GenBank-Updates@genbank.bio.net (01/19/91)
LOCUS HUMTS1 18596 bp ds-DNA PRI 19-JAN-1991 DEFINITION Human thymidylate syntase gene, complete cds. ACCESSION D00596 KEYWORDS thymidylate syntase. SOURCE Human DNA (genomic), clones lambdaHTS-1 and lambdaHTS-3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 18596) AUTHORS Kaneda,S., Nalbantoglu,J., Takeishi,K., Shimizu,K., Gotoh,O., Seno,T. and Ayusawa,D. TITLE Structural and functional analysis of the human thymidylate synthase gene JOURNAL J. Biol. Chem. 265, 20277-20284 (1990) STANDARD full staff_entry COMMENT These data kindly submitted in computer readable form by: Sumiko Kaneda National Institute of Genetics 1111 Yata Mishima 411 Japan Phone: +81-559-72-2732 Fax: +81-559-71-3651 FEATURES Location/Qualifiers CDS join(1001..1205,2895..2968, 5396..5570,11843..11944,13449..13624, 14133..14204,15613..15750) /note="thymidylate synthase [EC 2.1.1.45] (part of" repeat_region 1..148 /note="Alu sequence" repeat_region 202..477 /note="Alu sequence" precursor_RNA 822..16246 /note="thymidylate synthase mRNA and introns" precursor_RNA 824..16246 /note="thymidylate synthase mRNA and introns" precursor_RNA 828..16246 /note="thymidylate synthase mRNA and introns" precursor_RNA 841..16246 /note="thymidylate synthase mRNA and introns" repeat_region 862..889 /note="inverted repeat" repeat_region 904..993 /note="triple tandem repeats" exon 1001..1205 /note="thymidylate synthase [EC 2.1.1.45] (part of exon 1)" intron 1206..2894 /note="thymidylate synthase intron 1" misc_binding 1660..1665 /note="Sp1 binding site" misc_binding 1890..1895 /note="Sp1 binding site" misc_binding 1895..1900 /note="Sp1 binding site" exon 2895..2968 /note="thymidylate synthase (exon 2)" intron 2969..5395 /note="thymidylate synthase intron 2" repeat_region 3049..3347 /note="Alu sequence" repeat_region 4953..5245 /note="Alu sequence" exon 5396..5570 /note="thymidylate synthase (exon 3)" intron 5571..11842 /note="thymidylate synthase intron 3" repeat_region 5768..9405 /note="L1 sequence" repeat_region 10125..10389 /note="reiterated motif of GGA/TGAT" exon 11843..11944 /note="thymidylate synthase (exon 4)" intron 11945..13448 /note="thymidylate synthase intron 4" repeat_region 12135..12397 /note="Alu sequence" repeat_region 12567..12743 /note="Alu sequence" repeat_region 12807..13084 /note="Alu sequence" exon 13449..13624 /note="thymidylate synthase (exon 5)" intron 13625..14132 /note="thymidylate synthase intron 5" repeat_region 13875..14010 /note="Alu sequence" exon 14133..14204 /note="thymidylate synthase (exon 6)" intron 14205..15612 /note="thymidylate synthase intron 6" repeat_region 14531..14832 /note="Alu sequence" exon 15613..15750 /note="thymidylate synthase (part of exon 7)" misc_signal 15934..15939 /note="poly(A) signal" misc_signal 16228..16233 /note="poly(A) signal" repeat_region 17262..17553 /note="Alu sequence" BASE COUNT 4521 a 3991 c 4479 g 5605 t ORIGIN 18p11.32 on chromosome 18. 