GenBank-Updates@genbank.bio.net (09/02/90)
LOCUS YSCPAHMA 5798 bp ds-DNA PLN 02-SEP-1990 DEFINITION S.cerevisiae. ACCESSION M36822 KEYWORDS negative regulator; paired amphipathic helix motifs. SOURCE S.cerevisiae (strain GRF88) DNA. ORGANISM Saccharomyces cerevisiae Eukaryota; Plantae; Thallobionta; Eumycota; Hemiascomycetes; Endomycetales; Saccharomycetaceae. REFERENCE 1 (bases 1 to 5798) AUTHORS Wang,H., Clark,I., Nicholson,P.R., Herskowitz,I. and Stillman,D.J. TITLE the saccharomyces cerevisiae sin3 gene, a negative regulator of ho, contains four paired amphipathic helix motifs JOURNAL Unpublished (1990) STANDARD full staff_entry COMMENT Draft entry and computer-readable sequence for [1] kindly submitted by D.J.Stillman, 20-JUL-1990. Author address: University of Utah, School of Medicine, Dept. of Cellular, Viral and Molecular Biology, Salt Lake City, Utah 84132 Stillman@bioscience.biology.utah.edu SIN3 is a negative regulator of HO expression. sin3- was isolated as a suppressor of SWI5, permitting HO expression in a swi5- mutant. The normal asymmetric pattern of of HO expression is altered in sin3- mutants. Homozygous sin3- diploids are sporulation defective. The SIN3 protein is nuclear localized. The predicted SIN3 protein contains four copies of a paired amphipathic helix motif similar to those seen in the TPR proteins (SSN6, CDC16, CDC23, SKI3, and nuc2) and the HLH proteins (myc, myoD, etc). FEATURES from to/span description pept 1057 5673 SIN3 open reading frame pre-msg 836 > 5673 SIN3 mRNA and introns pre-msg 850 > 5673 SIN3 mRNA and introns pre-msg 852 > 5673 SIN3 mRNA and introns pre-msg 855 > 5673 SIN3 mRNA and introns pre-msg 858 > 5673 SIN3 mRNA and introns pre-msg 859 > 5673 SIN3 mRNA and introns pre-msg 861 > 5673 SIN3 mRNA and introns signal 422 433 REB1 protein binding site signal 448 457 REB1 protein binding site signal 685 694 REB1 protein binding site signal 711 720 REB1 protein binding site site 1771 1912 paired amphipathic helix motif site 2332 2473 paired amphipathic helix motif site 3097 3238 paired amphipathic helix motif site 4516 4663 paired amphipathic helix motif site 2494 2620 glutamine rich region BASE COUNT 1846 a 1215 c 1148 g 1589 t ORIGIN Chromosome XV. 1 aagcttgtta atgatgctgt tacaggcgtt tttcaaggca tccttcgggt cgtagccctc 61 ggtggtctgt attctcagct tgaaacgagc gaagaaggga tgctcaacct tgtaagcggc 121 aaacagcact tttctgtcgt tcagaagttc tgcacgaatc aggtttccca acgtgtggtc 181 ctccttctca aacgttatca ctactgcgtt gggggctttg gtgtcggggt caatctttag 241 cttggattcc ccttcaccca gaaggaacag ttcgaatctg tctggagcat tcatgatgca 301 gttgtgtcca aatgtatctg gtttggtggc tacgtagcta tctatttagg ctgcacggct 361 cagttctctc gctcttcttt taacggacct cttgtgtgtg ccaaagcagt gaacctagaa 421 ttttcgcgga cacttccact ttattaagtc cgggtaatga taatattgag cttgcaagtt 481 ttttgaactc ggatagcagc attatccatg acatgacacg gatctaccga cgaggcttac 541 cgacgaggct taccgacgag gcttaccgtg atccctctcc agtagtctgt aaattctgtt 601 tataatttaa aaaatctatc ttctactcca gtcttgtaac tactgttgtt acgcgctgcc 661 cagagtgtgg cacacactgc ggggttaccc