720 REB1 protein binding site
site 1771 1912 paired amphipathic helix motif
site 2332 2473 paired amphipathic helix motif
site 3097 3238 paired amphipathic helix motif
site 4516 4663 paired amphipathic helix motif
site 2494 2620 glutamine rich region
BASE COUNT 1846 a 1215 c 1148 g 1589 t
ORIGIN Chromosome XV.
1 aagcttgtta atgatgctgt tacaggcgtt tttcaaggca tccttcgggt cgtagccctc
61 ggtggtctgt attctcagct tgaaacgagc gaagaaggga tgctcaacct tgtaagcggc
121 aaacagcact tttctgtcgt tcagaagttc tgcacgaatc aggtttccca acgtgtggtc
181 ctccttctca aacgttatca ctactgcgtt gggggctttg gtgtcggggt caatctttag
241 cttggattcc ccttcaccca gaaggaacag ttcgaatctg tctggagcat tcatgatgca
301 gttgtgtcca aatgtatctg gtttggtggc tacgtagcta tctatttagg ctgcacggct
361 cagttctctc gctcttcttt taacggacct cttgtgtgtg ccaaagcagt gaacctagaa
421 ttttcgcgga cacttccact ttattaagtc cgggtaatga taatattgag cttgcaagtt
481 ttttgaactc ggatagcagc attatccatg acatgacacg gatctaccga cgaggcttac
541 cgacgaggct taccgacgag gcttaccgtg atccctctcc agtagtctgt aaattctgtt
601 tataatttaa aaaatctatc ttctactcca gtcttgtaac tactgttgtt acgcgctgcc
661 cagagtgtgg cacacactgc ggggttaccc gtgtaacgta gaataaacca gtacgggtaa
721 tgatatcgga ttttctagtg atttttttcc attcgcaaaa aagtcgcctt cattttgcag
781 ttcttcagca aacgtgattt gcaaaacaac ggttactccc cttccctatt acatttgtct
841 tccctttttc gcaccagcat tgctaatatt cgaggcaccg tacctaacta atcagctcat
901 tcacgtacca catattcttt gttacttccc tccctccaca acaggctacg ctattgaccg
961 ctttcagtat agtctcttta cccttttgtt gtgttcgttt gaggttattt ggaaaaggac
1021 aaaatatcta agaaacaagt tatacattgt acaaaaatgt cacaggtttg gcataattcg
1081 aattcgcaat caaacgatgt ggctacttca aatgacgcta cgggttccaa cgaaagaaac
1141 gaaaaagaac cgtccctcca gggaaataag cccggttttg ttcaacagca gcaacggatt
1201 actttaccct cgctatctgc cttgagtact aaggaggaag atagaagaga ttccaatggc
1261 caacaggctc taacttctca tgctgctcac atattaggtt atcctccccc acattcaaat
1321 gctatgccct caattgcaac tgattcagca ttgaaacagc cccacgagta tcaccctcgc
1381 cctaaatctt cgtcctcttc tccctctata aacgcttcgc ttatgaatgc tggtccagct
1441 cccctcccca cagtgggagc cgccagtttt tctttgtcga gatttgacaa tccattaccg
1501 ataaaagctc ctgttcatac agaggaacca aaaagttata atggtcttca ggaagaagaa
1561 aaggcgacgc aacggcctca agattgcaag gaagttcccg ctggtgtgca gcctgctgat
1621 gcccctgacc ctagcagcaa ccatgcagat gctaacgatg acaataataa caacgaaaat
1681 tctcacgatg aagatgctga ctacagacct ctaaacgtga aggatgccct atcttacctc
1741 gaacaggtca aatttcaatt tagttcgcgt ccggatatct ataatttatt tttagatatt
1801 atgaaggact ttaaatctca ggcaatagac acaccgggcg ttattgaaag agtatccact
1861 ttgttcagag gttatccaat tttgattcaa gggttcaata cttttctacc ccaaggctat
1921 agaatcgaat gctcctctaa tccggacgac cccattagag ttactacacc aatgggtact
