GenBank-Updates@genbank.bio.net (09/23/90)
LOCUS HUMT1418 2537 bp ds-DNA BAD 23-SEP-1990
DEFINITION Human bcl2 gene exon 2/switch mu rearranged DNA generated by 14/18
translocation (q32;q21).
ACCESSION X12660
KEYWORDS bcl2 gene; rearranged DNA; switch region; translocation.
SOURCE human (Homo sapiens).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2537; for [2])
AUTHORS Ganguly,S.
TITLE ;
JOURNAL Unpublished (1988) see COMMENT for author address
STANDARD simple automatic
REFERENCE 2 (sites)
AUTHORS Ganguly,S. and Chaganti,R.S.K.
TITLE ;
JOURNAL Unpublished (1988)
STANDARD simple automatic
COMMENT The sequence is generated by a translocation involving the switch
mu region of chromosome 14 and a region in the 3'-end of the 2nd
exon of the bcl2 gene on chromosome 18. The sequence contains 26 10
- 44 bp direct repeats, 51 inverted repeats and more than 20
putative Ig recombinational signal sequences. *source: cell
type=follicular lymphoma; library=lambda EMBL4;
EMBL features not translated to GenBank features:
key from to description
SITE <1 >2537 rearranged DNA
[1] Author address Sabayachi Ganguly., Sloan Kettering Cancer
Center, Dept. of Pathology, Lab. of Cancer Genetics, 1275 York Ave.
, New York, NY 1002, USA.
Mish mash of vector sequence (Stanford et al.). Moved to bad.
Submitted (22-AUG-1988) on tape to the EMBL data library.
FEATURES from to/span description
site 1 147 putative VECTOR sequence M13mp19
site 117 410 putative VECTOR sequence M13mp19
site 426 692 putative VECTOR sequence pBR322
site 688 1228 putative VECTOR sequence M13mp19
site 1508 1986 putative VECTOR sequence M13mp19
site 1766 1837 putative VECTOR sequence M13mp19
site 1988 2159 putative VECTOR sequence pBR322
site 2117 2533 putative VECTOR sequence M13mp19
BASE COUNT 784 a 636 c 584 g 533 t
ORIGIN
1 cctgcagacc aacagagata gaacccttct gccctaaaag cgtaaggata cggggcacag
61 acaatatttt tgccgggcta ttagtctata gtgcgcgtct gctagcccaa atgcaaacag
121 cgccaaaaca cgccattaaa aataccgaac gaaccaccag cagaagataa aacagaggtg
181 aggcggtcag tattaacacc gcctgcaaca gtgccagcac gtggaggcca gcagcaattg
241 ttttttctaa taaagcatca cctcgctgaa ctagtatcaa accctcaatc aatatctggt
301 cagttggcaa atcaacagtt gaaaggaatt gaggaaggtt atcaaaatat ctttaggagc
361 actaacaact aatagattag agccggatca atagataaat acatttgaag gactccacga
421 gaatacaagg gataacaaac gaaagaacat ttgagactta acccagcaaa aggccaggaa
481 ccggaaaaag gccgcgttgc gggcgttttt ccataggctc cgccccctga cgagcatcac
541 aaaaatcgac gctcaagtca gaggtggcga aacccgacag actataaaga taccaggcgt
601 ttcccccggg aagctccctc gtgctctcct gttccgaccc tgccgcttac cggatacctg
661 tccgcctttc tccctttcgg aaagcgtggc gcaagggtgg tttttctttt caccagtgag
721 acgggcaaca gctgattgcc cttcaccgcc tggccctgaa gagttgcagc aagcggtcct
781 cgtggtttgc cccagcaggc gaaaatcctg tttgatggtg gttccgaaat cggcaaaatc
841 ccttataaat caaaagaata gcccgggata gggttgagtg ttgttccagt ttggaacaag
901 agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt ctatcatggc
961 gatgccacat acggcaaaac ccacccaccc aaatccaagt tttttggggt cgacgtgccg
1021 taaagcataa atcggaaccc taaagggact cccccgattt agagcttgac ggggaaagcc
1081 ggcgaacgtg gcgagaaagg aagggaagaa agcgaaagaa gcgggcgtag ggcggcaagt
1141 gtagcggtca cgggggaacc accaccaccc ccgccccgct taagtccccc cttaaccagg
1201 gcaaagccca tcggttactt tgaccgaccc agtataccct taatcttagc caaagcaata
1261 aatagcaacc cgttattacc cctagaccgg aacgcataag aggcacatac actagtttac
1321 gcaatagcta tcagtcttta acgcgcgggc ttaattaagc cctcaaagag agatccgcat
1381 taaacggacc ggaattaact caaaccaacc ctaagcaaat tcagaggtgt agttggtcag
1441 ctattatcac cggcctgtaa cccataccac gtgaaggtta cccccagtaa ttggagcatg
1501 taacacttaa cttcatgaga agcattttga tctggaagcg gaaggaatta cgtggcagag
1561 aaagtatttt tgaatggcta ttagtattta atgcgcgaag tgcctagccc taaaacatcg
1621 ccattaaaaa taccgaacga accaccagca gaagataaaa caagaggtga ggcggtcagt
1681 attaacaccg cctgcaacag tgccacgtag agccagcagc aaaatgaaaa atcaacaagt
1741 cataaccctc aaattcaata ttccttccga acagttggca aatcaacaac tgaaaggaat
1801 tgaaggaacc aattatccta aaatatcctt tagcggagag aataacagca attagattag
1861 aagccaacaa aagctattac atttgaggct ccacatattc aagggttaac gaagaaaatg
1921 tcatgttaat gcttaaggcc tttgcccggt ccgttattcg ttttaaggcc ttgaggatgg
1981 cgatcttcca taggttccgc cccccaacag agcgtaaaga aaaaagaggc agaaacccga
2041 aagacctata acgaaaccaa gcgtttcccc catggaagtt ccctccgctg cgttatcctg
2101 ttccgaccct gccgcaaacc ggatacctgt ccgcctttct cccttcggaa gcgtggcgca
2161 agggtggttt ttcttttaac cagttgagac gggcaaaagc ttgattgccc tttaaccgcc
2221 ttggccctga gagagttgca gcaagcggtc cagtggtttg ccccagcagg ccgaaaatcc
2281 ctgtttgatg gtggtcccta accttggaaa aatcccttaa aaatcaaaaa gaatagcccg
2341 agatagggtt gagtgttgtt ccagtttgga aaagaattcc actattaaag aaggtggact
2401 ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg ccactacgta accatcaccc
2461 aaatcaagtt ttttggggtc gaggtgccgt aaagcataaa tcggaaccct aaaggagccc
2521 ccgatttaga gctgcag
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