gtgtaacgta gaataaacca gtacgggtaa 721 tgatatcgga ttttctagtg atttttttcc attcgcaaaa aagtcgcctt cattttgcag 781 ttcttcagca aacgtgattt gcaaaacaac ggttactccc cttccctatt acatttgtct 841 tccctttttc gcaccagcat tgctaatatt cgaggcaccg tacctaacta atcagctcat 901 tcacgtacca catattcttt gttacttccc tccctccaca acaggctacg ctattgaccg 961 ctttcagtat agtctcttta cccttttgtt gtgttcgttt gaggttattt ggaaaaggac 1021 aaaatatcta agaaacaagt tatacattgt acaaaaatgt cacaggtttg gcataattcg 1081 aattcgcaat caaacgatgt ggctacttca aatgacgcta cgggttccaa cgaaagaaac 1141 gaaaaagaac cgtccctcca gggaaataag cccggttttg ttcaacagca gcaacggatt 1201 actttaccct cgctatctgc cttgagtact aaggaggaag atagaagaga ttccaatggc 1261 caacaggctc taacttctca tgctgctcac atattaggtt atcctccccc acattcaaat 1321 gctatgccct caattgcaac tgattcagca ttgaaacagc cccacgagta tcaccctcgc 1381 cctaaatctt cgtcctcttc tccctctata aacgcttcgc ttatgaatgc tggtccagct 1441 cccctcccca cagtgggagc cgccagtttt tctttgtcga gatttgacaa tccattaccg 1501 ataaaagctc ctgttcatac agaggaacca aaaagttata atggtcttca ggaagaagaa 1561 aaggcgacgc aacggcctca agattgcaag gaagttcccg ctggtgtgca gcctgctgat 1621 gcccctgacc ctagcagcaa ccatgcagat gctaacgatg acaataataa caacgaaaat 1681 tctcacgatg aagatgctga ctacagacct ctaaacgtga aggatgccct atcttacctc 1741 gaacaggtca aatttcaatt tagttcgcgt ccggatatct ataatttatt tttagatatt 1801 atgaaggact ttaaatctca ggcaatagac acaccgggcg ttattgaaag agtatccact 1861 ttgttcagag gttatccaat tttgattcaa gggttcaata cttttctacc ccaaggctat 1921 agaatcgaat gctcctctaa tccggacgac cccattagag ttactacacc aatgggtact 1981 acgacagtaa acaataacat cagtccatct ggtagaggta caacggatgc acaggaactt 2041 ggttcttttc cagaaagcga tggaaatggt gttcaacagc cctccaatgt gccaatggtg 2101 ccttcgagtg tgtatcaatc ggaacaaaac caagaccaac aacaatcttt gcctctttta 2161 gctacttctt ctggtttacc ttcaattcaa caacctgaaa tgcctgcaca tcgccaaatc 2221 ccacaaagtc aatctttagt gcctcaagaa gatgctaaga aaaacgttga tgtcgaattt 2281 agtcaagcca taagctacgt taataaaatt aaaactagat ttgccgacca acctgatatt 2341 tacaagcatt ttctggaaat actacaaact tatcagcgag agcaaaagcc aataaacgaa 2401 gtctacgcac aagtgacgca tcttttccaa aatgctcctg atttactaga agatttcaag 2461 aaattcttgc cggactcttc agcttctgcc aatcagcagg tgcaacatgc tcagcaacat 2521 gctcaacaac aacatgaggc ccaaatgcat gcacaggcac aagctcaggc tcaggcacag 2581 gcacaggcac aggtggaaca acagaagcag caacagcaat tcttgtatcc agcttcgggc 2641 tattacggcc atccttctaa ccgaggtatt ccacagcaaa acttgcctcc tataggaagc 2701 ttctcgcctc caacaaacgg ttcgaccgta catgaagcct atcaggatca acagcacatg 2761 caaccacccc acttcatgcc cttaccatcg atcgttcaac acgggccaaa tatggtacat 2821 caagggatag cgaatgaaaa tccacctcta tcagatctaa gaacgtctct cactgaacag 2881 tacgctcctt ctagtataca acatcagcag cagcacccgc aaagtattag tcctatagca 2941 aatacgcagt atggtgatat ccctgttaga ccggaaattg atttagatcc tagcattgtg 3001 cctgtggtcc ctgaacccac tgagcccatc gaaaacaata tatcgcttaa tgaggaagtc 3061 actttcttcg aaaaggccaa gaggtatatc ggcaataaac atttatacac tgagtttttg 3121 aaaattttaa atttgtactc tcaagatata cttgatcttg acgatttagt ggaaaaggta 3181 gatttctact tgggttccaa taaagaacta tttacgtggt tcaaaaactt tgttggctac 3241 caagaaaaaa