GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMCD282 542 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human T-cell membrane glycoprotein CD28 mRNA, exon 2.
ACCESSION M37813
KEYWORDS glycoprotein CD28.
SEGMENT 2 of 4
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 542)
AUTHORS Lee,K.P., Taylor,C., Petryniak,B., Turka,L.A., June,C.H. and
Thompson,C.B.
TITLE The genomic organization of the CD28 gene: Implications for the
regulation of CD28 mRNA expression and heterogeneity
JOURNAL J. Immunol. 145, 344-352 (1990)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
intron order(M37812:813..984,1..64)
/note="number 1"
/=1
/gene="CD28"
exon 65..421
/note="number 2"
/gene="CD28"
/codon_start=65
BASE COUNT 161 a 107 c 116 g 158 t
ORIGIN
1 gctctcagga agaaaaatta tccttatatt cttgttctaa gcaaatgatt tttttttccc
61 ccaggaaaca agattttggt gaagcagtcg cccatgcttg tagcgtacga caatgcggtc
121 aaccttagct gcaagtattc ctacaatctc ttctcaaggg agttccgggc atcccttcac
181 aaaggactgg atagtgctgt ggaagtctgt gttgtatatg ggaattactc ccagcagctt
241 caggtttact caaaaacggg gttcaactgt gatgggaaat tgggcaatga atcagtgaca
301 ttctacctcc agaatttgta tgttaaccaa acagatattt acttctgcaa aattgaagtt
361 atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa
421 ggtaacatac aactttacca gtgtaccacc ctaaagtaat ggttttcaaa tgcagtcctg
481 aaaactgggt tgtggtcagt ggtggggttg aataaggcct aagtgatttg atactaacaa
541 ag
//GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMCD284 3230 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human T-cell membrane glycoprotein CD28 mRNA, exon 2.
ACCESSION M37815
KEYWORDS glycoprotein CD28.
SEGMENT 4 of 4
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3230)
AUTHORS Lee,K.P., Taylor,C., Petryniak,B., Turka,L.A., June,C.H. and
Thompson,C.B.
TITLE The genomic organization of the CD28 gene: Implications for the
regulation of CD28 mRNA expression and heterogeneity
JOURNAL J. Immunol. 145, 344-352 (1990)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
intron order(M37814:252..467,1..121)
/note="number 3"
/=3
/gene="CD28"
CDS join(M37812:761..812,
M37813:65..421,M37814:127..251,122..250)
/product="glycoprotein CD28"
mRNA join(M37812:539..812,
M37813:65..421,M37814:127..251,122..1003)
/gene="CD28"
mRNA join(M37812:539..812,
M37813:65..421,M37814:127..251,122..3169)
/gene="CD28"
/product="glycoprotein CD28"
CDS join(M37812:761..812,
M37813:65..130,M37813:383..421,M37814:127..251,
122..250)
/note="deleted form"
/gene="CD28"
/product="glycoprotein CD28"
exon 122..1003
/note="number 4"
/=4
/codon_start=122
exon 122..3169
/note="number 4"
/=4
/codon_start=122
polyA_signal 991..996
/gene="CD28"
repeat_unit 1074..1357
/rpt_family="Alu"
BASE COUNT 941 a 630 c 717 g 942 t
ORIGIN
1 aaaggttagt gttttagtgt ctctgtcatt tgacagttaa tattatgaat agttgtgccc
61 acagtcttag aactccttcc atgacattgt ccctccatac tgacacttct ctttcctgca
121 ggtgaggagt aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg
181 ccccgggccc acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta
241 tcgctcctga cacggacgcc tatccagaag ccagccggct ggcagccccc atctgctcaa
301 tatcactgct ctggatagga aatgaccgcc atctccagcc ggccacctca ggcccctgtt
361 gggccaccaa tgccaatttt tctcgagtga ctagaccaaa tatcaagatc attttgagac
421 tctgaaatga agtaaaagag atttcctgtg acaggccaag tcttacagtg ccatggccca
