GenBank-Updates@genbank.bio.net (09/17/90)
LOCUS FLAHAMY 1775 bp ss-RNA VRL 17-SEP-1990
DEFINITION Influenza A/wsn/33 (h1n1), hemagglutinin (seg 4), cDNA.
ACCESSION J02176 M25009 M25010 M38365
KEYWORDS glycoprotein; hemagglutinin.
SOURCE Influenza virus A/WSN/33, cDNA to viral RNA, grown in bovine kidney
cells from human.
ORGANISM Influenza virus type A
Viridae; ss-RNA enveloped viruses; Negative strand RNA viruses;
Orthomyxoviridae; Influenzavirus; Influenza A viruses.
REFERENCE 1 (bases 1 to 377 and 1038 to 1269)
AUTHORS Davis,A.R., Hiti,A.L. and Nayak,D.P.
TITLE Construction and characterization of a bacterial clone containing
the hemagglutinin gene of the WSN strain (H0N1) of influenza virus
JOURNAL Gene 10, 205-218 (1980)
STANDARD simple staff_entry
REFERENCE 2 (bases 1 to 1775)
AUTHORS Hiti,A.L., Davis,A.R. and Nayak,D.P.
TITLE complete sequence analysis shows that the hemagglutinins of the h0
and h2 subtypes of human influenza virus are closely related
JOURNAL Virology 111, 113-124 (1981)
STANDARD full staff_review
COMMENT Sequence derived from cloned cDNA (plasmid 2-29), except for bases
1762-1775, which were obtained using vRNA-directed cDNA synthesis.
Coding region assigned by consideration of open reading frames,
comparison to N-terminal amino acid sequences for other (H1N1)
hemagglutinins and comparison to an experimental estimate of
hemagglutinin mw. Signal, HA1 and HA2 bounds assigned by comparison
to sequences from other strains.
FEATURES from to/span description
pept 33 1730 hemagglutinin precursor
sigp 36 83 signal peptide
matp 84 1058 ha1 chain
matp 1062 1727 ha2 chain
BASE COUNT 618 a 323 c 404 g 430 t
ORIGIN 3' end of viral RNA.
1 agcaaaagca ggggaaaata aaaacaacca aaatgaaggc aaaactactg gtcctgttat
61 atgcatttgt agctacagat gcagacacaa tatgtatagg ctaccatgcg aacaactcaa
121 ccgacactgt tgacacaata ttcgagaaga atgtggcagt gacacattct gttaacctgc
181 tcgaagacag acacaacggg aaactatgta aattaaaagg aatagcccca ctacaattgg
241 ggaaatgtaa catcaccgga tggctcttgg gaaatccaga atgcgactca ctgcttccag
301 cgagatcatg gtcctacatt gtagaaacac caaactctga gaatggagca tgttatccag
361 gagatttcat cgactatgag gaactgaggg agcaattgag ctcagtatca tcattagaaa
421 gattcgaaat atttcccaag gaaagttcat ggcccaacca cacattcaac ggagtaacag
481 tatcatgctc ccatagggga aaaagcagtt tttacagaaa tttgctatgg ctgacgaaga
541 agggggattc atacccaaag ctgaccaatt cctatgtgaa caataaaggg aaagaagtcc
601 ttgtactatg gggtgttcat cacccgtcca gcagtgatga gcaacagagt ctctatagta
661 atggaaatgc ttatgtctct gtagcgtctt caaattataa caggagattc accccggaaa
721 tagctgcaag gcccaaagta aaagatcaac atgggaggat gaactattac tggaccttgc
781 tagaacccgg agacacaata atatttgagg caactggtaa tctaatagca ccatggtatg
841 ctttcgcact gagtagaggg tttgagtccg gcatcatcac ctcaaacgcg tcaatgcatg
901 agtgtaacac gaagtgtcaa acaccccagg gatctataaa cagcaatctc cctttccaga
961 atatacaccc agtcacaata ggagagtgcc caaaatatgt caggagtacc aaattgagga
1021 tggttacagg actaagaaac atcccatcca ttcaatacag aggtctattt ggagccattg
1081 ctggttttat tgagggggga tggactggaa tgatagatgg atggtatggt tatcatcatc
1141 agaatgaaca gggatcaggc tatgcagcgg atcaaaaaag cacacagaat gccattaacg
1201 ggattacaaa caaggtgaac tctgttatcg agaaaatgaa cactcaattc acagctgtgg
1261 gtaaagaatt caacaactta gaaaaaagga tggaaaattt aaataaaaaa gttgatgatg
1321 ggtttctgga catttggaca tataatgcag aattgttagt tctactggaa aatgaaagaa
1381 ctttggattt ccatgactta aatgtgaaga atctgtacga gaaagtaaaa agccaattaa
1441 agaataatgc caaagaaatc ggaaatgggt gttttgagtt ctaccacaag tgtgacaatg
1501 aatgcatgga aagtgtaaga aatgggactt atgattatcc aaaatattca gaagaatcaa
1561 agttgaacag ggaaaagata gatggagtga aattggaatc aatgggggtg tatcagattc
1621 tggcgatcta ctcaactgtc gccagttcac tggtgctttt ggtctccctg ggggcaatca
1681 gtttctggat gtgttctaat gggtctttgc agtgcagaat atgcatctga gattaggatt
1741 tcagaaatat aaggaaaaac acccttgttt ctact
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