GenBank-Updates@genbank.bio.net (01/19/91)
LOCUS HUMTS1 18596 bp ds-DNA PRI 19-JAN-1991
DEFINITION Human thymidylate syntase gene, complete cds.
ACCESSION D00596
KEYWORDS thymidylate syntase.
SOURCE Human DNA (genomic), clones lambdaHTS-1 and lambdaHTS-3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 18596)
AUTHORS Kaneda,S., Nalbantoglu,J., Takeishi,K., Shimizu,K., Gotoh,O.,
Seno,T. and Ayusawa,D.
TITLE Structural and functional analysis of the human thymidylate
synthase gene
JOURNAL J. Biol. Chem. 265, 20277-20284 (1990)
STANDARD full staff_entry
COMMENT These data kindly submitted in computer readable form by:
Sumiko Kaneda
National Institute of Genetics
1111 Yata
Mishima 411
Japan
Phone: +81-559-72-2732
Fax: +81-559-71-3651
FEATURES Location/Qualifiers
CDS join(1001..1205,2895..2968,
5396..5570,11843..11944,13449..13624,
14133..14204,15613..15750)
/note="thymidylate synthase [EC 2.1.1.45] (part of"
repeat_region 1..148
/note="Alu sequence"
repeat_region 202..477
/note="Alu sequence"
precursor_RNA 822..16246
/note="thymidylate synthase mRNA and introns"
precursor_RNA 824..16246
/note="thymidylate synthase mRNA and introns"
precursor_RNA 828..16246
/note="thymidylate synthase mRNA and introns"
precursor_RNA 841..16246
/note="thymidylate synthase mRNA and introns"
repeat_region 862..889
/note="inverted repeat"
repeat_region 904..993
/note="triple tandem repeats"
exon 1001..1205
/note="thymidylate synthase [EC 2.1.1.45] (part of exon
1)"
intron 1206..2894
/note="thymidylate synthase intron 1"
misc_binding 1660..1665
/note="Sp1 binding site"
misc_binding 1890..1895
/note="Sp1 binding site"
misc_binding 1895..1900
/note="Sp1 binding site"
exon 2895..2968
/note="thymidylate synthase (exon 2)"
intron 2969..5395
/note="thymidylate synthase intron 2"
repeat_region 3049..3347
/note="Alu sequence"
repeat_region 4953..5245
/note="Alu sequence"
exon 5396..5570
/note="thymidylate synthase (exon 3)"
intron 5571..11842
/note="thymidylate synthase intron 3"
repeat_region 5768..9405
/note="L1 sequence"
repeat_region 10125..10389
/note="reiterated motif of GGA/TGAT"
exon 11843..11944
/note="thymidylate synthase (exon 4)"
intron 11945..13448
/note="thymidylate synthase intron 4"
repeat_region 12135..12397
/note="Alu sequence"
repeat_region 12567..12743
/note="Alu sequence"
repeat_region 12807..13084
/note="Alu sequence"
exon 13449..13624
/note="thymidylate synthase (exon 5)"
intron 13625..14132
/note="thymidylate synthase intron 5"
repeat_region 13875..14010
/note="Alu sequence"
exon 14133..14204
/note="thymidylate synthase (exon 6)"
intron 14205..15612
/note="thymidylate synthase intron 6"
repeat_region 14531..14832
/note="Alu sequence"
exon 15613..15750
/note="thymidylate synthase (part of exon 7)"
misc_signal 15934..15939
/note="poly(A) signal"
misc_signal 16228..16233
/note="poly(A) signal"
repeat_region 17262..17553
/note="Alu sequence"
BASE COUNT 4521 a 3991 c 4479 g 5605 t
ORIGIN 18p11.32 on chromosome 18.