481 cattccaact taccatgtac ttagtgactt gactgagaag ttagggtaga aaacaaaaag
541 ggagtggatt ctgggagcct cttccctttc tcactcacct gcacatctca gtcaagcaaa
601 gtgtggtatc cacagacatt ttagttgcag aagaaaggct aggaaatcat tccttttggt
661 taaatgggtg tttaatcttt tggttagtgg gttaaacggg gtaagttaga gtagggggag
721 ggataggaag acatatttaa aaaccattaa aacactgtct cccactcatg aaatgagcca
781 cgtagttcct atttaatgct gttttccttt agtttagaaa tacatagaca ttgtctttta
841 tgaattctga tcatatttag tcattttgac caaatgaggg atttggtcaa atgagggatt
901 ccctcaaagc aatatcaggt aaaccaagtt gctttcctca ctccctgtca tgagacttca
961 gtgttaatgt tcacaatata ctttcgaaag aataaaatag ttctcctaca tgaagaaaga
1021 atatgtcagg aaataaggtc actttatgtc aaaattattt gagtactatg ggacctggcg
1081 cagtggctca tgcttgtaat cccagcactt tgggaggccg aggtgggcag atcacttgag
1141 atcaggacca gcctggtcaa gatggtgaaa ctccgtctgt actaaaaata caaaatttag
1201 cttggcctgg tggcaggcac ctgtaatccc agctgcccag gaggctgagg catgagaatc
1261 gcttgaacct ggcaggcgga ggttgcagtg agccgagata gtgccacagc tctccagcct
1321 gggcgacaga gtgagactcc atctcaaaca acaacaacaa caacaacaac aacaacaaac
1381 cacaaaatta tttgagtact gtgaaggatt atttgtctaa cagttcattc caatcagacc
1441 aggtaggagc tttcctgttt catatgtttc agggttgcac agttggtctc tttaatgtcg
1501 gtgtggagat ccaaagtggg ttgtggaaag agcgtccata ggagaagtga gaatactgtg
1561 aaaagggatg ttagcattca ttagagtatg aggatgagtc ccaagaaggt tctttggaag
1621 gaggacgaat agaatggagt aatgaaattc ttgccatgtg ctgaggagat agccagcatt
1681 aggtgacaat cttccagaag tggtcaggca gaaggtgccc tggtgagagc tcctttacag
1741 ggactttatg tggtttaggg ctcagagctc caaaactctg ggctcagctg ctcctgtacc
1801 ttggaggtcc attcacatgg gaaagtattt tggaatgtgt cttttgaaga gagcatcaga
1861 gttcttaagg gactgggtaa ggcctgaccc tgaaatgacc atggatattt ttctacctac
1921 agtttgagtc aactagaata tgcctgggga ccttgaagaa tgcccttcag tggccctcac
1981 catttgttca tgcttcagtt aattcaggtg ttgaaggagc ttaggtttta gaggcacgta
2041 gacttggttc aagtctcgtt agtagttgaa tagcctcagg caagtcactg cccacctaag
2101 atgatggttc ttcaactata aatggagata atggttacaa atgtctcttc ctatagtata
2161 atctccataa gggcatggcc caagtctgtc tttgactctg cctatccctg acgtttagta
2221 gcatgcccga catacaatgt tagctattgg tattattgcc atatagataa attatgtata
2281 aaaattaaac tgggcaatag cctaagaagg ggggaatatt gtaacacaaa tttaaaccca
2341 ctacgcaggg atgaggtgct ataatatgag gaccttttaa cttccatcat tttcctgttt
2401 cttgaaatag tttatcttgt aatgaaatat aaggcacctc ccacttttat gtatagaaag
2461 aggtctttta attttttttt aatgtgagaa ggaagggagg agtaggaatc ttgagattcc
2521 atatcgaaaa tactgtactt tggttgattt ttaagtgggc ttccattcca tggatttaat
2581 cagtcccaag aagatcaaac tcagcagtac ttgggtgctg aagaactgtt ggatttaccc
2641 tggcacgtgt gccacttgcc cagcttcttg ggcacacaga gttcttcaat ccaagttatc
2701 agattgtatt tgaaaatgac agagctggag agttttttga aatggcagtg gcaaataaat
2761 aaatactttt ttttaaatgg aaagacttga tctatggtaa taaatgattt tgttttctga
2821 ctggaaaaat aggcctacta aagatgaatc acacttgaga tgtttcttac tcactctgca
2881 cagaaacaaa gaagaaatgt tatacaggga agtccgtttt cactattagt atgaaccaag
2941 aaatggttca aaaacagtgg taggagcaat gctttcatag tttcagatat ggtagttatg
3001 aagaaaacaa tgtcatttgc tgctattatt gtaagagtct tataattaat ggtactccta
3061 taatttttga ttgtgagctc acctatttgg gttaagcatg ccaatttaaa gagaccaagt
3121 gtatgtacat tatgttctac atattcagtg ataaaattac taaactacta tatgtctgct
3181 ttaaatttgt actttaatat tgtcttttgg tattaagaaa gatatgcttt
//