GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMVWFAB 21033 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human von Willebrand factor pseudogene corresponding to exons 23
through 34.
ACCESSION M60676 M36185
KEYWORDS coagulation factor VIII; coagulation factor VIII VWF; pseudogene;
von Willebrand factor.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 21033)
AUTHORS Mancuso,D.J., Tuley,E.A., Westfield,L.A., Lester-Mancuso,T.L., Le
Beau,M.M., Sorace,J.M. and Sadler,J.E.
TITLE Human von Willebrand factor gene and pseudogene: Structural
analysis and differentiation by polymerase chain reaction
JOURNAL Biochemistry 30, 253-269 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
mRNA (1117..1257,1470..1583,3373..3529,
4264..4422,5289..5424,7582..8960,
10380..10496,10594..10734,11017..11160,
13599..13763,15108..15151,15444..15621)
/pseudo=von Willebrand factor gene
exon 1117..1257
/number=23
/pseudo=von Willebrand factor gene
/codon_start=1117
exon 1470..1583
/number=24
/pseudo=von Willebrand factor gene
/codon_start=1470
exon 3373..3529
/number=25
/pseudo=von Willebrand factor gene
/codon_start=3373
exon 4264..4422
/number=26
/pseudo=von Willebrand factor gene
/codon_start=4264
exon 5289..5424
/number=27
/pseudo=von Willebrand factor gene
/codon_start=5289
exon 7582..8960
/number=28
/pseudo=von Willebrand factor gene
/codon_start=7582
exon 10380..10496
/number=29
/pseudo=von Willebrand factor gene
/codon_start=10380
exon 10594..10734
/number=30
/pseudo=von Willebrand factor gene
/codon_start=10594
exon 11017..11160
/number=31
/pseudo=von Willebrand factor gene
/codon_start=11017
exon 13599..13763
/number=32
/pseudo=von Willebrand factor gene
/codon_start=13599
exon 15108..15151
/number=33
/pseudo=von Willebrand factor gene
/codon_start=15108
exon 15444..15621
/number=34
/pseudo=von Willebrand factor gene
/codon_start=15444
BASE COUNT 4924 a 4725 c 4852 g 6532 t
ORIGIN
1 gaccttaaaa tggagagatt atcctgaatt atctaggtgg gcccactgta gtcacaaaga
61 accttcaaac aggaaggccg aaagaccaga gtgagtagaa gagcttgggg aaactggagc
121 aagatagaat acattttttc tctttgtctc aacatcaggg ctctaagtat attgtaaaag
181 tatagcacct tttcttctcc aggccaaata tttccagttt tttctgtagt tttttttttg
241 ttttattatt atttttagtt gacatttaac tgtatgtatt tactggtgac agtgtgatat
301 ttcaatacat gtatacagtg tgtaatgatc aaatcagggt agttagtata tctcttccct
361 caaacattta ccatttcttt gtgttgggaa cattcaaagt ctgctcttcc agctacttga
421 aaatatacaa taaactgttg ataattatag tcaccctgtg gtgctacaga acactagaac
481 ttatccctcc tctttgtgta gttttcactt gtttctcact cattcataac tactttttca
541 gaacttgttg catgttgcac tccatgatgg gtgaacatgg agacaggtga gacatatctt
601 cctggttaca tttatgatag agcagaattc tgcccagcct ggtctgaaca ggctgcggtt
661 ctccaggcaa ggggactcac ctgcccagag gcaggcagtt ctataacgtt ccctccttgg
721 acccctacac ctccattggt ggagcagtgt acctggctcc tctctctgct tctacgcttg
781 ttggggacag cgatagttcc caccagtgat ctcagggcca aggctgcctg attcccactt
841 ctgcccttgg ctgactatgt gacatgggca tgttgcctct ctttgtttcc atagcttcaa
901 ataaaatggg gccagcaagg aagctcagga atagggcttg gcaatggcaa ggctttgctg
961 ctcacctcgg gcctcctctg agtctctgtc ccgctcctcc tcctctccct cgaatgccct
1021 ctgcctccat tgccgccagg aacgttcccc tttcccctga gccagagagc atgcccctgg
1081 gcttgacggt gctcatccct caacttgtct ctcaaggaga aagtgtgtgg cctgtgtggg
1141 aattttgatg gcatccagaa cagtgacctc accagcagca acctccaagt ggaggaagac
1201 cctgtggact ttgggaactc ctggaaagtg agctcgcagt ctgctgacac cagaaaacta