1 cctgtagtcc cagctacgcg agaggctgag gcagcagaat tacttgaacc caggaggcgg
61 aggttgcagt gagccgagat cgcgccactg cactccagcc tgggtgagag agcgagactc
121 tgtctcaaaa aaaaaaaaaa aagaccgcca gggctcaaac aaaaaacctc ggaaaagccc
181 tggcggtctt tttttttttt tttttttttt ttttttggga cagtcttgct ctgtcgccca
241 ggctggagta caatggtcgg atcttggctc actgcaacct ctgcctccca ggttcaagca
301 attcttctgc ctcagcctcc caagtagcca ccacgcccag ctaatttttg tacttttagt
361 agagacgggg gtttcaccat gttgtccagg ctggtcttga actcctgacc tcaggtgatc
421 cacccgcctc ggccccccaa agtactagga ttacaggcgt gagccaccgc gtccagcgcc
481 ctggcggttt ttaatcaagt agaaaagctg cattatacca cttgcttcgg ttgcttcagt
541 gagaacgaag aaatggaaat gcaaatccct tattagttgt aggaaacaga tctcaaacag
601 cagttttgtt gacaagaccg caggaaaacg tgggaactgt gctgctggct tagagaaggc
661 gcggtcgacc agacggttcc caaagggcgc agtccttccc agccaccgca cctgcatcca
721 ggttcccggg tttcctaaga ctctcagctg tggccctggg ctccgttctg tgccacaccc
781 gtggctcctg cgtttccccc tggcgcacgc tctctagagc gggggccgcc gcgaccccgc
841 cgagcaggaa gaggcggagc gcgggacggc cgcgggaaaa ggcgcgcgga aggggtcctg
901 ccaccgcgcc acttggcctg cctccgtccc gccgcgccac ttggcctgcc tccgtcccgc
961 cgcgccactt cgcctgcctc cgtcccccgc ccgccgcgcc atgcctgtgg ccggctcgga
1021 gctgccgcgc cggcccttgc cccccgccgc acaggagcgg gacgccgagc cgcgtccgcc
1081 gcacggggag ctgcagtacc tggggcagat ccaacacatc ctccgctgcg gcgtcaggaa
1141 ggacgaccgc acgggcaccg gcaccctgtc ggtattcggc atgcaggcgc gctacagcct
1201 gagaggtgac gccgcgggcc cctgcgggac gggtggcggg aaggagggag gcgcggctgg
1261 ggagagcgct cgggagctgc cgggcgctgc ggaccccgtt tagtcctaac ctcaatcctg
1321 ccagggaggg gacgcatcgt cctcctcgcc ttacagacgc cgaaacggag ggtcccatta
1381 gggacgtgac tggcgcgggc aacacacaca gcagcgacag ccgggaggta agccgcgtcc
1441 cagcggctcc gcggccgggc tcgcagtcgc cccagtgatg ccgtggcccc cgaggcgggc
1501 gtcatcgggc agcgtttgcc cagtgctgga gggttaggga gagctgcctg ggcttgaccg
1561 cgcgccggtc tcaaagtcct ggctttggcc cctcctccgt tttcccctgt ggaccattcc
1621 gcttcgcagc gttttcaaaa actggagcga aagtgatgtg ggcggggcaa aggcggcggg
1681 aagaggacag cactgaagct ggcgcgggaa cttggtttcc tggtggcctc ccatccaatc
1741 cccacgaacc agctttcctc ttaaaccttg aaaagagaaa ttcgggagtt cgagttctta
1801 gtcgtccttt cctctttcct ttccgacagg agcaccccag gcaaaaaatg tctcgcgggt
1861 cattggcgcc aggctttcag gggacagtgg ggcggggcgg ggtgggcaca ggacgttagg
1921 cagccgttgg ccctccctaa ggccacaccg tcctgccgtc ctggatcctg cgccagctgc
1981 gcgggggagg ggactcgaag gtgtgtgagc caggggctga ccttgaccgc tcagataaat
2041 ggagcgcagc cttgacacag gggtggaggt ggttttgaat ggggaaaccc attcgtggtg
2101 aagcagattc actgtagcta gcggaaaagc cctccggccc acggacccat ctagagacga
2161 atacatagca gctgctgtgg ctgattggcg tgggacagcg tggggagttt tgtctgagga
2221 gagggatcca cttttctgca gctccaagcc caggggcctt tgatgagcca tagacctcat
2281 ttttaaccca cctttctgct tagacattga gcaagttact tctcatatag cttccctata
2341 tgttaaaaat ggagaaaata atgcttagta ggcaattctg ataaaagcag gtgcttgcaa
2401 aaatctctct gttgtctgaa tataaactgt accacaagcg agtgcggatg aacgaggact
2461 gcatttaaag ataagttttt acactttcat ttctctgtgg ctcgacactt ctgatgcctc
2521 cctttttgtt cctgggacac atgcttggtg ttgtcttcac acctttgtga caggattagc
2581 actagtgggc agtggatgat agctcctcct cccttttgcc acatgttcat ccctgccctc
2641 gccaccatct cactgtgtgg aattcctgtg tccactggtc accggggcac agaagtgctg