1 cctgtagtcc cagctacgcg agaggctgag gcagcagaat tacttgaacc caggaggcgg 61 aggttgcagt gagccgagat cgcgccactg cactccagcc tgggtgagag agcgagactc 121 tgtctcaaaa aaaaaaaaaa aagaccgcca gggctcaaac aaaaaacctc ggaaaagccc 181 tggcggtctt tttttttttt tttttttttt ttttttggga cagtcttgct ctgtcgccca 241 ggctggagta caatggtcgg atcttggctc actgcaacct ctgcctccca ggttcaagca 301 attcttctgc ctcagcctcc caagtagcca ccacgcccag ctaatttttg tacttttagt 361 agagacgggg gtttcaccat gttgtccagg ctggtcttga actcctgacc tcaggtgatc 421 cacccgcctc ggccccccaa agtactagga ttacaggcgt gagccaccgc gtccagcgcc 481 ctggcggttt ttaatcaagt agaaaagctg cattatacca cttgcttcgg ttgcttcagt 541 gagaacgaag aaatggaaat gcaaatccct tattagttgt aggaaacaga tctcaaacag 601 cagttttgtt gacaagaccg caggaaaacg tgggaactgt gctgctggct tagagaaggc 661 gcggtcgacc agacggttcc caaagggcgc agtccttccc agccaccgca cctgcatcca 721 ggttcccggg tttcctaaga ctctcagctg tggccctggg ctccgttctg tgccacaccc 781 gtggctcctg cgtttccccc tggcgcacgc tctctagagc gggggccgcc gcgaccccgc 841 cgagcaggaa gaggcggagc gcgggacggc cgcgggaaaa ggcgcgcgga aggggtcctg 901 ccaccgcgcc acttggcctg cctccgtccc gccgcgccac ttggcctgcc tccgtcccgc 961 cgcgccactt cgcctgcctc cgtcccccgc ccgccgcgcc atgcctgtgg ccggctcgga 1021 gctgccgcgc cggcccttgc cccccgccgc acaggagcgg gacgccgagc cgcgtccgcc 1081 gcacggggag ctgcagtacc tggggcagat ccaacacatc ctccgctgcg gcgtcaggaa 1141 ggacgaccgc acgggcaccg gcaccctgtc ggtattcggc atgcaggcgc gctacagcct 1201 gagaggtgac gccgcgggcc cctgcgggac gggtggcggg aaggagggag gcgcggctgg 1261 ggagagcgct cgggagctgc cgggcgctgc ggaccccgtt tagtcctaac ctcaatcctg 1321 ccagggaggg gacgcatcgt cctcctcgcc ttacagacgc cgaaacggag ggtcccatta 1381 gggacgtgac tggcgcgggc aacacacaca gcagcgacag ccgggaggta agccgcgtcc 1441 cagcggctcc gcggccgggc tcgcagtcgc cccagtgatg ccgtggcccc cgaggcgggc 1501 gtcatcgggc agcgtttgcc cagtgctgga gggttaggga gagctgcctg ggcttgaccg 1561 cgcgccggtc tcaaagtcct ggctttggcc cctcctccgt tttcccctgt ggaccattcc 1621 gcttcgcagc gttttcaaaa actggagcga aagtgatgtg ggcggggcaa aggcggcggg 1681 aagaggacag cactgaagct ggcgcgggaa cttggtttcc tggtggcctc ccatccaatc 1741 cccacgaacc agctttcctc ttaaaccttg aaaagagaaa ttcgggagtt cgagttctta 1801 gtcgtccttt cctctttcct ttccgacagg agcaccccag gcaaaaaatg tctcgcgggt 1861 cattggcgcc aggctttcag gggacagtgg ggcggggcgg ggtgggcaca ggacgttagg 1921 cagccgttgg ccctccctaa ggccacaccg tcctgccgtc ctggatcctg cgccagctgc 1981 gcgggggagg ggactcgaag gtgtgtgagc caggggctga ccttgaccgc tcagataaat 2041 ggagcgcagc cttgacacag gggtggaggt ggttttgaat ggggaaaccc attcgtggtg 2101 aagcagattc actgtagcta gcggaaaagc cctccggccc acggacccat ctagagacga 2161 atacatagca gctgctgtgg ctgattggcg tgggacagcg tggggagttt tgtctgagga 2221 gagggatcca cttttctgca gctccaagcc caggggcctt tgatgagcca tagacctcat 2281 ttttaaccca cctttctgct tagacattga gcaagttact tctcatatag cttccctata 2341 tgttaaaaat ggagaaaata atgcttagta ggcaattctg ataaaagcag gtgcttgcaa 2401 aaatctctct gttgtctgaa tataaactgt accacaagcg agtgcggatg aacgaggact 2461 gcatttaaag ataagttttt acactttcat ttctctgtgg ctcgacactt ctgatgcctc 2521 cctttttgtt cctgggacac atgcttggtg ttgtcttcac acctttgtga caggattagc 2581 actagtgggc agtggatgat agctcctcct cccttttgcc acatgttcat ccctgccctc 2641 gccaccatct cactgtgtgg aattcctgtg tccactggtc accggggcac agaagtgctg 2701 tctcagcctg aatcgggcca ctgatgggac ttgcagcctg ggagctccac cgtgatctct 2761 ggcccacttt gcgggagtct aggctttctg gatgctccag gcctcacgtc ccagggcagt 