GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMVWFAA 21352 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human von Willebrand factor gene, exons 23 through 34.
ACCESSION M60675 M36184
KEYWORDS coagulation factor VIII; coagulation factor VIII VWF;
von Willebrand factor.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 21352)
AUTHORS Mancuso,D.J., Tuley,E.A., Westfield,L.A., Lester-Mancuso,T.L., Le
Beau,M.M., Sorace,J.M. and Sadler,J.E.
TITLE Human von Willebrand factor gene and pseudogene: Structural
analysis and differentiation by polymerase chain reaction
JOURNAL Biochemistry 30, 253-269 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
mRNA (1314..1454,1667..1780,3572..3728,
4461..4619,5324..5459,7616..8994,
10488..10604,10702..10842,11126..11269,
13713..13877,15227..15270,15563..15740)
/gene="F8VWF"
/partial
CDS (1314..1454,1667..1780,3572..3728,
4461..4619,5324..5459,7616..8994,
10488..10604,10702..10842,11126..11269,
13713..13877,15227..15270,15563..15740)
/codon_start=1
/partial
/product="von Willebrand factor"
exon 1314..1454
/number=23
/gene="F8VWF"
/codon_start=1314
exon 1667..1780
/number=24
/gene="F8VWF"
/codon_start=1667
exon 3572..3728
/number=25
/gene="F8VWF"
/codon_start=3572
exon 4461..4619
/number=26
/gene="F8VWF"
/codon_start=4461
exon 5324..5459
/number=27
/gene="F8VWF"
/codon_start=5324
exon 7616..8994
/number=28
/gene="F8VWF"
/codon_start=7616
exon 10488..10604
/number=29
/gene="F8VWF"
/codon_start=10488
exon 10702..10842
/number=30
/gene="F8VWF"
/codon_start=10702
exon 11126..11269
/number=31
/gene="F8VWF"
/codon_start=11126
exon 13713..13877
/number=32
/gene="F8VWF"
/codon_start=13713
exon 15227..15270
/number=33
/gene="F8VWF"
/codon_start=15227
exon 15563..15740
/number=34
/gene="F8VWF"
/codon_start=15563
BASE COUNT 5009 a 4709 c 4948 g 6686 t
ORIGIN
1 gagcagaatc tttggggaag ggagggaatg agtcatgcca gtatctaggg gagagagttt
61 aggcagacgg aacaagcacg tgccgaggcc ttaaggtggt aggtgtctgc agccgttgta
121 caaggaggtc agtgtggcta cagaggaggg acttgggggt aatggtagtt cacgagggca
181 gggaggggca gtagccatac catgggggct actaggccat gggaagatcg ttggcctttt
241 gcccaacagt gagaacattc ttcctctatg tttcctggtg acttacaccc cttgtaccaa
301 gctgaatgca gcttattgaa gcaagataga atacattttt tctctttgtc tcaacatcag
361 ggctctaagt atattgtaaa agtatagcac cttttcttct ccaggccaaa tatttccagt
421 tttttctgta gtttttttgt tttattatta tttttagttg acatttaact gtatgtattt
481 actggtgaca gtgtgatatt tcagtacatg tatacagtgt gtagtgatca aatcagggta
541 gttactatat ctgttccctc aaacatttac catttctttg tgttgggaac attcaaagtc
601 tgctcttcca gctacttgaa aatatacaat aaactgttga taattatagt caccctgtgg
661 tgctaccgaa cactagaact tatccctcct ctttgtgtag ttttcacttg tttctcactc
721 attcgtaact actttttcag aacttgttgc atgttgcact ccatgatggg tgaacatgga
781 gacaggtgag acatatcttc ctgattacat ttatgagaga gcagaattct gcccagccta
841 ctctgaacag gctgcacttc tccaggcaag gggactcacc ttcccagagg caggcagttc
901 tataactttc cctccttgga cccctacacc tccattggtg gagcagtgta cctggctcct
961 ctctctgctt ctatgcttgt tggggacagt gatagttccc accagtgatc tcagggccaa
1021 ggctgcctga ttcccacctc tgcccttggc tgactatgtg acatgggcat gttgcctctc
1081 tgtttccata gctttaaata aaatggggcc agcaaggaag ctcaggaatg ggtcttggca
1141 atggcaaggc tttgctgctc acctcgggcc tcctctgagt ctctgtcccg ctcctcctcc
1201 tcttcctcga atgccctctg cctccattgc cgccaggaat gttccccttt cccctgagcc
1261 ggagagcatg ctcctgggct tgacggtgct catccctcaa cttgtctctc aaggagaaag
1321 tgtgtggcct gtgtgggaat tttgatggca tccagaacaa tgacctcacc agcagcaacc
