GenBank-Updates@genbank.bio.net (12/22/90)
LOCUS MUSINT1A 5607 bp ds-DNA ROD 22-DEC-1990
DEFINITION Mouse mammary proto-oncogene Wnt-1 (int-1), complete cds.
ACCESSION K02593 M34750
KEYWORDS Wnt-1 oncogene; c-myc oncogene; int-1 oncogene; proto-oncogene.
SOURCE Mouse (BALB/c) DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1098 to 5606)
AUTHORS Van Ooyen,A. and Nusse,R.
TITLE Structure and nucleotide sequence of the putative mammary oncogene
int-1; Proviral insertions leave the protein-encoding domain intact
JOURNAL Cell 39, 233-240 (1984)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 5607)
AUTHORS Nusse,R., Theunissen,H., Wagenaar,E., Rijsewijk,F., Gennissen,A.,
Otte,A., Schuuring,E. and van Ooyen,A.
TITLE The Wnt-1 (int-1) oncogene promoter and its mechanism of activation
by insertion of proviral DNA of the mouse mammary tumor virus
JOURNAL Mol. Cell. Biol. 10, 4170-4179 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer readable sequence for [Mol. Cell. Biol.
10, 4170-4179 (1990)] kindly submitted
by R.Nusse, 31-MAY-1990.
FEATURES Location/Qualifiers
CDS join(1779..1882,2452..2705,
3279..3544,4002..4490)
/note="secretory glycoprotein"
/gene="Wnt-1"
misc_feature 1133..1134
/note="MMTV insertion site in tumor 17 [Cell 39, 233-240
(1984)]"
misc_feature 1394..1395
/note="MMTV insertion site in tumor 35 [Cell 39, 233-240
(1984)]"
mRNA 1428..5398
/note="Wnt-1 mRNA (alt.)"
misc_signal 1562..1566
/note="TATA box"
misc_signal 1573..1577
/note="TATA box"
mRNA 1595..5398
/note="Wnt-1 mRNA (alt.)"
misc_feature 1631..1632
/note="MMTV insertion site in tumor 102 [Cell 39, 233-240
(1984)]"
exon 1779..1882
/note="Wnt-1 protein (exon 1)"
intron 1883..2451
/note="Wnt-1 cds intron A"
exon 2452..2705
/note="Wnt-1 protein (exon 2)"
intron 2706..3278
/note="Wnt-1 cds intron B"
exon 3279..3544
/note="Wnt-1 protein (exon 3)"
intron 3545..4001
/note="Wnt-1 cds intron C"
exon 4002..4490
/note="Wnt-1 protein (exon 4)"
misc_feature 4495..4496
/note="MMTV insertion site in tumor 53 [Cell 39, 233-240
(1984)]"
BASE COUNT 1188 a 1681 c 1519 g 1219 t
ORIGIN Chromosome 15.
1 atgtatgtat gtatgtatgt atgtatgtat acgtgcgtgc acctgtgtgt gcttggtgtc
61 agtggggctc agacatcacc tgattccctg gaactggagt tacaggtggc tataagccac
121 cacttgggtg ctgagaacag agtccgggcc tctggcagag cagtcagtgc ttttagccac
181 tgagccactc tcatcccccc aattatgttc atcttgagtt gggcaggtac ggtggcggaa
241 taggcctgta atcccagcag tcactggacc atcatgggtt ctacatatta aacctttatg
301 ttaggtaggg tcacacagca agatccggtc acaaaaccag caacaacaaa aaccaaaagg
361 agccagcttc ttcccacaag cattctttcc ctcaggtctt cagctccatc tgacagctac
421 tcggctggtg gtcctatcct ttctgagcct agttgccaga gaaacaagcc cggttcatct
481 tcatgactag cacatctaat gataagcaca ggttgactca aggtgccata gagtgacact
541 aggtacccag agcgacagaa tgacacctat gagtgcacgt cgttaatcac aaacacacac
601 acacacacac acacacacac acacacacac tcatgcaccc acctgcaaac acaattgcag
661 ccttctggac gtctcctgtc acagccccac ctccttcctg atacactgcg ttaagtggtg