2701 tctcagcctg aatcgggcca ctgatgggac ttgcagcctg ggagctccac cgtgatctct
2761 ggcccacttt gcgggagtct aggctttctg gatgctccag gcctcacgtc ccagggcagt
2821 tttcttccct gaagaaagtt ggatggcatg atctgtcttc ccatcttgaa accgtatggc
2881 aaattgtttt tcagatgaat tccctctgct gacaaccaaa cgtgtgttct ggaagggtgt
2941 tttggaggag ttgctgtggt ttatcaaggt aaagaagtcg ctgctattag aagtcagtag
3001 tctgttctca acacagcagc cagtgagatc ctttcaaaac tcaaagcagc caggtgtggt
3061 ggctcacgcc tgtaatccca ccgctttggg aggctgagtc agatcacctg aggttaggaa
3121 tttgggacca gcctggccaa catggcgaca ccccagtctc tactaataac acaaaaaatt
3181 agccaggtgt gctggtgcat gtctgtaatc ccagctactc aggaggctga ggcatgagaa
3241 ttgctcacga ggcggaggtt gtagtgagct gagatcgtgg cactgtactc cagcctggcg
3301 acagagggag aacccatgtc aaaaacaaaa aaagacacca ccaaaggtca aagcatatca
3361 ttcctcaccc tcaagccctt agtggctcca tttcactcag taagagccac ggtccttatg
3421 gtgtccgttt ttcagctctg accttagctg ctgctctctg caccaccctg ctgttcttgt
3481 gagtttttga gcacaccggg acatccccac tccctggaac cttcttcccc cacacttggc
3541 ttcttccttt gagtctctac tccactcggg caagccttcc tagacctcct gatttaaaac
3601 tgtgactctc ccccaacctc cttggtgttt ctccgtagac gaacatcacc atctgatgta
3661 tgtcagcctt tcccttcccc tgttagaagg gggacagcag gtagtaaaag tgaaatgtgc
3721 tgtaagcttt atgagggcag aggatttgtt tctcgtgttc actgttgtat cgccagggcc
3781 tcaaacacag cctgccacat agtaggagtc aacatatatt gatcactaaa tgtagatacc
3841 acctgtgttc ccatgttcat ataaattcta gaagagtctc ttcagtaaca aggtgaaccc
3901 cttccagagg gctgagtagg tacctcaggc cggggccaga gtgctgtgaa gacagcagca
3961 gcccagacca agcttctctg tgttccgtgt cctggtctag aaccagcgat gttctttctg
4021 accagtgctt tttggaaggt ggctgaggtc tgggctcagg tctgggccat actagaagct
4081 gggatccctt ctatagagca cttggtatgg cttgtatggt cttggggcaa gccagaccca
4141 agccctctta tcccatttta gaaagggctt caatttggat ccagccccag gtctgcctta
4201 gctctgtatt cttggggtat tttgttctgt attggcctat cttgactaac aatgagcctt
4261 ggatttgaaa catatcatca gaaacctcag aagacaacat tcttaaactg gctagagcct
4321 ggtctgaatg gatgaaaagg agagactttt gaagcaatat gtaaaagatt gagaaatgat
4381 ttgttggaaa tttctcaatt ggagaaattt ctttgatttg ttggaaattt ctttgattct
4441 ttctcaatca aagaaaatcg ggacaaactc aacaatagaa agggaggaag caagatactc
4501 agaaataaaa tgcattcccc tgtttcaact taatgcttca attcaggatt ctaaggaatc
4561 cttgccagga atgtcagact caccttgata gttggagtta ctccattggt gactcgatca
4621 aatacaggag ttgaggcacc tgcactgtaa aatactgatt agtctgatca ttaggaatat
4681 cctgtatgcc aggtagaaga tacattgaac agattgcatg taggcattaa attcattttg
4741 gggtattaca tatagacaac acatttcatt aagaaacata aaactgtcag atcggtggaa
4801 tacttaaaag cacttggagg tgtttagcct aaaaagctta gttgagggga atggaagaaa
4861 agatctggga gggtggttcc aaagaaggga tcagactatc ctaaagccct caggaatctg
4921 ggctgggacc acctacttaa agataggatg ggcagctggg tgtggtggct cacgcctgta
4981 atcccagcac ttcgggaggc cgaagcgggc ggatcacctg aggtcaggag ttcgaggcca
5041 gcctgaccaa catggagaaa cgctgtctct actaaaaata caaaattagc tgggtgtagt
5101 ggcgcatgcc tgtaatccca gctactcggg aggctgaggc aggggaatcg cttgaacctg
5161 ggaggtggag ggtgccgtga gccacgatcg cgccattgca ctccagcctg ggcaacaaga
5221 gcgaaactct caaaaaacaa aaaaaaggat gggttccata tgggtggtgt caagtgccca
5281 cctcctagca agtcagcagg ggccagaggc ccttgtaagt ggtgtctcgg ggggatcaac
