GenBank-Updates@genbank.bio.net (09/13/90)
LOCUS HUMBCRA2 204 bp ds-DNA PRI 13-SEP-1990
DEFINITION Human chronic myelocytic leukemia c-abl oncogene breakpoint cluster
region (bcr) DNA, exon a1.
ACCESSION M25948
KEYWORDS break point cluster region; c-abl oncogene;
chronic myelocytic leukemia.
SEGMENT 2 of 3
SOURCE Human fibroblast cell line K562, cDNA to mRNA, clone pV1-3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 204)
AUTHORS De Klein,A., Hermans,A., Bootsma,D., Grosveld,G., Heisterkamp,H.,
Stam,K. and Groffen,J.
TITLE The role of the Philadelphia translocation in chronic myelocytic
leukemia
JOURNAL Ann. Clin. Res. 18, 278-283 (1986)
STANDARD simple staff_entry
FEATURES from to/span description
pept + 16 + 189 bcr/c-abl oncogene protein, exon a1
IVS < 1 15 bcr intron b3/c-abl intron a1
IVS 190 > 204 c-abl intron a2
BASE COUNT 51 a 52 c 49 g 52 t
ORIGIN About 500 bp downstream of segment 1.
1 ccctttctct tccagaagcc cttcagcggc cagtagcatc tgactttgag cctcagggtc
61 tgagtgaagc cgctcgttgg aactccaagg aaaaccttct cgctggaccc agtgaaaatg
121 accccaacct tttcgttgca ctgtatgatt ttgtggccag tggagataac actctaagca
181 taactaaagg taaaagggtt gtgg
//