GenBank-Updates@genbank.bio.net (01/16/91)
LOCUS HUMIGFBP1 6480 bp ds-DNA PRI 16-JAN-1991
DEFINITION Human insulin-like growth factor binding protein-1 (IGFBP-1) gene,
complete cds.
ACCESSION M59316 J05683
KEYWORDS insulin-like growth factor binding protein-1.
SOURCE Human leukocyte DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 6480)
AUTHORS Cubbage,M.L., Suwanichkul,A. and Powell,D.R.
TITLE Structure of the human chromosomal gene for the 25 kilodalton
insulin-like growth factor binding protein
JOURNAL Mol. Endocrinol. 3, 846-851 (1989)
STANDARD simple staff_entry
REFERENCE 2 (bases 1 to 6480)
AUTHORS Suwanichkul,A., Cubbage,M.L. and Powell,D.R.
TITLE The promoter of the human gene for insulin-like growth factor
binding protein-1: Basal promotor activity in HEP G2 cells depends
upon liver factor B1
JOURNAL J. Biol. Chem. 265, 21185-21193 (1990)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
mRNA join(1206..1719,3258..3427,
4643..4771,5662..6362)
/gene="IGFBP-1"
/partial
mat_peptide join(1446..1719,3258..3427,
4643..4771,5662..5790)
/gene="IGFBP-1"
/product="insulin-like growth factor binding
protein-1"
CDS join(1371..1445,1446..1719,
3258..3427,4643..4771,5662..5793)
/gene="IGFBP-1"
/product="insulin-like growth factor binding
protein-1"
exon 1206..1719
/number=1
/gene="IGFBP-1"
/codon_start=1206
sig_peptide 1371..1445
/gene="IGFBP-1"
/evidence=EXPERIMENTAL
/codon_start=1371
exon 3258..3427
/number=2
/gene="IGFBP-1"
/codon_start=3258
exon 4643..4771
/number=3
/gene="IGFBP-1"
/codon_start=4643
exon 5662..6362
/number=4
/gene="IGFBP-1"
/codon_start=5662
BASE COUNT 1614 a 1537 c 1626 g 1703 t
ORIGIN Chromosome 7.
1 ttcttgttca ggatccaccg ttatagcctc tgtgactttg acctggcaat agcttccttc
61 tctggcctca gtgttctcct ctataaagca aggggctgga caagcatctc cagtttccca
121 gtttggcaac accactccta aaggatctga agggacaaca ggaggcccag gctggaggta
181 gggtagccct gagcctgtgc ctagaatggg aggcaaagat ggtggcaggt gggtgggaaa
241 atgtggggtt tgggggtcac aggagagacc aaggggcagg cctggagcat ggcactctcc
301 ctgatcacag ctttccactg gaaggccatg gagggagtga tggggagagc ctgcaactcc
361 tggagataag ctgattctga ctttctttga aggatttttt tctttcgact tctttcctgt
421 gaaagagaat atccgagaaa tgagaatttt aactaaagag aaaacctttg catttgctac
481 tgataaatat ctggcctatg cgggaaagtc atgggtgccc tgggattctg gctccactgc
541 taacaagacc ttgttagacc ttcttaactg cccctccaga gaggagaaag gctcttggag
601 gtagagtgag attggggagc ttggcagagc cctaggatga actgtgtttt tgttttgttt
661 tgttgcaggt tggagccttt ttcctgcaga aagagaagca attccgggct tttccacaga
721 taacctgcta gggctcgcag agacctggat tctaacccca tctcgccttt cctcacctgg
781 ggcattgttt tctgcgtttg agaactgctg ggtgggctgg tgttacccag gatttttaaa
841 tttttgcagg agacgctttg caggagatct ctagggcttt tttctgtgtc aattaaagag
901 cctggccagc tggacctggg ctgtcttttt gacaaaaaca aacgtcatcc ccctcccagc
961 tgagcacttg ttagaactgg actttaactg agggcctgaa ccccctaaca acgggacaaa
1021 cagtatgaaa tcaaaaccgt ttaccctcct cccaccagcg gtttgcgtag ggccttgggt
1081 gcactagcaa aacaaactta ttttgaacac tcagctccta gcgtgcggcg ctgccaatca
1141 ttaacctcct ggtgcaagtg gcgcggcctg tgccctttat aaggtgcgcg ctgtgtccag
1201 cgagcatcgg ccaccgccat cccatccagc gagcatctgc cgccgcgccg ccgccaccct