2821 tttcttccct gaagaaagtt ggatggcatg atctgtcttc ccatcttgaa accgtatggc 2881 aaattgtttt tcagatgaat tccctctgct gacaaccaaa cgtgtgttct ggaagggtgt 2941 tttggaggag ttgctgtggt ttatcaaggt aaagaagtcg ctgctattag aagtcagtag 3001 tctgttctca acacagcagc cagtgagatc ctttcaaaac tcaaagcagc caggtgtggt 3061 ggctcacgcc tgtaatccca ccgctttggg aggctgagtc agatcacctg aggttaggaa 3121 tttgggacca gcctggccaa catggcgaca ccccagtctc tactaataac acaaaaaatt 3181 agccaggtgt gctggtgcat gtctgtaatc ccagctactc aggaggctga ggcatgagaa 3241 ttgctcacga ggcggaggtt gtagtgagct gagatcgtgg cactgtactc cagcctggcg 3301 acagagggag aacccatgtc aaaaacaaaa aaagacacca ccaaaggtca aagcatatca 3361 ttcctcaccc tcaagccctt agtggctcca tttcactcag taagagccac ggtccttatg 3421 gtgtccgttt ttcagctctg accttagctg ctgctctctg caccaccctg ctgttcttgt 3481 gagtttttga gcacaccggg acatccccac tccctggaac cttcttcccc cacacttggc 3541 ttcttccttt gagtctctac tccactcggg caagccttcc tagacctcct gatttaaaac 3601 tgtgactctc ccccaacctc cttggtgttt ctccgtagac gaacatcacc atctgatgta 3661 tgtcagcctt tcccttcccc tgttagaagg gggacagcag gtagtaaaag tgaaatgtgc 3721 tgtaagcttt atgagggcag aggatttgtt tctcgtgttc actgttgtat cgccagggcc 3781 tcaaacacag cctgccacat agtaggagtc aacatatatt gatcactaaa tgtagatacc 3841 acctgtgttc ccatgttcat ataaattcta gaagagtctc ttcagtaaca aggtgaaccc 3901 cttccagagg gctgagtagg tacctcaggc cggggccaga gtgctgtgaa gacagcagca 3961 gcccagacca agcttctctg tgttccgtgt cctggtctag aaccagcgat gttctttctg 4021 accagtgctt tttggaaggt ggctgaggtc tgggctcagg tctgggccat actagaagct 4081 gggatccctt ctatagagca cttggtatgg cttgtatggt cttggggcaa gccagaccca 4141 agccctctta tcccatttta gaaagggctt caatttggat ccagccccag gtctgcctta 4201 gctctgtatt cttggggtat tttgttctgt attggcctat cttgactaac aatgagcctt 4261 ggatttgaaa catatcatca gaaacctcag aagacaacat tcttaaactg gctagagcct 4321 ggtctgaatg gatgaaaagg agagactttt gaagcaatat gtaaaagatt gagaaatgat 4381 ttgttggaaa tttctcaatt ggagaaattt ctttgatttg ttggaaattt ctttgattct 4441 ttctcaatca aagaaaatcg ggacaaactc aacaatagaa agggaggaag caagatactc 4501 agaaataaaa tgcattcccc tgtttcaact taatgcttca attcaggatt ctaaggaatc 4561 cttgccagga atgtcagact caccttgata gttggagtta ctccattggt gactcgatca 4621 aatacaggag ttgaggcacc tgcactgtaa aatactgatt agtctgatca ttaggaatat 4681 cctgtatgcc aggtagaaga tacattgaac agattgcatg taggcattaa attcattttg 4741 gggtattaca tatagacaac acatttcatt aagaaacata aaactgtcag atcggtggaa 4801 tacttaaaag cacttggagg tgtttagcct aaaaagctta gttgagggga atggaagaaa 4861 agatctggga gggtggttcc aaagaaggga tcagactatc ctaaagccct caggaatctg 4921 ggctgggacc acctacttaa agataggatg ggcagctggg tgtggtggct cacgcctgta 4981 atcccagcac ttcgggaggc cgaagcgggc ggatcacctg aggtcaggag ttcgaggcca 5041 gcctgaccaa catggagaaa cgctgtctct actaaaaata caaaattagc tgggtgtagt 5101 ggcgcatgcc tgtaatccca gctactcggg aggctgaggc aggggaatcg cttgaacctg 5161 ggaggtggag ggtgccgtga gccacgatcg cgccattgca ctccagcctg ggcaacaaga 5221 gcgaaactct caaaaaacaa aaaaaaggat gggttccata tgggtggtgt caagtgccca 5281 cctcctagca agtcagcagg ggccagaggc ccttgtaagt ggtgtctcgg ggggatcaac 5341 tgagatggct taagatttac ctggatgcct gctctgctct ccccatctct tccagggatc 5401 cacaaatgct aaagagctgt cttccaaggg agtgaaaatc tgggatgcca atggatcccg 5461 agactttttg