GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB01 1090 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 1.
ACCESSION M23282 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 1 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1090)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
exon 610..983
/note="beta-hexosaminidase beta-subunit, exon 1A
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
/codon_start=610
/citation=J. Biol. Chem. 265, 20799-20806 (1990)
exon (640.641)..983
/note="beta-hexosaminidase beta-subunit, exon 1B
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
/codon_start=640
/citation=J. Biol. Chem. 265, 20799-20806 (1990)
exon (665.666)..983
/note="beta-hexosaminidase beta-subunit, exon 1C
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
/codon_start=665
/citation=J. Biol. Chem. 265, 20799-20806 (1990)
exon 694..983
/note="beta-hexosaminidase beta-subunit, exon 1D
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
/codon_start=694
/citation=J. Biol. Chem. 265, 20799-20806 (1990)
intron 984..>1090
/note="HEXB intron A"
BASE COUNT 149 a 350 c 368 g 223 t
ORIGIN 1 bp upstream of BamHI site.
1 ggatccacag gagagcgccc gtgttgacag cgtgagcggc gacccggtgt cggcctggcg
61 tcccgtgcct gtgcactggg ccgttttctt ttcttttctt ttcctttttt tttttttttt
121 gagacggagc ttgctctgtt acccaggctg gagtgcagtg gtgcgatctc ggctcactgc
181 acctccgcct tcccgggttc aagagattct cctgcctgag cctcccgagt agctgggact
241 acaggcaccc gccatcatgc tcggctaatt tttgtatttt tgtagagtcg gggtttcacc
301 aatttggcca ggctggtctt gaactcctga cctcaggtga tccgcccgcc tcggcctccc
361 aaagtgctgg ggctacaggc gtgagccacc acgtacggcc agcaccgggc atttttctta
421 ctttagccat cccgtgtttg aggttgctgt ctgggctctg ctcctacccg agggcacccc
481 tggaggaaat tctcgaggtg acctggacag ggcgggctgg gcgaggacgc tcccggggcc
541 tggaggcgga gtcgggggcg ggcgcgcgca gtcatctgac tcggtgactc acccgcggcc
601 gcgcttcctc tgatccgggc cgggcgggaa gtcgggtccc gaggctccgg ctcggcagac
661 cgggcggaaa gcagccgagc ggccatggag ctgtgcgggc tggggctgcc ccggccgccc
721 atgctgctgg cgctgctgtt ggcgacactg ctggcggcga tgttggcgct gctgactcag
781 gtggcgctgg tggtgcaggt ggcggaggcg gctcgggccc cgagcgtctc ggccaagccg
841 gggccggcgc tgtggcccct gccgctctcg gtgaagatga ccccgaacct gctgcatctc
901 gccccggaga acttctacat cagccacagc cccaattcca cggcgggccc ctcctgcacc
961 ctgctggagg aagcgtttcg acggtgagcg ctcggcccgg ccgggagttg tcctggggga
1021 ggggagaggc ggaccacccc ggagcgctgt gcagaccctc accaccccac tgcgcagacg
1081 agaaaccgcc
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB02 399 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 2.
ACCESSION M23283 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 2 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 399)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..112
/note="HEXB intron A"
exon 113..258
/note="beta-hexosaminidase beta-subunit, exon 2
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 259..>399
/note="HEXB intron B"
BASE COUNT 118 a 81 c 72 g 128 t
ORIGIN About 3.9 kb after segment 1.
1 ttacaatggg cagcatggat ttgaggagtt aactacaatg ttactagcac atctgtttta
61 aaaatttggc taaaatcctt ttaaaatgtg tttacattta tttctcaaac agatatcatg
121 gctatatttt tggtttctac aagtggcatc atgaacctgc tgaattccag gctaaaaccc
181 aggttcagca acttcttgtc tcaatcaccc ttcagtcaga gtgtgatgct ttccccaaca
241 tatcttcaga tgagtcttgt aagtacctat gcaatgtgag tgtattatat cccaggtgct
301 cgctgacgga cttaagtgcc aaaaactgac tccatgctag gaaccactga gttctcaacc
361 agtgagttta tgattcctat tttaaaaata accgggaaa
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB03 217 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 3.
ACCESSION M23284 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 3 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 217)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..55
/note="HEXB intron B"
exon 56..121
/note="beta-hexosaminidase beta-subunit, exon 3
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 122..>217
/note="HEXB intron C"
BASE COUNT 63 a 33 c 52 g 69 t
ORIGIN About 4.1 kp after segment 2.