1981 acgacagtaa acaataacat cagtccatct ggtagaggta caacggatgc acaggaactt
2041 ggttcttttc cagaaagcga tggaaatggt gttcaacagc cctccaatgt gccaatggtg
2101 ccttcgagtg tgtatcaatc ggaacaaaac caagaccaac aacaatcttt gcctctttta
2161 gctacttctt ctggtttacc ttcaattcaa caacctgaaa tgcctgcaca tcgccaaatc
2221 ccacaaagtc aatctttagt gcctcaagaa gatgctaaga aaaacgttga tgtcgaattt
2281 agtcaagcca taagctacgt taataaaatt aaaactagat ttgccgacca acctgatatt
2341 tacaagcatt ttctggaaat actacaaact tatcagcgag agcaaaagcc aataaacgaa
2401 gtctacgcac aagtgacgca tcttttccaa aatgctcctg atttactaga agatttcaag
2461 aaattcttgc cggactcttc agcttctgcc aatcagcagg tgcaacatgc tcagcaacat
2521 gctcaacaac aacatgaggc ccaaatgcat gcacaggcac aagctcaggc tcaggcacag
2581 gcacaggcac aggtggaaca acagaagcag caacagcaat tcttgtatcc agcttcgggc
2641 tattacggcc atccttctaa ccgaggtatt ccacagcaaa acttgcctcc tataggaagc
2701 ttctcgcctc caacaaacgg ttcgaccgta catgaagcct atcaggatca acagcacatg
2761 caaccacccc acttcatgcc cttaccatcg atcgttcaac acgggccaaa tatggtacat
2821 caagggatag cgaatgaaaa tccacctcta tcagatctaa gaacgtctct cactgaacag
2881 tacgctcctt ctagtataca acatcagcag cagcacccgc aaagtattag tcctatagca
2941 aatacgcagt atggtgatat ccctgttaga ccggaaattg atttagatcc tagcattgtg
3001 cctgtggtcc ctgaacccac tgagcccatc gaaaacaata tatcgcttaa tgaggaagtc
3061 actttcttcg aaaaggccaa gaggtatatc ggcaataaac atttatacac tgagtttttg
3121 aaaattttaa atttgtactc tcaagatata cttgatcttg acgatttagt ggaaaaggta
3181 gatttctact tgggttccaa taaagaacta tttacgtggt tcaaaaactt tgttggctac
3241 caagaaaaaa ccaaatgtat cgagaatatt gttcatgaaa aacatagatt ggatttagat
3301 ttatgtgagg catttggccc aagttacaag aggctaccaa aaagtgacac tttcatgcca
3361 tgctcaggta gggatgatat gtgttgggaa gtcttgaacg atgaatgggt tggacatcct
3421 gtatgggctt ccgaagattc gggatttatt gctcatcgta aaaaccagta tgaggaaaca
3481 ctattcaaga tcgaagagga aagacatgag tatgattttt acattgaatc aaatttaaga
3541 actattcaat gtttggaaac aattgtaaat aagatcgaga acatgactga gaatgaaaaa
3601 gccaatttta aactgcctcc aggtcttggc catacttcaa tgactattta taaaaaagtg
3661 ataaggaaag tttatgataa ggaaaggggg ttcgagatta ttgatgcttt gcatgagcac
3721 cctgcagtga cagccccagt cgttctgaaa aggttaaagc aaaaagacga agaatggaga
3781 agagctcaac gtgaatggaa taaagtttgg agggagttag aacagaaggt ttttttcaag
3841 tcattagatc atttaggctt aacatttaaa caggctgaca agaaattatt aactacaaag
3901 cagttgatat cagagattag cagcatcaaa gttgatcaaa caaacaaaaa aattcactgg
3961 ttaactccta aaccaaagag ccagttagat tttgatttcc ctgataaaaa cattttctat
4021 gatatcttgt gtttggctga cacttttata acccatacca cagcctattc taatcccgat
4081 aaagaaagat tgaaagattt actaaaatac ttcatctctt tgtttttttc tatttctttc
4141 gaaaaaatcg aagaatcgtt gtactcccat aagcaaaacg tgtcagaatc tagcggatct