1381 tccaagtgga ggaagaccct gtggactttg ggaactcctg gaaagtgagc tcgcagtgtg
1441 ctgacaccag aaaagtacgt ctgggtctct gtgtggacag agccctagag cttgcttcct
1501 ggaatgtccc tctgtcccca ttgtcatggg ggctggaagg ggggttgtgg gtggtatgac
1561 ctccaggtgg ctgcagggtg ggaaggaggg tctcttggat ccttctgggc tgaataaccc
1621 cagtttgacc agctgacggc tggcctatct cttgcctggt tcccaggtgc ctctggactc
1681 atcccctgcc acctgccata acaacatcat gaagcagacg atggtggatt cctcctgtag
1741 aatccttacc agtgacgtct tccaggactg caacaagctg gtgaggacct tgagggtagt
1801 gggaagcaga cggtcccaag gcttggcctg gtggtatgga cacagagtgt gaccttctaa
1861 cgtggacact accctcgtgt cttgacatga tctgcaccaa gacaccactt cggctttttt
1921 tcttggcttt caatctggga aacaaaaagt aaaatcaaca gtttctaggg gaagcaatgc
1981 ctggcaaaac atttccttct gcatgagaag taactcccct tggcatgtgc caatgcttct
2041 ctttcagccc cagtcttagg atttgttctc ttattgaagt atcttgtttt caacaccaga
2101 gccagagatt tccttttcct gtcactgctg catttgtcca gaccaaaaga ccttcctctc
2161 ccacccccta aaaccccttg gtgcccattt cttgtctcac agaaattctt ttctggcctt
2221 aattttggtg attttgagtc ctcgtattat gacttatttt tgtgtcttca tctctaatga
2281 caaggaggaa ttccgcaagg ttaagtgcag ttgtctctct cttttttttt ttttttgaga
2341 cagagtctcg ctctgtcacc caggctggag tgcaatggca tgatcttggc ttagtgcagc
2401 ctctgcctcc tgggctcaag cgattctcct gcctcaacct cccgagtacc tgggattaca
2461 ggcacctgcc accacgccca gctaattttt gtatttttag tagagtcaag gtttcaccat
2521 gttggtcagg ctggccttga actcctgact caggtgatct acccacctcg gcctcccaaa
2581 gtgctgggat tacaggtgtg agccaccatg cccgaccata gtgcagttgt ctcttatctg
2641 ctgcatgtat gtgtgtacac acatgtggac atgggcttgt acatggacat atgtgactac
2701 agaagtctgt gtacacacac agccatgcac acatacatgc tgctgtgtaa caccaccaat
2761 gtgggagaga ctggttgaaa acatggatct caattctctt tctatctatg cagtgatttt
2821 cggtctctga ggactccaaa ggatacttac attccctggt ttggtggaaa tcctgggcat
2881 ctgagttgga agagtgagga caggggagga gttggggaca ttgagactgt tggaacgtct
2941 tggaaacaat gacccactca gtgtctgaat tcattttctg tcataactgc cctgaaaaag
3001 tccagtgtgt ttagaggcgt gttttgggga tgaggaaggg ttggaactgg ttgaactgga
3061 tttggaatca gagtctaggc cctattgtcc tgcatacctg ccccatagca ctgcagtgag
3121 gcagctgcag ggcctgatgt atttccccat tctctttgct gaattgaggc aaagaaagac
3181 agtgaccagc acatatgtgt gtttgtgttt ttgtaaaagc acccacatgc tcatgaggct
3241 aagagtgggt tgtgaggaca gatgggtggc tgagcaggga ggtaggcaga gggacagagg
3301 gaatgttctt ctggaaaatc ctcaggctca ttgtgttctg cagaaggcca gcagcactgc
3361 attattcaac tcttcttgct ggaatgcaga ttagaaacta agaatcttgc cttcccactc
3421 attccctctt tgagaccatt gagctgcatt tctccttcta cctggacccc cttatcctta
3481 aattgaccat cagaacattt gcacccagac taagagccag agttcctgac acctggccat
3541 aggcctgggc cacctgaggc tgcctttgca ggtggacccc gagccatatc tggatgtctg
3601 catttacgac acctgctcct gtgagtccat tggggactgc gcctgcttct gcgacaccat
3661 tgctgcctat gcccacgtgt gtgcccagca tggcaaggtg gtgacctgga ggacggccac
3721 attgtgccgt gagtactgac gccctcatgt tctcagatgc cctcccttct tcccatgtgt
3781 ctatgcttga agaccttgtg agtgcagggg gatatcttca tgggcgagag aagacagagt
3841 gttagtaggg actggatggc caagggctaa ggagggttaa gacattggct gtgtaagaag
3901 tttatattac gggtgaggtg ggacatggat tcaaggcatg aacatgtgga gacttttctt
3961 ctggagagat tctggcaggg gagaagaggg aatactgatg aaaagaagga agtcgattta
4021 tgtctttaat taggcgtgat tatatttgcc aatatgagtg atcaactcat acattcatgt
4081 ctatagaatc ttgcttcttt ggacagaagc aacttaatgt ttttatgtag aaaactgggc
4141 cgggcacagt gactcatacc tgtaatccct gtgttttggg aggctgaggc cagaggattc
4201 cttgagccca ggagttcaag accagcctgg gcaacatagc aagaccccat ctgtacaaaa