gacagcctgg gattctccac cagagaagaa ggggacttgg gcccagttta 5521 tggcttccag tggaggcatt ttggggcaga atacagagat atggaatcag gtgaggagat 5581 agaacaatgc cttccatttc cgggtgccct tcctagcacg tgtttgctcc gttgttttag 5641 ataaggtctg ggggatgagt caatgtcaca ggagctgatg tatagctttg accttgtgag 5701 gggtggtgcc aggttgaagc cacaattaac gcctactgaa ggccgtttca catctttttt 5761 tttttttttt ttttaattat tatactttaa gttttagggt acatgtgcac aatgtgcagg 5821 ttagttacat atgtatacat gtgccatgct ggtgcgctgc accactaact caccatctag 5881 catcaggtat atctcccaat gctatccctc ccccctcctc ccaccccaca acatccccag 5941 agtgtgatgt tccccttcct gtgtccatat gttctcgttg ttcgattccc actatgagtg 6001 agaatatgcg gtgtttggtt ttttgttctt gcgatagttt actgagaatg atgatttcca 6061 tttcaccacg tccctacaga ggacatgaac tcatcatttt ttatggctgc atagtattcc 6121 atggtgtata tgtgccacat tttcttaatc cagtctatca tgttggacat ttgggttggt 6181 tccaagtctt tgcctattgt gaatagtgcc acaataaaca tacgtgtgca tgtgtcttta 6241 tagcagcatg atttaatagt cctttgggta tatacccagt aatgggatgg ctgggtcaaa 6301 tggtatttct agttctagat ccccgaggaa tcgccacact gacttccaca atggttgaac 6361 tagtttacag tcccaccaac agtgtcaaag tgtcctattt ctccacatcc tctccagcac 6421 ctgttgtttc ctgacttttt aatgattgcc attctaactg gtgtgagatg gtatctcatt 6481 gtggttttga tttgcgtttc tctgatggcc agtgatggtg agcatttttt catgtgtttt 6541 ttggctgcat aaatgtcttc ttttgagaag tgtctgttca tgtccttcgc ccactttttg 6601 atggggttgt ttttttctta taaatttgtt tgagttcatt gtagattctg gatattagcc 6661 ctttgtcaga tgagtaggtt gcaaaaatgt tctcccattt tgtgggttgc ctgttcactc 6721 tgatggtagt ttcttttgct gtgcagaagc tctttagttt aattagatcc catttgtcaa 6781 ttttggcttt tgttgccatt gcttttggca taggcatgaa gtccttgccc atgcctatgt 6841 cctgaatggt aatgcctagg ttttcttcta gggtttttat ggttttaggt ctaacgttta 6901 agtctttaat ccatcttgaa ttgatttttg tataaggtgt aaggaaggga tccagtttca 6961 gctttttaca tatggctagc cagttttccc agcaccattt attacatagg gaatcctttc 7021 cccattgctt gtttttctca ggtttgtcaa agatcagata gttgtagata tgcggcgtta 7081 tttctgaggg ctctgttctg ttccattgat ctatgtgtct gttttggtac cagtaccata 7141 ctgttttggt tactgtagcc ttgtagtata gtttgaagtc aggtagcgtg atgcctccag 7201 ctttgttctt ttggcttagg attgacttgg cgatgcgggc tcttttttgg ttccatatga 7261 actttaaagt agttttttcc aattctgtga agaaagtcat tggtagcttg atggggatgg 7321 cattgaatct ataaattacc ttgggcagta tggccatttt cacgatattg attcttccta 7381 cccatgagca tggaatggtc ttccatttct ttgtatcctc ttttatttca ttgagcagtg 7441 gtttgtagtt ctccttgaag aggtccttca catccctttt aaggtggatt cctaggtatt 7501 ttattctctt tgaagcaatt gtgagtggaa gttcactcat gatttggctc tctgtttgtc 7561 tgttattggt gtataagaat gcttgtgatt tttgcagatt gattttatat cctgagactt 7621 tgctgaagct gcttatcagc ttaaggagat tttgggctga gacaatgggg ttttctagat 7681 atacaatcat gtcgtctgca aacagggaca atttgacttc ctcttttcct aattgaatac 7741 cctttatttc cttctcctgc ctaattgccc tggccagaac ttccaacact atgttgaata 7801 ggagtggtga gagagggcat ccctgtcttg tgccagtttt caaagggaat gcttccagtt 7861 tttgcccatt cactatgata ttggctgtgg ctttgtcata gatagctctt attattttga 7921 aatatgttcc atcaatacct aatttattga gagtttttag catgatgtgt tgttgaattt 7981 tgtcaaaggc tttttctgca tctattgaga taatcatgtg gtttttgtct ttggatctgt 8041 ttatatgctg gattacattt attgatttgc gtatattgaa ccagccttgc atcctaggga 8101 tgaagcccac atgatcatgg