1261 cgtctgggtc tctgtgtgga cagagcccga gagcttgctt cctggaatgt ccctctgtcc
1321 ccattcttat gggggctgga aggggggttg tgggtggtat gaccttcagg tggctgcagg
1381 gtgggaagga gggtctcttg gatccttctg ggctgaataa ccccagtttg accagctgac
1441 ggctggccta tctcttgcct ggttcccagg tgcctctgga ctcatcccct gccacctgcc
1501 ataacaacat catgaagcag acgatggtgg attcctcctg tagaatcctt accagtgacg
1561 tcttccagga ctgcaacaag ctggtgagga ccttgagggt agtgggaagc agatggtccc
1621 aaggcttggc ccagtggtat ggacacagag tgtgaccttc taacgtggac actacccttg
1681 tgtcttgaca tgatctgcac caagacacca ctttagcttt tttttcttgg ctttcaatct
1741 gggaaacaaa aagtaaaatc aacagtttct aggggaagca atgcctggca aaacatttcc
1801 ttctgcatga gaagtaactc cccttggcat gtgccaacgt ttctctttcg gccccagtct
1861 taggatttgt tctcttatgg aagtatcttg ttttcaacac cagagccaga gatttccttt
1921 tcctgtcact gctgcatttg tccagaccaa aagaccgtcc tctcccactc ctcaaaaccc
1981 cttggtgccc atttcttgtc tcacagaaat tcttttctgg ccttactttt ggtgattttg
2041 agtcctcgta ttatgactta tttttgtgtc ttcatctcta atgacaagga ggaactcccc
2101 agggttaagt gcagttgtct ctcttctttt tttttgagac agagtctcgc tctgtcactc
2161 aggctggagt gcaatggcat gatcttggct tagtgcagcc tctgcttccc gggttcaagc
2221 gattctcctg cctcaacctc ccgagtagct gggattacag gtacccgcca ccacacccag
2281 ctaatttttg tatttttagt agagacgagg tttcaccacg ttggtcaggc tggcctcgaa
2341 ctcctgacct caggtgatct acccacctga gcctcccaaa gtgctgggat tacaggtgta
2401 agccaccatg cccgaccata gtgcggttgt ctcttatctg ctgcatgtat gtgtgtacac
2461 acatgtggac atgggcttgt acatggacat atgtgactac agaagtctat gtacacacac
2521 acagccatgc acacatacat gttgctgtgt agcaccacca atgtgggaga gactggttga
2581 aaacatggat ctcaattctc tttctatcta tgcagtgatt ttcagtctct gaggactcca
2641 aaggatactt acattcccgg tttggtggaa atcctgggca tctgagttgg aagagtgagg
2701 acaggggagg agctggggac attgggactg ttggaacgtc ttggaaacaa tgacccactc
2761 agtgtctgaa ttcattttct gtcataactg ccctgaaaaa gtccagtgtg tttagaggcg
2821 tgttttggga tgaggaaggg tgggaactgg ttgaactgga tttggaatca gagtctaggc
2881 cctattgttc tgcatacctg ccccatagca ctgcagtgag gcagctgcag ggcttgatgt
2941 atttccccat tctgcttgct gaattgaggc aaagaaagac agtgaccagc acatatgtgt
3001 gtttgtgttt ttgtaaaaac acccacatgc tcatgaggcc aagagtgggt tgtgaggaca
3061 gatgggtggc tgagcaggga ggcaggcaga gggacagagg gaatgttctt ctggaatatc
3121 ctcaggctca ttgtgttctg cagaaggcca gcagcactgc attattcaac tcttcttgct
3181 ggaatgcaga ttagaaacta agaatcttgc cttcccactc attccctctt tgagaccatt
3241 gagctacatt tctccttcta cctggacccc ccttatcctt aaattgacca tcagaacatt
3301 tgcacccaga ctaagagcca gagtttctga cacctggcca taggcctggg ccacctgagg
3361 ctacctttgc aggtggaccc cgagccatac ctggatgtct gcatttacga cacctgctcc
3421 tgtgagtcca ttggggactg cgcctgcttc tgcgacacca ttgctgccta tgcccacgtg
3481 tgtgcccagc atggcaaggt ggtgacctgg aggacggcca cattgtgcca tgagtcctga
3541 caccctcatg ttctcagatg ccctcccttc ttcccatgtg tctatgcttg aagaccttgt
3601 gagtgcaggg ggatatcttc atgggcgaga gaagacagtg ctagtatggg actggatggc
3661 caagggctaa cgagggttaa gacgttggct gagtaagaag tttatattat ggactttgag
3721 gcgggacatg gattcaaggc atgaacatgt ggatactttt cttctggaga gattctggca
3781 gaggagaaga gggaatactg atgaaaagaa ggaagttgat ttatgtcttt aattaggcgt
3841 gattatattt gccaatatga gtgatcaact catacattca tgtctataga atcttccttc
3901 tttggacata agcaacttaa tgcttttatg tagaaaactg ggccaggcac agtgactcac
3961 acctgtgata cctgtgtttt gggaggctga ggccagagga ttccttgagc ccaggagttc
4021 aagaccagcc tgggcaacat agcaagaccc catctctaca aaaattaaaa aaagaaatga
