GenBank-Updates@genbank.bio.net (01/12/91)
LOCUS RABTNFB 6577 bp ds-DNA MAM 12-JAN-1991
DEFINITION Rabbit lymphotoxin gene, complete cds.
ACCESSION M60340 M35326
KEYWORDS lymphotoxin; tumor necrosis factor-beta.
SOURCE Rabbit DNA.
ORGANISM Oryctolagus cuniculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Lagomorpha; Leporidae.
REFERENCE 1 (bases 1 to 6577)
AUTHORS Shakhov,A., Kuprash,D., Azizov,M., Jongeneel,C. and Nedospasov,S.
TITLE Structural analysis of the rabbit TNF locus, containing the genes
encoding TNF-beta (lymphotoxin) and TNF-alpha (tumor necrosis
factor)
JOURNAL Gene 95, 215-221 (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS join(1168..1242,1326..1431,
1629..2041)
/gene="TNF-beta"
/product="lymphotoxin"
mRNA join(718..866,1160..1242,
1326..1431,1629..2639)
/gene="TNF-beta"
CDS join(4042..4227,4677..4731,
4892..4939,5230..5648)
/gene="TNF"
/product="tumor necrosis factor"
mat_peptide join(4894..4939,5230..5645)
/gene="TNF"
/product="tumor necrosis factor"
mRNA join(3869..4227,4677..4731,
4892..4939,5230..6447)
/gene="TNF"
/product="tumor necrosis factor"
misc_feature 611..620
/note="NF-kappaB-related site"
protein_bind 643..648
/note="Sp1"
TATA_signal 688..693
/note="pot."
/gene="TNF"
exon 718..866
/number=1
/gene="TNF-beta"
/codon_start=718
intron 867..1159
/number=1
/gene="TNF-beta"
misc_feature 988..997
/note="NF-kappaB-related site"
exon 1160..1242
/number=2
/gene="TNF-beta"
/codon_start=1160
intron 1243..1325
/number=2
/gene="TNF-beta"
exon 1326..1431
/number=3
/gene="TNF-beta"
/codon_start=1326
intron 1432..1628
/number=3
/gene="TNF-beta"
exon 1629..2639
/number=4
/gene="TNF-beta"
/codon_start=1629
polyA_signal 2634..2639
/note="pot."
/gene="TNF-beta"
misc_feature 2917..2926
/note="NF-kappaB-related site"
misc_feature 3029..3038
/note="NF-kappaB-related site"
misc_feature 3251..3262
/note="NF-kappaB/CK1-related site"
misc_feature 3281..3292
/note="H2TF1-related site"
protein_bind 3811..3816
/note="Sp1"
TATA_signal 3835..3840
/gene="TNF"
exon 3869..4227
/number=1
/gene="TNF"
/codon_start=3869
exon 4677..4731
/number=2
/gene="TNF"
/codon_start=4677
exon 4892..4939
/number=3
/gene="TNF"
/codon_start=4892
exon 5230..6447
/number=4
/gene="TNF"
/codon_start=5230
misc_feature 5483..5492
/note="NF-kappaB-related site"
misc_feature 6107..6138
/note="ttatttat-element"
polyA_signal 6424..6429
/note="pot."