tggataagct ttttgatgtg ctgctggatt cggtttgcca 8161 gtattttatt gaggattttt gcatcaatgt tcatcaagga tattggtcta aaattctctt 8221 ttttggtgtg tctctgccca gctttggtat caggatgatg ttggcttcat aaaatgagtt 8281 agggaggatt ccctcttttt ctattgattg gaatagtttc agaaggaatg gtaccagttc 8341 ctctttgtac ctctggagaa ttcggctgtg aatccatctg gtcctggact ctctttggtt 8401 ggtaagctat tgattattgc cacaatttca gctcctgtta ttggtctatt cagagattca 8461 acttcttcct ggtttagtct tgggagagtg tatgtgtcaa ggaatttatc catttcttct 8521 agattttcta gtttatttgc gtagaggtgt ttgtagtaat ctctgatggt agtttgtatt 8581 tctgtgggat cggtggtgat atccccttta tcatttttta ttgcgtctat ttgattcttc 8641 tctttttctt tattagtctt gctagcggtc tataaatttt gttgatcctt tcaaaaaacc 8701 agctcctgga ttcattaatt ttttgaaggg ttttttgtgt ctctatttcc ttcagttctg 8761 ctctgatttt agttatttct tgccttctgc tagcttttga atatgtttgc tcttgctttt 8821 ctagttcttt taattgtgat gttagggtgt caattttgga tctttcctgc tttctcttgt 8881 gggcatttag tgctataaat ttccctctac acactgcttt gaatgtgtcc cagaggttct 8941 ggtatgttgt gtctttgttc ttgttggttt caaagaacat ctttatttct gccttcattt 9001 cgttatgtac ccagtagtca ttcaggagca ggttgttcag tttccatgta gttgagcagt 9061 tttgagtgag attcttaatc ctgagttcta gtttgattgc actgtggtct gagagatagt 9121 ttgttataat ttctgttctt ttacatttgc tgaggagagc tttacttcca actatgtggt 9181 cggttttgga ataggtgtgg tgtggtgctg aaaaaaatgt atattctgtt gatttgggat 9241 ggagttctgt agatgtctat taggtctgct tggtgcagag ctgagttcaa ttcctgggta 9301 tccttgttga ctttctgtct cgttgatctg tgtactgttg acagtgggtg ttaaagtctc 9361 ccattattaa tgtgtggagt ctaagtctct ttgtaggtca ctcagatgat tggcacttac 9421 tgggcgcttg gcactttcca tactgtgtca tcggcagata gctgcatggt tggtgttcgt 9481 gctggggaat gggaagttca tcggtgggac aaggacaaaa tgcccccatt gctttgttgt 9541 ggctttaatc tccctttcga ggctgagcca cagcgtgctg taggtggcgc tgctgtgaag 9601 cgcagtacca gggtcacact ccactcccag ctctgcagag gtggagaaag aatgaaacat 9661 ctcactcctg gacttccact ttcctgtcac tgttggtgtc acctcttact ggatgtcaca 9721 gagcccagcc cctcccacct gtgcctagga aaagcagatg ccaccttgga atgtggggtt 9781 tgtgtgtgca atttactagc tgggcagaga ccagcaacct ggagagcagg tgtctcgtct 9841 aaggggacag tcacatttca cctccagcca cctggaggaa tttgggcctg gtgatgtcag 9901 aattcttcaa taaaagccta aaatctatat tttatgtgcg gtcatgagat ctgttaaatg 9961 ttagcaactt caggaagttt aaaaatgctg tgtggaccta gaataggcaa gttcttaaag 10021 gcagaaagtg gaatgctagt ttccagggac tggggaacag ggaggaatgg ggagttcatg 10081 tttaatgggc acagaggttt tgttagggat gacgaaaaag ttcgggagat ggtgatggtg 10141 atggagatgg tgatggtgat ggagatggtg atggtgatgg tgatggtgat gggtgatggt 10201 gatggtgatg gtgatggtga tggagatggt gatggtgatg gtgatggaga tggtgatggt 10261 gatggtgatg gtgatggaga tggtgatggt gatggagatg gtgatggtga tggtgatgga 10321 gatggtgatg gtgatggtga tggtgatggt gatggtgatg gtgatggaga tggagatggt 10381 gatggtgatg gttgcctaac atcaggaacg tgcttaatgc ttctgaattg cacacaaaaa 10441 tggcaagttt aatattatgt gtactttatc acaatgaaaa aagctgctgc gtgggccaag 10501 ttacttgtgc aggtaatgtt ctgcaggtgg ttgcctgcac ctcagttgta gggtgtccgt 10561 aggatgtgag gccagtcccc gggcttaatg atgctttaaa tcctgcctag tattcaatta 10621 tttcttgtcg cttaaaaggc ctaataaaat tatggtctta gtttacagtg gtatgaatgc 10681 ttagctgttg gattttagta ggaaagttcg tccctttttg tttttaattt tgttttacag 10741 attcacagga