5341 tgagatggct taagatttac ctggatgcct gctctgctct ccccatctct tccagggatc
5401 cacaaatgct aaagagctgt cttccaaggg agtgaaaatc tgggatgcca atggatcccg
5461 agactttttg gacagcctgg gattctccac cagagaagaa ggggacttgg gcccagttta
5521 tggcttccag tggaggcatt ttggggcaga atacagagat atggaatcag gtgaggagat
5581 agaacaatgc cttccatttc cgggtgccct tcctagcacg tgtttgctcc gttgttttag
5641 ataaggtctg ggggatgagt caatgtcaca ggagctgatg tatagctttg accttgtgag
5701 gggtggtgcc aggttgaagc cacaattaac gcctactgaa ggccgtttca catctttttt
5761 tttttttttt ttttaattat tatactttaa gttttagggt acatgtgcac aatgtgcagg
5821 ttagttacat atgtatacat gtgccatgct ggtgcgctgc accactaact caccatctag
5881 catcaggtat atctcccaat gctatccctc ccccctcctc ccaccccaca acatccccag
5941 agtgtgatgt tccccttcct gtgtccatat gttctcgttg ttcgattccc actatgagtg
6001 agaatatgcg gtgtttggtt ttttgttctt gcgatagttt actgagaatg atgatttcca
6061 tttcaccacg tccctacaga ggacatgaac tcatcatttt ttatggctgc atagtattcc
6121 atggtgtata tgtgccacat tttcttaatc cagtctatca tgttggacat ttgggttggt
6181 tccaagtctt tgcctattgt gaatagtgcc acaataaaca tacgtgtgca tgtgtcttta
6241 tagcagcatg atttaatagt cctttgggta tatacccagt aatgggatgg ctgggtcaaa
6301 tggtatttct agttctagat ccccgaggaa tcgccacact gacttccaca atggttgaac
6361 tagtttacag tcccaccaac agtgtcaaag tgtcctattt ctccacatcc tctccagcac
6421 ctgttgtttc ctgacttttt aatgattgcc attctaactg gtgtgagatg gtatctcatt
6481 gtggttttga tttgcgtttc tctgatggcc agtgatggtg agcatttttt catgtgtttt
6541 ttggctgcat aaatgtcttc ttttgagaag tgtctgttca tgtccttcgc ccactttttg
6601 atggggttgt ttttttctta taaatttgtt tgagttcatt gtagattctg gatattagcc
6661 ctttgtcaga tgagtaggtt gcaaaaatgt tctcccattt tgtgggttgc ctgttcactc
6721 tgatggtagt ttcttttgct gtgcagaagc tctttagttt aattagatcc catttgtcaa
6781 ttttggcttt tgttgccatt gcttttggca taggcatgaa gtccttgccc atgcctatgt
6841 cctgaatggt aatgcctagg ttttcttcta gggtttttat ggttttaggt ctaacgttta
6901 agtctttaat ccatcttgaa ttgatttttg tataaggtgt aaggaaggga tccagtttca
6961 gctttttaca tatggctagc cagttttccc agcaccattt attacatagg gaatcctttc
7021 cccattgctt gtttttctca ggtttgtcaa agatcagata gttgtagata tgcggcgtta
7081 tttctgaggg ctctgttctg ttccattgat ctatgtgtct gttttggtac cagtaccata
7141 ctgttttggt tactgtagcc ttgtagtata gtttgaagtc aggtagcgtg atgcctccag
7201 ctttgttctt ttggcttagg attgacttgg cgatgcgggc tcttttttgg ttccatatga
7261 actttaaagt agttttttcc aattctgtga agaaagtcat tggtagcttg atggggatgg
7321 cattgaatct ataaattacc ttgggcagta tggccatttt cacgatattg attcttccta
7381 cccatgagca tggaatggtc ttccatttct ttgtatcctc ttttatttca ttgagcagtg
7441 gtttgtagtt ctccttgaag aggtccttca catccctttt aaggtggatt cctaggtatt
7501 ttattctctt tgaagcaatt gtgagtggaa gttcactcat gatttggctc tctgtttgtc
7561 tgttattggt gtataagaat gcttgtgatt tttgcagatt gattttatat cctgagactt
7621 tgctgaagct gcttatcagc ttaaggagat tttgggctga gacaatgggg ttttctagat
7681 atacaatcat gtcgtctgca aacagggaca atttgacttc ctcttttcct aattgaatac
7741 cctttatttc cttctcctgc ctaattgccc tggccagaac ttccaacact atgttgaata
7801 ggagtggtga gagagggcat ccctgtcttg tgccagtttt caaagggaat gcttccagtt
7861 tttgcccatt cactatgata ttggctgtgg ctttgtcata gatagctctt attattttga
7921 aatatgttcc atcaatacct aatttattga gagtttttag catgatgtgt tgttgaattt
7981 tgtcaaaggc tttttctgca tctattgaga taatcatgtg gtttttgtct ttggatctgt