4261 attaaaaaaa gaaatgaatt cagaaccaat agattctggt ttaggtgctt caacaatcca
4321 gaagtctcta atattggtga cgcccatagt cccctagttc cccaacatta tctccagatg
4381 gcgcaggcca tcaccacatg ggtctgcagt cctggaggct ttgcctgttg tggccacagc
4441 cttgtctcct gtctacacag cccagagctg cgaggagagg aatctccggg agaacgggta
4501 tgagtgtgag tggcgctata acagctgtgc acctgcctgt caagtcacgt gtcagcaccc
4561 tgagccactg gcctgccctg tgcagtgtgt ggagggctgc catgcccact gccctccagg
4621 tgaggcctct atccctgggg gtcaggctgg tgggatggga tagggatgga tggaaaggtg
4681 cttctaggtc ttgcttcatc tcagcctcca cctgccacgt cctatctctg acctgcaagg
4741 ctgctgcagg ttccgtgggt tctttcatca gagtcaggac agtcgtgatt tttctcaagt
4801 cgagctcctc caaaatgctt ttctgtgcct atttatggga ttctcaccta aagcagcccc
4861 tgccgataga actttctgca gtgggggaat gttgtattga atgtaactgt gacgagtgtg
4921 tctgaggaac tgaagttttg aattttattg aattttactt aatttaacgt aaatagccac
4981 acgcagtttg tgacgatcct atggtacagc acagctctag agttactgaa ggtgttattc
5041 agaagagcag aaagagcccc ggagataaga tttcatttgt cctgaggctt ggggaggtga
5101 ggtagggtga aggaatcccc gctcccagtt ttgcagaggg atcaatcaag gcacaagcag
5161 gagagatgct ccttgagtga tggggtgacc cctgggagtg caggcaggag gagttggctt
5221 ctagggcagg aggaggagtt ggctcctccc ttttagttaa aaatgaggct tcctcgtggg
5281 aaaggggagc gttttggttc ctaatgagag ctttcttttg cagggaaaat cctggatgag
5341 cttttgcaga cctgcgttga ccctgaagac tgtccagtgt gtgaggtggc tggccggcgt
5401 tttgcctcag gaaagaaagt caccttgaat cccagtgacc ctgagcactg ccagatttgg
5461 taaaacagat tcctgggttg tttgaagtga tgaatcttat tgcttctcca ggggccagct
5521 tagagactag gttttgggta aaaagtccta gccacatgag ttgagagact gagtttattt
5581 tatttgttta tttatttaat tcattattta atgtagttta ttgttttgtt tgttcctagg
5641 gtttgcttct ttttctttag ggatggacta gactgcttcc tccacatata ttcctccaca
5701 gtgtttttgc tcttaatagg tttttaagtc ctaacaggtt tttgcttttc tcactgaagg
5761 tgggggtatg gtcacttatt gtccttgtag gtcatgacta gtctgagcac aggtgtccat
5821 atactggagg tggggactca ggagaggaaa gtgagatgga acccagggcc ctcaggtaac
5881 atgaacgtcg tgggggccat agtcaaggtg gcagggtgtg gctgtcataa tggggaggga
5941 aggtgctcgt tgctctcacc ctggcttctc actggacttg cctctgggaa actggccttt
6001 ggggaggtga gaaggagtcc tcagggtgag ctctgagccc tctgaagtcc tgctcataag
6061 tagggagcat ttattaaaat ccagatctat tcaacaccac tccctgacac taatcaagcc
6121 ttctgggagc ttaaacttga gaacgtaaat tcgctgggga ggggctatgg tcacagctgc
6181 tagagtcaga tcctgccgcc accatctgta caaacaagaa tgaacactgc ctggggtgag
6241 ttttctagca aacacaggaa actagaaagt atgtcactca tgcactgtta accaaggatt
6301 gaagcaataa atcttgtgga tcacgggaag gaggaattaa cttcctagta agactctacc
6361 tgcgcacact ctttatgctg aaacagagac tgtagggagc aaaggactgg gtgattctga
6421 tgctggcttg gggttctgtg ccaaaagggc atgagagctt cgagccctct ccccacctcc
6481 tttgctggca cacgggcagg ggcagctgcc acggtgcacg ctgaagctgc aagcagtgtg
6541 tggacagaag tcccacagca ggctggtggc atcacctggt atcaagccgc agggggacac
6601 ttcccaggct cagggcgctg ccgccttgtc agctttactg ggagtgctga aggccaggtg
6661 cctccaaggc tgagagtcca aagaggagat ggtcctggcc catattggtc tccaccacac
6721 ggtcacttga tttcacctgt gggctggcag gccgtgccac tttccgggac actggcaaaa
6781 aggtgatgtt accagcagag cctggaaatt tggcatggta gtgtaggaat ttgtgtgtgg
6841 ggggccactg ctctactaca gacttgtggt gtgtgcttgg ggctgggcac agagcctggc
6901 cagtacctgg cacatgagag gtgctcaccc tatgtctgct ggaggaatga gtgaatgtct
6961 tttcctaggc ctgacaccgt ggagacccct gtctgctact cccaaataat ttgttctgct
7021 agataaagct ggggttttga atctttattc atctttctac aatgtttttg ctccaatttt
7081 ttctctcttc gttagggccc aacatatcaa acatgtttta aaactcatgc aatttacatt