attttttttt tttttttttt tttttttttt taatgcacag aaagtttccc 10801 tggactctct acccagtttc cccagtgata atatcttggg taacatcctg tatacattca 10861 cattggtgca ttcctcagag ttgtcagatt ttgctagttt tacgtgcact tgtgtatgtg 10921 tgtatttgca attttagcac gtgtagactc ttgtaaccac tacaatcaag ttacagaact 10981 acactaccaa ggttcatctt tttaaaatct ttgatgttac cttttttgga acagtgacca 11041 tgagaggact ttcctcccaa aattttgaaa actactgaac cagaatatag tctgacacta 11101 ataggtagaa atttaaccaa aggagattat gaagctctgc acttgagtta acaaaatcac 11161 ttctcagctt ccagttccat ctcagaagga aggaaaaggg attaaaaatc cagagaccag 11221 aaaatgggag caaagtacaa ggtggtgtaa tcattacaga ggtttcctga tgtttccaag 11281 tcagtcgtgt gttgagctgc taaactctaa agtaatttta ggtggaatgt tggaaacatg 11341 ctgctgaggt gatagaaagg aatccatggt cctctgttag ttggaaagta tatggaatac 11401 tatattctac ataagataca atactctctg tgagacaagg ataaagtaga ttttgtcagt 11461 gaaattgtga caagaatcgc tgatgggttt agagcctaag tttgcgagga gcactggaag 11521 aaattaagat tgttgagatt ggaaagggtt agctatgggg gaacaggagg aggtgactcc 11581 atgacagacc aaatattcaa aggactgtgt agaagaggaa aaagactttg ttagggctcc 11641 agaggacaga gccaggagtc agacagggcc ttgaactcaa cccaccgaga tctgcaaact 11701 ttgcaggatg caccagatgt cttgtagcca tgggtcaagg ggggaccctg ggtaagagac 11761 tgtaatagat gacctctaag gccatctcat gacatgtgtg attaatgtat gtacctgtcc 11821 tctctttttg acaattctac agattattca ggacagggag ttgaccaact gcaaagagtg 11881 attgacacca tcaaaaccaa ccctgacgac agaagaatca tcatgtgcgc ttggaatcca 11941 agaggttgaa agaaccccgt cgtcttcatt tatactaacc atactcttag agggaagcaa 12001 tctggttttg tgcagaggca ctgagggagg caggaccctg ggcaacttcc cccagccaca 12061 tggttgtgtg acgttgggca agtcacattt tgctgcactt tcaccttcag atcatgaggt 12121 tgggcccaga ggattttttt tttttttttt ttttttgaga cagagttttg ctctgttgcc 12181 caggctggaa tgcaacggcg tgatcttggc tcactgtaac ctctgcctcc tgggttcgag 12241 tgattctcct gcctcagcct ccaagtagct gggattacag catgtgccac catgcctggc 12301 taattttgta tttttagtag agacgggttc acatgttggt caggctggtc ttgactcctg 12361 accctcagat gatctgcctt gcctcagcct cccaaccgag tgatcttaag ttgtgtatta 12421 tactcattct tacacaaaaa gggctttaaa tgcctagaaa ctacatgaag atgttaacat 12481 tttaaatgga agcagatgaa gttccagctc gctgccacct cactaacatt tttaacaatt 12541 atattgtaaa attcaactct accagggtgt agagccaggt gtggtggctc acacctgtaa 12601 ttccaacaac tccagaggcc aaggcgagag gatcatttga acccacggaa tttgaggctg 12661 tagtgagtca tgatcacgcc attgcactcc atcctgggca acagagtgag accctgaata 12721 tttaaaaaca acaacaacaa caaaactcta tcaggatatc ataagtactt agagtgaaat 12781 acttgcatct gtaatagaga cttatttttt ttttttttga gacacagtct caccctgttg 12841 cccaggctgg agtgcagtgg tttgatctcc gctcacggca acctccatct cccaggttca 12901 agtgagttcc cattcctcag ccccagagct gggaccacag gcgcgcgaat ttttgtattt 12961 ttagcagaga cggggtttca ctatgttggc caggctagtc tcaaactcaa gttggcctca 13021 agtgatctgc ccaccctggc gtcccagtgt tgggatttca ggcatgagcc actgtgcctg 13081 gccatgtaat agagactttt aatataggag ggtgtaccag aagcaccagt ttcctgtggc 13141 aaacagaatt attcctgctg tatttgtaat ttggtgccac gaggtagccc agatcccttc 13201 agctctgatg gaagagcatt gcttcagccg taaatggaca cctgcagaaa ccttgcaccg 13261 atggatagtc tccctcagct ccgtgccatc gctgcagggg ctgttatgga catcactgca 13321 gcccagtggc tctctctcct ggtctccacc atatgagttg gcttctgttt