4201 gacgatggca gttctattgc atcaaggaag aggccctatc aacaagaaat gagtttactt
4261 gatattttac acaggagcag atatcaaaag ctaaagcgtt ctaatgatga agatggcaaa
4321 gttccccagc tctctgaacc acccgaagaa gaacctaata ccattgagga ggaagagctc
4381 atcgatgaag aagctaaaaa tccgtggcta actgggaatt tagtggagga agcaaactct
4441 cagggtatta tccaaaatcg cagtattttt aatctattcg ctaatacgaa tatttacata
4501 tttttccgtc attggacaac gatttatgag cggcttttgg aaattaagca aatgaatgaa
4561 agggtcacaa aggaaatcaa cacaaggtcg acagttactt ttgccaaaga tctagattta
4621 ttatcgagtc aactttccga aatgggacta gattttgttg gtgaagacgc gtacaaacag
4681 gttttaagac tgagtagaag gttgattaat ggggatcttg aacatcagtg gtttgaagag
4741 agtttgcggc aagcttacaa taacaaagcg tttaaactct atacaattga taaagtcacc
4801 caatcgttgg taaagcatgc tcataccttg atgactgacg ctaaaactgc ggaaataatg
4861 gctttgttcg ttaaagatag aaatgcctcc accacgagtg cgaaggacca aattatctat
4921 cgcttgcagg tgcgctcaca tatgtccaac acagaaaata tgtttagaat agagtttgat
4981 aaaagaactc tgcatgtttc cattcaatat attgcacttg atgatttgac actaaaggaa
5041 ccaaaggcag acgaagataa atggaaatat tatgtaacat cgtatgctct gccacatcca
5101 acagaaggca ttccgcacga gaaactgaag ataccatttt tggaaaggct catcgaattt
5161 ggacaagata ttgatggaac agaggtagat gaggagtttt cccccgaagg catctctgta
5221 tcgacattga aaattaagat ccagcctata acctaccaac tgcatattga aaacgggtct
5281 tacgatgttt ttacccgtaa ggctactaac aaatatccta ctattgctaa tgataatact
5341 caaaaaggaa tggtttctca gaagaaggag ttgatatcaa aatttctaga ctgtgcagtt
5401 ggtttgagaa ataatttaga tgaggctcaa aaattaagta tgcaaaaaaa atgggagaac
5461 ctaaaagaca gcatagcaaa gacgagtgct ggaaaccagg gaatagagag tgaaaccgaa
5521 aaaggtaaaa ttacgaaaca ggagcagtcg gataatttgg acagctctac tgcaagtgta
5581 ctgcctgcat ccattactac tgtaccacaa gatgataata tagaaacgac tgggaatact
5641 gaatcttcag acaagggggc taagattcaa taagtagttt taactagatt tagaacaaaa
5701 atctttagta cgacagggtc tttcttctga tgtgtacctt taattaatgt caacgatata
5761 acattgtaat tttaaaattc taagtgtttt tgaagctt
//GenBank-Updates@genbank.bio.net (09/07/90)
LOCUS YSCPAHMA 5798 bp ds-DNA PLN 07-SEP-1990
DEFINITION S.cerevisiae SIN3 gene encoding a paired amphipathic helix protein.
ACCESSION M36822
KEYWORDS negative regulator; paired amphipathic helix motifs.
SOURCE S.cerevisiae (strain GRF88) DNA.
ORGANISM Saccharomyces cerevisiae
Eukaryota; Plantae; Thallobionta; Eumycota; Hemiascomycetes;
Endomycetales; Saccharomycetaceae.
REFERENCE 1 (bases 1 to 5798)
AUTHORS Wang,H., Clark,I., Nicholson,P.R., Herskowitz,I. and Stillman,D.J.
TITLE The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO,
contains four paired amphipathic helix motifs
JOURNAL Mol. Cell. Biol. (1990) In press
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [1] kindly submitted
by D.J.Stillman, 20-JUL-1990.