1261 cccagagagc actggccacc gctccaccat cacttgccca gagtttgggc caccgcccgc
1321 cgccaccagc ccagagagca tcggcccctg tctgctgctc gcgcctggag atgtcagagg
1381 tccccgttgc tcgcgtctgg ctggtactgc tcctgctgac tgtccaggtc ggcgtgacag
1441 ccggcgctcc gtggcagtgc gcgccctgct ccgccgagaa gctcgcgctc tgcccgccgg
1501 tgtccgcctc gtgctcggag gtcacccggt ccgccggctg cggctgttgc ccgatgtgcg
1561 ccctgcctct gggcgccgcg tgcggcgtgg cgactgcacg ctgcgcccgg ggactcagtt
1621 gccgcgcgct gccgggggag cagcaacctc tgcacgccct cacccgcggc caaggcgcct
1681 gcgtgcagga gtctgacgcc tccgctcccc atgctgcagg taccacagtc ccgcccctgc
1741 tccagcacct cctgccgccc gcccccgccc ggcacctccc gcccccactc ccctaactac
1801 tgggtggggc tgcagcgggc aggggcttgt ccacaactag agcttgaaac cagagcacgt
1861 agttggggaa ggagcttggg tcacccagtg gagcccgctc attgcacggt cttggcagga
1921 cgtgctctgg gagaagaagg aagatgttcc aggggcacac atagcttagt ggagactcaa
1981 ggaggaagct cccacttggc cctcgtagcc cagagatctt tagagaccca gacagcaaga
2041 gtagagggag gcggtggggc tgcctccgca gttgggatgc caccctgggt tcccccacca
2101 gtctccttgc cagcacgtgg gcagccccag tggctggagc atccgggaag gcctaagaag
2161 ggaatccctc ctgctggcct ccccaggagt gtttggaatg tcctttgtaa tatacgtcct
2221 ggatacagta tgtgcttccc agatgtttac agaacataat gtgagagttg aggctaaaag
2281 cttcacttcc attcattgcc atagaaaaac aatgtttgat gtgtatgttg ccccctaaga
2341 acatgacaat caggttcttt cctggattta agcaggcatt tgtttgtagc gggaagtgga
2401 ggaaatgcct ctttctctac tccagcccct atctcctcat ctggactgct tgcagctcct
2461 gtcctgtgcc attcttggag gaattaggac ttccatacct gatagggtgt tagagtgagt
2521 gtgtgagagt cagtgaccct tccaaggagg gaacagggat ttctgcggat tctctgccct
2581 tcagaggaaa tgaaagggag tcgtctcact gatcctcaag gagatggatt tccacagggg
2641 gtcccttata ggccagtgtg ctgattctgt tcatgtacct ttggactcta tctgcaagat
2701 cctcttgcca tgggggtgga gggggtgttg cagagaagtc cattaggagc tgggaaggca
2761 ggggccccaa atagaagagg gtagtagttt gggtcaggag agctgcattc tagactccac
2821 ttctagatga actgtaccat ccattcaggg atattagtaa aatccccatt taaggatgga
2881 gaagctgagg tttcgaggct ccctactaat gcggttagga actgaactct aatcctggct
2941 tctttagggt tgttctcaac ctcagcaaat gcatttgttg ctctgctccc ctgctgcttt
3001 aaaagcagaa acgtggggca cccttgccag gccctgaaac ttactattgt caggaacaga
3061 gctggcatgc tgttgggaca taactcttcc tggaaaccat tacaaggtcc tttacagtga
3121 gagtcagtga aaatcaggtt agggaatgtg ccatcctcat gcccagcctg gttttgaggg
3181 aagaagtgat ctcctggggg ccgaaagggg cagatgcttt gggagggctc atggggtctg
3241 caatgtttcc tttccagagg cagggagccc tgaaagccca gagagcacgg agataactga
3301 ggaggagctc ctggataatt tccatctgat ggccccttct gaagaggatc attccatcct
3361 ttgggacgcc atcagtacct atgatggctc gaaggctctc catgtcacca acatcaaaaa
3421 atggaaggtg aggcccagca ggtgggtggt gggaactctc ctgtcagagg atgtagcttg
3481 agtcggctgt gacaagcaga cctggcccac tccttcctgg tcctgatgcc ctggaaagaa
3541 atgcttttcc cccaaaacct agtggccatt tctcagttaa actttgtcaa actgtgaaca
3601 catggacttt caggagagga gcccactgga tgcaaagaaa atgtagttcc ggacgatagg
3661 ttacttcatg tctctgagct cctctctaaa gggtgtgaga acattgagtt acattgttcc
3721 aaaacttagt acaagggcct aactgctttc acccccattg tatgatttgc ctccctttaa
3781 aaaagttgtc ataaaataga cataaaatgt actgttttaa ctattttgaa ggcataggtt