7141 ctgttagaat atgtactgta aagcatttat cttcaacaga acatgtacaa acacaggtta
7201 gcgtctacat tttagtaaca tttgttcttg gagacacttg taagaaggct tggattataa
7261 ttaagtattc atgttgctaa agatgtaggt tgaaaagaaa tcagctttga gtggttgtgt
7321 ggatggccta gaacaacgag tatatttttt catatcctag gatgggctaa agctttggtt
7381 tctagaatca aaggaagtcg gctatgtgtg tgttttgaag gtggggggca tgctatttgg
7441 ggacagatgt taaacaatga catctcactt ggatgtggaa tggtccatgg gatctcaagt
7501 tcaggtggaa cagaggagat tctgtgggaa tatggaagtc attgtacact gtagggctca
7561 gaagtgtcca caggttcttc ctgaaccatt ttaatttctt cgctcttttc tgcagccact
7621 gtgatgttgt caacctcacc tgtgaagcct gccaggagcc gggaggcctg gtggtgcctc
7681 ccacagatgc cccggtgagc cccaccactc tgtatgtgga ggacatctcg gaaccgccgt
7741 tgcacgattt ctactgcagc aggctactgg acctggtctt cctgctggat ggctcctcca
7801 ggctgtccga ggctgagttt gaagtgctga aggcctttgt ggtggacatg atggagcggc
7861 tgcgcatctc ccagaagtgg gtccgcgtgg ccgtggtgga gtaccacgac ggctcccacg
7921 cctacatcgg gctcaaggac cggaagcgac cgtcagagct gcggcgcatt gccagccagg
7981 tgaagtatgc gggcagccag gtggcctcca ccagcgaggt cttgaaatac acactgttcc
8041 aaatcttcag caagatcgac cgccctgaag cctcccgcat cgccctgctc ctgatggcca
8101 gccaggagcc ccaacggatg tcccggaact ttgtccgcta cgtccagggc ctgaagaaga
8161 agaaggtcat tgtgatcccg gtgggcattg ggccccatgc caacctcaag cagatccgcc
8221 tcatcgagaa gcaggcccct gagaacaagg ccttcgtgct gagcagtgtg gatgagctgg
8281 agcagcaaag ggacgagatc gttagctacc tctgtgacct tgcccctgaa gcccctcctc
8341 ctactctgcc cccccacatg gcacaagtca ctgtgggccc ggggctcttg ggggtttcga
8401 ccctggggcc caagaggaac tccatggttc tggatgtggc gttcgtcctg gaaggatcgg
8461 acaaaattgg tgaagccgac ttcaacagga gcaaggagtt catggaggag gtgattcagc
8521 ggatggatgt gggccaggac agcatccacg tcacggtgct gcagtactcc tacatggtga
8581 ccgtggagta ccccttcagc gaggcacagt ccaaagggga catcctgcag cgggtgcgag
8641 agatccgcta ccagggcggc aacaggacca acactgggct ggccctgcgg tacctctctg
8701 accacagctt cttggtcagc cagggtgacc gggagcaggc gcccaacctg gtctacatgg
8761 tcaccggaaa tcctgcctct gatgagatca agaggctgcc tggagacatc caggtggtgc
8821 ccattggagt gggccctaat gccaacgtgc aggagctgga gaggattggc tggcccaatg
8881 cccctatcct catccaggac tttgagacgc tcccccgaga ggctcctgac ctggtgctgc
8941 agaggtgctg ctccggagag gggctgcaga tccccaccct ctcccctgca cctggtatgc
9001 tggcaccttg tgtgcaggtg ggagggctgg gcgagggctg gcatggcctt ggtgctacat
9061 gcatctgcca agatacgact cgggttctaa tcctggcttc cctggtctgt gtggccttgg
9121 ttgaaacttg ccttcaaagg gcctgtgttt cctcacctcc ctggcaggga gacaaactgt
9181 gatccttttt cgggggaaga tcttttctta ttgtgtgtgc ttctataaat tcaaaggtaa
9241 tggaagccta ttgttaacat ttaaacaatg ccaataagga gtaaaaaaaa aaaaaaatgc
9301 aagtcttact ttatcacaca gcctcttccc cacccaattc caccctctgc cttcaaggta
9361 acctctgtta aaggtggtga tgataagctt cattttgacc acactgggtg ggtgaaatta
9421 ttccgagtag ctgacattct tcagggcaag accaggatgt caggtgtcag gtagcaggtg
9481 cagtcttcag acactggagt cagactgcct tagtttgaat cttatctctg ctacttgcta
9541 gctgggtaat tttgggcaaa tacttaacct ctttgtatat cgtctataca aaggatgagg
9601 caaatactta acctctttgt atatcatcta tacaaaggat acacatcttt gtgtatcctc
9661 atctataaaa tggggataat aatagcacct acttgcttaa aatagtatct ggcacatgac
9721 aagtgctcaa aaaaaaatgc ttgctcccac tgctgttact actacctttt actgacactg
9781 gcgtctaatc cattcctagt tcctgaacat ctttattcgg tgtgtttggg accatcccag
9841 aataataagc cttcttttag tatcttttga gtcacacact tgtcagtact tttgtttctt
9901 tgtttttgtt tttattcacg gccatagatt tatttaaatt cttgtaatat ttctgctgag
9961 gaaaacaaca attacatcat ttcatcaaat ctcagatgtg ctcagacact aacaggagca