/gene="TNF"
BASE COUNT 1322 a 2060 c 1912 g 1283 t
ORIGIN
1 aagcttgtac tacagatcac acagcagtgg ccccagcact gaccctggag ggggtgtttc
61 cacgggatac agaaatctga tgtggggggg ctgaggctgg agtgaggggg caggcactgt
121 tcagggtggg acgggagctt gtcatccaag agcatgtagc atcatcttgg cacgggggtg
181 attcatcttc caagccagga cacttgggga gggagagggg gctcctttcc ccaaggcagc
241 aggtacacag ccctgatttg agacctgcca gacagcctgg aaagtgcaca cactgggacg
301 agcaaagacg agggccaggg ctgcccgaga aggaagctgg tggggtgcag aggtgttcac
361 tgcgctggct gttcagggaa ctggcctgca gcccacaccc aggctgctgc cgctcgtcct
421 ccccgaaacg cctgtccctt ctctggaact gctgggcctg ccctccctcc gcggccgtcc
481 cagcccacgg ttcccctgac cccactcgcc ttcccagaac tcaatcgccc gagcccccag
541 cctgtggttc cctcctaggc cccagccttt cctgccttcg actgaaacag cagcatcttc
601 tgagccctgg gggcttcccc gggccccagc cccgacctag aacccgcccg ccgcctgcca
661 cgctgccgct gccactgccg cttcctctat aaagggaccc aagcgtccgg gcccaggggc
721 cccgcacagc aggtgagagt cttctgccca gctgcctggc tgccgcacag cctcctgccc
781 cctccgcccg ggcacaggcc ggcgccacct gcctggcacc ccgcgcctcc cctccccgcc
841 ccccacctgc ctgggcctgg gccttggtgg gtttgctttt ggtttgttct tgtgtctgcc
901 tctccagctg tgcgtcatcc ctgtcacggg ctctctgttt ctgccacctt cctgtctgtc
961 tctttctctt tctctcctgt tcacctcggg gctcccctgc ctgcatctcc tcctcttctc
1021 tctctgtcgc cctgtcgttg gggtggctgt ctcggtgggc gggcgggcgg gcgggaggtc
1081 cctcttccgc tgcgtgcccc gccccaccca ccgtctctca ctccgcgggg cgcgctctct
1141 ttctctctct ccctgcaggt tctccccatg acaccacctg gacgtctcta cctccccctc
1201 cttctggggc tgctgctggc cccgccgccg cctggggccc aggtgaggcc gcaggagaat
1261 ggggagctgc cggggtgcgc ccaaccttga gcctcgcagc tcccctcaac tctgttctcc
1321 cctaggggct ccctggggct gagttcccgc cctcagctgc ccggaatgcc cagcagcgcc
1381 ttcagaaaca tttcggccac agcaccctca aacctgctgc gcacctcgtt ggtaaacacc
1441 caccgggccc cagacacaca gccccctggc tctcctgcta cagccccacc agggtccaag
1501 tacaacccac acccctcctc caagtcctcc cccactagca cctcccccag ccctcacctg
1561 agctcagctg tccagtgctg ctccctcagg ggctgacact ctaacctgcc cttccctccc
1621 caccccagga gaccccagcg cgcaggactc gctgcgctgg agagcgaaca cggatcgggc
1681 cttcctccgc cacggcttct ccctgagcaa caattccctg ctggtgccca gcagcgggct
1741 ctacttcgtg tactcgcagg tggttttctc tggggaaggc tgctccccca aggccgtgcc
1801 cacgcctctc tacctggctc acgaggtcca gctcttctcc tcccagtact ccttccatgt
1861 gcctctcctc agcgcccaga agtctgtgtg cccagggccg cagggaccct gggtgcgctc
1921 cgtgtaccag ggggccgtgt tcctgctcac ccagggagac cagctgtcca cccacacaga
1981 tggcatcgcc cacctgctcc tcagccccag tagtgtcttc tttggagcct ttgctctgta
2041 gaccttagaa aaatccagaa agaaaaaaaa atgggcttca aggccttctc cccattttga
2101 ctccattctg actgtttcaa ggatcaccac cacctctcct tggaccattc caacagtctc