721 actgtaacaa aatgacttca tgctctccct gtcctgagcc aaattacaca attatttgga
781 aagggctcaa aatgttcttc gttagaagtt tctggataca ccaatacaca ggagcgtgca
841 ccctcagaac acatgtacac tttgacttaa tctcacgggt gacacaccga cgcttacact
901 ccccctagcc cacagaggca aactgctggg cgcttctgag tttctcactg ccaccagctc
961 ggtttgctca gcctaccccc gcaccccgcg cccgggaatc cctgaccaca gctccaccca
1021 tgctctgtct ccttcttttc cttctctgtc cagccgtcgg ggttcctggg tgaggaagtg
1081 tctccacgga gtcgctggct agaaccacaa ctttcatcct gccattcaga atagggaaga
1141 gaagagacca cagcgtaggg gggacagagg agacggactt cgagaggaca gccccaccgg
1201 cgcgtgtggg ggaggcaatc caggctgcaa acaggttgtc cccagcgcat tgtccccgcg
1261 ccccctggcg gatgctggtc cccgacgggc tccggacgcg cagaagagtg aggccggcgc
1321 gcgtgggagg ccatcccaag gggaggggtc ggcggccagt gcagacctgg aggcggggcc
1381 accaggcagg gggcgggggt gagccccgac ggttagcctg tcagctcttt gctcagaccg
1441 gcaagagcca cagcttcgct cgccactcat tgtctgtggc cctgaccagt gcgccctggt
1501 gcttttagtg ccgcccgggc ccggaggggc agcctcttct cactgcagtc agcgccgcaa
1561 ctataagagg cctataagag gcggtgcctc ccgcagtggc tgcttcagcc cagcagccag
1621 gacagcgaac catgctgcct gcggcccgcc tccagactta ttagagccag cctgggaact
1681 cgcatcactg ccctcaccgc tgtgtccagt cccaccgtcg cggacagcaa ccacagtcgt
1741 cagaaccgca gcacagaacc agcaaggcca ggcaggccat ggggctctgg gcgctgctgc
1801 ccagctgggt ttctactacg ttgctactgg cactgaccgc tctgcccgca gccctggctg
1861 ccaacagtag tggccgatgg tggtaagtga gctagtacgg ggtccgccac ttgtcctggg
1921 gcaaagagcc aggcacgggc cttacccagc tcccacgctg tggggatcac caacctacag
1981 acccccctcg tgcattgtga cttcacatcc agggtgctca cacctagaac tagctctgct
2041 gaagtggggc acatcattgg catgcagaag cccagataca ccaggctcag agaccattcc
2101 catttaatac gaccccgttt ctgctgagca acaggtccca acctcgctgt ggtgggtgct
2161 caggtgtccc ttaggtcttg aaccaaaaaa aaaaaaaaaa aaaaaaaaaa accagatatt
2221 agctttgagg tgagggagtg gaattcctaa gtttttcaag gtgggcaagg ctgcaggtgg
2281 ggtttctcct cgggggctga cttgaagaaa ggaagagcta aggtagccat gccttttctg
2341 tccactcact agactctgga gctcagggcc aggcaaggat agggtggtac agcctgtatg
2401 gttaggatgc aggtcccctc ccctggactg aacccttatg catcccgcca ggggcatcgt
2461 gaacatagcc tcctccacga acctgttgac ggattccaag agtctgcagc tggtgctcga
2521 gcccagtctg cagctgctga gccgcaagca gcggcgactg atccgacaga acccggggat
2581 cctgcacagc gtgagtggag ggctccagag cgctgtgcga gagtgcaaat ggcaattccg
2641 aaaccgccgc tggaactgcc ccactgctcc ggggccccac ctcttcggca agatcgtcaa
2701 ccgaggtggg tgcccaggaa agcgacgctt ccgggattaa gggaaaagca gggtcatctc
2761 cagggcatag gcgggcgaag gcagggaaga catcccaggg ttatatgtga tcaaactgag
2821 aatcgcctgg tgccggcagt taccgtaggt cagcaccaga ttctttctag ccttgcgttg
2881 tgagcatgat ctttaacgtt gctggccact ggcccacaga aagggaattc cggatcgtgg
2941 gcgctgggcg acagctgttt ttccctagcc ttcctcaaag gtacctggga agctgatctc
3001 tgagggctag ctagggttgt gcttcgcacc cagcaaagtt tgcactgcca atactagtag
3061 cgatcttggc tatgcagatt tgttctactt gggaatctcc ccttggagct gctctgctag
3121 ggctctggag tctcagtaaa gcttagagag gagggcattc catgcttcgc acacatgact