4081 attcagaacc aatagattct ggtttaggtg cttcaacaat ccagaagtct ctaatattgg
4141 tgacgcccat agtcccttag ttccccaaca ttatctccag atgctgcagg ccatcaccac
4201 atgggtctgc agtcctggag gctttgcctt ttgtggccac agccttgtct cctgtctaca
4261 cagcccagag ctgcgaggag aggaatctcc gggagaatgg gtatgagtgt gagtggcaat
4321 agaacagctg tgcacctgcc tgtcaagtta cgtgccagca ccctgagccg ctggcctgcc
4381 ctgtgcagtg tgtggaggtc tgccatgccc actgccctcc aggtgaggcc tctatccctg
4441 ggggtcgggc tggtgggatg ggatagggat ggatggaaag gtgcttctag gtcttgcttc
4501 atctcagcct ccacctgcca catcccatct ctgacctgca agcctgccac cccatctctg
4561 acctgcaagc ctgccacccc atctctgacc tgcaagcctg ccgccccatc tctgacctgc
4621 aagcctgccg ccccatctct gacctgcaag cctgccgccc catctctgac ctgcaagcct
4681 gctgccccat ctctgacctg caagcctgcc gcaggttcca tgggttcttt catcagagtc
4741 aggccagttg tgatttttct caagtcgagc tcctccaaaa tgcttttctg tgcctatttg
4801 tggcattctc atctaaagca gcccctgccg atagaacttt ctgcagtggg ggaatgttgt
4861 attgaatgta actgtgacga gtgtgtctga ggaactgaat ttttgaattt tattgaattt
4921 tacttaattt aacttaaata gccacatgca gtttatgact atcctatggt acagcacagc
4981 tcgagagtta ctgaaggtgt tattcagaag agcagaaaga gccctggaga taagatttca
5041 tttgtcctga ggcttgggga ggtgaggtag gatgaaggaa tccccgctcc cagttttgca
5101 gagggatcaa tcaaggcaca aggaggagag atgctccttg agtggcaggg tgacccctag
5161 gggtgcaggc aggaggagtt ggcttctagg gcaggaggag gagttggctc ctccctttta
5221 gttaaaaatg agacttcctt gtgggaaagg ggagcgtttt ggttcctaat gagagctttc
5281 ttttgcaggg aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgccc
5341 ggtgtgtgag gtggctggct ggcgttttgc ctcaagaaag aaagtcacct tgaatcccag
5401 tgaccctgag cactgccaga tttggtaaaa cagatgcctg gattgtttga agtgacgaat
5461 cttattgctt ctccaggggc cagctcagag actaggtttt gggtaaaaag tcctagccac
5521 atgagttgag agactgagtt tattttattt gtttatttat ttaattcatt atttagtgta
5581 gtttattgtt ttgtttgttc ctagggtttg cttctttttc tttagggatg gactagactg
5641 cttcctccac atatattcct ctacaatgtt tttgctctta ataggttttt aagtcctaac
5701 aggtttttgc ttttctcact gaaggtgggg gtatggtcac ttattgtcct tgtaggtcat
5761 gactagtctg agcacaggtg tccatatact ggaggtggcg actcaggaga ggaaagtgag
5821 atggaacgcg gggccctcag ggtaacatga acgtcgtggg ggccatagtc aaggtggcag
5881 ggtgtggctg tcataatggg gagggaaggt gctcgttgct ctcaccctgg gttctcactg
5941 gacttgcctc tgggaaactg gcctttgggg aggtgagaag gagtcctcag ggtgagctct
6001 gagccctctg aagtcctgct cataagtagg gaacatttat taaaatccac atctattcaa
6061 caccactccc tgacactgat caggccttct gggagcttaa acttgagaat gtaaattcgc
6121 tggggagggg ctatggtcac agctgccaga gtcagatcct gccaccacca tctgcacaaa
6181 caagaacgaa cactgcctgg ggtgagtttt ctagcaaaca caggaaacta gaaagtatgt
6241 cactcacgca ccgttaacca aggattgaag caataaatct catggatcat gggaaggagg
6301 aattaacttc ctagtaagac tctacctgcg cacactcttt atgctgaaac agggactgta
6361 gggagcaaag gattgggtga ttctgatgct ggcttggggt tctgtgccaa aagggcatga
6421 gagcttcgag ccctctcccc acctcctttg ctggcacacg ggcaggggca gctgccacgg
6481 tgcacgctga agctgcaagc agtgtgtgga cagaagtccc acagcaggct gggggcatca
6541 cctggtatca agccacaggg ggacacttcc caggctcagg gcactgccgc cttgtcagct
6601 ttactgggag tgctgaaggc caggtgcctc caaggctgag agtccaaaga ggagatggtc
6661 ctggcccata ttggtctcca ccacatggcc acttgatttc acctgtgggc tggcaggccg
6721 tgccactttc cgggacactg gcaaaaaggt gatgttacca gcagagcctc gaaatttggc
6781 atagtagtgt aggaatttgt gtgtgtgggg ccactgctct actacagact tgtggtgtgt
6841 gcttggggct gggcacagag cctggccaat acctggcaca tgagaggtgc tcaccctatg
6901 tctgctggag gaatgagtga atgtcttttc ttaggcctaa caccttgggg acccctgtct