1 gtgtggtgat tgaggattaa caaagtgtgt gtgtgatttt aaatcctcaa tacagatact
61 ttacttgtga aagaaccagt ggctgtcctt aaggccaaca gagtttgggg agcattacga
121 ggtaagttcc atgcagtttc attgttagtt ccactaaaga aaattttcag ttggtgcttt
181 gtgtaaatta agcagagcaa aactttgccg ccttaga
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB04 269 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 4.
ACCESSION M23285 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 4 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 269)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..58
/note="HEXB intron C"
exon 59..105
/note="beta-hexosaminidase beta-subunit, exon 4
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 106..>269
/note="HEXB intron D"
BASE COUNT 86 a 34 c 36 g 113 t
ORIGIN About 3.2 kb after segment 3.
1 ttttatcatc tcaatttgtt gatttataaa ttaatgcaat aaattttact ttcctcaggt
61 ttagagacct ttagccagtt agtttatcaa gattcttatg gaactgtaag tatgattatt
121 atatgttagt aaaaattgtt agacaaatta ctaatagaaa aaaatgtaac ctgtttagct
181 attgcttcct gaagatttca tttccccaga tatttgtctt agccggtaaa tgtaaatttc
241 atacattttg gttgttctaa ttaatattt
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB05 249 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 5.
ACCESSION M23286 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 5 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 249)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..68
/note="HEXB intron D"
exon 69..179
/note="beta-hexosaminidase beta-subunit, exon 5
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 180..>249
/note="HEXB intron E"
BASE COUNT 77 a 44 c 29 g 99 t
ORIGIN About 0.2 kb after segment 4.
1 tttagtcttc attcacttca agacaacaga aaattctaaa actaaattaa aattttattt
61 tgtcatagtt caccatcaat gaatccacca ttattgattc tccaaggttt tctcacagag
121 gaattttgat tgatacatcc agacattatc tgccagttaa gattattctt aaaactctgg
181 taagtaatta cttcattcta atctgttgtc tattctgaag atgtctcctt tatgttgtaa
241 ctttatgtt
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB06 286 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 6.
ACCESSION M23287 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 6 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 286)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..93
/note="HEXB intron E"
exon 94..195
/note="beta-hexosaminidase beta-subunit, exon 6
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 196..>286
/note="HEXB intron F"
BASE COUNT 89 a 39 c 54 g 104 t
ORIGIN About 7.7 kb after segment 5.
1 gcagacatat ggaagcaatt ccaaatgtag ataggtaata tggattgtat atgatatctg
61 cagtaaataa tttttaaata tgtttgcttg caggatgcca tggcttttaa taagtttaat
121 gttcttcact ggcacatagt tgatgaccag tctttcccat atcagagcat cacttttcct
181 gagttaagca ataaagtgag taaattgtat tgtactctgt ctacaaaaac attgggtata
241 gtttcattac aagtttgtag cttaaatgtt tgttcttatg gataga
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB07 309 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 7.
ACCESSION M23288 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 7 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 309)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..90
/note="HEXB intron F"
exon 91..220
/note="beta-hexosaminidase beta-subunit, exon 7
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 221..>309
/note="HEXB intron G"
BASE COUNT 87 a 50 c 61 g 111 t
ORIGIN About 8.2 kb after segment 6.
1 caaatatcaa atgcaagcac aattgttaac aatttccagg atcaaatcta cgttgtacat
61 tttaacttgt aataaatatg gcttttacag ggaagctatt ctttgtctca tgtttataca
121 ccaaatgatg tccgtatggt gattgaatat gccagattac gaggaattcg agtcctgcca
181 gaatttgata cccctgggca tacactatct tggggaaaag gtaaggagtt gtattttatt
241 tcattttatc ttatttttta ttttttgaga tggagtcttg ttctgtcacc caggctggag
301 tgcagtagt
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB08 309 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 8.
ACCESSION M23289 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 8 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 309)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..76
/note="HEXB intron G"
exon 77..257
/note="beta-hexosaminidase beta-subunit, exon 8
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 258..>309
/note="HEXB intron H"
BASE COUNT 111 a 51 c 53 g 94 t
ORIGIN About 2.1 kb after segment 7.
