GenBank-Updates@genbank.bio.net (09/19/90)
LOCUS HUMHCII 2182 bp ss-mRNA PRI 19-SEP-1990
DEFINITION Human heparin cofactor II (HC-II) mRNA, complete cds.
ACCESSION M12849 M19241
KEYWORDS heparin cofactor II; protease inhibitor.
SOURCE Human fetal liver, cDNA to mRNA, clone lambda-HCII.7 [2]; adult
liver, cDNA to mRNA, clone lambda HCII.7.1 [3].
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1025 to 2182)
AUTHORS Inhorn,R.C. and Tollefsen,D.M.
TITLE Isolation and characterization of a partial cDNA clone for heparin
cofactor II
JOURNAL Biochem. Biophys. Res. Commun. 137, 431-436 (1986)
STANDARD simple staff_review
REFERENCE 2 (bases 1025 to 2182; revises [1])
AUTHORS Inhorn,R.C. and Tollefsen,D.M.
JOURNAL Unpublished (1986) Washington Univ, St Louis, MO
STANDARD simple staff_review
REFERENCE 3 (bases 1 to 2182)
AUTHORS Blinder,M.A., Marasa,J.C., Reynolds,C.H., Deaven,L.L. and
Tollefsen,D.M.
TITLE Heparin cofactor II: cDNA sequence, chromosome localization,
restriction fragment length polymorphism, and expression in
Escherichia coli
JOURNAL Biochemistry 27, 752-759 (1988)
STANDARD simple staff_review
COMMENT Draft entry and computer-readable sequence of [1] kindly provided
by D.M.Tollefsen, 18-AUG-1986.
Draft entry and computer-readable sequence of [3] kindly provided
by Blinder,M.A. 24-MAR-1988
FEATURES from to/span description
pept 29 1528 heparin cofactor II precursor /nomgen="HCF2"
/map="22" /hgml_locus_uid="LZ0043Z"
sigp 29 85 heparin cofactor II signal protein
matp 86 1525 heparin cofactor II
mRNA < 1 2182 heparin cofactor II mRNA
revision 1611 1612 gc in [2]; gtc in [1]
revision 1617 1619 ttt in [2]; tttt in [1]
revision 1608 1608 c in [3]; t in [1]
BASE COUNT 603 a 581 c 500 g 498 t
ORIGIN 142 bp upstream from PstI site; chromosome 22.
1 cgaaacacag agctttagct ccgccaaaat gaaacactca ttaaacgcac ttctcatttt
61 cctcatcata acatctgcgt ggggtgggag caaaggcccg ctggatcagc tagagaaagg
121 aggggaaact gctcagtctg cagatcccca gtgggagcag ttaaataaca aaaacctgag
181 catgcctctt ctccctgccg acttccacaa ggaaaacacc gtcaccaacg actggattcc
241 agagggggag gaggacgacg actatctgga cctggagaag atattcagtg aagacgacga
301 ctacatcgac atcgtcgaca gtctgtcagt ttccccgaca gactctgatg tgagtgctgg
361 gaacatcctc cagctttttc atggcaagag ccggatccag cgtcttaaca tcctcaacgc
421 caagttcgct ttcaacctct accgagtgct gaaagaccag gtcaacactt tcgataacat
481 cttcatagca cccgttggca tttctactgc gatgggtatg atttccttag gtctgaaggg
541 agagacccat gaacaagtgc actcgatttt gcattttaaa gactttgtta atgccagcag
601 caagtatgaa atcacgacca ttcataatct cttccgtaag ctgactcatc gcctcttcag
661 gaggaatttt gggtacacac tgcggtcagt caatgacctt tatatccaga agcagtttcc
721 aatcctgctt gacttcagaa ctaaagtaag agagtattac tttgctgagg cccagatagc
781 tgacttctca gaccctgcct tcatatcaaa aaccaacaac cacatcatga agctcaccaa
841 gggcctcata aaagatgctc tggagaatat agaccctgct acccagatga tgattctcaa
901 ctgcatctac ttcaaaggat cctgggtgaa taaattccca gtggaaatga cacacaacca
961 caacttccgg ctgaatgaga gagaggtagt taaggtttcc atgatgcaga ccaaggggaa
1021 cttcctcgca gcaaatgacc aggagctgga ctgcgacatc ctccagctgg aatacgtggg
1081 gggcatcagc atgctaattg tggtcccaca caagatgtct gggatgaaga ccctcgaagc
1141 gcaactgaca ccccgggtgg tggagagatg gcaaaaaagc atgacaaaca gaactcgaga
1201 agtgcttctg ccgaaattca agctggagaa gaactacaat ctagtggagt ccctgaagtt
1261 gatggggatc aggatgctgt ttgacaaaaa tggcaacatg gcaggcatct cagaccaaag
1321 gatcgccatc gacctgttca agcaccaagg cacgatcaca gtgaacgagg aaggcaccca
1381 agccaccact gtgaccacgg tggggttcat gccgctgtcc acccaagtcc gcttcactgt
1441 cgaccgcccc tttcttttcc tcatctacga gcaccgcacc agctgcctgc tcttcatggg
1501 aagagtggcc aaccccagca ggtcctagag gtggaggtct aggtgtctga agtgccttgg
1561 gggcaccctc attttgtttc cattccaaca acgagaacag agatgttctg gcatcattta
1621 cgtagtttac gctaccaatc tgaattcgag gcccatatga gaggagctta gaaacgacca
1681 agaagagagg cttgttggaa tcaattctgc acaatagccc atgctgtaag ctcatagaag
1741 tcactgtaac tgtagtgtgt ctgctgttac ctagagggtc tcacctcccc actcttcaca
1801 gcaaacctga gcagcgcgtc ctaagcacct cccgctccgg tgaccccatc cttgcacacc
1861 tgactctgtc actcaagcct ttctccacca ggcccctcat ctgaatacca agcacagaaa
1921 tgagtggtgt gactaattcc ttacctctcc caaggagggt acacaactag caccattctt
1981 gatgtccagg gaagaagcca cctcaagaca tatgaggggt gccctgggct aatgttaggg
2041 cttaattttc tcaaagcctg acctttcaaa tccatgatga atgccatcag tccctcctgc
2101 tgttgcctcc ctgtgacctg gaggacagtg tgtgccatgt ctcccatact agagataaat
2161 aaatgtagcc acatttactg tg
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