6961 gctactccca aataatttgt tctgctagat aaagctgggg ttttgaatct ttattcatct
7021 ttccacaatg tttttgctcc aattttttct ctcttcgtta gggcccaacg tattaaacat
7081 gttttaaaac tcatgcaatt tacattctgt tagaatatgt actgtaaagc atttatcttc
7141 aacagaacat gtacaagcac aggttagcgt ctacatttta gtaacatttg ttcttggaga
7201 cacttgtaag aaggcttaga ttataattaa gtattcatgt tgctaaagat gtaggttgaa
7261 aagaaatcag ctttgagtgg ctgtgtggat ggcctagaac aacgagtata ttttttcata
7321 tcctaggatg ggctaaagct ttggtttcta gaatcaaagg aagtcggcta tgtgtgtgtt
7381 ttgaagtggg ggggcatgct atttggggac agatgttaaa cagtgacatc tcacttgggt
7441 gtggaatggt ccgtgggatc tcaagttcag gtggaacaga ggagattctg tgggaatatg
7501 gaagtagtca tacactgtag ggctcagaag tgtccatagg ttctttctga accattttaa
7561 tttcttcgct cttttctgca gccactgtga tggtgtcacc ctcacctgtg aagcctgcca
7621 ggagccggga ggcctggtgg tacctcccac agatgccccg gtgagcccca ccactctgta
7681 tgtggaggac atctcagaac cgctgttgca cgatttctac tgcagcaggc tactggacct
7741 gatcttcctg ctggatggct cctccaggct gtccgaggct gagtttgaag tgctgaaggc
7801 ctttgtggtg gacatgatgg agcggctgcg catctcctag aagtgggtcc gcgtggctgt
7861 ggtggagtac cacgacggct cccacgccta catcgggctc aaggaccgga agcgaccgtc
7921 agagctgcgg cgcgttgcca gccaggtgaa gtatgcgggc agccaggtgg cctccaccag
7981 cgaggccttg aaatacacac tgttccaaat catcagcaag atcgaccgcc ctgaagcctt
8041 ccgcatcgcc ctgctcctga tggccagcca ggagccccaa cggatgtccc ggaactttgt
8101 ccgctacgtc cagggcctga agaagaagaa ggtcatcgtg atcccggtgg gcattgggcc
8161 ccatgccaac ctcaagcaga tccgcctcat tgagaagcag gcccctgaga acaaggcctt
8221 cgtgctgagc ggtgtggatg agctggagca gcaaagggaa gagatcgtta gctacctctg
8281 tgaccttgcc cctgacgccc ctcctcctac tctgcccccc cacatggcac aagtcactgt
8341 gggcccgggg ctcttggggc tttcgaccct ggggcccaag aggaactcca tggttctgga
8401 tgtggcattt gtcctggaag gatcggacaa aattggtgaa gccaacttca acaggagcaa
8461 ggagttcatg gaggaggtga ttcagcggat ggatgtgggc caggacagca tccacgtcac
8521 ggtgctgcag tactcctaca tggtgaccgt ggagtacccc ttcagcgagg cacagtccaa
8581 aggggacatc ctgcagcggg tgcgagagat ccgctaccag ggtggcaaca ggaccaacac
8641 tggggtggcc ctgctgtacc cctccgacca cagcttcttg gtcagccagg gtgaccggga
8701 gcaggtgccc aacctggtct ccatggtcac cagaaatcct gcctctgata agatcaagag
8761 gttgcctgga gacatccagg tggtgcccat tggagtgggc cctaatgcca acgttcagga
8821 gctggagagg atcggctggc ccaatgcccc catcctcatc caggactttg agacgctccc
8881 ctgagaggct cctgacctgg tgctgcagag gtgctgctcc ggagaggggc tgcagatccc
8941 cacccgctcc cctgcccctg gtatgctggc accttgtgtg caggtgggag ggctgggcga
9001 gggctggcat ggccttggta ctacatgcat ctgccaagat atgacttggg ttctaatcct
9061 ggcttccctg gtctgtgtgc ccttggttga aacttgcctt caaagggcct gtgtttcctc
9121 acctccctgg cagggagaca aactgtgatc cttttgcggg ggaagatctt ttcttattgt
9181 gtgtgcttct gtaaattcaa aggtaatgga agcctattgt taacatttaa acaatgccac
9241 taaggagtaa aaaaaaaaat atgcaagtct tactttatca cacggcctct tccccaccca
9301 attccaccct ccaccttcaa ggtaacctct gttaaaggtg atgatgataa gcttcgtttt
9361 gaccacactg ggtgggtgaa attattctga gtagctgaca ttcttcaggg cgagaccagg
9421 atgtcaggtg ccaggtagca ggtgcagtct tcagacactg gagtcagtgt ctgccttagt
9481 ttgaatctta tctctgccac ttgctagctg ggtaattttg ggcaaatact taacctcttt
9541 gtatatcagt ctcctcatct ataaaatggg gataataata gcacctactt gcttaaaata
9601 gtatctggca catgacagtg ctcaaaaaaa atgcttgctc ccactgctgt tattactacc
9661 ttttactgac actggtgtct aatccattcc tagttcctga acatctttat tcggtgtgtt
9721 tgggaccatc tcagaataat aagccttctt ttagtatctt ttgagtctca cacttgtcag
