GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB01 1090 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 1. ACCESSION M23282 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 1 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 1090) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers exon 610..983 /note="beta-hexosaminidase beta-subunit, exon 1A /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" /codon_start=610 /citation=J. Biol. Chem. 265, 20799-20806 (1990) exon (640.641)..983 /note="beta-hexosaminidase beta-subunit, exon 1B /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" /codon_start=640 /citation=J. Biol. Chem. 265, 20799-20806 (1990) exon (665.666)..983 /note="beta-hexosaminidase beta-subunit, exon 1C /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" /codon_start=665 /citation=J. Biol. Chem. 265, 20799-20806 (1990) exon 694..983 /note="beta-hexosaminidase beta-subunit, exon 1D /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" /codon_start=694 /citation=J. Biol. Chem. 265, 20799-20806 (1990) intron 984..>1090 /note="HEXB intron A" BASE COUNT 149 a 350 c 368 g 223 t ORIGIN 1 bp upstream of BamHI site. 1 ggatccacag gagagcgccc gtgttgacag cgtgagcggc gacccggtgt cggcctggcg 61 tcccgtgcct gtgcactggg ccgttttctt ttcttttctt ttcctttttt tttttttttt 121 gagacggagc ttgctctgtt acccaggctg gagtgcagtg gtgcgatctc ggctcactgc 181 acctccgcct tcccgggttc aagagattct cctgcctgag cctcccgagt agctgggact 241 acaggcaccc gccatcatgc tcggctaatt tttgtatttt tgtagagtcg gggtttcacc 301 aatttggcca ggctggtctt gaactcctga cctcaggtga tccgcccgcc tcggcctccc 361 aaagtgctgg ggctacaggc gtgagccacc acgtacggcc agcaccgggc atttttctta 421 ctttagccat cccgtgtttg aggttgctgt ctgggctctg ctcctacccg agggcacccc 481 tggaggaaat tctcgaggtg acctggacag ggcgggctgg gcgaggacgc tcccggggcc 541 tggaggcgga gtcgggggcg ggcgcgcgca gtcatctgac tcggtgactc acccgcggcc 601 gcgcttcctc tgatccgggc cgggcgggaa gtcgggtccc gaggctccgg ctcggcagac 661 cgggcggaaa gcagccgagc ggccatggag ctgtgcgggc tggggctgcc ccggccgccc 721 atgctgctgg cgctgctgtt ggcgacactg ctggcggcga tgttggcgct gctgactcag 781 gtggcgctgg tggtgcaggt ggcggaggcg gctcgggccc cgagcgtctc ggccaagccg 841 gggccggcgc tgtggcccct gccgctctcg gtgaagatga ccccgaacct gctgcatctc 901 gccccggaga acttctacat cagccacagc cccaattcca cggcgggccc ctcctgcacc 961 ctgctggagg aagcgtttcg acggtgagcg ctcggcccgg ccgggagttg tcctggggga 1021 ggggagaggc ggaccacccc ggagcgctgt gcagaccctc accaccccac tgcgcagacg 1081 agaaaccgcc //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB02 399 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 2. ACCESSION M23283 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 2 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 399) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..112 /note="HEXB intron A" exon 113..258 /note="beta-hexosaminidase beta-subunit, exon 2 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 259..>399 /note="HEXB intron B" BASE COUNT 118 a 81 c 72 g 128 t ORIGIN About 3.9 kb after segment 1. 1 ttacaatggg cagcatggat ttgaggagtt aactacaatg ttactagcac atctgtttta 61 aaaatttggc taaaatcctt ttaaaatgtg tttacattta tttctcaaac agatatcatg 121 gctatatttt tggtttctac aagtggcatc atgaacctgc tgaattccag gctaaaaccc 181 aggttcagca acttcttgtc tcaatcaccc ttcagtcaga gtgtgatgct ttccccaaca 241 tatcttcaga tgagtcttgt aagtacctat gcaatgtgag tgtattatat cccaggtgct 301 cgctgacgga cttaagtgcc aaaaactgac tccatgctag gaaccactga gttctcaacc 361 agtgagttta tgattcctat tttaaaaata accgggaaa //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB03 217 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 3. ACCESSION M23284 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 3 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 217) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..55 /note="HEXB intron B" exon 56..121 /note="beta-hexosaminidase beta-subunit, exon 3 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 122..