GenBank-Updates@genbank.bio.net (09/23/90)
LOCUS HUMPROLA 1433 bp ds-DNA PRI 23-SEP-1990
DEFINITION Human cathepsin L gene, complete cds.
ACCESSION M20496
KEYWORDS cathepsin L; collagenolytic lysosomal enzyme;
elastinolytic lysosomal enzyme.
SOURCE Human kidney, cDNA to mRNA, clone SL12.1.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1433)
AUTHORS Joseph,L.J., Chang,L.C., Stamenkovich,D. and Sukhatme,V.P.
TITLE Complete nucleotide and deduced amino acid sequences of human and
murine preprocathepsin L: An abundant transcript induced by
transformation of fibroblasts
JOURNAL J. Clin. Invest. 81, 1621-1629 (1988)
STANDARD simple staff_review
FEATURES from to/span description
pept 163 1164 preprocathepsin L precursor
sigp 163 213 cathepsin L signal peptide
matp 502 1161 cathepsin L
site 1 29 putative VECTOR sequence pUC18
BASE COUNT 388 a 276 c 384 g 385 t
ORIGIN 421 bp upstream of EcoRI site.
1 gggctgcagg tcgactctcg aggatcccca cctccacgtg ccctgttttt ctggaggcac
61 atccttggcc tcttccacag tccttgggta aatgcttggg agaataattt aaatattttt
121 attctaccat ggtggcccta atttttcagg gggcagtaag atatgaatcc tacactcatc
181 cttgctgcct tttgcctggg aattgcctca gctactctaa catttgatca cagtttagag
241 gcacagtgga ccaagtggaa ggcgatgcac aacagattat acggcatgaa tgaagaagga
301 tggaggagag cagtgtggga gaagaacatg aagatgattg aactgcacaa tcaggaatac
361 agggaaggga aacacagctt cacaatggcc atgaacgcct ttggagacat gaccagtgaa
421 gaattcaggc aggtgatgaa tggctttcaa aaccgtaagc ccaggaaggg gaaagtgttc
481 caggaacctc tgttttatga ggcccccaga tctgtggatt ggagagagaa aggctacgtg
541 actcctgtga agaatcaggg tcagtgtggt tcttgttggg cttttagtgc tactggtgct
601 cttgaaggac agatgttccg gaaaactggg aggcttatct cactgagtga gcagaatctg
661 gtagactgct ctgggcctca aggcaatgaa ggctgcaatg gtggcctaat ggattatgct
721 ttccagtatg ttcaggataa tggaggcctg gactctgagg aatcctatcc atatgaggca
781 acagaagaat cctgtaagta caatcccaag tattctgttg ctaatgacac cggctttgtg
841 gacatcccta agcaggagaa ggccctgatg aaggcagttg caactgtggg gcccatttct
901 gttgctattg atgcaggtca tgagtccttc ctgttctata aagaaggcat ttattttgag
961 ccagactgta gcagtgaaga catggatcat ggtgtgctgg tggttggcta cggatttgaa
1021 agcacagaat cagataacaa taaatattgg ctggtgaaga acagctgggg tgaagaatgg
1081 ggcatgggtg gctacgtaaa gatggccaaa gaccggagaa accattgtgg aattgcctca
1141 gcagccagct accccactgt gtgagctgtg gacggtgatg aggaaggact tgactgggga
1201 tggcgcatgc atgggaggaa ttcttcagtc taccagcccc cgctgtgtcg gatacacact
1261 cgaatcattg aagatccgag tgtgatttga attctgtgat attttcacac tggtaaatgt
1321 tacctctatt ttaattactg ctataaatag gtttatatta ttgattcact tactgacttt
1381 gcattttcgt ttttaaaagg atgtataaat ttttacctgt ttaaataaaa tcg
//