10021 ctaggcattt atagctggaa gaatcacagt atgttcacct gccctgcaag atctgaggac
10081 acagcagctc attgtccagg gaggggctgc cgctccattt ccttttgcag tctccttgta
10141 ttgccaggcc agtattttac tcatttctag aagaatggtg gccccttctt accgaggaag
10201 cctatgcctg ctgcttttat ttgtagacat ttaaacttcc tttgggtaga attggagtct
10261 tctcagtgtc tctaaatctg aggtagtccg gacccaggaa ctccatctcc ccatcccctc
10321 ctccctggcc cacattgccc ttgtactcac gaaggcaccc cccgcccccc ttggtggtgc
10381 cacgtggtca gcacgccctg cagatcctat tggatgtcag gttgtaggcc tggtggccat
10441 tgtccctgct ggcacctgtg tgctcacctt cctggttgtc tttgcagact gcagccagcc
10501 cctggacgtg atccttctcc tggatggctc ctccagtttc ccagcttctt attttgatga
10561 aatgaagagt ttcgccaagg ctttcatttc aaaagccaat ataggtgggt gagcgaggca
10621 cctgaagcag caggtgacga agaggctctt tttgtggctc tacttgattc aaaataatcc
10681 gcattttctc gttccgttta gggcctcgtc tcactcaggt gtcagtgctg cagtatggaa
10741 gcatcaccac cattgacgtg ccatggaacg tggtcccgga gaaagcccat ttgctgagcc
10801 ttgtggacgt catgcagcgg gagggaggcc ccagccaaat cggtaacgtt ggtgccacag
10861 gctggatgca gaagctgcat tctggttctt atttttggca taagtgactg tgtgacctcg
10921 gccagtcact ttgctccttg gccttagttt cttctcctgg aaagtgaggg gctagatgct
10981 cttccacgtc tctccagatc tcaactgggt gttccttgga gtttctgaat cattcagctt
11041 ttaagtgact taaggatcca ccgttaagac agggtgtcga gccgcagtca gtactgactt
11101 ggcgtgatct gttctccatc ctcaggggat gccttgggct ttgctgtgcg atacttgact
11161 tcagaaatgc atggtgccag gccgggagcc tcaaaggcgg tggtcatcct ggtcacggac
11221 gtctctgtgg attcagtgga tgcagcagct gatgccgcca ggtccaacag taagaatctg
11281 gtgtacagtc ctcaattcag gagagcgaga cttcagaaat gatagaggat taaaagtggg
11341 ctggggttac ttttggatgt tgtggctgat attaaatatg ctcaatacca acctctgtcc
11401 tggtttcaaa cagcaggaaa ttatccaacc acgatgtgat taggaaacca aacaataaaa
11461 agtgtgtgtt gatcctatat ctttataact aattataatc tttaatttct ccacattttc
11521 cctttgtgtc caggagtgat catacctcta tgccctttct ttctaaagta ggattcgtgg
11581 tctcttacta aaatgtcatg tctgaggcca gagtgattca ttgtagggcc ttgagaacca
11641 atgggggctt tcatgtattt agagtccttt cctggtacca ggtaatgggc ttggcagggt
11701 tgatggatga gagacaaagg atcatgctgt aggaaaggga aggatccaga tgtccagcct
11761 tgtgctccat aagaacatgt gcttatcatg ttcttaatat caacaggatg tgagctggga
11821 caggtggtag agtctaggga ccacctccca gctgaaggag gtctgggtga gtggagtgac
11881 attgagtccc ctcgtggcca cctggagaac tgttcatctt tcagaaccct gcctaggagt
11941 gctgtcagaa ccctgtcttt tctctgctgt cttcctgatg ttcttcctga ggaagttatt
12001 tgctccgttc tctatgtcac atatgagcta ctcaaaatgt gcaaatcgta ttgtattgta
12061 ttgtatttgt aacatatcta ttccttgcaa aaaactggga gttctttgaa ggcaagggaa
12121 gatcttgctt atttttgtat catctgtgta tgatgcacaa aataggtgac catttaacgt
12181 ttgttgagtg aatgaatgtg acatgtttat gaaatctatg attttagggt aaaggacact
12241 aaaagggaaa ggatatatat ttggataata taacgaactt acaagagctg aaaagctgct
12301 aatagaaaat ccgttccaac ctgaagcaca ttgcaaattc ctagaacttt ctggagagct
12361 gaattgagga atttcaggat ggagattttt tctccttcag tatcaagaat ccaaagaaag
12421 attttcactg ggaaagaaag cagttgtggt cttgaagcag atatgatcca gagcaagtca
12481 tttaaccgtc caaagcctcg gtttctcatg tgtaaatgag catgcacatt ctctgggctc
12541 agccctgtga tattttctct tctcttctta catatacccc cttggtggtc tagttcagtg
12601 tcatgggtct aaatacattt atacatcttt gactttgaaa ttcgtatctc cagcctcacc
12661 tcaactcagt ttgcatgctc taataggcaa aactaaactc ctgattttca catctgtctt
12721 tcttatctta gaaaatggca attccaacct tccagttgtt cagttcaaaa agctcagcat
12781 ccttgattct tcttcctttt ccctgatacc tccatgcaag ccacgaacaa actatagctc