>217 /note="HEXB intron C" BASE COUNT 63 a 33 c 52 g 69 t ORIGIN About 4.1 kp after segment 2. 1 gtgtggtgat tgaggattaa caaagtgtgt gtgtgatttt aaatcctcaa tacagatact 61 ttacttgtga aagaaccagt ggctgtcctt aaggccaaca gagtttgggg agcattacga 121 ggtaagttcc atgcagtttc attgttagtt ccactaaaga aaattttcag ttggtgcttt 181 gtgtaaatta agcagagcaa aactttgccg ccttaga //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB04 269 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 4. ACCESSION M23285 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 4 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 269) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..58 /note="HEXB intron C" exon 59..105 /note="beta-hexosaminidase beta-subunit, exon 4 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 106..>269 /note="HEXB intron D" BASE COUNT 86 a 34 c 36 g 113 t ORIGIN About 3.2 kb after segment 3. 1 ttttatcatc tcaatttgtt gatttataaa ttaatgcaat aaattttact ttcctcaggt 61 ttagagacct ttagccagtt agtttatcaa gattcttatg gaactgtaag tatgattatt 121 atatgttagt aaaaattgtt agacaaatta ctaatagaaa aaaatgtaac ctgtttagct 181 attgcttcct gaagatttca tttccccaga tatttgtctt agccggtaaa tgtaaatttc 241 atacattttg gttgttctaa ttaatattt //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB05 249 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 5. ACCESSION M23286 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 5 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 249) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..68 /note="HEXB intron D" exon 69..179 /note="beta-hexosaminidase beta-subunit, exon 5 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 180..>249 /note="HEXB intron E" BASE COUNT 77 a 44 c 29 g 99 t ORIGIN About 0.2 kb after segment 4. 1 tttagtcttc attcacttca agacaacaga aaattctaaa actaaattaa aattttattt 61 tgtcatagtt caccatcaat gaatccacca ttattgattc tccaaggttt tctcacagag 121 gaattttgat tgatacatcc agacattatc tgccagttaa gattattctt aaaactctgg 181 taagtaatta cttcattcta atctgttgtc tattctgaag atgtctcctt tatgttgtaa 241 ctttatgtt //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB06 286 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 6. ACCESSION M23287 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 6 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 286) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..93 /note="HEXB intron E" exon 94..195 /note="beta-hexosaminidase beta-subunit, exon 6 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 196..>286 /note="HEXB intron F" BASE COUNT 89 a 39 c 54 g 104 t ORIGIN About 7.7 kb after segment 5. 1 gcagacatat ggaagcaatt ccaaatgtag ataggtaata tggattgtat atgatatctg 61 cagtaaataa tttttaaata tgtttgcttg caggatgcca tggcttttaa taagtttaat 121 gttcttcact ggcacatagt tgatgaccag tctttcccat atcagagcat cacttttcct 181 gagttaagca ataaagtgag taaattgtat tgtactctgt ctacaaaaac attgggtata 241 gtttcattac aagtttgtag cttaaatgtt tgttcttatg gataga //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB07 309 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 7. ACCESSION M23288 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 7 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 309) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..90 /note="HEXB intron F" exon 91..220 /note="beta-hexosaminidase beta-subunit, exon 7 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 221..>309 /note="HEXB intron G" BASE COUNT 87 a 50 c 61 g 111 t ORIGIN About 8.2 kb after segment 6. 