GenBank-Updates@genbank.bio.net (01/19/91)
LOCUS HUMCYPB1 1482 bp ds-DNA PRI 19-JAN-1991
DEFINITION Human steroid 11-beta-hydroxylase (CYP11B1) gene, exons 1 and 2.
ACCESSION M32863 J05140
KEYWORDS steroid 11-beta-hydroxylase.
SEGMENT 1 of 3
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1482)
AUTHORS Mornet,E., Dupont,J., Vitek,A. and White,P.C.
TITLE ;
JOURNAL Unpublished (1989) Cornell Univ., Ithaca, N.Y. 10021
STANDARD full staff_entry
REFERENCE 2 (bases 1 to 1482)
AUTHORS Mornet,E., Dupont,J., Vitek,A. and White,P.C.
TITLE Characterization of two genes encoding human steroid 11-beta-
hydroxylase (P-450-11-beta)
JOURNAL J. Biol. Chem. 264, 20961-20967 (1989)
STANDARD full staff_entry
COMMENT
[J. Biol. Chem. 264, 20961-20967 (1989)] with intronic gaps.
Draft entry and computer-readable sequence for [J. Biol. Chem. 264,
20961-20967 (1989)] kindly submitted
by P.C.White, 15-NOV-1989.
FEATURES Location/Qualifiers
misc_signal 595..601
/note="put. TATA box"
precursor_RNA 630..>1482
/note="CYP11B1 mRNA and introns"
exon 637..875
/note="steroid 11-beta-hydroxylase, exon 1
/nomgen='CYP11B1'/malp='8q21-q22'
/hgml_locus_uid='LBOOO1K'"
intron 876..1255
/note="CYP11B1 intron A"
exon 1256..1411
/note="steroid 11-beta-hydroxylase, exon 2"
intron 1412..>1482
/note="CYP11B1 intron B"
BASE COUNT 320 a 368 c 447 g 347 t
ORIGIN
1 ttttctagtt cttttaattg tgatgttagg gtgtcagttt tggatctttc ctgctttctc
61 ttgtgggcat ttagtgctat aaatttccct ctacacactg ctttgaatgt gttccagaga
121 ttctggtatg ctgtgtcttt gttctcgttg gtttcaagaa catctttatt tctgccttca
181 ttttgttacg tacccagtag tcattcagga gcaggttgct cagtttccat gtaattgagc
241 ggttttgagt gagtttctta atcctgagtt ctagtttgat tgcactaaaa tttttaaaaa
301 gtaaaaaaaa tacatgtggt ttaatacaat tcatgccaac tcattccctc gttttttgct
361 ataaaccttg caaggagatg aataatccaa ggctcttgga taagataagg gccccatcca
421 tcttgctcct ctcagccctt ggaggaggag ggagagtcct tttcccctgt ctacgctcat
481 gcacccccaa tgagtccctg cctccagccc tgacctctgc cctcggtctc tcaggcagat
541 ccagggccag ttctcccatg acgtgatccc tctcgaaggc aaggcaccag gcaagataaa
601 aggattgcag ctgaacaggg tggagggagc attggaatgg cactcagggc aaaggcagag
661 gtgtgcatgg cagtgccctg gctgtccctg caaagggcac aggcactggg cacgagagcc
721 gcccgggtcc ccaggacagt gctgcccttt gaagccatgc cccggcgtcc aggcaacagg
781 tggctgaggc tgctgcagat ctggagggag cagggttatg aggacctgca cctggaagta
841 caccagacct tccaggaact ggggcccatt ttcaggtaaa gccctccctg gccctcgctg
901 gaacacccag tgccctgccc ttgctgccca ggaccctgcc gggcactcag cactgccatt
961 cccagcaggt cccggcactc tgcatccttt ggaagaggga agatcgagca cgtgctgtct
1021 gtgcgctgca gggcagggca tgtgcagagc aaatgggagc tcggctgcag agagggcagg
1081 actcagaggc actgaagtta agaggttccg ggcagtcagc aagagggcgt ttagctgtga
1141 agccgctaat ccaggagagg ggagggtgga caggagacac tttggattgg gactgcaggg
1201 tggggccagc agggactaga ccccgtccag cagggcctcc tgcttggccc cacaggtacg
1261 atttgggagg agcaggcatg gtgtgtgtga tgctgccgga ggacgtggag aagctgcaac
1321 aggtggacag cctgcatccc cacaggatga gcctggagcc ctgggtggcc tacagacaac
1381 atcgtgggca caaatgtggc gtgttcttgc tgtaagcggc gagctgagag ctgggagcag
1441 ggtgggcagc ctgggtgtag gggggaggcg agagaggcag ga
//GenBank-Updates@genbank.bio.net (01/19/91)
LOCUS HUMCYPB2 2633 bp ds-DNA PRI 19-JAN-1991
DEFINITION Human steroid 11-beta-hydroxylase (CYP11B1) gene, exon 3-8.