12841 catcttcaaa atacttcgag agtcacacct ccccacacca tgtccactag ggtcacctca
12901 atccgagtcc ccatcatctc tcacctggac tattgaaata gctgtctaac tggaacccca
12961 gcttccacct ttgtcccctg cagatcattc tcagcacagc agctgcagtg gccctttaat
13021 atcaaaatca gctcctgtcc ctctgctctg tagtcttggc tggctttgtt tcattcacag
13081 aacatggtga gcccttactg tggccaatgg agcattgcct gatccatgcc ctttccctct
13141 cttgcttgtc cctctctccc cagcccccgg gagcatgcag tcacatttct gctctggggc
13201 ctttgcactc actcttctct ctgcttggga tgtccctccc tcagacatcc tcttggctcc
13261 ttccatcctt acatcaggtt tctgctcaga tgccatcttt tcaccaaatg cttctccaac
13321 tgccatatat gcaacgataa cccacacctc agccctgggc attctcatcc cccttatctc
13381 attttgtttt tttcctaagc atttatccac atctgaaatt ctatatattt actttgtttg
13441 tgtgtttgtt gtctatctct ccatgaggac gggggacagg gagggacttt atgtgcttgg
13501 ttcactgctg tacccctatt gcttacaata gtacctgaca cagagtagca gctcattaat
13561 atctgttgac tgaacatctt cctcataggg ctgatgtatg tgaccagcct ggaaaacatg
13621 aggctgtatt cagatgctgg atataacgtc aggccagtcc attttgagcc ttcttgccca
13681 cagatccttt cttgtctctt tgctaactct aggagtgaca gtgttcccta ttggaattgg
13741 agatcgctac gatgcagccc agctacggat cttggcaggc ccagcaggcg actccaacgt
13801 ggtgaagctc cagcgaatcg aagacctccc taccatggtc accttgggca attccttcct
13861 ccacaaactg tgctctggtg agtcttataa tacctttctt acttccctca aaaaaaagtt
13921 ccaaaataaa cccgccaaag aaacaaaaat agtattcaag agaccccagg gtgcccatgc
13981 ataagatttg gccttgaatg aagattatta tatagaccag gacctttaag tttctgttca
14041 tgggaggtgt ataccacaag cccccatggg gccagcagaa agctttctgt gtatggtcct
14101 atttccactc taattgtcca tgtgaacttg gcagagagag cctaagctta tttgtgtaga
14161 gggatcttgg acaaaagaat cagaagacat aagcaaggaa ccccagcgtt ccgtaggtat
14221 agtcttcttc cccatgggcc tagactaact ctcaacatgg gtataaaggg ctttagaaat
14281 acgataacac ggagactcat atcaaagtac catagtttaa gttgatttta ggttagaaac
14341 ttaaaaaata tgcttttggc caggtgcagt ggctcacgtc tgtaatccca gcactttggg
14401 aggccgaggc gggcggatca tgaggtcagg agatcgagac catcttggct aacacagtga
14461 aaccctgtct ctactaaaaa tacaaaaaat tagccaggcg tggtggcggg cacctgtagt
14521 accagctact tgggaggctg aggcaggaga atggtgtgaa cccgggaggc agagcttgca
14581 gtgagccgag atcgcgccac tgtactccag cctgggcaac agagtgagac tccatctcaa
14641 aaaaaaaaaa aaatacacac acacacacac acacgctttt tttgtggcgg gggcctgggt
14701 ttgtatattt tcccgttact agatgtaagt caaaacctgc ataaagctac tgtccttcgg
14761 gggaataagt caatgcaagt ttgcccttaa agggcaataa ctctatgcaa gttttgactt
14821 atagctaata acattagctg tacagagaga tggcagctct cctggtagga atcttcaagt
14881 agatctcttt caggtttcca ggatcttgct tcatctcccc accttcccca tccctggcgt
14941 gatctacatg tgaaccaaga taatgacagc gtaagctgta gttattgcca tattatcgct
15001 gttgttggca tcataattat taataactgc agagcatgtc tgaagaacca caggatgacc
15061 acctcagcct catgtcccta tgtctccact gttaaccttg ttcagattct tttcagagtt
15121 gagttgactt caaaaactag accaggttgc ttaagcagac attgtgaatg gttcagaatt
15181 tctgggtgaa agatgggaac taaggtctta tttgtgtctg ttgcaggatt tgttaggatt
15241 tgcatggatg aggatgggaa tgagaagagg gtaagttcct ttctgttgac tttgaaagaa
15301 aggttagaga tgtgtttggg gctcttgttc ccactggtta atttttcctc ctttggtctt
15361 agtccagtgc ttccttttac tattatcttg tttttgcggg tccatctgta catcttgtgt
15421 tttgcttcct gtctcatgta cagggggcct ccttgctgtg taggcctgtg ttcaattcta
15481 ggggtcagtt gtctggcaga tgggcttaga gttggagtac ctcatcttat tccctgcctg
15541 aatctgctgt tttcttctgc agcccgggga cgtctggacc ttgccagacc agtgccacac
15601 cgtgacttgc cagccagatg gccagacctt gctgaagagt catcgggtca actgtgaccg