ccaaatgtat cgagaatatt gttcatgaaa aacatagatt ggatttagat 3301 ttatgtgagg catttggccc aagttacaag aggctaccaa aaagtgacac tttcatgcca 3361 tgctcaggta gggatgatat gtgttgggaa gtcttgaacg atgaatgggt tggacatcct 3421 gtatgggctt ccgaagattc gggatttatt gctcatcgta aaaaccagta tgaggaaaca 3481 ctattcaaga tcgaagagga aagacatgag tatgattttt acattgaatc aaatttaaga 3541 actattcaat gtttggaaac aattgtaaat aagatcgaga acatgactga gaatgaaaaa 3601 gccaatttta aactgcctcc aggtcttggc catacttcaa tgactattta taaaaaagtg 3661 ataaggaaag tttatgataa ggaaaggggg ttcgagatta ttgatgcttt gcatgagcac 3721 cctgcagtga cagccccagt cgttctgaaa aggttaaagc aaaaagacga agaatggaga 3781 agagctcaac gtgaatggaa taaagtttgg agggagttag aacagaaggt ttttttcaag 3841 tcattagatc atttaggctt aacatttaaa caggctgaca agaaattatt aactacaaag 3901 cagttgatat cagagattag cagcatcaaa gttgatcaaa caaacaaaaa aattcactgg 3961 ttaactccta aaccaaagag ccagttagat tttgatttcc ctgataaaaa cattttctat 4021 gatatcttgt gtttggctga cacttttata acccatacca cagcctattc taatcccgat 4081 aaagaaagat tgaaagattt actaaaatac ttcatctctt tgtttttttc tatttctttc 4141 gaaaaaatcg aagaatcgtt gtactcccat aagcaaaacg tgtcagaatc tagcggatct 4201 gacgatggca gttctattgc atcaaggaag aggccctatc aacaagaaat gagtttactt 4261 gatattttac acaggagcag atatcaaaag ctaaagcgtt ctaatgatga agatggcaaa 4321 gttccccagc tctctgaacc acccgaagaa gaacctaata ccattgagga ggaagagctc 4381 atcgatgaag aagctaaaaa tccgtggcta actgggaatt tagtggagga agcaaactct 4441 cagggtatta tccaaaatcg cagtattttt aatctattcg ctaatacgaa tatttacata 4501 tttttccgtc attggacaac gatttatgag cggcttttgg aaattaagca aatgaatgaa 4561 agggtcacaa aggaaatcaa cacaaggtcg acagttactt ttgccaaaga tctagattta 4621 ttatcgagtc aactttccga aatgggacta gattttgttg gtgaagacgc gtacaaacag 4681 gttttaagac tgagtagaag gttgattaat ggggatcttg aacatcagtg gtttgaagag 4741 agtttgcggc aagcttacaa taacaaagcg tttaaactct atacaattga taaagtcacc 4801 caatcgttgg taaagcatgc tcataccttg atgactgacg ctaaaactgc ggaaataatg 4861 gctttgttcg ttaaagatag aaatgcctcc accacgagtg cgaaggacca aattatctat 4921 cgcttgcagg tgcgctcaca tatgtccaac acagaaaata tgtttagaat agagtttgat 4981 aaaagaactc tgcatgtttc cattcaatat attgcacttg atgatttgac actaaaggaa 5041 ccaaaggcag acgaagataa atggaaatat tatgtaacat cgtatgctct gccacatcca 5101 acagaaggca ttccgcacga gaaactgaag ataccatttt tggaaaggct catcgaattt 5161 ggacaagata ttgatggaac agaggtagat gaggagtttt cccccgaagg catctctgta 5221 tcgacattga aaattaagat ccagcctata acctaccaac tgcatattga aaacgggtct 5281 tacgatgttt ttacccgtaa ggctactaac aaatatccta ctattgctaa tgataatact 5341 caaaaaggaa tggtttctca gaagaaggag ttgatatcaa aatttctaga ctgtgcagtt 5401 ggtttgagaa ataatttaga tgaggctcaa aaattaagta tgcaaaaaaa atgggagaac 5461 ctaaaagaca gcatagcaaa gacgagtgct ggaaaccagg gaatagagag tgaaaccgaa 5521 aaaggtaaaa ttacgaaaca ggagcagtcg gataatttgg acagctctac tgcaagtgta 5581 ctgcctgcat ccattactac tgtaccacaa gatgataata tagaaacgac tgggaatact 5641 gaatcttcag acaagggggc taagattcaa taagtagttt taactagatt tagaacaaaa 5701 atctttagta cgacagggtc tttcttctga tgtgtacctt taattaatgt caacgatata 5761 acattgtaat tttaaaattc taagtgtttt tgaagctt //