ctctcctgtt 13381 ttactttgcc tttagctgtg gtctttcaaa ccaccatccc tccttatctt cctctgctgg 13441 ttcctcagat cttcctctga tggcgctgcc tccatgccat gccctctgcc agttctatgt 13501 ggtgaacagt gagctgtcct gccagctgta ccagagatcg ggagacatgg gcctcggtgt 13561 gcctttcaac atcgccagct acgccctgct cacgtacatg attgcgcaca tcacgggcct 13621 gaaggtgggc tgtctcggga agggtgactt gccagcctac cacatgagct cttcagttct 13681 ttaatatggg aaaacaaatt gcagagttta gtctctgatt agcttttaaa tttgatatgt 13741 gtaagtaaga catgaaccag cttttacttt gaaaccttcc ttttctggaa ggttttctgg 13801 ccctgtggta tatgcactaa cagatctata caggttgttt gtgatacagc ttctatggat 13861 cttctcaaaa gctatgctga ggttgggtat ggtggctcat gcctgtaatc ccagcacttt 13921 ggaagactga gacaggagca attgcttgag gtctggagtt caataccagc ctgggcaaca 13981 taacaagatg ctgttgctac aaaaaaatgg aaaagctaca ctaaattatt tttttaaaaa 14041 aagccttgcg gtgtctgcat attctaatgt ttttaaatga tgttttaaag aattgaaact 14101 aacatactgt tctgctttct cccggtttat agccaggtga ctttatacac actttgggag 14161 atgcacatat ttacctgaat cacatcgagc cactgaaaat tcaggtaaga attagatgtt 14221 atacttttgg gtttggtacc ttctcttgat aaaaggttga ctgtggaaca ggtatctgct 14281 caatgctgtg tccaagataa agatgactgc tccaaatgtg gggcttcagt ttagggagaa 14341 gtggtgggca ggtgggcagg acaaggcagg catctgcctc agcaaccatg gcacttaact 14401 tgtcaggtgc tgtgaggtac taagcaccag taccagagag ggaagagcca cattcaagcc 14461 aggggattgt ccaaaaggag gcattttaac tcattttaac ttgaaggaga attgaagtgc 14521 aaatgttttt ccttttcttt ttttttgaga tggagtcttt ctctgtcggc caggctggag 14581 tgtgccgtgg tgcgatctca gctcactgca acctccacct cccgggttca agcaattctt 14641 ctgcctcagc ctcccaggta gctgggatta caggcacatg ccaccacacc cagctaattt 14701 tttgtattat tagtagagat ggggtttcgt catgttggcc aggctgatct caaactcctg 14761 acttcaagtg taccacctgc ctcagcctcc gaaagttctg gaattacagg cataagccac 14821 caccctggcc ataaatattt tttgttaatt ttacattaag tacaatattt aggtccaaac 14881 ttcaaaagtc tgttgaaatc cctgaagtta tagcagccaa caattgatat gaaatggcaa 14941 taaaaatgta agttcatctg cttcatgagc cttaaggaaa aaaactcaga accagacact 15001 ttttagcccc ttccaggtta gatccaggtt ttaaaagtta ttcctttgag ggagtttggc 15061 tgcttttgag tggaggtgac ttcaggctta ttctctctgg ctctctgctc tggtcatttt 15121 tagacatagt aataggttgt gacctgtctt cacatcctaa ttgccactgt ctgttcatcc 15181 caggaatcct ggctttcatc cctttctgtt cactgtccat gcatgtcatc tttccttctt 15241 tctgccaggg accagatggg ttagggattg tgaattcaag taaacgtaga gctactatga 15301 gttacagatt gactgtgttc ctgtctttaa taaatttgcc aagagtggtt ataagaactt 15361 acacctgatg aggcaccagg ctcctgatgc tgtgtaatgt cacaaaatac ccctcactct 15421 cgatctgtgc aagagaacag ctggttgcgc tccaatcatg ttacataacc tacgcgaagg 15481 tatcgacagg atcatactcc tgtaaaatag aactttgttg atcacatcct gtgtacttgt 15541 ttcacggaca tgaggagcaa ttacaacagg tcgtacaatt atggcaaaat aatggcctta 15601 ttttgttttt agcttcagcg agaacccaga cctttcccaa agctcaggat tcttcgaaaa 15661 gttgagaaaa ttgatgactt caaagctgaa gactttcaga ttgaagggta caatccgcat 15721 ccaactatta aaatggaaat ggctgtttag ggtgctttca aaggagctcg aaggatattg 15781 tcagtcttta ggggttgggc tggatgccga ggtaaaagtt ctttttgctc taaaagaaaa 15841 aggaactagg tcaaaaatct gtccgtgacc tatcagttat taatttttaa ggatgttgcc 15901 actggcaaat gtaactgtgc cagttctttc cataataaaa ggctttgagt taactcactg 15961 agggtatctg acaatgctga