ACCESSION M32878 J05140
KEYWORDS steroid 11-beta-hydroxylase.
SEGMENT 2 of 3
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2633)
AUTHORS Mornet,E., Dupont,J., Vitek,A. and White,P.C.
TITLE ;
JOURNAL Unpublished (1989) Cornell Univ., Ithaca, N.Y. 10021
STANDARD full staff_entry
REFERENCE 2 (bases 1 to 2633)
AUTHORS Mornet,E., Dupont,J., Vitek,A. and White,P.C.
TITLE Characterization of two genes encoding human steroid 11-beta-
hydroxylase (P-450-11-beta)
JOURNAL J. Biol. Chem. 264, 20961-20967 (1989)
STANDARD full staff_entry
COMMENT
[J. Biol. Chem. 264, 20961-20967 (1989)] with intronic gaps.
Draft entry and computer-readable sequence for [J. Biol. Chem. 264,
20961-20967 (1989)] kindly submitted
by P.C.White, 15-NOV-1989.
FEATURES Location/Qualifiers
precursor_RNA <1..>2633
/note="CYP11B1 mRNA and introns"
intron <1..368
/note="CYP11B1 intron B"
exon 369..568
/note="steroid 11-beta-hydroxylase, exon 3
/nomgen='CYP11B1'/malp='8q21-q22'/hgml_locus_u
id='LBOOO1K'"
intron 569..703
/note="CYP11B1 intron C"
exon 704..907
/note="steroid 11-beta-hydroxylase, exon 4"
intron 908..1190
/note="CYP11B1 intron D"
exon 1191..1345
/note="steroid 11-beta-hydroxylase, exon 5"
intron 1346..1712
/note="CYP11B1 intron E"
exon 1713..1879
/note="steroid 11-beta-hydroxylase, exon 6"
intron 1880..2263
/note="CYP11B1 intron F"
exon 2264..2342
/note="steroid 11-beta-hydroxylase, exon 7"
intron 2343..2420
/note="CYP11B1 intron G"
exon 2421..2618
/note="steroid 11-beta-hydroxylase, exon 8"
intron 2619..>2633
/note="CYP11B1 intron H"
BASE COUNT 486 a 794 c 819 g 534 t
ORIGIN About 900 bp after segment 1; 2 bp upstream of HindIII site.