Author address:
University of Utah, School of Medicine,
Dept. of Cellular, Viral and Molecular Biology,
Salt Lake City, Utah 84132
Stillman@bioscience.biology.utah.edu
SIN3 is a negative regulator of HO expression. sin3- was isolated
as a suppressor of SWI5, permitting HO expression in a swi5-
mutant. The normal asymmetric pattern of of HO expression is
altered in sin3- mutants. Homozygous sin3- diploids are
sporulation defective. The SIN3 protein is nuclear localized.
The predicted SIN3 protein contains four copies of a paired
amphipathic helix motif similar to those seen in the TPR proteins
(SSN6, CDC16, CDC23, SKI3, and nuc2) and the HLH proteins
(myc, myoD, etc).
FEATURES from to/span description
pept 1057 5673 SIN3 open reading frame
mRNA 836 > 5673 SIN3 mRNA
mRNA 850 > 5673 SIN3 mRNA
mRNA 852 > 5673 SIN3 mRNA
mRNA 855 > 5673 SIN3 mRNA
mRNA 858 > 5673 SIN3 mRNA
mRNA 859 > 5673 SIN3 mRNA
mRNA 861 > 5673 SIN3 mRNA
site 4992 4997 potential 5' splice site
site 5685 5724 potential 3' splice site
site 5304 5311 TACTAACA splice sequence
signal 422 433 REB1 protein binding site
signal 448 457 REB1 protein binding site
signal 685 694 REB1 protein binding site
signal 711 720 REB1 protein binding site
site 1771 1912 paired amphipathic helix motif
site 2332 2473 paired amphipathic helix motif
site 3097 3238 paired amphipathic helix motif
site 4516 4663 paired amphipathic helix motif
site 2494 2620 glutamine rich region
BASE COUNT 1846 a 1215 c 1148 g 1589 t
ORIGIN Chromosome XV.
1 aagcttgtta atgatgctgt tacaggcgtt tttcaaggca tccttcgggt cgtagccctc
61 ggtggtctgt attctcagct tgaaacgagc gaagaaggga tgctcaacct tgtaagcggc
121 aaacagcact tttctgtcgt tcagaagttc tgcacgaatc aggtttccca acgtgtggtc
181 ctccttctca aacgttatca ctactgcgtt gggggctttg gtgtcggggt caatctttag
241 cttggattcc ccttcaccca gaaggaacag ttcgaatctg tctggagcat tcatgatgca
301 gttgtgtcca aatgtatctg gtttggtggc tacgtagcta tctatttagg ctgcacggct
361 cagttctctc gctcttcttt taacggacct cttgtgtgtg ccaaagcagt gaacctagaa
421 ttttcgcgga cacttccact ttattaagtc cgggtaatga taatattgag cttgcaagtt
481 ttttgaactc ggatagcagc attatccatg acatgacacg gatctaccga cgaggcttac
541 cgacgaggct taccgacgag gcttaccgtg atccctctcc agtagtctgt aaattctgtt
601 tataatttaa aaaatctatc ttctactcca gtcttgtaac tactgttgtt acgcgctgcc
661 cagagtgtgg cacacactgc ggggttaccc gtgtaacgta gaataaacca gtacgggtaa
721 tgatatcgga ttttctagtg atttttttcc attcgcaaaa aagtcgcctt cattttgcag
781 ttcttcagca aacgtgattt gcaaaacaac ggttactccc cttccctatt acatttgtct
841 tccctttttc gcaccagcat tgctaatatt cgaggcaccg tacctaacta atcagctcat
901 tcacgtacca catattcttt gttacttccc tccctccaca acaggctacg ctattgaccg
961 ctttcagtat agtctcttta cccttttgtt gtgttcgttt gaggttattt ggaaaaggac
1021 aaaatatcta agaaacaagt tatacattgt acaaaaatgt cacaggtttg gcataattcg