1 agtaaaatca tgtggaaacc agatctttat aatgagtgac acttctttta aaaagaatct
61 taatattttc ttctaggtca gaaagacctc ctgactccat gttacagtag acaaaacaag
121 ttggactctt ttggacctat aaaccctact ctgaatacaa catacagctt ccttactaca
181 tttttcaaag aaattagtga ggtgtttcca gatcaattca ttcatttggg aggagatgaa
241 gtggaattta aatgttggta agatgattcc ttaaaacccc tttaaaaaaa aaaaaaagag
301 aggctgggt
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB09 178 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 9.
ACCESSION M23290 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 9 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 178)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..18
/note="HEXB intron H"
exon 19..105
/note="beta-hexosaminidase beta-subunit, exon 9
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 106..>178
/note="HEXB intron I"
BASE COUNT 58 a 24 c 27 g 69 t
ORIGIN About 0.8 kb after segment 8.
1 aaccactttt tgcttcaggg aatcaaatcc aaaaattcaa gatttcatga ggcaaaaagg
61 ctttggcaca gattttaaga aactagaatc tttctacatt caaaagtaag ttgtttgaaa
121 gcctatttct gtattaatgc tttttgtaaa agtttatttg taatgtgctt tatttttt
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB10 279 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 10.
ACCESSION M23291 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 10 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 279)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..106
/note="HEXB intron I"
exon 107..179
/note="beta-hexosaminidase beta-subunit, exon 10
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 180..>279
/note="HEXB intron J"
BASE COUNT 93 a 38 c 55 g 93 t
ORIGIN About 1.4 kb after segment 9.
1 aggcacctct caaaatgcaa gaaatccttg gtagaaaatg tacatgtttt aaaatatatt
61 gttaagctta tgatctaaaa taactataat ttttttgtaa tactagggtt ttggatatta
121 ttgcaaccat aaacaaggga tccattgtct ggcaggaggt ttttgatgat aaagcaaagg
181 tgagcattgt gaagactgca tctgatcaat ataagagact taattatttt tcttggggca
241 actgggaatt tgcaagtcta actactagta ggacctttc
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB11 358 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 11.
ACCESSION M23292 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 11 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 358)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..78
/note="HEXB intron J"
exon 79..253
/note="beta-hexosaminidase beta-subunit, exon 11
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 254..>358
/note="HEXB intron K"
BASE COUNT 95 a 66 c 79 g 118 t
ORIGIN About 0.5 kb after segment 10.
1 gtaataatgc cttaaacttt caatttcatc tactgttcta ggcctaataa tatgtattgc
61 aatttgtaac gttaatagct tgcgccgggc acaatagttg aagtatggaa agacagcgca
121 tatcctgagg aactcagtag agtcacagca tctggcttcc ctgtaatcct ttctgctcct
181 tggtacttag atttgattag ctatggacaa gattggagga aatactataa agtggaacct
241 cttgattttg gcggtaagtg aagcagttgg tccaagtgtt gtgggttact gtgaagctga
301 tggtaagtga agcaaccatt gttacctttg ttttatgagt tttcttccct aacctccc
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB12 335 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 12.
ACCESSION M23293 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 12 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 335)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
intron <1..93
/note="HEXB intron K"
exon 94..184
/note="beta-hexosaminidase beta-subunit, exon 12
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 185..>335
/note="HEXB intron L"
BASE COUNT 106 a 50 c 74 g 105 t
ORIGIN About 1.4 kb after segment 11.
1 taggataaag atggaggaaa caaatcttga tgaaatattg cctctgtgta taagctttga
61 acttctgaac ttaattcaat gattttaatt taggtactca gaaacagaaa caacttttca
121 ttggtggaga agcttgtcta tggggagaat atgtggatgc aactaacctc actccaagat
181 tatggtatgg gatttacctg ataacattta agaataaggt gccttagctt tccttctctg
241 tctaaacaca aaagtgctaa acataaattt aaaactgctt gcggggggat gtgtgattta
301 aattttaggc ctcgggcaag tgctgttggt cagag
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB13 939 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exons 13 and
14.
ACCESSION M23294 J03055
KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit;
lysosomal enzyme.
SEGMENT 13 of 13
SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 939)
AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M.,
Mahuran,D.J. and Gravel,R.A.
TITLE Characterization of the human HEXB gene encoding lysosomal beta-
hexosaminidase
JOURNAL Genomics 3, 279-286 (1988)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A.