GenBank-Updates@genbank.bio.net (09/07/90)
LOCUS YSCPAHMA 5798 bp ds-DNA PLN 07-SEP-1990 DEFINITION S.cerevisiae SIN3 gene encoding a paired amphipathic helix protein. ACCESSION M36822 KEYWORDS negative regulator; paired amphipathic helix motifs. SOURCE S.cerevisiae (strain GRF88) DNA. ORGANISM Saccharomyces cerevisiae Eukaryota; Plantae; Thallobionta; Eumycota; Hemiascomycetes; Endomycetales; Saccharomycetaceae. REFERENCE 1 (bases 1 to 5798) AUTHORS Wang,H., Clark,I., Nicholson,P.R., Herskowitz,I. and Stillman,D.J. TITLE The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs JOURNAL Mol. Cell. Biol. (1990) In press STANDARD full staff_entry COMMENT Draft entry and computer-readable sequence for [1] kindly submitted by D.J.Stillman, 20-JUL-1990. Author address: University of Utah, School of Medicine, Dept. of Cellular, Viral and Molecular Biology, Salt Lake City, Utah 84132 Stillman@bioscience.biology.utah.edu SIN3 is a negative regulator of HO expression. sin3- was isolated as a suppressor of SWI5, permitting HO expression in a swi5- mutant. The normal asymmetric pattern of of HO expression is altered in sin3- mutants. Homozygous sin3- diploids are sporulation defective. The SIN3 protein is nuclear localized. The predicted SIN3 protein contains four copies of a paired amphipathic helix motif similar to those seen in the TPR proteins (SSN6, CDC16, CDC23, SKI3, and nuc2) and the HLH proteins (myc, myoD, etc). FEATURES from to/span description pept 1057 5673 SIN3 open reading frame mRNA 836 > 5673 SIN3 mRNA mRNA 850 > 5673 SIN3 mRNA mRNA 852 > 5673 SIN3 mRNA mRNA 855 > 5673 SIN3 mRNA mRNA 858 > 5673 SIN3 mRNA mRNA 859 > 5673 SIN3 mRNA mRNA 861 > 5673 SIN3 mRNA site 4992 4997 potential 5' splice site site 5685 5724 potential 3' splice site site 5304 5311 TACTAACA splice sequence signal 422 433 REB1 protein binding site signal 448 457 REB1 protein binding site signal 685 694 REB1 protein binding site signal 711 720 REB1 protein binding site site 1771 1912 paired amphipathic helix motif site 2332 2473 paired amphipathic helix motif site 3097 3238 paired amphipathic helix motif site 4516 4663 paired amphipathic helix motif site 2494 2620 glutamine rich region BASE COUNT 1846 a 1215 c 1148 g 1589 t ORIGIN Chromosome XV. 1 aagcttgtta atgatgctgt tacaggcgtt tttcaaggca tccttcgggt cgtagccctc 61 ggtggtctgt attctcagct tgaaacgagc gaagaaggga tgctcaacct tgtaagcggc 121 aaacagcact tttctgtcgt tcagaagttc tgcacgaatc aggtttccca acgtgtggtc 181 ctccttctca aacgttatca ctactgcgtt gggggctttg gtgtcggggt caatctttag 241 cttggattcc ccttcaccca gaaggaacag ttcgaatctg tctggagcat tcatgatgca 301 gttgtgtcca aatgtatctg gtttggtggc tacgtagcta tctatttagg ctgcacggct 361 cagttctctc gctcttcttt taacggacct cttgtgtgtg ccaaagcagt gaacctagaa 421 ttttcgcgga cacttccact ttattaagtc cgggtaatga taatattgag cttgcaagtt 481 ttttgaactc ggatagcagc attatccatg acatgacacg gatctaccga cgaggcttac 541 cgacgaggct taccgacgag gcttaccgtg atccctctcc agtagtctgt aaattctgtt 601 tataatttaa aaaatctatc ttctactcca gtcttgtaac tactgttgtt acgcgctgcc 661 cagagtgtgg