1 caaatatcaa atgcaagcac aattgttaac aatttccagg atcaaatcta cgttgtacat 61 tttaacttgt aataaatatg gcttttacag ggaagctatt ctttgtctca tgtttataca 121 ccaaatgatg tccgtatggt gattgaatat gccagattac gaggaattcg agtcctgcca 181 gaatttgata cccctgggca tacactatct tggggaaaag gtaaggagtt gtattttatt 241 tcattttatc ttatttttta ttttttgaga tggagtcttg ttctgtcacc caggctggag 301 tgcagtagt //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB08 309 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 8. ACCESSION M23289 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 8 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 309) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..76 /note="HEXB intron G" exon 77..257 /note="beta-hexosaminidase beta-subunit, exon 8 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 258..>309 /note="HEXB intron H" BASE COUNT 111 a 51 c 53 g 94 t ORIGIN About 2.1 kb after segment 7. 1 agtaaaatca tgtggaaacc agatctttat aatgagtgac acttctttta aaaagaatct 61 taatattttc ttctaggtca gaaagacctc ctgactccat gttacagtag acaaaacaag 121 ttggactctt ttggacctat aaaccctact ctgaatacaa catacagctt ccttactaca 181 tttttcaaag aaattagtga ggtgtttcca gatcaattca ttcatttggg aggagatgaa 241 gtggaattta aatgttggta agatgattcc ttaaaacccc tttaaaaaaa aaaaaaagag 301 aggctgggt //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB09 178 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 9. ACCESSION M23290 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 9 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 178) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..18 /note="HEXB intron H" exon 19..105 /note="beta-hexosaminidase beta-subunit, exon 9 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 106..>178 /note="HEXB intron I" BASE COUNT 58 a 24 c 27 g 69 t ORIGIN About 0.8 kb after segment 8. 1 aaccactttt tgcttcaggg aatcaaatcc aaaaattcaa gatttcatga ggcaaaaagg 61 ctttggcaca gattttaaga aactagaatc tttctacatt caaaagtaag ttgtttgaaa 121 gcctatttct gtattaatgc tttttgtaaa agtttatttg taatgtgctt tatttttt //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB10 279 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 10. ACCESSION M23291 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 10 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 279) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..106 /note="HEXB intron I" exon 107..179 /note="beta-hexosaminidase beta-subunit, exon 10 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 180..>279 /note="HEXB intron J" BASE COUNT 93 a 38 c 55 g 93 t ORIGIN About 1.4 kb after segment 9. 1 aggcacctct caaaatgcaa gaaatccttg gtagaaaatg tacatgtttt aaaatatatt 61 gttaagctta tgatctaaaa taactataat ttttttgtaa tactagggtt ttggatatta 121 ttgcaaccat aaacaaggga tccattgtct ggcaggaggt ttttgatgat aaagcaaagg 181 tgagcattgt gaagactgca tctgatcaat ataagagact taattatttt tcttggggca 241 actgggaatt tgcaagtcta actactagta ggacctttc //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB11 358 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 11. ACCESSION M23292 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 11 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 358) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..78 /note="HEXB intron J" exon 79..253 /note="beta-hexosaminidase beta-subunit, exon 11 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 254..>358 /note="HEXB intron K" BASE COUNT 95 a 66 c 79 g 118 t ORIGIN About 0.5 kb after segment 10. 