9781 tacttttgtt tctttgtttt tgtttttatt catggccata gatttattta aattcttgta
9841 atatttctgc tgaggaaaac aacaattaca tcatttcatc aaatctcaga tgtgctcaga
9901 cactaacagg agcactaggc atttatagct ggaagaatca cagtacgttc acctgccttg
9961 caagatctga ggacacagca gctcattgtc cagggagggg ctgccgctcc atttcctttt
10021 gcagtcttgt attgccaggc cagtatttta ctcatttcta gaagagtggc ggccccttct
10081 taccgaggaa gcccatgcct actgctttta tttgtagaca tttaagcttc ctttgggtag
10141 aactggaggc ttctcagtgt ctccaaacct gaggtagtcc agccccagga actccatctc
10201 ccctatcccc tcctccctgg cccacgttgc ccttgcactc acaaaggcac cccccgcccc
10261 ccttggtggt gccacgtggt cagcacgccc tgcagatcct atgggatgtc aggttgtagg
10321 cctggcggcc agtgcccctg ctggcacctg tgtgctcacc ttcctggtta tctttgcaga
10381 ctgcagccag cccctggacg tgatccttct cctggatggc tcctccagtt tcccagcttc
10441 ttcttttgat gaaatgaaga gttttgctaa ggctttcatt tcaaaagcca atataggtga
10501 gtgagtgagg cacctgaagc agcaggtgac gaagaggctc tttttggggc tccacttgat
10561 tcagaataat ccccattttc ttgttccgtt tagggcctca tctcactcag gggtcagtgc
10621 tccagtatgg aagcatcacc accattgacg tgccatggaa cgtggccccg gagaaagccc
10681 atttgctgag ccttgtggac gtcatgcagc gggagggagg ccccagccaa atcggtaacg
10741 ttggtgccac aggctggatg cagaagctgc attctggttc ttatttttgg cataagtgac
10801 tgtgtgacct tggccagtca ctttgctcct tggccttagt ttcttcccct ggaaagtgag
10861 gggctagatg ctcttccacg tctctccaga tctcaactgg gtgttccttg gagtctctga
10921 atcattcagc ttttaagtga cttaaggatc caccgtgaga cagggtgtcc agccgcagtc
10981 agtactgact tggtgtgatc tgttctccat cctcagggga tgccttgggc tttgctgtgc
11041 gacacttgac ttcagaaatg catggtgcca ggctgggagc ctcgaaggcg gtggtcatcc
11101 tggtcacgga tgtctctgtg gattcagtgg atgcagcagc tgatgccgcc aggtccaaca
11161 gtaagaatct ggtgtacagt cctcaattca ggagagcgag acttcagaaa tgatagagga
11221 ttaaaagtgg cctggggtta cttttggatg ttgtggctga tattaaatat gctcagtacc
11281 aacctctgtc ctggtttcaa acagcaggaa attatccaat cacgatgtga ttaggaaacc
11341 aaacaataat aagtgtgtgt tgatcctata tctttataac taattataac cctttaattt
11401 ctccgcattt tccctttgtg tccaggagtg atcatacctc tatgcccttt ctttctaaag
11461 taggattcgt ggtctcttac taaaatgtca tgtctgaggc cagagtgatt cattgtgggg
11521 ccttgagaac caatggggac tttcatgtat ttagagtcct ttcctggtac caggtaatga
11581 gcttggcagg gttgatggat gagagacaaa ggatcatgct gtaggaaagg gaaggatcca
11641 gatgtccagc cttgtgctcc ataagaacat gtgcttatca tgttcttaat atcaacagga
11701 tgtgagctgg gacaggtggt agagtctgag ggaccacctc ccagctgaag gaggtctggg
11761 tgagtggagt gacattgagt cccctcgtgg ccacctggag aactgttcat ctttcagaac
11821 cctgcctagg agtgctgtca gaaccctgtc ttttctctgc tgtcttcctg atgttcttcc
11881 tgaggaagtt atttgctccg ttctctatgt cacatatgag ctactaaaaa tgtgcaaatc
11941 gtattgtatt gtatttgtaa catatctatt ccttgcaaaa aactgggagt tctttgaagg
12001 caagggaaga tcttgcttat ttttgtatca tctgtgtatg atgcacaaaa taggtgacca
12061 tttaatgttt gttgagtgaa tgaatgtgac atgtttatga aatctataat tttagggtaa
12121 aggacactaa aaaggaaagg atatatattt ggatgatata acgaacttac aagggctgaa
12181 aagctgctag tagaaaatcc attccaacct gaagcacatt gcaaattcct agaactttct
12241 ggagagctga attgaggaat ttcaggatgg agattttttc tcctttagta tcaagaatcc
12301 aaagaaagat tttcactggg aaaggaagca gttgtggtct tgaggaagca gatatgatcc
12361 agagcacgtc atttaaccat ctaaagcctc ggtttctcat gtgtaaatga gcatgcacat
12421 tctctgggct cagccctgtg atattttctc ttctcttctt acatataccc tgttggtggt
12481 ctagttcagt gtcatgggtc tgaatatatt tatacatctc tgactttgaa attcgtatct
12541 ccagcctcac ctcaactcag cttgcatgct ctaacaggca aaactaaact cctgattttc