8041 ttatatgctg gattacattt attgatttgc gtatattgaa ccagccttgc atcctaggga
8101 tgaagcccac atgatcatgg tggataagct ttttgatgtg ctgctggatt cggtttgcca
8161 gtattttatt gaggattttt gcatcaatgt tcatcaagga tattggtcta aaattctctt
8221 ttttggtgtg tctctgccca gctttggtat caggatgatg ttggcttcat aaaatgagtt
8281 agggaggatt ccctcttttt ctattgattg gaatagtttc agaaggaatg gtaccagttc
8341 ctctttgtac ctctggagaa ttcggctgtg aatccatctg gtcctggact ctctttggtt
8401 ggtaagctat tgattattgc cacaatttca gctcctgtta ttggtctatt cagagattca
8461 acttcttcct ggtttagtct tgggagagtg tatgtgtcaa ggaatttatc catttcttct
8521 agattttcta gtttatttgc gtagaggtgt ttgtagtaat ctctgatggt agtttgtatt
8581 tctgtgggat cggtggtgat atccccttta tcatttttta ttgcgtctat ttgattcttc
8641 tctttttctt tattagtctt gctagcggtc tataaatttt gttgatcctt tcaaaaaacc
8701 agctcctgga ttcattaatt ttttgaaggg ttttttgtgt ctctatttcc ttcagttctg
8761 ctctgatttt agttatttct tgccttctgc tagcttttga atatgtttgc tcttgctttt
8821 ctagttcttt taattgtgat gttagggtgt caattttgga tctttcctgc tttctcttgt
8881 gggcatttag tgctataaat ttccctctac acactgcttt gaatgtgtcc cagaggttct
8941 ggtatgttgt gtctttgttc ttgttggttt caaagaacat ctttatttct gccttcattt
9001 cgttatgtac ccagtagtca ttcaggagca ggttgttcag tttccatgta gttgagcagt
9061 tttgagtgag attcttaatc ctgagttcta gtttgattgc actgtggtct gagagatagt
9121 ttgttataat ttctgttctt ttacatttgc tgaggagagc tttacttcca actatgtggt
9181 cggttttgga ataggtgtgg tgtggtgctg aaaaaaatgt atattctgtt gatttgggat
9241 ggagttctgt agatgtctat taggtctgct tggtgcagag ctgagttcaa ttcctgggta
9301 tccttgttga ctttctgtct cgttgatctg tgtactgttg acagtgggtg ttaaagtctc
9361 ccattattaa tgtgtggagt ctaagtctct ttgtaggtca ctcagatgat tggcacttac
9421 tgggcgcttg gcactttcca tactgtgtca tcggcagata gctgcatggt tggtgttcgt
9481 gctggggaat gggaagttca tcggtgggac aaggacaaaa tgcccccatt gctttgttgt
9541 ggctttaatc tccctttcga ggctgagcca cagcgtgctg taggtggcgc tgctgtgaag
9601 cgcagtacca gggtcacact ccactcccag ctctgcagag gtggagaaag aatgaaacat
9661 ctcactcctg gacttccact ttcctgtcac tgttggtgtc acctcttact ggatgtcaca
9721 gagcccagcc cctcccacct gtgcctagga aaagcagatg ccaccttgga atgtggggtt
9781 tgtgtgtgca atttactagc tgggcagaga ccagcaacct ggagagcagg tgtctcgtct
9841 aaggggacag tcacatttca cctccagcca cctggaggaa tttgggcctg gtgatgtcag
9901 aattcttcaa taaaagccta aaatctatat tttatgtgcg gtcatgagat ctgttaaatg
9961 ttagcaactt caggaagttt aaaaatgctg tgtggaccta gaataggcaa gttcttaaag
10021 gcagaaagtg gaatgctagt ttccagggac tggggaacag ggaggaatgg ggagttcatg
10081 tttaatgggc acagaggttt tgttagggat gacgaaaaag ttcgggagat ggtgatggtg
10141 atggagatgg tgatggtgat ggagatggtg atggtgatgg tgatggtgat gggtgatggt
10201 gatggtgatg gtgatggtga tggagatggt gatggtgatg gtgatggaga tggtgatggt
10261 gatggtgatg gtgatggaga tggtgatggt gatggagatg gtgatggtga tggtgatgga
10321 gatggtgatg gtgatggtga tggtgatggt gatggtgatg gtgatggaga tggagatggt
10381 gatggtgatg gttgcctaac atcaggaacg tgcttaatgc ttctgaattg cacacaaaaa
10441 tggcaagttt aatattatgt gtactttatc acaatgaaaa aagctgctgc gtgggccaag
10501 ttacttgtgc aggtaatgtt ctgcaggtgg ttgcctgcac ctcagttgta gggtgtccgt
10561 aggatgtgag gccagtcccc gggcttaatg atgctttaaa tcctgcctag tattcaatta
10621 tttcttgtcg cttaaaaggc ctaataaaat tatggtctta gtttacagtg gtatgaatgc