ggttatgaac aaagtgagga gaatgaaatg tatgtgctct 16021 tagcaaaaac atgtatgtgc atttcaatcc cacgtactta taaagaaggt tggtgaattt 16081 cacaagctat ttttggaata tttttagaat attttaagaa tttcacaagc tattccctca 16141 aatctgaggg agctgagtaa caccatcgat catgatgtag agtgtggtta tgaactttaa 16201 agttatagtt gttttatatg ttgctataat aaagaagtgt tctgcattcg tccacgcttt 16261 gttcattctg tactgccact tatctgctca gttccttcct aaaatagatt aaagaactct 16321 ccttaagtaa acatgtgctg tattctggtt tggatgctac ttaaaagagt atattttaga 16381 aataatagtg aatatatttt gccctatttt tctcatttta actgcatctt atcctcaaaa 16441 tataatgacc atttaggata gagttttttt tttttttttt taaactttta taaccttaaa 16501 gggttatttt aaaataatct atggactacc attttgccct cattagcttc agcatggtgt 16561 gacttctcta ataatatgct tagattaagc aaggaaaaga tgcaaaacca cttcggggtt 16621 aatcagtgaa atatttttcc cttcgttgca taccagatac ccccggtgtt gcacgactat 16681 ttttattctg ctaatttatg acaagtgtta aacagaacaa ggaattattc caacaagtta 16741 tgcaacatgt tgcttatttt caaattacag tttaatgtct aggtgccagc ccttgatata 16801 gctatttttg taagaacatc ctcctggact ttgggttagt taaatctaaa cttatttaag 16861 gattaagtag gataacgtgc attgatttgc taaaagaatc aagtaataat tacttagctg 16921 attcctgagg gtggtatgac ttctagctga actcatcttg atcggtagga ttttttaaat 16981 ccatttttgt aaaactattt ccaagaaatt ttaagccctt tcacttcaga aagaaaaaag 17041 ttgttggggc tgagcactta attttcttga gcaggaagga gtttcttcca aacttcacca 17101 tctggagact ggtgtttctt tacagattcc tccttcattt ctgttgagta gccgggatcc 17161 tatcaaagac caaaaaaatg agtcctgtta acaaccacct ggaacaaaaa cagattttat 17221 gcatttatgc tgctccaaga aatgctttta cgtctaagcc agaggcaatt aattaatttt 17281 tttttttttg acatggagtc actgtccgtt gcccaggctg cagtgcagtg gcgcaatctt 17341 ggctcactgc aacctccacc tcccaggttc aagtgattct cctgcctcag cctcccatgt 17401 agctgggatc acaggcacct gccaccatgc ccggctaatt ttttgtattt tttgtagaga 17461 cagggtttca ccatgttggc caggctggtc tcaaacacct gacctcaaat gatccacctg 17521 cctcagcctc ccaaagtgtt gggattacag gcgtaagcca ccatgcccag ccctgaatta 17581 atatttttaa aataagtttg gagactgttg gaaataatag ggcagaggaa catattttac 17641 tggctacttg ccagagttag ttaactcatc aaactctttg ataatagttt gacctctgtt 17701 ggtgaaaatg agccatgatc tcttgaacat gatcagaata aatgccccag ccacacaatt 17761 gtagtccaaa ctttttaggt cactaacttg ctagatggtg ccaggttttt ttgcacaagg 17821 agtgcaaatg ttaagatctc cactagtgag gaaaggctag tattacagaa gccttgtcag 17881 aggcaattga acctccaagc cctggccctc aggcctgagg attttgatac agacaaactg 17941 aagaaccgtt tgttagtgga tattgcaaac aaacaggagt caaagcttgg tgctccacag 18001 tctagttcac gagacaggcg tggcagtggc tggcagcatc tcttctcaca ggggccctca 18061 ggcacagctt accttgggag gcatgtagga agcccgctgg atcatcacgg gatacttgaa 18121 atgctcatgc aggtggtcaa catactcaca caccctagga ggagggaatc agatcggggc 18181 aatgatgcct gaagtcagat tattcacgtg gtgctaactt aaagcagaag gagcgagtac 18241 cactcaattg acagtgttgg ccaaggctta gctgtgttac catgcgtttc taggcaagtc 18301 cctaaacctc tgtgcctcag gtccttttct tctaaaatat agcaatgtga ggtggggact 18361 ttgatgacat gaacacacga agtccctctg agaggttttg tggtgccctt taaaagggat 18421 caattcagac tctgtaaata tccagaatta tttgggttcc tctggtcaaa agtcagatga 18481 atagattaaa atcaccacat tttgtgatct atttttcaag aagcgtttgt attttttcat 18541 atggctgcag cagctgccag gggcttgggg tttttttggc aggtagggtt gggagg //