12601 acatccgtct ttcttatctt agaaaatggc gattccaacc ttccagttgt tcagttcaaa
12661 aagcccagca tccttgattc ttcttccttt ttcctgatac ctccatgcaa gccacgaaca
12721 aactatagct ccatcttcaa aatactttga gagttgcacc tctccacacc atgtccacca
12781 gggtcacctc aatctgagtc cccagcatct ctcacctgga ctattgaaat agctgtctaa
12841 ctggaatccc agcttccacc tttgtcccct gcagctcatt ctcagcacag cagctgcagt
12901 agccctttac tatcaaagtc agcccctgtc cctctgctct gtagtcttgg ctggtttgtt
12961 tcattcacag aacatggtga gcccttactg tggccaatgg agcattgcct gatccatgcc
13021 ctttccctct cttgcttgtc cctctctccc cagcccccgg gagcatgcag tcacacttct
13081 actctggggc ctttgcactc actcttctct ctgcttggga tgtccctccc tcagacatcc
13141 tcttggctcc ttccctcctt acatcaggtc tctgctcaga tgccatcttt tcaccaaatg
13201 cttctccaac tgccatatat acaacgataa cccacacctc agccctgggc attctcatcc
13261 cccttatctc attttgtttt tttcctaagc atttatccac atctgaaatt ctatatattt
13321 actttgtgtg tttgttgtct gtctctccat gaggacgggg gacagggagg gactttatgt
13381 gcttggttca ctgctgtacc cctattgctg acaatagtac ctgacacaga gtaggagctc
13441 attaatatct gttgactgaa catcttcctc atagggctgg tgtatgtgac cagcctggaa
13501 aacatgaggc tgtattcaga tgctggatat aacgtcaggc cagtccattt tgaaccttct
13561 tgcccacaga tcctttcttg tctctttgct gactctagga gtgacagtgt tccctattgg
13621 aattggagat cgctacgatg cagcccagct acggatcttg gccggcccag caggcgactc
13681 caacatggtg aagctccagc aaatcgaaga cctccctacc atggtcacct tgggcaattc
13741 cttcctccac aaactgtgct ctcgtgagtc ttataatacc tttcttactt ccctcaaaaa
13801 aagttccaaa acaaacccgc caaagaaaca aaaatactat tcaagagacc ccagggtgcc
13861 catgcataag atttggcctt gaaagaagat tattatatag accaggacat tcaagtttct
13921 gctcatggga ggtgtatacc acaagccccc gtggggccag cagaaagctt tctgtgtatg
13981 gtcctatttc cactctaatt ggccatgtga acttggcaga gagcctaagc ttatttgtgt
14041 agagggatct tggacaaagg aatcagaaga cataagcaag gaaccccaga gttccataga
14101 gtcttcttcc ccatgggcct agactcactc tcaacatggg tataaagggc tttagaaata
14161 caataacatg gagactcata tcaaagtacc atagtttaag ttgattttag gttagaaact
14221 taaaaaatac gcttttggcc aggcacggtg gctcatgtct gtaatcccag cactttggga
14281 ggccgaggcg ggtggatcac gaggtcagga gatcgagacc gtcttggcta acacagtgaa
14341 accccgcctc tactaaagat acaaaaaatt agccgggcat ggtggcgggc acctgtagta
14401 ccagctactt gggaggctga ggcaggagaa tggcgtgaac ccaggaggcg gagcttgcag
14461 tgagccgaga tcgcgtcact gcactccagc ctgggcgaca gagcaagact ctgtctcaaa
14521 acacacacac acacacacac acacacacac acacatgctt tttttggggg gaggcctggg
14581 tttatatatt ttcccgttac tagatgtaag tcaaaacctg cataaagcta ctgtctttca
14641 ggggaataag tcagtgcaag tttgccctta aagggcaata actctacaca agttttgact
14701 tatagcaaat cacattagct gtacagagag atggcagctc tcctggtagg aatcttcaag
14761 tagatctctt tcaggtttcc aggatcttgc ttcatctccc caccttcccc atccctggcg
14821 tgatctacat gtgaaccaag ataatgacag cgtaagctgt agttattgcc atattatcgc
14881 tgttgttgac atcataatta ttaacaaccg cagagcatgt ctgaagaacc acaggatgac
14941 cacctcagcc acatgtccct aggtctccac tgttaacctt gttcagattc ttttcagagt
15001 tgagttgact tcaaaaacta gaccaggttg cttaagcaga cattgtgaat ggttcagaat
15061 ttctgggtga aagatgggaa ctaaggtctt atttgtgtct gttgcaggat ttgttaggat
15121 tcgcatggat gaggatggga atgagaagag ggtaagttcc tttctgttga ctttgaaaga
15181 aagattagag atgtgtttgg ggctcttgtt cccactgttt aatttttcct cctttggtct
15241 tagtccagcg cttcctctta ctattatctt gtttttgagg gtccatctgt acatcttgtg
15301 ttttgcttcc tgtctcatgt acaggaggcc tccttgctgt gtaggcccgt gttcaattct
15361 aggggtcagt tgtctggcag atgggcttag agttggagta cctcatctta ttccctgcct