1081 aattcgcaat caaacgatgt ggctacttca aatgacgcta cgggttccaa cgaaagaaac
1141 gaaaaagaac cgtccctcca gggaaataag cccggttttg ttcaacagca gcaacggatt
1201 actttaccct cgctatctgc cttgagtact aaggaggaag atagaagaga ttccaatggc
1261 caacaggctc taacttctca tgctgctcac atattaggtt atcctccccc acattcaaat
1321 gctatgccct caattgcaac tgattcagca ttgaaacagc cccacgagta tcaccctcgc
1381 cctaaatctt cgtcctcttc tccctctata aacgcttcgc ttatgaatgc tggtccagct
1441 cccctcccca cagtgggagc cgccagtttt tctttgtcga gatttgacaa tccattaccg
1501 ataaaagctc ctgttcatac agaggaacca aaaagttata atggtcttca ggaagaagaa
1561 aaggcgacgc aacggcctca agattgcaag gaagttcccg ctggtgtgca gcctgctgat
1621 gcccctgacc ctagcagcaa ccatgcagat gctaacgatg acaataataa caacgaaaat
1681 tctcacgatg aagatgctga ctacagacct ctaaacgtga aggatgccct atcttacctc
1741 gaacaggtca aatttcaatt tagttcgcgt ccggatatct ataatttatt tttagatatt
1801 atgaaggact ttaaatctca ggcaatagac acaccgggcg ttattgaaag agtatccact
1861 ttgttcagag gttatccaat tttgattcaa gggttcaata cttttctacc ccaaggctat
1921 agaatcgaat gctcctctaa tccggacgac cccattagag ttactacacc aatgggtact
1981 acgacagtaa acaataacat cagtccatct ggtagaggta caacggatgc acaggaactt
2041 ggttcttttc cagaaagcga tggaaatggt gttcaacagc cctccaatgt gccaatggtg
2101 ccttcgagtg tgtatcaatc ggaacaaaac caagaccaac aacaatcttt gcctctttta
2161 gctacttctt ctggtttacc ttcaattcaa caacctgaaa tgcctgcaca tcgccaaatc
2221 ccacaaagtc aatctttagt gcctcaagaa gatgctaaga aaaacgttga tgtcgaattt
2281 agtcaagcca taagctacgt taataaaatt aaaactagat ttgccgacca acctgatatt
2341 tacaagcatt ttctggaaat actacaaact tatcagcgag agcaaaagcc aataaacgaa
2401 gtctacgcac aagtgacgca tcttttccaa aatgctcctg atttactaga agatttcaag
2461 aaattcttgc cggactcttc agcttctgcc aatcagcagg tgcaacatgc tcagcaacat
2521 gctcaacaac aacatgaggc ccaaatgcat gcacaggcac aagctcaggc tcaggcacag
2581 gcacaggcac aggtggaaca acagaagcag caacagcaat tcttgtatcc agcttcgggc
2641 tattacggcc atccttctaa ccgaggtatt ccacagcaaa acttgcctcc tataggaagc
2701 ttctcgcctc caacaaacgg ttcgaccgta catgaagcct atcaggatca acagcacatg
2761 caaccacccc acttcatgcc cttaccatcg atcgttcaac acgggccaaa tatggtacat
2821 caagggatag cgaatgaaaa tccacctcta tcagatctaa gaacgtctct cactgaacag
2881 tacgctcctt ctagtataca acatcagcag cagcacccgc aaagtattag tcctatagca
2941 aatacgcagt atggtgatat ccctgttaga ccggaaattg atttagatcc tagcattgtg
3001 cctgtggtcc ctgaacccac tgagcccatc gaaaacaata tatcgcttaa tgaggaagtc
3061 actttcttcg aaaaggccaa gaggtatatc ggcaataaac atttatacac tgagtttttg
3121 aaaattttaa atttgtactc tcaagatata cttgatcttg acgatttagt ggaaaaggta
3181 gatttctact tgggttccaa taaagaacta tttacgtggt tcaaaaactt tgttggctac
3241 caagaaaaaa ccaaatgtat cgagaatatt gttcatgaaa aacatagatt ggatttagat
3301 ttatgtgagg catttggccc aagttacaag aggctaccaa aaagtgacac tttcatgcca
3361 tgctcaggta gggatgatat gtgttgggaa gtcttgaacg atgaatgggt tggacatcct
3421 gtatgggctt ccgaagattc gggatttatt gctcatcgta aaaaccagta tgaggaaaca