2161 aagtctcccc cactcaagtc acctggagtc ttcaaagaag gaattctagg ccccccaggg
2221 gaccgcaccc ccctgaatcc aggatgtcac gcctgcctag aaattcagag ccggagctgt
2281 cctgctgttc cccactgtct aggtggggcc tgcgcctgga ccggaccggg acacagggca
2341 gcttgggagg aagactagag gcagggaagg gggactattt atgaaggggg ggaattaagt
2401 tatttattta tggagcatgg agagagggga ataacacaag gatgtcagga gagagagagt
2461 gttgaacagg ctcaagagct aaagacaagg cacttggaca aggctcagag agagagagag
2521 agaggtctga ggaactgggg ggctcgagaa ggaagcgaaa gggccgctga gccagcaccg
2581 cttgaccaga cacccccggg gagacacctg cgccctcgcc ctcagtgaag cccaataaac
2641 ctcttttctc tgaagtgctg tctgctcgtg tgtcggtctc taactctggg aggggagaat
2701 tccccaggtc tctctacgga atggagagag ggacgggggc cacagagggg tcgggaactg
2761 tgggcagagg tccaggagat aaaaagcccc caaggagctc caggggtgtg tggccgactc
2821 ccaggggaga ggagccaaag tgctgcacgg gaaccaaagg atgagctggg aagactggag
2881 agatggggtc cccggggtct tggggggtgg gagtcagggg gtccccggga gacctctcct
2941 agaggcttga gggagggggt cacagggggc ctctggggag aagggaccac acaaagggag
3001 ggctgtccca gatggtgagg gtgcagatgg agaccccctg aggaggagct ttgcacagga
3061 ccccaaggag caaccagggg gtgtggaaca cagcagactt tctggacacg cagccgcata
3121 acagggcttg gaagggaggg gtggattcat gaaaaaaaat cagggacctc agagtccctt
3181 ggaaatcaag attgaaaccg tagtggggat ccgggttcag aatgaaagga gaagcctgcc
3241 ctgtggggcc gtgaattccc agggctgatt tccctccctc tggggctgtc ccaggcttgt
3301 ccctgctatc ctccacccag ccctgccagg gccccatgca caccccatgc acccagcccc
3361 cagcgccttt tgcccccccg gggacccaga cacctgtctc agacccagca ccgcccaggt
3421 ttctcccgct caaggtctca gccttctgaa gcccctccta cttcaagttc taccccccac
3481 aggagtcctg tctggaaatc agagggaaac agcacaccca tcggtccccc aaagtaggcg
3541 tggtgggggc aggggcaacc aggatccagc ttccaggttg ctctgcttgc actggtaact
3601 ggcccaagac attcgcctcc aaatccgggt cgggagggtg aggagtatcc ttgatgcctg
3661 ggtgtcccca actttccaaa gccccgcccc caccccccga gatggagaag aaaccgagag
3721 agaaggtgta gagcccacta ccgcttcctc cagatgagct catgggtttc tccaccaagg
3781 aagttttccg ctgggtgaat gagagccttt ccccgccccc ctctcgcccg cgggctataa
3841 aggcagctgt gtgcacaccc agccagagaa gctccctcag tgaggacacg ggcaccagct
3901 aggagggaga gcagcaactc caggctcccc cggcagtaac tcccagacgc cgccccgcca
3961 gacaagctgc cagccggtgt gccgtcttcc tctctcacgc accagcccct ggttccacca
4021 cctccctctg gagagagcgc catgagcact gagagtatga tccgggacgt cgagctggcg
4081 gaggggccgc tccccaagaa ggcagggggg ccccagggct ccaagcgctg cctctgcctc
4141 agcctcttct ctttcctgct cgtggctgga gccaccacgc tcttctgcct gctgcacttc
4201 agggtgatcg gccctcagga ggaagaggtg agtgcgtggc ggccgacaga aatgaatgag
4261 ttagctgacg ggatgggggc gggaaaccat ggggccagat ggggaggcag agggagatgt
4321 ggagaggagg agggtgctca ctagaccttg gctgcatgca tgcaagaatg aatgaatgaa