1 aaagcttgac aacaggggtc agttcctttc ttgcagaaaa tccctccccc ctactacagg
61 gagggcccgc atgggtgagg tggtgccaga cttggggcgc caggtcccgg gaatgacctc
121 agttaccctg tcagcacctg tgggcagaag ctaccatctc atccctgctt agacctgagt
181 ggcctttgtc cagcacctgg aggccgtctg agaaaaggct gcagctcgaa cacaaacagg
241 cagcttctac cagggccccc agtcagctcc ctgcaggccg attccccttg ggacaaggag
301 gatgggatac gggtcagggc ctgtgttttg ctggggcggc ctcacaagct ctgccctggc
361 ctctgtagga atgggcctga atggcgcttc aaccgattgc ggctgaatcc agaagtgctg
421 tcgcccaacg ctgtgcagag gttcctcccg atggtggatg cagtggccag ggacttctcc
481 caggccctga agaagaaggt gctgcagaac gcccggggga gcctgaccct ggacgtccag
541 cccagcatct tccactacac catagaaggt gtgggccaca tgggttgatc cagcctcaga
601 gaccctggag tggccaggga cggggatggg ggactgaagg gagtgtgggg aggcagccag
661 gaggcccggt tcccttgtgc tcagcagtgc atcctccccg cagccagcaa cttggctctt
721 tttggagagc ggctgggcct ggttggccac agccccagtt ctgccagcct gaacttcctc
781 catgccctgg aggtcatgtt caaatccacc gtccagctca tgttcatgcc caggagcctg
841 tctcgctgga ccagccccaa ggtgtggaag gagcactttg aggcctggga ctgcatcttc
901 cagtacggtg aggccaggga cccgggcagt gctatgggga aggacaccat cgggccccca
961 atttctccct ctccaccacc cagtggggaa tggaggccac agggaggggt cggggattcc
1021 tcaccgtcct gccagggaga ttggtgtgag gctggggctg ggctgggctg atccggagaa
1081 tttgggatga gagcagggag acttggtgct gggctagctg gcaggaggag gacactgaag
1141 gatgtttccc agcaccaaag tctgagggct gcctcccgct ccccggatag gcgacaactg
1201 tatccagaaa atctatcagg aactggcctt cagccgccct caacagtaca ccagcatcgt
1261 ggcggagctc ctgttgaatg cggaactgtc gccagatgcc atcaaggcca actctatgga
1321 actcactgca gggagcgtgg acacggtcag gccggcaacc agccccaccc agagagggtg
1381 atgccaagcc tgcctcccag gcactgcctg ccaatgtcac acggcgccca cgtgtcccat
1441 gcccaggcta tgggccccac atttcttact tgggattgtg atgtgataaa cacgtttgca
1501 ggttgccatg gttggaatgg ggggttcctt tccttctgtg gaggactcag ggaaacgggg
1561 tttggatggg cattaggatt tgaagtcttg ggctctgtcg tgctcagggt atgcatgtct
1621 gcacccctca cagggaggtt gtcctgggag gggtgtcccg ggggctgagt cctcctgtgc
1681 aaggtctgac cctgcagctg tgtctcctgc agacggtgtt tcccttgctg atgacgctct
1741 ttgagctggc tcggaacccc aacgtgcagc aggccctgcg ccaggagagc ctggccgccg
1801 cagccagcat cagtgaacat ccccagaagg caaccaccga gctgcccttg ctgcgtgcgg
1861 ccctcaagga gaccttgcgg tgggtgctgg ctgaggcctc cctgtggccc tggccctgct
1921 ggagagtcag cccccactgg gtggttgcag acagaatctg ggctataaac acctacccag
1981 cagccatcct gactgctctc tcgcgtcaag gacagggagc tcttcttcct ctggaatccc
2041 tcttcaacgc cctggggatt aacgtggggg catgtccttc tgcgctcggg gctgcttaag
2101 ttaggggagg tttggccggg ctcagcaggt gcaaggaagc acttcctaca cctgggcttc
2161 ccatggatct gggacctctg cggggtcttc ggtaggaagg gtgcagagag cacaggaacc
2221 ccatcccagc tgagaccctt tctatggatg cccccacctc caggctctac cctgtgggtc
2281 tgtttctgga gcgagtggcg agctcagact tggtgcttca gaactaccac atcccagctg
2341 gggtgagtga gccccacacc ctcgagctga gaacctccct ccccagtcat tccctgatcc
2401 ccgctctgct ccgtccgcag acattggtgc gcgtgttcct ctactctctg ggtcgcaacc
2461 ccgccttgtt cccgaggcct gagcgctata acccccagcg ctggctagac atcaggggct
2521 ccggcaggaa cttctaccac gtgccctttg gctttggcat gcgccagtgc cttgggcggc
2581 gcctggcaga ggcagagatg ctgctgctgc tgcaccatgt gagcaggccc ggg
//GenBank-Updates@genbank.bio.net (01/19/91)
LOCUS HUMCYPB3 1155 bp ds-DNA PRI 19-JAN-1991
DEFINITION Human steroid 11-beta-hydroxylase (CYP11B1) gene, exon 9.