cacacactgc ggggttaccc gtgtaacgta gaataaacca gtacgggtaa 721 tgatatcgga ttttctagtg atttttttcc attcgcaaaa aagtcgcctt cattttgcag 781 ttcttcagca aacgtgattt gcaaaacaac ggttactccc cttccctatt acatttgtct 841 tccctttttc gcaccagcat tgctaatatt cgaggcaccg tacctaacta atcagctcat 901 tcacgtacca catattcttt gttacttccc tccctccaca acaggctacg ctattgaccg 961 ctttcagtat agtctcttta cccttttgtt gtgttcgttt gaggttattt ggaaaaggac 1021 aaaatatcta agaaacaagt tatacattgt acaaaaatgt cacaggtttg gcataattcg 1081 aattcgcaat caaacgatgt ggctacttca aatgacgcta cgggttccaa cgaaagaaac 1141 gaaaaagaac cgtccctcca gggaaataag cccggttttg ttcaacagca gcaacggatt 1201 actttaccct cgctatctgc cttgagtact aaggaggaag atagaagaga ttccaatggc 1261 caacaggctc taacttctca tgctgctcac atattaggtt atcctccccc acattcaaat 1321 gctatgccct caattgcaac tgattcagca ttgaaacagc cccacgagta tcaccctcgc 1381 cctaaatctt cgtcctcttc tccctctata aacgcttcgc ttatgaatgc tggtccagct 1441 cccctcccca cagtgggagc cgccagtttt tctttgtcga gatttgacaa tccattaccg 1501 ataaaagctc ctgttcatac agaggaacca aaaagttata atggtcttca ggaagaagaa 1561 aaggcgacgc aacggcctca agattgcaag gaagttcccg ctggtgtgca gcctgctgat 1621 gcccctgacc ctagcagcaa ccatgcagat gctaacgatg acaataataa caacgaaaat 1681 tctcacgatg aagatgctga ctacagacct ctaaacgtga aggatgccct atcttacctc 1741 gaacaggtca aatttcaatt tagttcgcgt ccggatatct ataatttatt tttagatatt 1801 atgaaggact ttaaatctca ggcaatagac acaccgggcg ttattgaaag agtatccact 1861 ttgttcagag gttatccaat tttgattcaa gggttcaata cttttctacc ccaaggctat 1921 agaatcgaat gctcctctaa tccggacgac cccattagag ttactacacc aatgggtact 1981 acgacagtaa acaataacat cagtccatct ggtagaggta caacggatgc acaggaactt 2041 ggttcttttc cagaaagcga tggaaatggt gttcaacagc cctccaatgt gccaatggtg 2101 ccttcgagtg tgtatcaatc ggaacaaaac caagaccaac aacaatcttt gcctctttta 2161 gctacttctt ctggtttacc ttcaattcaa caacctgaaa tgcctgcaca tcgccaaatc 2221 ccacaaagtc aatctttagt gcctcaagaa gatgctaaga aaaacgttga tgtcgaattt 2281 agtcaagcca taagctacgt taataaaatt aaaactagat ttgccgacca acctgatatt 2341 tacaagcatt ttctggaaat actacaaact tatcagcgag agcaaaagcc aataaacgaa 2401 gtctacgcac aagtgacgca tcttttccaa aatgctcctg atttactaga agatttcaag 2461 aaattcttgc cggactcttc agcttctgcc aatcagcagg tgcaacatgc tcagcaacat 2521 gctcaacaac aacatgaggc ccaaatgcat gcacaggcac aagctcaggc tcaggcacag 2581 gcacaggcac aggtggaaca acagaagcag caacagcaat tcttgtatcc agcttcgggc 2641 tattacggcc atccttctaa ccgaggtatt ccacagcaaa acttgcctcc tataggaagc 2701 ttctcgcctc caacaaacgg ttcgaccgta catgaagcct atcaggatca acagcacatg 2761 caaccacccc acttcatgcc cttaccatcg atcgttcaac acgggccaaa tatggtacat 2821 caagggatag cgaatgaaaa tccacctcta tcagatctaa gaacgtctct cactgaacag 2881 tacgctcctt ctagtataca acatcagcag cagcacccgc aaagtattag tcctatagca 2941 aatacgcagt atggtgatat ccctgttaga ccggaaattg atttagatcc tagcattgtg 3001 cctgtggtcc ctgaacccac tgagcccatc gaaaacaata tatcgcttaa tgaggaagtc 3061 actttcttcg aaaaggccaa gaggtatatc ggcaataaac atttatacac tgagtttttg 3121 aaaattttaa atttgtactc tcaagatata cttgatcttg acgatttagt ggaaaaggta 3181 gatttctact tgggttccaa taaagaacta tttacgtggt tcaaaaactt tgttggctac 