GenBank-Updates@genbank.bio.net (09/19/90)
LOCUS HUMEL06 151 bp ds-DNA PRI 19-SEP-1990
DEFINITION Human elastin gene, intron M with a possible exon 14.
ACCESSION M17269 J02948
KEYWORDS alternative splicing; elastin.
SEGMENT 6 of 20
SOURCE Human fetal aorta, cDNA to mRNA, clones cHEL[2,3,4]; DNA, clones
HEL[1,2,3].
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 151)
AUTHORS Indik,Z., Yeh,H., Ornstein-Goldstein,N., Sheppard,P., Anderson,N.,
Rosenbloom,J.C., Peltonen,L. and Rosenbloom,J.
TITLE Alternative splicing of human elastin mRNA indicated by sequence
analysis of cloned genomic and complementary DNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84, 5680-5684 (1987)
STANDARD full staff_review
COMMENT Even though none of the mRNAs described in [1] contained the
sequences in segment 6, this sequence resembles elastin exon 14 in
other organisms, and could be included in a different variant of
elastin mRNA by alternative splicing.
The alternate products elastin A, B, and C given in the Features
table correspond to cDNA clones cHEL4, cHEL3 and cHEL2
respectively.
Entry awaiting author review 18-JAN-1990. ORF + 55 + 141
elastin precursor, possible exon
FEATURES from to/span description
pre-msg < 1 > 151 elastin mRNA and intron /nomgen="ELN"
/map="2q31-qter" /hgml_locus_uid="LC0146D"
IVS < 1 > 151 elastin A intron E
IVS < 1 > 151 elastin B intron E
IVS < 1 > 151 elastin C intron E
BASE COUNT 29 a 39 c 60 g 23 t
ORIGIN About 0.4 kb after segment 5.
1 cccccaaaaa gtgagtactg gaggggcaag gctgaaagtt ctccactccc cgaggtgctg
61 caggagcagg agtgctgggt gggctagtgc caggtcccca ggcggcagtc ccaggtgtgc
121 cgggcacggg aggagtgcca ggtgagctgt g
//