GenBank-Updates@genbank.bio.net (01/19/91)
LOCUS HUMGMCSFG 3043 bp ds-DNA PRI 19-JAN-1991
DEFINITION Human gene for granulocyte-macrophage colony stimulating factor
(GM-CSF).
ACCESSION X03021
KEYWORDS colony stimulating factor;
granulocyte-macrophage colony stimulating factor; growth factor.
SOURCE human (Homo sapiens).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3043)
AUTHORS Miyatake,S., Otsuka,T., Yokota,T., Lee,F. and Arai,K.
TITLE Structure of the chromosomal gene for granulocyte-macrophage colony
stimulating factor: comparison of the mouse and human genes
JOURNAL EMBO J. 4, 2561-2568 (1985)
STANDARD simple automatic
COMMENT
[EMBO J. 4, 2561-2568 (1985)] enum. 1 to 3043.
Data kindly reviewed (02-SEP-1986) by S. Miyatake
EMBL features not translated to GenBank features:
key from to description
PRM 597 603 put. TATA box
SITE 620 622 transcription initiation region
IVS 821 913 intron I
IVS 956 1642 intron II
IVS 1769 2577 intron III
SITE 2998 2998 polyadenylation site
FEATURES Location/Qualifiers
CDS join(662..820,914..955,1643..1768,
2578..2685)
/note="put. GM-CSF precursor (aa 1-53) /nomgen='CSF2'
/map='5q23-q31' /hgml_locus_uid='LM0083T'"
exon 662..820
/note="put. GM-CSF precursor (aa 1-53) /nomgen='CSF2'
/map='5q23-q31' /hgml-locus_uid='LM0083T'"
exon 914..955
/note="put. GM-CSF precursor (exon 2) (aa 54-67)"
exon 1643..1768
/note="put. GM-CSF precursor (exon 3) (aa 68-109)"
exon 2578..2685
/note="put. GM-CSF precursor (exon 4) (aa 110-144)"
BASE COUNT 668 a 824 c 878 g 673 t
ORIGIN
1 ttctcagagt ggctgcagtc tcgctgctgg atgtgcacat ggtggtcatt ccctctgctc
61 acaggggcag gggtcccccc ttactggact gaggttgccc cctgctccag gtcctgggtg
121 ggagcccatg tgaactgtca gtggggcagg tctgtgagag ctcccctcac actcaagtct
181 ctctcacagt ggccagagaa gaggaaggct ggagtcagaa tgaggcacca gggcgggcat
241 agcctgccca aaggcccctg ggattacagg caggatgggg agccctatct aagtgtctcc
301 cacgccccac cccagccatt ccaggccagg aagtccaaac tgtgcccctc agagggaggg
361 ggcagcctca ggcccattca gactgcccag ggagggctgg agagccctca ggaaggcggg
421 tgggtgggct gtcggttctt ggaaaggttc attaatgaaa acccccaagc ctgaccacct
481 agggaaaagg ctcaccgttc ccatgtgtgg ctgataaggg ccaggagatt ccacagttca
541 ggtagttccc ccgcctccct ggcattttgt ggtcaccatt aatcatttcc tctgtgtatt
601 taagagctct tttgccagtg agcccagcta cacagagaga aaggctaaag ttctctggag
661 gatgtggctg cagagcctgc tgctcttggg cactgtggcc tgcagcatct ctgcacccgc
721 ccgctcgccc agccccagca cgcagccctg ggagcatgtg aatgccatcc aggaggcccg
781 gcgtctcctg aacctgagta gagacactgc tgctgagatg gtaagtgaga gaatgtgggc
841 ctgtgctagg caccagtggc cctgactggc cacgcctgtc agcttgataa catgacattt
901 tccttttcta cagaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggtaag
961 atgcttctct ctgacatagc tttccagaag cccctgccct ggggtggagg tggggactcc
1021 attttagatg gcaccacaca gggttgtcca ctttctctcc agtcagctgg ctgcaggagg
1081 agggggtagc aactgggtgc tcaagaggct gctggccgtg cccctatggc agtcacatga
1141 gctcctttat cagctgagcg gccatgggca gacctagcat tcaatggcca ggagtcacca
1201 ggggacaggt ggtaaagtgg gggtcacttc atgagacagg agctgtgggt ttggggcgct
1261 cactgtgccc cgagaccaag tcctgttgag acagtgctga ctacagagag gcacagaggg
1321 gtttcaggaa caacccttgc ccacccagca ggtccaggtg aggccccacc cccctctccc
1381 tgaatgatgg ggtgagagtc acctccttcc ctaaggctgg gctcctctcc aggtgccgct
1441 gagggtggcc tgggcggggc agtgagaagg gcaggttcgt gcctgccatg gacagggcag
1501 ggtctatgac tggacccagc ctgtgcccct cccaagccct actcctgggg gctgggggca
1561 gcagcaaaaa ggagtggtgg agagttcttg taccactgtg ggcacttggc cactgctcac
1621 cgacgaacga cattttccac aggagccgac ctgcctacag acccgcctgg agctgtacaa
1681 gcagggcctg cggggcagcc tcaccaagct caagggcccc ttgaccatga tggccagcca
1741 ctacaagcag cactgccctc caaccccggt gagtgcctac ggcagggcct ccagcaggaa
1801 tgtcttaatc tagggggtgg ggtcgacatg gggagagatc tatggctgtg gctgttcagg
1861 accccagggg gtttctgtgc caacagttat gtaatgatta gccctccaga gaggaggcag
1921 acagcccatt tcatcccaag gagtcagagc cacagagcgc tgaagcccac agtgctcccc
1981 agcaggagct gctcctatcc tggtcattat tgtcattacg gttaatgagg tcagaggtga
2041 gggcaaaccc aaggaaactt ggggcctgcc caaggcccag aggaagtgcc caggcccaag
2101 tgccaccttc tggcaggact ttcctctggc cccacatggg gtgcttgaat tgcagaggat
2161 caaggaaggg aggctacttg gaatggacaa ggacctcagg cactccttcc tgcgggaagg
2221 gagcaaagtt tgtggccttg actccactcc ttctgggtgc ccagagacga cctcagccca
2281 gctgccctgc tctgccctgg gaccaaaaag gcaggcgttt gactgcccag aaggccaacc
2341 tcaggctggc acttaagtca ggcccttgac tctggctgcc actggcagag ctatgcactc
2401 cttggggaac acgtgggtgg cagcagcgtc acctgaccca ggtcagtggg tgtgtcctgg
2461 agtgggcctc ctggcctctg agttctaaga ggcagtagag aaacatgctg gtgcttcctt
2521 cccccacgtt acccacttgc ctggactcaa gtgtttttta tttttctttt tttaaaggaa
2581 acttcctgtg caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt
2641 ctgcttgtca tcccctttga ctgctgggag ccagtccagg agtgagaccg gccagatgag
2701 gctggccaag ccggggagct gctctctcat gaaacaagag ctagaaactc aggatggtca
2761 tcttggaggg accaaggggt gggccacagc catggtggga gtggcctgga cctgccctgg
2821 gcacactgac cctgatacag gcatggcaga agaatgggaa tattttatac tgacagaaat
2881 cagtaatatt tatatattta tatttttaaa atatttattt atttatttat ttaagttcat
2941 attccatatt tattcaagat gttttaccgt aataattatt attaaaaata tgcttctact
3001 tgtccagtgt tctagtttgt ttttaaccat gagcaaatgc cat
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