4381 cgagcaagca gatagagaga tgtgggagat acgcgagata aggagggaca tgcggagaca
4441 gagacgagag ggggtgaaga cagggcgtct ggtacacaga aggaacctcc cgaaagagtt
4501 gttaggggga aggaagggag ggagggaggg agggagggag ggagggaggg agggagggaa
4561 ggagcccgat gagtggatgg atgaagagac agcagagcaa aagccggctg agctgccacc
4621 gtgttgctcc tttgagcgtg attcccccat gctaatcctc tccttttttc tcccagcagt
4681 ccccaaacaa cctccatcta gtcaaccctg tggcccagat ggtcaccctc agtaagtgtc
4741 tctagcttct cctaccgtcc tgggtttgag tgggagggga gctgtagtcc cgggaagcaa
4801 gcagcgaagg gcggggatta gagtctgggt tttgggaggg gatatcatct cctgagggta
4861 ggggtctcag ctctgtcttt cttcttctca ggatcagctt ctcgggccct gagtgacaag
4921 cctctagccc acgtagtagg taagagctct gactgggtgt ccagggcgcg aaggagcacg
4981 cgggacttgg agggagggga tctgagggct gcagacatgg gagacggagt gagaagcact
5041 gctgagctca aggggagggt ggaggaacag agggggcact gagaacccca cggctagatg
5101 ggatgtggga aggcccacgg aggagcagga accggatgtg agggcaggca gaacgtgggg
5161 cccaggatgt gagggtgaac cgtcacagtt accctgactc acccctccct cccttctctt
5221 tttctccagc aaacccgcaa gtggagggcc agctccagtg gctgagccag cgtgcgaacg
5281 ccctgctggc caacggcatg aagctcacgg acaaccagct ggtggtgccg gccgacgggc
5341 tgtacctcat ctactcccag gttctcttca gcggtcaagg ctgccgctcc tacgtgctcc
5401 tcactcacac tgtcagccgc ttcgccgtct cctacccgaa caaggtcaac ctcctctctg
5461 ccatcaagag cccctgccac cgggagaccc ccgaggaggc tgagcccatg gcctggtacg
5521 agcccatcta cctgggcggc gtcttccagt tggagaaggg tgaccggctc agcaccgagg
5581 tcaaccagcc tgagtacctg gaccttgccg agtccgggca ggtctacttt gggatcattg
5641 ccctgtgagg ggactgacca ccactcctcc ccctctccca ccccagcccc ctcactctgg
5701 gcgccctcag cccctctcat cctcctctag cttagaaaca gaaatgaggg gctcagaatc
5761 agacctcaga acttttaaca ccaccactta gaaacctgga ccgtggtggt gtaggcctgc
5821 acagtcaggg ccctggccac accaaagcat tcaaactgag gcttccagga ctcactgggg
5881 ccttcagaac tccattctca gattgagccc ggaacatccg gaatgtgggg accacgtagc
5941 cgtgggttca ggccagaacc ttctagaaga gcccttgaga gaagttgtca cccagaccta
6001 ggccttcctc tcctcagatg tttctacact cttctctgca atgtggagcc ccgccccccg
6061 cccagggcag ggcccctcta tttatagttg cactggtgat tattgattat ttattattta
6121 tttaatattt atttatttgc cgatgaatgt atttatttgg aagctcagcg catcctgggg
6181 tacccagcgt aggagctgcc ttggttctca cacgttttcc gtgaaaacag agcagaacca
6241 tgggtcgatc ccacctggcc tcctggcccc tgtgcctccc ttcacttatg tttttaagaa
6301 gatatttatc tgatcaggtt gtctcactaa tgctgatttg gtgactgacc cgtcgctaca
6361 tcaccgaacc tctgctccct aagggagttg tgttggtaac cgccctactg gtcagtggcg
6421 agaaataaag actccttaaa aaataaacct gttctctttt ccttctttct tgcttctagt
6481 tatttgaaag gcagagacag ataaagagag agtgcccacc cactggttct tatcccataa
6541 tgccttgcca tgggctgcag ccagaagtca ggaattc
//