10681 ttagctgttg gattttagta ggaaagttcg tccctttttg tttttaattt tgttttacag
10741 attcacagga attttttttt tttttttttt tttttttttt taatgcacag aaagtttccc
10801 tggactctct acccagtttc cccagtgata atatcttggg taacatcctg tatacattca
10861 cattggtgca ttcctcagag ttgtcagatt ttgctagttt tacgtgcact tgtgtatgtg
10921 tgtatttgca attttagcac gtgtagactc ttgtaaccac tacaatcaag ttacagaact
10981 acactaccaa ggttcatctt tttaaaatct ttgatgttac cttttttgga acagtgacca
11041 tgagaggact ttcctcccaa aattttgaaa actactgaac cagaatatag tctgacacta
11101 ataggtagaa atttaaccaa aggagattat gaagctctgc acttgagtta acaaaatcac
11161 ttctcagctt ccagttccat ctcagaagga aggaaaaggg attaaaaatc cagagaccag
11221 aaaatgggag caaagtacaa ggtggtgtaa tcattacaga ggtttcctga tgtttccaag
11281 tcagtcgtgt gttgagctgc taaactctaa agtaatttta ggtggaatgt tggaaacatg
11341 ctgctgaggt gatagaaagg aatccatggt cctctgttag ttggaaagta tatggaatac
11401 tatattctac ataagataca atactctctg tgagacaagg ataaagtaga ttttgtcagt
11461 gaaattgtga caagaatcgc tgatgggttt agagcctaag tttgcgagga gcactggaag
11521 aaattaagat tgttgagatt ggaaagggtt agctatgggg gaacaggagg aggtgactcc
11581 atgacagacc aaatattcaa aggactgtgt agaagaggaa aaagactttg ttagggctcc
11641 agaggacaga gccaggagtc agacagggcc ttgaactcaa cccaccgaga tctgcaaact
11701 ttgcaggatg caccagatgt cttgtagcca tgggtcaagg ggggaccctg ggtaagagac
11761 tgtaatagat gacctctaag gccatctcat gacatgtgtg attaatgtat gtacctgtcc
11821 tctctttttg acaattctac agattattca ggacagggag ttgaccaact gcaaagagtg
11881 attgacacca tcaaaaccaa ccctgacgac agaagaatca tcatgtgcgc ttggaatcca
11941 agaggttgaa agaaccccgt cgtcttcatt tatactaacc atactcttag agggaagcaa
12001 tctggttttg tgcagaggca ctgagggagg caggaccctg ggcaacttcc cccagccaca
12061 tggttgtgtg acgttgggca agtcacattt tgctgcactt tcaccttcag atcatgaggt
12121 tgggcccaga ggattttttt tttttttttt ttttttgaga cagagttttg ctctgttgcc
12181 caggctggaa tgcaacggcg tgatcttggc tcactgtaac ctctgcctcc tgggttcgag
12241 tgattctcct gcctcagcct ccaagtagct gggattacag catgtgccac catgcctggc
12301 taattttgta tttttagtag agacgggttc acatgttggt caggctggtc ttgactcctg
12361 accctcagat gatctgcctt gcctcagcct cccaaccgag tgatcttaag ttgtgtatta
12421 tactcattct tacacaaaaa gggctttaaa tgcctagaaa ctacatgaag atgttaacat
12481 tttaaatgga agcagatgaa gttccagctc gctgccacct cactaacatt tttaacaatt
12541 atattgtaaa attcaactct accagggtgt agagccaggt gtggtggctc acacctgtaa
12601 ttccaacaac tccagaggcc aaggcgagag gatcatttga acccacggaa tttgaggctg
12661 tagtgagtca tgatcacgcc attgcactcc atcctgggca acagagtgag accctgaata
12721 tttaaaaaca acaacaacaa caaaactcta tcaggatatc ataagtactt agagtgaaat
12781 acttgcatct gtaatagaga cttatttttt ttttttttga gacacagtct caccctgttg
12841 cccaggctgg agtgcagtgg tttgatctcc gctcacggca acctccatct cccaggttca
12901 agtgagttcc cattcctcag ccccagagct gggaccacag gcgcgcgaat ttttgtattt
12961 ttagcagaga cggggtttca ctatgttggc caggctagtc tcaaactcaa gttggcctca
13021 agtgatctgc ccaccctggc gtcccagtgt tgggatttca ggcatgagcc actgtgcctg
13081 gccatgtaat agagactttt aatataggag ggtgtaccag aagcaccagt ttcctgtggc
13141 aaacagaatt attcctgctg tatttgtaat ttggtgccac gaggtagccc agatcccttc
13201 agctctgatg gaagagcatt gcttcagccg taaatggaca cctgcagaaa ccttgcaccg
13261 atggatagtc tccctcagct ccgtgccatc gctgcagggg ctgttatgga catcactgca