15421 gaatctgctg ttttcttctg cagcccgggg acgtctggac cttgccagac cagtgccaca
15481 ccgtgacttg ccagccagat ggccagacct tgctgaagag tcatcgggtc aactgtgacc
15541 gggggccgag gccttcatgc cctaacagcc agtcccctgt taaagtggaa gacacctgtg
15601 gctgccgctg gacctgcccc tgtgagtcct ttgcttctcc agccagggca gcgtcaaagg
15661 ggcagtgctt ttagcttggc tgtgcagaaa agtagagcag gcacccacca gcccagaagt
15721 accctttccc tcatcaccac atgcacagtg ctaccttcac tcaccttcct ttcctcctgt
15781 gctctttgga catgcatgca gccagtctca gggatcactg ccctctttct ctgtctttgg
15841 aaggcacttc cccagattat gcataaccgg aaggaagaat tgcttttctg aggtcagtgc
15901 tcagcttggc tgttggcaag tcaaccttta ggaatctatg tattcagggt atagcagtgg
15961 aagtatagca gtgagagaga tgcttccaga aaactctcca accacaccta tagcaagagt
16021 acatcaccaa ggtggcctga attaagagga ggaaatattt aaagtccatc tcacgtacac
16081 ttgtggagag catttcatcc atgggctggg ttagccttct gtctcatgtt tgggagcaat
16141 gactgcttat ggtgaccatg actcagcagt ggattgtaac tttatgctga acaggcataa
16201 ctggtgggat gcaatcaaaa ctgtatgtta tagctcattc cccctttaga atttatttag
16261 tgagataaat ttccctcttg gtctaggtga aaactccacc agactttagg tttcttctgt
16321 ttattcataa agaattctat agttactttg tcagaagaca aagtctcagt tgataattag
16381 atacccactc ttgtgtaata atcaaaactt tgaatttgat tagagttaaa acacctccca
16441 gttccaattt gcgctgcctg cctctgggaa ggagggtatg gtcagctttc ctctgtacaa
16501 agagcattgc cttttgtgat taaaagcata tcctggaaat tacccgatgt catttcaaag
16561 agagcttcct aatacttcac tgtgtaccat aggttaccca actgttcttc tatggatgtg
16621 catttaggct gtttacagtg tcttgtaatg acaagcaatg ctgcaatgag taaacctgca
16681 catacgaatt gtcatatggt tggaggtgtg tcttcagggt agattcctag aagtgagatt
16741 cttgggtcaa aagataagtg catatgaagt tccccttaga tattcccaga ttctcctcta
16801 acaggtgaga tgtggttgtg caaaactgga atgtccatca gtttgctttt cgatcagcga
16861 ggtatgagag tgcaagcttc tccatggcct tgctgagtgc gttgttacag tgtttttttt
16921 ttttcaaatt tcttactttt caggaaagaa atagtatctg agtgtacttg aaattcattt
16981 ctctaatgat gagtgagggt aaacattttt catatgttta attgccattt tttggtctaa
17041 ttttatgaat tttctgctca tgccttgccc cattttccca ttagaagagt tgtgataaaa
17101 aacacatgag atctacccta ttaataaatt ttccagtgta caatacaata ttgttagcta
17161 tttgcaagtt gttgtacagc agacctttag aagtttttgt tttgtgtggc tgaaactatg
17221 cccactgaac agcaacttcc cattttcccc ttcccctagc ccccacaacc accattctgc
17281 tttttgcttc tatgaatttg acgattttag atacctcctg taagtggatt catgcagtag
17341 ttatccttct gtgactggct catttcactt agcttaatgt cctccaagtt catctatgtt
17401 gtggcatatg aaaggatttc cttctttcta aagactgaat agtattccat tgcatgtata
17461 taccacattt tctttatcca tttgtccact gatgtgcatt tggattgttt ctaactcttg
17521 gctattgtga ataatgttgc agtgaacgtg gaagtgtaag tatctttttg agatcctgat
17581 ttcaatgctt ttggatgaat acccagaagt gggattgcgg ggtcatatgc taataccagt
17641 tttaattttc tgaggaacct tcttaccgtt ttctgtagtg gctacaccac tttacattcc
17701 taccatcaat gcacaagggt ttcagtttct tcacattctt gttaacactt ggtatttcct
17761 ggtgtgtgtg tgtgtgtgtg tgtgtgtgtt tgataatggc cattctagca cgtatgaggt
17821 aatacctcat tatggttttg atttgcattt ccctgatgat cagtaatgtt ggatattttt
17881 tcatataatt gactttttag atgtctcttt ggaggaatgt cttttcaagt cctttgctca
17941 tttttaaatt gggttatttg catttttttt ttttttgcta ttgagttgtg tgagttccta
18001 atatattttg gatattaacc ttttatcaaa tgtacggttt gcaaatattt tcttccattc
18061 tgtaggctgc ctttttattc tgttgattgt ttctttggct gcacagaagc tttttggttt
18121 gatgtagtcc cacttgtcta tttttgcttt tgttgccttg tttttggtaa cgatatccaa
18181 gaaatcgtcg ccaagaccaa tgttgcaaag ttcttgtgtt ttcttttagg agttttataa