3241 caagaaaaaa ccaaatgtat cgagaatatt gttcatgaaa aacatagatt ggatttagat 3301 ttatgtgagg catttggccc aagttacaag aggctaccaa aaagtgacac tttcatgcca 3361 tgctcaggta gggatgatat gtgttgggaa gtcttgaacg atgaatgggt tggacatcct 3421 gtatgggctt ccgaagattc gggatttatt gctcatcgta aaaaccagta tgaggaaaca 3481 ctattcaaga tcgaagagga aagacatgag tatgattttt acattgaatc aaatttaaga 3541 actattcaat gtttggaaac aattgtaaat aagatcgaga acatgactga gaatgaaaaa 3601 gccaatttta aactgcctcc aggtcttggc catacttcaa tgactattta taaaaaagtg 3661 ataaggaaag tttatgataa ggaaaggggg ttcgagatta ttgatgcttt gcatgagcac 3721 cctgcagtga cagccccagt cgttctgaaa aggttaaagc aaaaagacga agaatggaga 3781 agagctcaac gtgaatggaa taaagtttgg agggagttag aacagaaggt ttttttcaag 3841 tcattagatc atttaggctt aacatttaaa caggctgaca agaaattatt aactacaaag 3901 cagttgatat cagagattag cagcatcaaa gttgatcaaa caaacaaaaa aattcactgg 3961 ttaactccta aaccaaagag ccagttagat tttgatttcc ctgataaaaa cattttctat 4021 gatatcttgt gtttggctga cacttttata acccatacca cagcctattc taatcccgat 4081 aaagaaagat tgaaagattt actaaaatac ttcatctctt tgtttttttc tatttctttc 4141 gaaaaaatcg aagaatcgtt gtactcccat aagcaaaacg tgtcagaatc tagcggatct 4201 gacgatggca gttctattgc atcaaggaag aggccctatc aacaagaaat gagtttactt 4261 gatattttac acaggagcag atatcaaaag ctaaagcgtt ctaatgatga agatggcaaa 4321 gttccccagc tctctgaacc acccgaagaa gaacctaata ccattgagga ggaagagctc 4381 atcgatgaag aagctaaaaa tccgtggcta actgggaatt tagtggagga agcaaactct 4441 cagggtatta tccaaaatcg cagtattttt aatctattcg ctaatacgaa tatttacata 4501 tttttccgtc attggacaac gatttatgag cggcttttgg aaattaagca aatgaatgaa 4561 agggtcacaa aggaaatcaa cacaaggtcg acagttactt ttgccaaaga tctagattta 4621 ttatcgagtc aactttccga aatgggacta gattttgttg gtgaagacgc gtacaaacag 4681 gttttaagac tgagtagaag gttgattaat ggggatcttg aacatcagtg gtttgaagag 4741 agtttgcggc aagcttacaa taacaaagcg tttaaactct atacaattga taaagtcacc 4801 caatcgttgg taaagcatgc tcataccttg atgactgacg ctaaaactgc ggaaataatg 4861 gctttgttcg ttaaagatag aaatgcctcc accacgagtg cgaaggacca aattatctat 4921 cgcttgcagg tgcgctcaca tatgtccaac acagaaaata tgtttagaat agagtttgat 4981 aaaagaactc tgcatgtttc cattcaatat attgcacttg atgatttgac actaaaggaa 5041 ccaaaggcag acgaagataa atggaaatat tatgtaacat cgtatgctct gccacatcca 5101 acagaaggca ttccgcacga gaaactgaag ataccatttt tggaaaggct catcgaattt 5161 ggacaagata ttgatggaac agaggtagat gaggagtttt cccccgaagg catctctgta 5221 tcgacattga aaattaagat ccagcctata acctaccaac tgcatattga aaacgggtct 5281 tacgatgttt ttacccgtaa ggctactaac aaatatccta ctattgctaa tgataatact 5341 caaaaaggaa tggtttctca gaagaaggag ttgatatcaa aatttctaga ctgtgcagtt 5401 ggtttgagaa ataatttaga tgaggctcaa aaattaagta tgcaaaaaaa atgggagaac 5461 ctaaaagaca gcatagcaaa gacgagtgct ggaaaccagg gaatagagag tgaaaccgaa 5521 aaaggtaaaa ttacgaaaca ggagcagtcg gataatttgg acagctctac tgcaagtgta 5581 ctgcctgcat ccattactac tgtaccacaa gatgataata tagaaacgac tgggaatact 5641 gaatcttcag acaagggggc taagattcaa taagtagttt taactagatt tagaacaaaa 5701 atctttagta cgacagggtc tttcttctga tgtgtacctt taattaatgt caacgatata 5761 acattgtaat tttaaaattc taagtgtttt tgaagctt //