1 gtaataatgc cttaaacttt caatttcatc tactgttcta ggcctaataa tatgtattgc 61 aatttgtaac gttaatagct tgcgccgggc acaatagttg aagtatggaa agacagcgca 121 tatcctgagg aactcagtag agtcacagca tctggcttcc ctgtaatcct ttctgctcct 181 tggtacttag atttgattag ctatggacaa gattggagga aatactataa agtggaacct 241 cttgattttg gcggtaagtg aagcagttgg tccaagtgtt gtgggttact gtgaagctga 301 tggtaagtga agcaaccatt gttacctttg ttttatgagt tttcttccct aacctccc //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB12 335 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exon 12. ACCESSION M23293 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 12 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 335) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers intron <1..93 /note="HEXB intron K" exon 94..184 /note="beta-hexosaminidase beta-subunit, exon 12 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 185..>335 /note="HEXB intron L" BASE COUNT 106 a 50 c 74 g 105 t ORIGIN About 1.4 kb after segment 11. 1 taggataaag atggaggaaa caaatcttga tgaaatattg cctctgtgta taagctttga 61 acttctgaac ttaattcaat gattttaatt taggtactca gaaacagaaa caacttttca 121 ttggtggaga agcttgtcta tggggagaat atgtggatgc aactaacctc actccaagat 181 tatggtatgg gatttacctg ataacattta agaataaggt gccttagctt tccttctctg 241 tctaaacaca aaagtgctaa acataaattt aaaactgctt gcggggggat gtgtgattta 301 aattttaggc ctcgggcaag tgctgttggt cagag //
GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMHEXB13 939 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exons 13 and 14. ACCESSION M23294 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 13 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 939) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers mRNA join(M23282:610..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..>724) /note="beta-hexosaminidase beta-subunit mRNA" /citation=J. Biol. Chem. 265, 20799-20806 (1990) mRNA join(M23282:(640.641)..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..>724) /note="beta-hexosaminidase beta-subunit mRNA" /citation=J. Biol. Chem. 265, 20799-20806 (1990) mRNA join(M23282:(665.666)..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..>724) /note="beta-hexosaminidase beta-subunit mRNA" /citation=J. Biol. Chem. 265, 20799-20806 (1990) mRNA join(M23282:694..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..>724) /note="beta-hexosaminidase beta-subunit mRNA" /citation=J. Biol. Chem. 265, 20799-20806 (1990) intron <1..99 /note="HEXB intron L" CDS join(M23282:685..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..631) /note="beta-hexosaminidase beta-subunit" exon 100..204 /note="beta-hexosaminidase beta-subunit, exon 13 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 205..573 /note="HEXB intron M" exon 574..>724 /note="beta-hexosaminidase beta-subunit, exon 14" BASE COUNT 315 a 146 c 160 g 318 t ORIGIN About 0.3 kb after segment 12. 1 ttaagaatta aggtgcctta gctttccttc tctgtctaaa cacaaaatgc taaatataaa 61 tttaaactgc ttgcggggac tgtgtgattt aaattttagg cctcgggcaa gtgctgttgg 121 tgagagactc tggagttcca aagatgtcag agatatggat gacgcctatg acagactgac 181 aaggcaccgc tgcaggatgg tcgagtaaga aatctattaa gtccagtgtg atttttaacc 241 ttcttattca gtgttagttt cttttgctat aaatagaaat gtatgttacc taacaaatag 301 taattagaag aaaccaggaa ttattttttg taagtaataa tacctgtaaa gatatattca 361 gacttgtgga ctgttttata gatacaaaaa tgttggtgta acttagaact ccatcttgag 421 ttgctttaat tttcttccct tattttcagt aatgctgtga tttagtgatt ctaatttaag 481 tttctaagat gacatgaaca tcaatctaaa atatctttat gaatgatatc aatctaaatc 541 aatctaaaat atctttattc atgttatcta cagacgtgga atagctgcac aacctcttta 601 tgctggatat tgtaaccatg agaacatgta aaaaatggag gggaaaaagg ccacagcaat 661 ctgtactaca atcaacttta ttttgaaatc atgtaaaata agatattaga cttttttgaa 721 taaaatattt ttattgattg aacctttgac cctctatctt attacattta gaggcctggc 781 atctttcttg tgagacaagc ttaaggacac aaaagaaaca caactttgtg ataccactct 841 tctgaaggct acttatagta ataacttcat agatgaacag catgattcag gtacagtggc 901 tttaaacatc aaagcacatt tctcattata taaattaaa //