13321 gcccagtggc tctctctcct ggtctccacc atatgagttg gcttctgttt ctctcctgtt
13381 ttactttgcc tttagctgtg gtctttcaaa ccaccatccc tccttatctt cctctgctgg
13441 ttcctcagat cttcctctga tggcgctgcc tccatgccat gccctctgcc agttctatgt
13501 ggtgaacagt gagctgtcct gccagctgta ccagagatcg ggagacatgg gcctcggtgt
13561 gcctttcaac atcgccagct acgccctgct cacgtacatg attgcgcaca tcacgggcct
13621 gaaggtgggc tgtctcggga agggtgactt gccagcctac cacatgagct cttcagttct
13681 ttaatatggg aaaacaaatt gcagagttta gtctctgatt agcttttaaa tttgatatgt
13741 gtaagtaaga catgaaccag cttttacttt gaaaccttcc ttttctggaa ggttttctgg
13801 ccctgtggta tatgcactaa cagatctata caggttgttt gtgatacagc ttctatggat
13861 cttctcaaaa gctatgctga ggttgggtat ggtggctcat gcctgtaatc ccagcacttt
13921 ggaagactga gacaggagca attgcttgag gtctggagtt caataccagc ctgggcaaca
13981 taacaagatg ctgttgctac aaaaaaatgg aaaagctaca ctaaattatt tttttaaaaa
14041 aagccttgcg gtgtctgcat attctaatgt ttttaaatga tgttttaaag aattgaaact
14101 aacatactgt tctgctttct cccggtttat agccaggtga ctttatacac actttgggag
14161 atgcacatat ttacctgaat cacatcgagc cactgaaaat tcaggtaaga attagatgtt
14221 atacttttgg gtttggtacc ttctcttgat aaaaggttga ctgtggaaca ggtatctgct
14281 caatgctgtg tccaagataa agatgactgc tccaaatgtg gggcttcagt ttagggagaa
14341 gtggtgggca ggtgggcagg acaaggcagg catctgcctc agcaaccatg gcacttaact
14401 tgtcaggtgc tgtgaggtac taagcaccag taccagagag ggaagagcca cattcaagcc
14461 aggggattgt ccaaaaggag gcattttaac tcattttaac ttgaaggaga attgaagtgc
14521 aaatgttttt ccttttcttt ttttttgaga tggagtcttt ctctgtcggc caggctggag
14581 tgtgccgtgg tgcgatctca gctcactgca acctccacct cccgggttca agcaattctt
14641 ctgcctcagc ctcccaggta gctgggatta caggcacatg ccaccacacc cagctaattt
14701 tttgtattat tagtagagat ggggtttcgt catgttggcc aggctgatct caaactcctg
14761 acttcaagtg taccacctgc ctcagcctcc gaaagttctg gaattacagg cataagccac
14821 caccctggcc ataaatattt tttgttaatt ttacattaag tacaatattt aggtccaaac
14881 ttcaaaagtc tgttgaaatc cctgaagtta tagcagccaa caattgatat gaaatggcaa
14941 taaaaatgta agttcatctg cttcatgagc cttaaggaaa aaaactcaga accagacact
15001 ttttagcccc ttccaggtta gatccaggtt ttaaaagtta ttcctttgag ggagtttggc
15061 tgcttttgag tggaggtgac ttcaggctta ttctctctgg ctctctgctc tggtcatttt
15121 tagacatagt aataggttgt gacctgtctt cacatcctaa ttgccactgt ctgttcatcc
15181 caggaatcct ggctttcatc cctttctgtt cactgtccat gcatgtcatc tttccttctt
15241 tctgccaggg accagatggg ttagggattg tgaattcaag taaacgtaga gctactatga
15301 gttacagatt gactgtgttc ctgtctttaa taaatttgcc aagagtggtt ataagaactt
15361 acacctgatg aggcaccagg ctcctgatgc tgtgtaatgt cacaaaatac ccctcactct
15421 cgatctgtgc aagagaacag ctggttgcgc tccaatcatg ttacataacc tacgcgaagg
15481 tatcgacagg atcatactcc tgtaaaatag aactttgttg atcacatcct gtgtacttgt
15541 ttcacggaca tgaggagcaa ttacaacagg tcgtacaatt atggcaaaat aatggcctta
15601 ttttgttttt agcttcagcg agaacccaga cctttcccaa agctcaggat tcttcgaaaa
15661 gttgagaaaa ttgatgactt caaagctgaa gactttcaga ttgaagggta caatccgcat
15721 ccaactatta aaatggaaat ggctgtttag ggtgctttca aaggagctcg aaggatattg
15781 tcagtcttta ggggttgggc tggatgccga ggtaaaagtt ctttttgctc taaaagaaaa
15841 aggaactagg tcaaaaatct gtccgtgacc tatcagttat taatttttaa ggatgttgcc
15901 actggcaaat gtaactgtgc cagttctttc cataataaaa ggctttgagt taactcactg