ACCESSION M32879 J05140
KEYWORDS steroid 11-beta-hydroxylase.
SEGMENT 3 of 3
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1155)
AUTHORS Mornet,E., Dupont,J., Vitek,A. and White,P.C.
TITLE ;
JOURNAL Unpublished (1989) Cornel Univ., Ithaca, N.Y. 10021
STANDARD full staff_entry
REFERENCE 2 (bases 1 to 1155)
AUTHORS Mornet,E., Dupont,J., Vitek,A. and White,P.C.
TITLE Characterization of two genes encoding human steroid 11-beta-
hydroxylase (P-450-11-beta)
JOURNAL J. Biol. Chem. 264, 20961-20967 (1989)
STANDARD full staff_entry
COMMENT
[J. Biol. Chem. 264, 20961-20967 (1989)] with intronic gaps.
Draft entry and computer-readable sequence for [J. Biol. Chem. 264,
20961-20967 (1989)] kindly submitted
by P.C.White, 15-NOV-1989.
FEATURES Location/Qualifiers
precursor_RNA <1..>1155
/note="CYP1B1 mRNA and introns"
intron <1..170
/note="CYP11B1 intron H"
CDS join(M32863:637..875,
M32863:1256..1411,M32878:369..568,M32878:704..907,
M32878:1191..1345,M32878:1713..1879,
M32878:2264..2342,M32878:2421..2618,171..284)
/note="steroid 11-beta-hydroxylase"
exon 171..284
/note="steroid 11-beta-hydroxylase, exon 9
/nomgen='CYP11B1'/malp='8q21-q22'/hgml_locus_u
id='LBOOO1K'"
misc_signal 825..830
/note="poly-A signal"
BASE COUNT 226 a 359 c 303 g 267 t
ORIGIN About 500 bp after segment 2; 1 bp upstream of EcoRI site.
1 gaattctggg cctgggctgt aaggtggggc tggtcaggaa tgaaacaggt tggaggccag
61 gctgctgttc ccccttcagc ataatctctg caactttgag ggtctgagaa ggctgcacca
121 cgtcgatggg ctgcggacca agccagatgg aaacccggct tctgtcctag gtgctgaaac
181 acctccaggt ggagacacta acccaagagg acataaagat ggtctacagc ttcatattga
241 ggcccagcat gtgccccctc ctcaccttca gagccatcaa ctaatcacgt ctctgcaccc
301 agggtcccag cctggcacca gcctcccttt ctgcctgacc ccaggccacc cctcttctct
361 cccacatgca cagcttcctg agtcacccct ctgtctaacc agccccagca caaatggaac
421 tcccgagggc ctctaggacc agggtttgcc aggctaagca gcaatgccag ggcacagctg
481 gggaagatct tgctgacctt gtccccagcc ccacctggcc ctttctccag caagcactgt
541 cctctggcag tttgccccca tccctcccag tgctggctcc aggctcctcg tgtggccatg
601 caagggtgct gtggttttgt cccttgcctt cctgcctcta gtctcacatg tccctgttcc
661 tcttcccctg ccagggcccc tgcgcagact gtcagagtca ttaagcggga tcccagcatc
721 tagagtccag tcaagttccc tcctgcagcc tgccccctag gcagctcgag catgccctga
781 gctctctgaa agttgtcgcc ctggaatagg gtcctgcagg gtagaataaa aaggcccctg
841 tggtcacttg tcctgacatc cccattttca agtgatacaa ctgagtctcg agggacgtgt
901 gttccccagc tgatcgtgtc agcctcatgc ccctggcctc atctttcatg gaccaggcct
961 tgttccagga gtgggcgttg ggtcctctgc ttcctgtgct gtcccctggg gaaggtccca
1021 aggatgctgt caggagatgg aagagtcatg tggggtggga acctggggtg tggttccaga
1081 aatgtttttg gcaacaggag agacaggatt gggccaacaa ggactcagac gagttttatt
1141 gactattctc tgaca
//