GenBank-Updates@genbank.bio.net (09/14/90)
LOCUS HUMCRYABA 4206 bp ds-DNA PRI 14-SEP-1990
DEFINITION Human alpha-B-crystallin gene, 5' end.
ACCESSION M28638
KEYWORDS alpha-crystallin; crystallin.
SOURCE Human DNA, clones 730 and cp8.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 4206)
AUTHORS Dubin,R.A., Ally,A.H., Chung,S. and Piatigorsky,J.
TITLE Human alpha-B-crystallin gene and preferential promoter function in
lens
JOURNAL Genomics 7, 594-601 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [1] kindly submitted
by R.A.Dubin, 04-OCT-1989.
FEATURES from to/span description
pept 999 1199 alpha-B2-crystallin, exon 1 /nomgen="CRYA2"
/map="11" /hgml_locus_uid="LR0090S"
2274 2396 alpha-B2-crystallin, exon 2
3754 3957 alpha-B2-crystallin, exon 3
pre-msg 949 > 4040 A-B2-cry mRNA and introns
IVS 1200 2273 A-B2-cry, intron A
IVS 2397 3753 A-B2-cry, intron B
signal 924 930 TATA box
signal 4075 4080 poly-A signal
BASE COUNT 1028 a 1041 c 985 g 1152 t
ORIGIN
1 gtcgacacca cccaaaatag tgccgagcct cttggggggg gaggggctgg gagtgggggc
61 cctgagtgag agcaacgagg gtgtgaccag cgccgcccgg acccctagtc ccctcccccg
121 cacactcttc agctgtcgca gggggcctga gaggacagct gagggtcctg gctgggaacg
181 agctggggag ggggagctgg tggtgcctgg ggcatgaaga ggcctcgctg agaccctcac
241 aaacggtttg cacgtttcca cacctcattt tctcctcttc ggtggcaggc actgtgcacc
301 caattcctaa agcactcctg gatttaatgt tctgagagcc acatagaacg aaagatgcaa
361 gaaatctgtt tgctcttttt tcagggggtg gggtctttct gcccagatgt gggatcctct
421 cctaaaccca ggtcaaccca gggcacgagg cagatggctg gtgctgacat gttgaccatc
481 actgctctct tccaaggact cacaaagagt taatgtccct ggggctcagc ctaggaagat
541 tccagtccct gcccaggccc aagatagttg ctggcctgat tcccctggca ttcaggactg
601 gaaaggagga ggaggggcac actacgccgg ctcccatcct ccccccaccc cgcgtgcctg
661 cttgggattc ctgactctgt accagcttca gagaacaggg gtgggggtgg gtgccattgg
721 gtgtggacag aaagctagtg aaacaagacc atgacaagtc actggccggc tcagacgtgt
781 ttgtgtctct cttttcttag ctcagtgagt actgggtatg tgtcacattg ccaaatcccg
841 gatcacaagt ctccatgaac tgctggtgag ctaggataat aaaacccctg acatcaccat
901 tccagaagct tcacaagact gcatatataa ggggctggct gtagctgcag ctgaaggagc
961 tgaccagcca gctgacccct cacactcacc tagccaccat ggacatcgcc atccaccacc
1021 cctggatccg ccgccccttc tttcctttcc actcccccag ccgcctcttt gaccagttct
1081 tcggagagca cctgttggag tctgatcttt tcccgacgtc tacttccctg agtcccttct
1141 accttcggcc accctccttc ctgcgggcac ccagctggtt tgacactgga ctctcagagg
1201 tgagtctccc cacagctagg acgggagagt ccttactgga acctcctgga aacttctcca
1261 tccattttcc tttcctaccc tgcctaaacc attttaggca catgtgtgtc caaatgtgaa
1321 gaaaaatgag gaggttgcta gtgccttcct cccccatcac ctgtttctat ttgatagtcc
1381 tctgtatccc atttattaca ttttttcatg cactgtcaag tttatcctcc gtcccctaac
1441 ttctctacag gatacccctt tctggtttgg ttcatgacaa tctgcaggga aagagctgcc
1501 ttcaaactcc tttgcttatc tcttccaaca ccttggactc ttgaccgatt ttaccatctc
1561 aggtttcaga gccaggagag agccctgcct catcctgagc tgttcatccc catgggtatt
1621 ttctgccttt ctattccctc ttctatgatt ttctgggttt ctcagggcta cgacagggcg