15961 agggtatctg acaatgctga ggttatgaac aaagtgagga gaatgaaatg tatgtgctct
16021 tagcaaaaac atgtatgtgc atttcaatcc cacgtactta taaagaaggt tggtgaattt
16081 cacaagctat ttttggaata tttttagaat attttaagaa tttcacaagc tattccctca
16141 aatctgaggg agctgagtaa caccatcgat catgatgtag agtgtggtta tgaactttaa
16201 agttatagtt gttttatatg ttgctataat aaagaagtgt tctgcattcg tccacgcttt
16261 gttcattctg tactgccact tatctgctca gttccttcct aaaatagatt aaagaactct
16321 ccttaagtaa acatgtgctg tattctggtt tggatgctac ttaaaagagt atattttaga
16381 aataatagtg aatatatttt gccctatttt tctcatttta actgcatctt atcctcaaaa
16441 tataatgacc atttaggata gagttttttt tttttttttt taaactttta taaccttaaa
16501 gggttatttt aaaataatct atggactacc attttgccct cattagcttc agcatggtgt
16561 gacttctcta ataatatgct tagattaagc aaggaaaaga tgcaaaacca cttcggggtt
16621 aatcagtgaa atatttttcc cttcgttgca taccagatac ccccggtgtt gcacgactat
16681 ttttattctg ctaatttatg acaagtgtta aacagaacaa ggaattattc caacaagtta
16741 tgcaacatgt tgcttatttt caaattacag tttaatgtct aggtgccagc ccttgatata
16801 gctatttttg taagaacatc ctcctggact ttgggttagt taaatctaaa cttatttaag
16861 gattaagtag gataacgtgc attgatttgc taaaagaatc aagtaataat tacttagctg
16921 attcctgagg gtggtatgac ttctagctga actcatcttg atcggtagga ttttttaaat
16981 ccatttttgt aaaactattt ccaagaaatt ttaagccctt tcacttcaga aagaaaaaag
17041 ttgttggggc tgagcactta attttcttga gcaggaagga gtttcttcca aacttcacca
17101 tctggagact ggtgtttctt tacagattcc tccttcattt ctgttgagta gccgggatcc
17161 tatcaaagac caaaaaaatg agtcctgtta acaaccacct ggaacaaaaa cagattttat
17221 gcatttatgc tgctccaaga aatgctttta cgtctaagcc agaggcaatt aattaatttt
17281 tttttttttg acatggagtc actgtccgtt gcccaggctg cagtgcagtg gcgcaatctt
17341 ggctcactgc aacctccacc tcccaggttc aagtgattct cctgcctcag cctcccatgt
17401 agctgggatc acaggcacct gccaccatgc ccggctaatt ttttgtattt tttgtagaga
17461 cagggtttca ccatgttggc caggctggtc tcaaacacct gacctcaaat gatccacctg
17521 cctcagcctc ccaaagtgtt gggattacag gcgtaagcca ccatgcccag ccctgaatta
17581 atatttttaa aataagtttg gagactgttg gaaataatag ggcagaggaa catattttac
17641 tggctacttg ccagagttag ttaactcatc aaactctttg ataatagttt gacctctgtt
17701 ggtgaaaatg agccatgatc tcttgaacat gatcagaata aatgccccag ccacacaatt
17761 gtagtccaaa ctttttaggt cactaacttg ctagatggtg ccaggttttt ttgcacaagg
17821 agtgcaaatg ttaagatctc cactagtgag gaaaggctag tattacagaa gccttgtcag
17881 aggcaattga acctccaagc cctggccctc aggcctgagg attttgatac agacaaactg
17941 aagaaccgtt tgttagtgga tattgcaaac aaacaggagt caaagcttgg tgctccacag
18001 tctagttcac gagacaggcg tggcagtggc tggcagcatc tcttctcaca ggggccctca
18061 ggcacagctt accttgggag gcatgtagga agcccgctgg atcatcacgg gatacttgaa
18121 atgctcatgc aggtggtcaa catactcaca caccctagga ggagggaatc agatcggggc
18181 aatgatgcct gaagtcagat tattcacgtg gtgctaactt aaagcagaag gagcgagtac
18241 cactcaattg acagtgttgg ccaaggctta gctgtgttac catgcgtttc taggcaagtc
18301 cctaaacctc tgtgcctcag gtccttttct tctaaaatat agcaatgtga ggtggggact
18361 ttgatgacat gaacacacga agtccctctg agaggttttg tggtgccctt taaaagggat
18421 caattcagac tctgtaaata tccagaatta tttgggttcc tctggtcaaa agtcagatga
18481 atagattaaa atcaccacat tttgtgatct atttttcaag aagcgtttgt attttttcat
18541 atggctgcag cagctgccag gggcttgggg tttttttggc aggtagggtt gggagg
//