18241 tttcaggttt tacgtatcag tgtttaagtt tgattttggg ttaactttgt gtatgatata
18301 agataagggt ccaacttcat tctttttcat gtggacaggt cattgttagt gtataaaaac
18361 aaatggtttt ctatgttgat tttgtattct gcaactgaat ttgtttcaac tttgctgaat
18421 ttgctaacaa atttttggtg aaatctttag agttttctac acataagatt atgtcatctg
18481 caaattgaga taattttact tcttttttga tttgggtgat gtttatatct tcttgattca
18541 ttgctctagc taagacttct ggtactatgt tgaatagaag tggtgagagt gggcatcctt
18601 gctgtcttcc tgattagagg aaaagctttt agttttgcac tattcaggtg atgttagctg
18661 tggtattttc attaatggcc ttaattttgt tgaggtaatt tccttctatt cttagtttgt
18721 tgaatgtttt aatcatgaaa tggtgtttga attttgacaa atgctttatc tgcatctatt
18781 gacatgacag tatgattttt atcctttgtc ctgttaatgc tgtgtatcac atttactgat
18841 ttttagatgc tgagccattc tcccatctga gggataaatc ccactcagag tgtatgatcc
18901 tttgattgtg ctgttgaatt cagtttgcta tcattttgtt gagaattttt gcatctatgt
18961 tcatcaggaa tattgacttg tagttttctt taacgtaaag tctttggctt tggtatcagg
19021 gtaattctgg cttcaggttt cccacttcaa tgttttggaa gagtttgaga aagactggca
19081 ttaattcttc tttaaatctt tggtagaatt atccagtgaa agcatctgag ctcttctttg
19141 ttgggagatt atgattatta atttgatctc cttactaatt gtggggctgt tcagattttc
19201 tgtttattca tcattcagtc ttggtaggtt gtatgtttca gggatttatt catttcttta
19261 ggttatccaa tttgttagtg tgtagttgtt catagtagtc tcttactagc ctttttattt
19321 ctgtgctatc aattgtaata taacctcttc tatttctgat tttatttatt tgagtctttt
19381 tttgtcttgg ttaatctagc taaagatttg ttaattttgt tgacctttaa aaaaccaatt
19441 ctaagtttta ttgatatttt gtattctata tttcatttat ttttcctcaa atcttaattt
19501 ccttccttct gctaacttag ggcttagttt attcattttc tagttcctta tgttgtaaaa
19561 ttaggttgtt tgagatcttt cttactgtag acatttactg ctgtaaactt tccttttatt
19621 gcttttgctg tttcccataa gctttgctat gttgtgcttt agtttttgtt tttctcaaaa
19681 tattttctga tttttctttt gatttcttct ttgacccatt ggttgttcaa gagtgttttt
19741 taatttccac atatttgaga actttctgaa attatttcta ttagcaatgt ctcattccgt
19801 tgtggtcaga aaagatactt ggtatgattt tagtctcctt aaatttgtta agatttgttt
19861 tgtgggctag catgtgaact attctggaga ctgttctatg tgtgtttgag gagaatgtat
19921 aatttgctgt tgttgggtag aatattctgt atttgtttga taggtccact tgggccatag
19981 tgttgtttga gttatctgtt tccttattga tcttctgtct ggatttttta tccattattg
20041 aaagtgagat attacaattt ctcactatta tgttgttcta tatttatcat cacttctgtc
20101 aacatttgct tcttatattt gtgtgcttta atgttgggtg caatgtattt ataattatat
20161 cttcctgatg aattgatgca tttatcacta tataatgtcc gtttttttgt ctcttgtgac
20221 catctttgac ttaaagttta atttgtctaa gtatggctac ctcttttagt taacattggc
20281 atgaaatatc tttttccatc ttctcacttt caacctatgt gcattcttaa atccaaagtg
20341 agtctctctc ttgtagacag cacatagttg gatcttgttt tatatttatt tatttattta
20401 tttatttatt tatttattta atttatttag atggagtctg gctctgttgc ccaggctgga
20461 gtgcaatggc tcgatctcgg ctcactgcaa tctatgcctc ccgggttcaa gtgattctcc
20521 tccctcagcc tcctaagtag ctggaactag aagcgcatgc caccactcct ggctaatttt
20581 ttgtattttt agtagagacg gggtttcact gtgttagcca ggatggtctt gatctcctga
20641 tctctcatga tctgcctacc tcagcgtccc aaagtgctgg gattacagac gtgagccacc
20701 acacctggct gttttatttt atttttaaaa attcatttca gccacttcat agcttttgat
20761 tggagagttt attctattta tacttaaagt aactactgat agggaaggac ttactgttgc
20821 cattttggta attattttca gtcagtcttg tagctttttt gtccctcttt tctactctta
20881 ctgcccttct ttgtgtttca ttgatgtttt ttgggtaatg atgagatttg attcctttct
20941 catttccttt tgtgtatctt ctatagatat tttctttgtg gttaccatga agcttactta
21001 aaacagccta tacttataac agtctattct aag
//