15661 ggggctgagg ccttcgtgcc ctaacagcca gtcccctgtt aaagtggaag agacctgtgg
15721 ctgccgctgg acctgcccct gtgagtcctt tgcttctcca gccagggcag cgtcaaaggg
15781 gcagtgcttt tagcttggct gtgcagaaaa gtagagcagg cacccaccag cccagaagta
15841 ccctttccct catcaccaca tgcacagtgc taccttcact caccttcctt tcctcctgtg
15901 ctctttggac atgcatgcag ccagtctcag ggatcactgc cctctttctc tgtctttgga
15961 aggcacttcc ccagattatg cataactgga aggaagaatt gcttttctga ggtcaatgct
16021 cagcttggct gttggcaagt caacctttag gaatctgtgt attcagggta tagcagtgga
16081 agtatagcag tgagagagac gcttccagaa aactctccaa ccacacctat agcaacagta
16141 catcaccaag gcggcctgga ttaagaggag gaaatattta aagtccatct catgtacact
16201 tgtggagagc atgtcatcca tgggctgggt tagccttctg tctcatgttt gggagcaatg
16261 actgcttatg gtgaccatga ctcagcagtg gattgtaacc tttatgctga acaggcataa
16321 ctggtgggat gcaatcaaaa ctgtatttat agctcattcc ccctttagaa tttatttagt
16381 gagataaatt tccctcttgg tctaggtgaa aactccacca gactttaggt ttcttctgtt
16441 tattcataaa gaattctata gttactttgt cagaagacaa agtctcagtt gataactaga
16501 tacccactct tgcgtaataa tcaaaacttt gaatttgatt agagttaaaa cacctcccag
16561 ttccaattta ggctgcctgc ctctgggaag gagggtatgg tcagctttcc tctgtacaaa
16621 gagctttgcc ttttgtgatt aaaagcatat cctggaaatt actcgatgtc atttcaaaga
16681 gagcttccta atacttcact gtgtaccata ggttacccaa ctgttcttct atggatgtgc
16741 gtttaggctg tttccagtgt tttgtaatga caagcaatgc tgcaatgagt aaacctgaac
16801 atacgaacga attttcatat ggttggaggt gtgtcttcag ggtagattcc tagaagtgag
16861 attcttgggt caaaagataa gtgcatatga agttcccctt agacattccc agattctcct
16921 ctaacaggtg agatgtggtt gtgcaaaact ggaatgtcca tcagtttggt tttcgatcag
16981 cgaggtatga gagtgcatgc atctccacgg ccttgctgag tgtgttgtta cagtttttat
17041 ttattttttt tgcaaatttc ttacttttca ggaaagaaat agtatctcag tgtacttgaa
17101 attcatttct ctaatgatga gtgaggttaa acattttatc atatgtttaa ttgccatttt
17161 ttggtctaat tttgtgaatt ttctgctcat gccttgcccc atttgcccat tagaaaagtt
17221 gtgataagaa acacatgaga tctaccctat taataaattt tccagtgtac aataccatat
17281 tgttagctat ttgcaagttg ttgtacagca gatctctaga agtttttgtt ttgtgtgact
17341 gaaactatgc ccactgaaca gcaacttccc attttcccct tcccctagcc cccgcaacca
17401 ccattctgct ttttgcttct atgaatttga cgattttaga tacctcctgt aagtggattc
17461 atgcagtagt tatccttctg tgactggctc atttcactta gcttaacatc ctccaagttc
17521 atctatgttg tggcatatga aaggatttcc ttctttctaa agactgaata gtattccatt
17581 gcatgtatat accacatttt ctttatccat ttgtccactg atgtgcattt ggattatttc
17641 taactcttgg ctattgtgaa taatgttgca gtgaatgtgg aagtgtataa gtaccttttt
17701 gagatcctga tttcaatgct tttggatgaa tacccagaag tgggattact gggtcatatg
17761 ctaatactag ttttaatttt ttgaggaacc ttcttactgt tttctgtagt cgcgacacca
17821 ctttacattc ctaccatcaa tgcacaaggg tttcaatttc ttcacattct tgttaacacg
17881 tggtatttcc tggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtttgata atggccattc
17941 tagcacgtat gaggtgatac ctcattatgg ttttgatttg catttccctg atgatcagta
18001 atgttggata ttttttcata taattgagtt tttggatgtc tctttggagg aatgtctttt
18061 caagtccttt gctcattttt aaattgggtt atttgcattt tttttttttt tgctattgag
18121 ttgtatgagt tcctaatata ttttggatat taacccttta tcaaatgtac ggtttgcaaa
18181 tattttcttc cattctgtag gctgcctttt tattctgttg attgtttctt tggctgcaca
18241 gaagcttttt ggtttgatgt agtcccactt gtctattttt gcttttgttg ccttgttttt
18301 ggcaatgata tccaagaaat cgtcgccaag accaatgttg caaagttctt gtgttttctt
18361 ttaggagttt tataatttca ggttttacgt atcagtgttt aagtttgatt ttgggttaac
18421 tttgtgtatg atataaggta agggtccaat ttcattcttt ttcatgtgga caggttcatt
18481 gttagtgtat tgaaacaaat ggttttgtat gttgattttg tattctgcaa ctgaatttgt
