GenBank-Updates@genbank.bio.net (09/21/90)
LOCUS HUMARA 3061 bp ss-mRNA PRI 21-SEP-1990
DEFINITION Human androgen receptor mRNA, complete cds.
ACCESSION M21748 J04150
KEYWORDS androgen receptor.
SOURCE Human prostate, cDNA to mRNA, clones A1 and J8.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3061)
AUTHORS Tilley,W.D., Marcelli,M., Wilson,J.D. and McPhaul,M.J.
TITLE Characterization and expression of a cDNA encoding the human
androgen receptor
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86, 327-331 (1989)
STANDARD full staff_review
REFERENCE 2 (sites; androgen resistant mutation)
AUTHORS Marcelli,M., Tilley,W.D., Wilson,C.M., Griffin,J.E.,
Wilson,J.D. and McPhaul,M.J.
TITLE Definition of the human androgen receptor gene structure permits
the identification of mutations that cause androgenic resistance:
Premature termination of the receptor protein at amino acid residue
588 causes complete androgen resistance
JOURNAL Mol. Endocrinol. 4, 1105-1116 (1990)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence [1] kindly submitted by
M.J. McPhaul, 09-DEC-1988.
FEATURES from to/span description
pept 163 2916 androgen receptor /nomgen="AR" /map="Xcen-q13"
/hgml_locus_uid="LL0058U"
mut 1924 1924 a in wt; t in androgen-resistant mutant
Lys->stop [2]
BASE COUNT 676 a 894 c 875 g 616 t
ORIGIN Chromosome Xcen-q13.
1 tttttgcgtg gttgctcccg aagtttcctt ctctggagct tcccgcacgt gggcagctag
61 ctgcagcgac taccgcatca tcacagcctg ttgaactctt ctgagcaaga gaaggggagg
121 cggggtaagg gaagtaggtg gaagattcag ccaagctcaa ggatggaagt gcagttaggg
181 ctgggaaggg tctaccctcg gccgccgtcc aagacctacc gaggagcttt ccagaatctg
241 ttccagagcg tgcgcgaagt gatccagaac ccgggcccca ggcacccaga ggccgcgagc
301 gcagcacctc ccggcgccag tttgctgctg ctgcagcagc agcagcagca gcagcagcag
361 cagcagcagc agcagcagca gcagcagcag caagagacta gccccaggca gcagcagcag
421 cagcagggtg aggatggttc tccccaagcc catcgtagag gccccacagg ctacctggtc
481 ctggatgagg aacagcaacc ttcacagccg cagtcggccc tggagtgcca ccccgagaga
541 ggttgcgtcc cagagcctgg agccgccgtg gccgccagca aggggctgcc gcagcagctg
601 ccagcacctc cggacgagga tgactcagct gccccatcca cgttgtccct gctgggcccc
661 actttccccg gcttaagcag ctgctccgct gaccttaaag acatcctgag cgaggccagc
721 accatgcaac tccttcagca acagcagcag gaagcagtat ccgaaggcag cagcagcggg
781 agagcgaggg agcgctcggg ggctcccact tcctccaagg acaattactt agggggcact
841 tcgaccattt ctgacaacgc caaggagttg tgtaaggcag tgtcggtgtc catgggcctg
901 ggtgtggagg cgttggagca tctgagtcca ggggaacagc ttcgggggga ttgcatgtac
961 gccccacttt tgggagttcc acccgctgtg cgtcccactc cttgtgcccc attggccgaa
1021 tgcaaaggtt ctctgctaga cgacagcgca ggcaagagca ctgaagatac tgctgagtat
1081 tcccctttca agggaggtta caccaaaggg ctagaaggcg agagcctagg ctgctctggc
1141 agcgctgcag cagggagctc cgggacactt gaactgccgt ctaccctgtc tctctacaag
1201 tccggagcac tggacgaggc agctgcgtac cagagtcgcg actactacaa ctttccactg
1261 gctctggccg gaccgccgcc ccctccgccg cctccccatc cccacgctcg catcaagctg
1321 gagaacccgc tggactacgg cagcgcctgg gcggctgcgg cggcgcagtg ccgctatggg
1381 gacctggcga gcctgcatgg cgcgggtgca gcgggacccg gttctgggtc accctcagcc
1441 gccgcttcct catcctggca cactctcttc acagccgaag aaggccagtt gtatggaccg
1501 tgtggtggtg gtgggggtgg tggcggcggc ggcggcggcg gcggcggcgg cggcggcggc
1561 ggcggcggcg gcgaggcggg agctgtagcc ccctacggct acactcggcc ccctcagggg
1621 ctggcgggcc aggaaagcga cttcaccgca cctgatgtgt ggtaccctgg cggcatggtg
1681 agcagagtgc cctatcccag tcccacttgt gtcaaaagcg aaatgggccc ctggatggat
1741 agctactccg gaccttacgg ggacatgcgt ttggagactg ccagggacca tgttttgccc
1801 attgactatt actttccacc ccagaagacc tgcctgatct gtggagatga agcttctggg
1861 tgtcactatg gagctctcac atgtggaagc tgcaaggtct tcttcaaaag agccgctgaa
1921 gggaaacaga agtacctgtg cgccagcaga aatgattgca ctattgataa attccgaagg
1981 aaaaattgtc catcttgtcg tcttcggaaa tgttatgaag cagggatgac tctgggagcc
2041 cggaagctga agaaacttgg taatctgaaa ctacaggagg aaggagaggc ttccagcacc
2101 accagcccca ctgaggagac aacccagaag ctgacagtgt cacacattga aggctatgaa
2161 tgtcagccca tctttctgaa tgtcctggaa gccattgagc caggtgtagt gtgtgctgga
2221 cacgacaaca accagcccga ctcctttgca gccttgctct ctagcctcaa tgaactggga
2281 gagagacagc ttgtacacgt ggtcaagtgg gccaaggcct tgcctggctt ccgcaactta
2341 cacgtggacg accagatggc tgtcattcag tactcctgga tggggctcat ggtgtttgcc
2401 atgggctggc gatccttcac caatgtcaac tccaggatgc tctacttcgc ccctgatctg
2461 gttttcaatg agtaccgcat gcacaagtcc cggatgtaca gccagtgtgt ccgaatgagg
2521 cacctctctc aagagtttgg atggctccaa atcacccccc aggaattcct gtgcatgaaa
2581 gcactgctac tcttcagcat tattccagtg gatgggctga aaaatcaaaa attctttgat
2641 gaacttcgaa tgaactacat caaggaactc gatcgtatca ttgcatgcaa aagaaaaaat
2701 cccacatcct gctcaagacg cttctaccag ctcaccaagc tcctggactc cgtgcagcct
2761 attgcgagag agctgcatca gttcactttt gacctgctaa tcaagtcaca catggtgagc
2821 gtggactttc cggaaatgat ggcagagatc atctctgtgc aagtgcccaa gatcctttct
2881 gggaaagtca agcccatcta tttccacacc cagtgaagca ttggaaaccc tatttcccca
2941 ccccagctca tgcccccttt cagatgtctt ctgcctgtta taactctgca ctactcctct
3001 gagtgccttg gggaatttcc tctattgatg tacagtctgt catgaacatg ttcctgaatt
3061 c
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