TITLE Translation initiation in the HEXB gene encoding the beta-subunit
of human beta-hexosaminidase
JOURNAL J. Biol. Chem. 265, 20799-20806 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286
(1988)] kindly submitted
by K.Neote, 19-AUG-1988.
FEATURES Location/Qualifiers
mRNA join(M23282:610..983,
M23283:113..258,M23284:56..121,M23285:59..105,
M23286:69..179,M23287:94..195,M23288:91..220,
M23289:77..257,M23290:19..105,M23291:107..179,
M23292:79..253,M23293:94..184,100..204,574..>724)
/note="beta-hexosaminidase beta-subunit mRNA"
/citation=J. Biol. Chem. 265, 20799-20806 (1990)
mRNA join(M23282:(640.641)..983,
M23283:113..258,M23284:56..121,M23285:59..105,
M23286:69..179,M23287:94..195,M23288:91..220,
M23289:77..257,M23290:19..105,M23291:107..179,
M23292:79..253,M23293:94..184,100..204,574..>724)
/note="beta-hexosaminidase beta-subunit mRNA"
/citation=J. Biol. Chem. 265, 20799-20806 (1990)
mRNA join(M23282:(665.666)..983,
M23283:113..258,M23284:56..121,M23285:59..105,
M23286:69..179,M23287:94..195,M23288:91..220,
M23289:77..257,M23290:19..105,M23291:107..179,
M23292:79..253,M23293:94..184,100..204,574..>724)
/note="beta-hexosaminidase beta-subunit mRNA"
/citation=J. Biol. Chem. 265, 20799-20806 (1990)
mRNA join(M23282:694..983,
M23283:113..258,M23284:56..121,M23285:59..105,
M23286:69..179,M23287:94..195,M23288:91..220,
M23289:77..257,M23290:19..105,M23291:107..179,
M23292:79..253,M23293:94..184,100..204,574..>724)
/note="beta-hexosaminidase beta-subunit mRNA"
/citation=J. Biol. Chem. 265, 20799-20806 (1990)
intron <1..99
/note="HEXB intron L"
CDS join(M23282:685..983,
M23283:113..258,M23284:56..121,M23285:59..105,
M23286:69..179,M23287:94..195,M23288:91..220,
M23289:77..257,M23290:19..105,M23291:107..179,
M23292:79..253,M23293:94..184,100..204,574..631)
/note="beta-hexosaminidase beta-subunit"
exon 100..204
/note="beta-hexosaminidase beta-subunit, exon 13
/nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'"
intron 205..573
/note="HEXB intron M"
exon 574..>724
/note="beta-hexosaminidase beta-subunit, exon 14"
BASE COUNT 315 a 146 c 160 g 318 t
ORIGIN About 0.3 kb after segment 12.
1 ttaagaatta aggtgcctta gctttccttc tctgtctaaa cacaaaatgc taaatataaa
61 tttaaactgc ttgcggggac tgtgtgattt aaattttagg cctcgggcaa gtgctgttgg
121 tgagagactc tggagttcca aagatgtcag agatatggat gacgcctatg acagactgac
181 aaggcaccgc tgcaggatgg tcgagtaaga aatctattaa gtccagtgtg atttttaacc
241 ttcttattca gtgttagttt cttttgctat aaatagaaat gtatgttacc taacaaatag
301 taattagaag aaaccaggaa ttattttttg taagtaataa tacctgtaaa gatatattca
361 gacttgtgga ctgttttata gatacaaaaa tgttggtgta acttagaact ccatcttgag
421 ttgctttaat tttcttccct tattttcagt aatgctgtga tttagtgatt ctaatttaag
481 tttctaagat gacatgaaca tcaatctaaa atatctttat gaatgatatc aatctaaatc
541 aatctaaaat atctttattc atgttatcta cagacgtgga atagctgcac aacctcttta
601 tgctggatat tgtaaccatg agaacatgta aaaaatggag gggaaaaagg ccacagcaat
661 ctgtactaca atcaacttta ttttgaaatc atgtaaaata agatattaga cttttttgaa
721 taaaatattt ttattgattg aacctttgac cctctatctt attacattta gaggcctggc
781 atctttcttg tgagacaagc ttaaggacac aaaagaaaca caactttgtg ataccactct
841 tctgaaggct acttatagta ataacttcat agatgaacag catgattcag gtacagtggc
901 tttaaacatc aaagcacatt tctcattata taaattaaa
//