18541 tttaacttcg ctgaatttgc taacaaattt ttggtgaaat ctttagagtt ttctatgcat
18601 atgatcatgt catctgcaaa tggagataat tttacttctt ttttgatttg ggtgatgttc
18661 atatcttctt gattcattgc tctagctaag acttctcgta ctatgttgaa tagaagtggt
18721 gagagtgggc atccttgccg tcttcctgat tagaggaaaa gcttttagtt ttgcactatt
18781 cggtgtgatg ttagctgtgg tattttcatt aatggccttt attttgttga ggtaattttc
18841 ttctattctt agtttgttga atgttttaat catgaaatgg tgtttgaatt atgacaaatg
18901 ctttatctgt atctgttgac atgatagtat gatttttatc ctttgttctg ttaatgctat
18961 gtatcacctt tattgatttt tagacgttga gccattctcc tatctgaggg ataaatccca
19021 ctccgtcaga gtgtattatc ctttgattgt gctgtttaat tcagtttgct gtcattttgt
19081 tgagaatttt tgcatctgtg ttcatcagga atattgactt gtagtttttt tttaatgtaa
19141 agtctttgac tttggtatca gggtaattct ggcttcataa agtaggtttc ccacttcagt
19201 gttttggaag agtgtgagaa agattggcat taattcttct ttaaatcttt ggtagaatta
19261 tccagtgaaa gcatctgagc tcttatttat tgagagatta tgattactaa tttcatctcc
19321 ttactaatga tggggctgtt cagattttct gtttattcat cattcaggct tggtaggttg
19381 tatgtttcag ggatttattc atttctttag gttatccaat ttgttagtgt gtagttgttc
19441 atagtagtct cttactaacc tttttatttc tgcgctatca attgtaatgt aagctcttct
19501 atttctgatt ttatttattt gagtcttctc tttttgtctt ggttaatcta gctaaagctt
19561 tgttaatttt gttgaccttt aaaaaaccaa ttctaagttt tattgatatt ttgtattcta
19621 tatttcattt atttttcctc aaatctttat tatttccttc cttctgctaa cttacggctt
19681 agtttattca ttttctagtt cttacattgt aaaattaggt tatttgtttg agatctttct
19741 tactgtagac atttactgct ataaactttc cttttattgc ttttgctgtt tcccataagc
19801 tttgctatgt tgtgctttag tttttgtttt tctcaaaata ttttctgatt tttcttttga
19861 tttcttcttt gactcattgg ttgttcaaga gtgtttttta atttccacat atttgagaac
19921 tttctgaaat tatttctctt agcaatgtct cattttattc tgttgtcaga aaagatactt
19981 ggtatgattt tagcctcctt aaatttgtta agatttgttt cgtgggctag catgtgagct
20041 attctggaga ctgttctatg tgtgtttgag aagaatgtat aatttgctgt tgttgggtag
20101 aatgttctgt atttgtttga taggtccact tgggccatag tgttgtttga gttctctgtt
20161 tccttattga tcttctatct ggatttttta tccattattg aaagtgagat attaaaatct
20221 ctcactatta tgttgttcta tatttatcat cacttctgtc aatatttgct tcttatattt
20281 gtgtgcttta atgttgggtg caatgtactt atatcttcct ggtgaattga tgcatttatc
20341 actatataat gtccgttttt ttgtctcttg tgaccatctt tgacttgaag tttaatttct
20401 ctaagtatgg ctacctgtgc tgtcttttag ttaacattgg catgaaatat ctttttccat
20461 cttctcactt taaacctatg tgcattctta aatctaaagt gagtctctct cttgtagaca
20521 gcacatagtt ggatcttgtt ttatatttta tttatttatt tacttaattt atttagatgg
20581 agtcttgctc tgttgcccag gctggagtgc aatggctcga tctcggctca ctgcaacctc
20641 tgcctcccgg gttcaagtga ttctcctccc tcagcctcct aagtagctgg aactacaagc
20701 acgtgccacc atgcctggct aattttttgt atttttagta gagacggggt ttcaccatgt
20761 tagccaggat ggtctcgatc tcctgatctc tcacgatctg cctacctcag cctcccaaag
20821 tgctgggatc acagacatga gccaccgcac ctggctgttt tattttattt ttaaaaattc
20881 atttcagcca cttcatagct tttgattgga gagtttattc tacttatact taaagtaact
20941 atggataggg aaggacttac tgttgccatt ttgtaattat tttcagtcag tcttgtagct
21001 tttttgtccc tcttttctac tcttactgcc cttctttgtg tttcattgat ttttttgggt
21061 aatgatgaga tttgactcct tcctcatttc cttttgtgta tcttctatag atattttctt
21121 tgtggttacc atgaagctta cataaaacag cctatactta taacagtcta ttctaagctt
21181 ataacaactt aatttcaatt gctcacgaaa actctactct tttactgcct ctcccccact
21241 ttacattatt gatgtcacaa attatatttt ttaatgttgt gtattcatta actgattttt
21301 atagtgatag ttatttttat aagtttgtct tttaagtact ataccagaat tc
//