1681 ctggcctggg tccaatcaag ccctacgagg aaacaatata gggacgccca tttgtcctaa
1741 gagggtggaa gaacagggtg aacaaataag gttgacagag ctgtcacaga taacactctg
1801 gtttaaaaat attcaagtgt gagtaaacag gagctgagtg ggcaagggct ttggaaggac
1861 aagcaggacc agcagaacat tccagattgg gtgggtggaa aactggcaaa gagacctgag
1921 ccagaagaag aggcctttgt ctcacagaca aaccacaaag ccaggcattg gagtcagaga
1981 ggcagcagat gccaggcttg cacccatcct tgcgactggt cccctgggtg atctgtcttc
2041 ttctctgtcc ctgtaaataa agtttgggtc tgatcaccat gagccttagg tatcactgtg
2101 gtggctccct gaagcagaca gctatgttta tttaaaaagg agatttttta agcagagaag
2161 agaaggatga attacccgga cagaaagcag ctctgcagaa taagacagca cctgtgtaat
2221 cagtattttt gccctctttc tcccatccca ttcccttacc ttgctatttc tagatgcgcc
2281 tggagaagga caggttctct gtcaacctgg atgtgaagca cttctcccca gaggaactca
2341 aagttaaggt gttgggagat gtgattgagg tgcatggaaa acatgaagag cgccaggtat
2401 gtagcttgtt tttttgtttt ctgctcattc attcagtgat actgtaatag tccaggtagt
2461 gctatcagct ttggaggctg gctacattcc agtcccaagc cataacagtc gggatcaggg
2521 gttacaaatc aatgtctaga agactaagtt aggatagaca tattgctgtt gttactatta
2581 tggccagaga tgtggccttt gatttgatcg ccttagatgg gatgatggga tgctgatgcc
2641 ccatttaagc cagtggttct gaatctgggc cacattagaa tcaccagggg aactttcaaa
2701 aacctaatgc tcgggcatcc tccagaccaa ttagcatatg tgctgccgaa gcgagcacta
2761 ctccagacca attaaatcag catttttaag ggtgggaccc aggcatcagc aatttttaag
2821 gtaattctaa tctacagtca aggttgagaa ccactgatta ggtatagggc tgtcagacac
2881 ctagttgctt tgcataatta cattaactac aggtacccta aaagcacttg agttgtgact
2941 tctcttttag ctgtgcaaga atccgtgtct cttctttagc ccatcttaat gctgaactac
3001 ttggtttgtc taaatttcag agctgtgctc agtctttaat cccctacagc ccatgtggta
3061 atcagttaac gagagcctgt ttggctacat gcttgagagt cagcaggcat acgggttaag
3121 gtcatctact ctttggggga gttctgacaa atggaacagc ttgttatgac tttataagag
3181 ggctttaaaa ttgcttctca ccatttaacg atagctcaga acctgtgcgt caaccagtac
3241 agtttgtcct cagtaatgtc ctcaggctgt ttcaattttg cttatatgat ttaggtttgg
3301 gtcatagtct ccttggatgg agtcattttt tttttttttt aatttcagca gcagtcctat
3361 tgttctggaa ccttctggga cattcctgaa gagtcaggac aatttcaggg cttcctcagg
3421 gactcagatt ctaaatgaga ttccaaattc tgtaggccca gccaacattg atctaaacct
3481 ttgggaaata cccctaaaca tatctatgcc tcagggtttg aaaaacaatg aagtgttgga
3541 ctgtttcaga cttctcagat tctcactggt aggagtgact acctaggcaa tttcatctta
3601 gctgcaaccc tgaaacgaag ctctatttat ttttcctatg ttgtcatggc atttggtctc
3661 acctaagggg aaatcaggat gcctgagttc tgggcaggtg ataatagttc ctgttcttat
3721 ctctctgcct ctttcctcat tcttttgggt taggatgaac atggtttcat ctccagggag
3781 ttccacagga aataccggat cccagctgat gtagaccctc tcaccattac ttcatccctg
3841 tcatctgatg gggtcctcac tgtgaatgga ccaaggaaac aggtctctgg ccctgagcgc
3901 accattccca tcacccgtga agagaagcct gctgtcaccg cagcccccaa gaaatagatg
3961 ccctttcttg aattgcattt tttaaaacaa gaaagtttcc ccaccagtga atgaaagtct
4021 tgtgactagt gctgaagctt attaatgcta agggcaggcc caaattatca agctaataaa
4081 atatcattca gcaacagata actgtcttgt gtttgaatat tccacacact tttaaataaa
4141 tatacagata ccacagatct atttatgatt gcattatgat ttagagggct ccaaggattt
4201 tagagt
//