3841 tctgtggcat taagtaacaa taagtaatgc atgttattct gcaaccacta ccaatatcta
3901 ccttcagaat tttcatcttc ccaaactgaa gctcggaact cattaaacat caactctcca
3961 ttatcttaat tatgtctgtt ttgaattcta ccacttgagg gcgacagaga atcaaagtcg
4021 ggagtgattt gatttgagaa aataaattac ttccacaaac atgcctaccc agaaaaaggg
4081 aggattaaac cattttctca acattttgga atttcatctg agaataacga taaatggagg
4141 aaagttaatt cttaaattat ccaaatgaat gccttaatcc tcacttgatt tagtttatgt
4201 aaaagaacct tgtagattgc agaggaaagt tattcaaaat ctagaaacgt cttctgctaa
4261 attcttaatt aagagttatg cccactcttc taaccagatg gcgggtgcca aaagtattca
4321 gtaggtggca ggaagagttg ggaagagttt tgtggtgttg gtgaggctct tgccagggga
4381 tgtctctgtg caggtgttga gagagtgatt ggtgagggag agaatggtgt tcttgttctt
4441 tatctgaaca acttaagaca gactaactgc aggtgggaaa aagaggccag agggagcaca
4501 tcacatgaca cctagtccca ggtccccgtg gccagatcgt agggccactc ctgcttctac
4561 aaaacctctt ccatcagtca ttgtctaggc tgataattca ctgtgtcttg ttagatatgc
4621 taatgtcaag ttattctctt aggagccctg ccgaatagaa ctctacagag tcgtagagag
4681 tttagccaag gcacaggaga catcaggaga agaaatttcc aaattttacc tgccaaactg
4741 caacaagaat ggattttatc acagcagaca ggtaggtggc cttgccagtg tgcgtcgtca
4801 gggtgaaagg gactactgcc ctacattcct gccaagccac ggtcattcat gtcaaagaag
4861 gtccactcca aagtagacac cagaagtggt tgtattgagc cagatccacc cctctggaac
4921 ctggaacagc taggtgaaga aagcctattg aacaggtcaa tatgtcacca ccagaggata
4981 aacctgcgct ggaccagggg ccctggggct aagccttgag ctccatcact cagcaagcca
5041 atagctatgg aagactttcc taggccccct aacgcttgga tcttgggttc ctcacctatc
5101 aagagaggaa gggaacaaac ttaacttaga aaagcaagta tctatttgga cagctcttaa
5161 cacttttttc tccttgaact gtctaataaa acacaacaac atttttgtgg cttgcagata
5221 ataaatgaga tcaaacagac caagatttca tattgaggag tgctttaggt ctcagtgaag
5281 tacaggttct gtagatttta ttgggagaaa ctgaggacta ggccctgctt cacaggcaat
5341 gaacagtggg gcacacacga gacatgttcc tctgggttgg gctcccctga catcaggcta
5401 tgaagcagac agctgtgcac acactgtact gttaacacac atggaagtca ttattgcaca
5461 tgccactcgg tcactgtctc tatttatgat gagaaccagg aggtgtgaga tttgcctgca
5521 tcatgggcag ctggtctcac agccgggact cttggcttgg ctctgcagtg ctcggctgca
5581 ctgaaaaaag ggccagctat ggctctactt tccctgtcag cttgtcatct gctgctcttg
5641 accttggtct tgtctttgca gtgtgagaca tccatggatg gagaggcggg actctgctgg
5701 tgcgtctacc cttggaatgg gaagaggatc cctgggtctc cagagatcag gggagacccc
5761 aactgccaga tatattttaa tgtacaaaac tgaaaccaga tgaaataatg ttctgtcacg
5821 tgaaatattt aagtatatag tatatttata ctctagaaca tgcacattta tatatatatg
5881 tatatgtata tatatatagt aactactttt tatactccat acataacttg atatagaaag
5941 ctgtttattt attcactgta agtttatttt ttctacacag taaaaacttg tactatgtta
6001 ataacttgtc ctatgtcaat ttgtatatca tgaaacactt ctcatcatat tgtatgtaag
6061 taattgcatt tctgctcttc caaagctcct gcgtctgttt ttaaagagca tggaaaaata
6121 ctgcctagaa aatgcaaaat gaaataagag agagtagttt ttcagctagt ttgaaggagg
6181 acggttaact tgtatattcc accattcaca tttgatgtac atgtgtaggg aaagttaaaa
6241 gtgttgatta cataatcaaa gctacctgtg gtgatgttgc cacctgttaa aatgtacact
6301 ggatatgttg ttaaacacgt gtcgataatg gaaacattta caataaatat tctgcatgga
6361 aatactgtta tctctgtgga tgtttattta gtgatattat ctttttgaaa tcccttggtc
6421 cttcaccctc accttcctta tgcattttgt gcttttgtga taccaagatg gtgttttggg
//