3181 ccaaggatgt tggactgtag ggtaccaagt cttccaaaca gggtgctgag ttggccccac
3241 gccttctctc aactgatgcg gggtcgcttc acccacaggc tgccgagaaa cagcgttcat
3301 cttcgcaatc acctccgccg gggtcacaca ttccgtggcg cgctcctgct ccgaaggctc
3361 catcgagtcc tgcacctgcg actaccggcg gcgcggccct gggggccccg actggcactg
3421 ggggggctgc agtgacaaca tcgattttgg tcgcctcttt ggccgagagt tcgtggactc
3481 cggggagaag gggcgggacc tacgcttcct catgaacctt cacaacaacg aggcagggcg
3541 aacggtacgt cggtgtgtcc ggaaccaatg gcaggggaga tgtaagacag gtgcacgggg
3601 acagaggcac agggaggggc ttcccgagag agtgggactc taggagggaa gacagagaag
3661 aggtggtggt tgagggcaaa gaggttcctg agctgatgac agaacagaag agattagcag
3721 gctatcaaca cgtgggatgt attgagatgg ctccatggca cacttttgaa agataaaagt
3781 gacttgctgg cgtggagcag agtctggccg aatgtcccta tctcagcggg ccattttgca
3841 cttcctctct cccgagctta gtcacacctg gaccttggct gaagtttcca cagcatcgac
3901 gtgacccggg tggggtgggg gtggggaagt atgggtggtg gttcgtggga tgttggcttt
3961 gaccttttct tccctcctcc cctcgtcccc tcctccccca gaccgtgttc tctgagatgc
4021 gccaagagtg caaatgccac gggatgtccg gctcctgcac ggtgcgcacg tgttggatgc
4081 ggctgcccac gctgcgcgct gtgggcgacg tgctgcgcga ccgcttcgac ggcgcctccc
4141 gcgtccttta cggcaaccga ggcagcaacc gcgcctcgcg ggcggagctg ctgcgcctgg
4201 agcccgaaga ccccgcgcac aagcctccct cccctcacga cctcgtctac ttcgagaaat
4261 cgcccaactt ctgcacgtac agtggccgcc tgggcacagc tggcacagct ggacgagctt
4321 gcaacagctc gtctcccgcg ctggacggct gtgagctgct gtgctgtggc cgaggccacc
4381 gcacgcgcac gcagcgcgtc acggagcgct gcaactgcac cttccactgg tgctgccacg
4441 tcagctgccg caactgcacg cacacgcgcg ttctgcacga gtgtctatga ggtgccgcgc
4501 ctccgggaac gggaacgctc tcttccagtt ctcagacaca ctcgctggtc ctgatgtttg
4561 cccaccctac cgcgtccagc cacagtccca gggttcatag cgatccatct ctcccacctc
4621 ctacctgggg actcctgaaa ccacttgcct gagtcggctc gaaccctttt gccatcctga
4681 gggccctgac ccagcctacc tccctccctc tttgagggag actccttttg cactgccccc
4741 caatttggcc agagggtgag agaaagattc ttcttctggg gtgggggtgg ggaggtcaac
4801 tcttgaaggt gttgcggttc ctgatgtatt ttgcgctgtg acctctttgg gtattatcac
4861 ctttccttgt ctctcgggtc cctataggtc ccttgagttc tctaaccagc acctctgggc
4921 ttcaaggcct ttcccctccc acctgtagct gaagagtttc cgagttgaaa gggcacggaa
4981 agctaagtgg gaaaggaggt tgctggaccc agcagcaaaa ccctacattc tccttgtctc
5041 tgcctcggag ccattgaaca gctgtgaacc atgcctccct cagcctcctc ccaccccttc
5101 ctgtcctgcc tcctcatcac tgtgtaaata atttgcaccg aaatgtggcc gcagagccac
5161 gcgttcggtt atgtaaataa aactatttat tgtgctgggt tccagcctgg gttgcagaga
5221 ccaccctcac cccacctcac tgctcctctg ttctgctcgc cagtcctttt gttatccgac
5281 cttttttctc ttttacccag cttctcatag gcgcccttgc ccaccggatc agtatttcct
5341 tccactgtag ctattagtgg ctcctcgccc ccaccaatgt agtatcttcc tctgaggaat
5401 aaaatatcta tttttatcaa cgactctggt ccttgaatcc agaacacagc atggcttcca
5461 acgtcctctt cccttccaat ggacttgctt ctcttctcat agccaaacaa aagagataga
5521 gttgttgaag atctcttttc cagggcctga gcaaggaccc tgagatcctg acccttggat
5581 gaccctaaat gagaccaact agggatc
//