GenBank-Updates@genbank.bio.net (01/10/91)
LOCUS RABIGHVDJB 752 bp ds-DNA MAM 10-JAN-1991
DEFINITION Rabbit rearranged Ig heavy chain gene VDJ-region, clone PCR4-3.
ACCESSION M55382
KEYWORDS diversity exon; immunoglobulin heavy chain; joining exon;
processed gene; variable region.
SOURCE Rabbit adult spleen DNA, clone PCR4-3.
ORGANISM Oryctolagus cuniculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Lagomorpha; Leporidae.
REFERENCE 1 (bases 1 to 752)
AUTHORS Becker,R.S. and Knight,K.L.
TITLE Somatic diversification of immunoglobulin heavy chain VDJ genes:
Evidence for somatic gene conversion in rabbits
JOURNAL Cell 63, 987-997 (1990)
STANDARD full staff_review
FEATURES Location/Qualifiers
sig_peptide join(236..281,384..394)
/gene="IgH"
CDS join(236..281,384..752)
/gene="IgH"
/partial
/product="Ig heavy chain"
misc_feature 1..29
/note="5' PCR primer"
intron 282..383
/gene="IgH"
exon 384..752
/number=2
/gene="IgH"
/partial
mat_peptide 395..752
/gene="IgH"
/codon_start=395
/partial
/product="Ig heavy chain"
misc_feature 743..752
/note="3' PCR primer"
BASE COUNT 158 a 225 c 211 g 158 t
ORIGIN
1 gaattcctgt cacagccatc actctacata cccaggacac cacatctgcc ctgggccctc
61 tcctgtctga ggcgtctacc tcctgcctgc tatatagggg cagcacatgc aaatagggcc
121 tccctctgcc catgaaaacc agcccagccc tcaccctgca gttctggcac aggagctcca
181 gccccagcac tcccaggtgt ccactcagtg atcgcactca acacagacac tcaccatgga
241 gactgggctg cgctggcttc tcctggtcgc tgtgctcaaa ggtaatgatg gagaacgcgg
301 ggcactgagt ctgggagagg acgtgagtga gagacacaga cagtgtgagt gacagtacct
361 gaccatgtcg tctgtgtttg caggtgtcca gtgtcagtcg ttggaggagt ccgggggaga
421 cctggtcaag cctggggcat ccctgacact cacctgcaca gcctctggat tctccttcag
481 tagcagctac tggatatgct gggtccgcca ggctccaggg aaggggctgg agtggatcgc
541 atgcattggt gctggtagta gtggtagcac ttactacgcg agctgggcga aaggccgatt
601 caccatctcc aaaacctcgt cgaccacggt gactctagcg atgaccagtc tgacagccgc
661 ggacacggcc acctatttct gtgcgagaat agggtctact aatgatggtt atcacttgtg
721 gggcccaggc accctggtca ccgtctcctc ag
//