3481 ctattcaaga tcgaagagga aagacatgag tatgattttt acattgaatc aaatttaaga
3541 actattcaat gtttggaaac aattgtaaat aagatcgaga acatgactga gaatgaaaaa
3601 gccaatttta aactgcctcc aggtcttggc catacttcaa tgactattta taaaaaagtg
3661 ataaggaaag tttatgataa ggaaaggggg ttcgagatta ttgatgcttt gcatgagcac
3721 cctgcagtga cagccccagt cgttctgaaa aggttaaagc aaaaagacga agaatggaga
3781 agagctcaac gtgaatggaa taaagtttgg agggagttag aacagaaggt ttttttcaag
3841 tcattagatc atttaggctt aacatttaaa caggctgaca agaaattatt aactacaaag
3901 cagttgatat cagagattag cagcatcaaa gttgatcaaa caaacaaaaa aattcactgg
3961 ttaactccta aaccaaagag ccagttagat tttgatttcc ctgataaaaa cattttctat
4021 gatatcttgt gtttggctga cacttttata acccatacca cagcctattc taatcccgat
4081 aaagaaagat tgaaagattt actaaaatac ttcatctctt tgtttttttc tatttctttc
4141 gaaaaaatcg aagaatcgtt gtactcccat aagcaaaacg tgtcagaatc tagcggatct
4201 gacgatggca gttctattgc atcaaggaag aggccctatc aacaagaaat gagtttactt
4261 gatattttac acaggagcag atatcaaaag ctaaagcgtt ctaatgatga agatggcaaa
4321 gttccccagc tctctgaacc acccgaagaa gaacctaata ccattgagga ggaagagctc
4381 atcgatgaag aagctaaaaa tccgtggcta actgggaatt tagtggagga agcaaactct
4441 cagggtatta tccaaaatcg cagtattttt aatctattcg ctaatacgaa tatttacata
4501 tttttccgtc attggacaac gatttatgag cggcttttgg aaattaagca aatgaatgaa
4561 agggtcacaa aggaaatcaa cacaaggtcg acagttactt ttgccaaaga tctagattta
4621 ttatcgagtc aactttccga aatgggacta gattttgttg gtgaagacgc gtacaaacag
4681 gttttaagac tgagtagaag gttgattaat ggggatcttg aacatcagtg gtttgaagag
4741 agtttgcggc aagcttacaa taacaaagcg tttaaactct atacaattga taaagtcacc
4801 caatcgttgg taaagcatgc tcataccttg atgactgacg ctaaaactgc ggaaataatg
4861 gctttgttcg ttaaagatag aaatgcctcc accacgagtg cgaaggacca aattatctat
4921 cgcttgcagg tgcgctcaca tatgtccaac acagaaaata tgtttagaat agagtttgat
4981 aaaagaactc tgcatgtttc cattcaatat attgcacttg atgatttgac actaaaggaa
5041 ccaaaggcag acgaagataa atggaaatat tatgtaacat cgtatgctct gccacatcca
5101 acagaaggca ttccgcacga gaaactgaag ataccatttt tggaaaggct catcgaattt
5161 ggacaagata ttgatggaac agaggtagat gaggagtttt cccccgaagg catctctgta
5221 tcgacattga aaattaagat ccagcctata acctaccaac tgcatattga aaacgggtct
5281 tacgatgttt ttacccgtaa ggctactaac aaatatccta ctattgctaa tgataatact
5341 caaaaaggaa tggtttctca gaagaaggag ttgatatcaa aatttctaga ctgtgcagtt
5401 ggtttgagaa ataatttaga tgaggctcaa aaattaagta tgcaaaaaaa atgggagaac
5461 ctaaaagaca gcatagcaaa gacgagtgct ggaaaccagg gaatagagag tgaaaccgaa
5521 aaaggtaaaa ttacgaaaca ggagcagtcg gataatttgg acagctctac tgcaagtgta
5581 ctgcctgcat ccattactac tgtaccacaa gatgataata tagaaacgac tgggaatact
5641 gaatcttcag acaagggggc taagattcaa taagtagttt taactagatt tagaacaaaa
5701 atctttagta cgacagggtc tttcttctga tgtgtacctt taattaatgt caacgatata
5761 acattgtaat tttaaaattc taagtgtttt tgaagctt
//