GenBank-Updates@genbank.bio.net (11/21/90)
LOCUS HUMMGPA 7734 bp ds-DNA PRI 21-NOV-1990 DEFINITION Human matrix Gla protein (MGP) gene, complete cds. ACCESSION M55270 J05572 KEYWORDS matrix Gla protein; vitamin K-dependent protein. SOURCE Human leukocyte DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 7734) AUTHORS Cancela,L., Hsieh,C.-L., Francke,U. and Price,P.A. TITLE Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene JOURNAL J. Biol. Chem. 265, 15040-15048 (1990) STANDARD full staff_review FEATURES from to/span description pept 3455 3515 matrix Gla protein, exon 1 5060 5092 matrix Gla protein, exon 2 6258 6333 matrix Gla protein, exon 3 7025 7166 matrix Gla protein, exon 4 IVS 3516 5059 matrix Gla protein intron 1 IVS 5093 6257 matrix Gla protein intron 2 IVS 6334 7024 matrix Gla protein intron 3 BASE COUNT 2303 a 1580 c 1470 g 2381 t ORIGIN Chromosome 12 1 ccagtgagaa agctcatcac ttggtctcct ttaaggccag ttggctgcct aacaattttt 61 taaataagag gagccagtat taaatttttg ttcaaagagc acacttgatg catgagacag 121 ggcccatatc tgtatttttc tctactgtat ttccagccta gagttgacaa acagtagatg 181 ctcagtacat ttgttggcta gatagataac ttgatggatg gctggctggc tggctggctg 241 gctggatgga tggatggatg ggagaattat gaaatcatga agctccttct ggccctgaca 301 ggcatggtca ttcttctctt ttctgcctga gagtaggtgg aataggagat ctgtattact 361 ccatggcttc tcttgcttca gttcctacgt tgccaacctc acatgaggag aatcctacac 421 atgtttaaaa actggcaatc atatcactgt ctcatatttc tgttatcact tctgggagtt 481 tcttcaaata ttctctcctc tgaataacac ttcttttttg ttaagggaaa atgtctatat 541 aagtgtcttt cataattatc taaaatctaa ttagaattta gagtttcatg tggtctcgtc 601 ttgacaagat atcccaatta agaaaatgca aactagctgg caaaattaat ttgttcaaat 661 ttcaatattt tctgaaaatt ttcagacagt attctgcaat ctcaaacaat gctattccta 721 accaaagcaa cttttatttc tctgttccca tgtctcgctt ttaatatgtc tcaccttcta 781 caactgcctc cgtttttctc tgtcactcag tctctaccta aaactcaccc agcaaaccaa 841 attggtaagg ctcttctcat ttccccttct ccgttttttt ttttttccta cttccattct 901 tttcttctgt cttctctcag atgagtcaat cttggtcctt tctaatgcaa agctcccatc 961 cctgcttcat gcgttagtcc aagtcctcat cataaaaaca tatgactgga gttggcattc 1021 acaaagttgt ctttgaaatg gggagtaagg tgacagagga gaaaaagaag agctctggat 1081 tctcagacat gttaataatt tttacatatc atatataaat gggattttgc agagaagaac 1141 cagaaataga tgggagagca atggacagga aaggcagatg agggaccgaa gagacacagc 1201 tcccaaaaga aagttagcct tacaaaaacc aagacgataa agagaaatgc ttaagtttag 1261 ggaatccagt ggaagcagtg atttaaggtg aacaaaaggt gaaccttaag ttgaaatgag 1321 aagtgtagga ttttcaagtt tagtttctgg gagtgtaaaa ataaaaaaac aattgtgatg 1381 tcagaggctg aaagattata gttgtcattt gaacttgggg ataaaggaga catctatgac 1441 ttggctggaa aagacagagc taatgtacat tgcaaagcac atatttatag caggaaaatg 1501 ggaagatttc tctttaattc tggagatgga gtggggatgg ggagagtaga ctactcattt 1561 taagggtgaa acattggaat tcaacttgtt tgatgttata ttaattggtg gttaattact 1621 aagctaagta cgtataaaac ttttatctat ggctagcttg tccccccaaa gtcatgcaat 1681 atagtgaact ggctttcgca ctttaaatta ttcattgatc atgtaatgat tcagatgatt 1741 catcttccaa gatggacact gaaactaaca ctcatagtag gttgtggttt aaagagtgga 1801 acaaccgcca gtctcattag tggaaattgt gatggttgaa tttatcaagg atgaacatac 1861 acggtcttct ttctgagatt ttctttaaga ttttcgcaca gataatctat ttcttaggtt 1921 ttggagagaa aacttgaatt ttattgatcc ctcagaactc aatctttcag atttcaaagg 1981 agctatttct tttaatgggg actctgttaa tatttataaa agctcttcac aggatggagg 2041 gtgggaggga aactccatcc caacaagaca aaaagaatga agcatgaggc tccacctagt 2101 tcatcactgc tccttgaaat acatcagtat tgaaagacac atccacccca cccccaaccc 2161 agccctattg ctgttccagc tcaagagtca gaggtcccga agctgtagct cttctacaat 2221 agtctccaaa aaatatggtt tatgatttga ttaaagaata ctgcctcgcc agaagctccc 2281 gagaggcaca tctggtagga cagattttgt gattgcaaaa gaagggggaa aaaaagaaag 2341 aaagaaaaga cctctctata caagataacc agaggcatca aactgaaatc ctcctgtgga 2401 aaataagcta gtacttctgg gcctgatggt gtagtgaaaa cctgtgcttg aggatacatt 2461 acagtgaaag agcaaagtga atagtaagta gctattactt acctccttag ggaggtgtgt 2521 tgtttgtctg tacatccccc acagcaccta gcacagtacc ttgcatctca cctgccactc 2581 actaaaaagt ctatcaagtt agttaattat cgagacaacg ccctcagaaa tgagagaaca 2641 gtaccctctt atccttgctg cactttccag cactgatacg ctgcctaaaa gaggactagg 2701 gcacaggttt gaattaatgt cacaaaactg gatgggcaag ttacaacggt gttgattaag 2761 gaaacagaac tcatggggca ccggatatct ccatcctgat gaacccttgg aaaaatgcca 2821 aagatgcata tccccaggca aatgcctgat tagtctggga ttgatagatt ggtctaggat 2881 tcagccctac tgggaagatg tctaaattat aatcagtgta gaaagcgaag ttctcctaga 2941 agaagaggca aaggttaaaa agaagaaaag aaaagaaagt gaagtccttt ctcccccaaa 3001 acctctcatc aatcaatcag ggtaacaaac agaacactag ggctctgtct gtggaccaaa 3061 cccaaaagcc ctgcggtcag ggccaggagg gtagatcatg tgtttgtggc aacttcctct 3121 gtgggctttt gcccaggtct gtccccaagc atacgatggc caaaacttct gcaccagagc 3181 agcatcctgt gtaacacagt caggtccagc agttagggaa aactgcccac tcagagtaga 3241 taatatctgg aaggaatgac tgtttgggaa aagttccaat gctagttcag tgccaaccct 3301 tccccacctt ctccagctct ctcccactgg ttcctcccct ctcaactgct ctggttctta 3361 taaaaacctc acagccttcc actaacatcc cataggagcc tctctcccta ctgctgctac 3421 acaagaccct gagactgacc tgcaggacga aaccatgaag agcctgatcc ttcttgccat 3481 cctggccgcc ttagcggtag taactttgtg ttatggtgag aaacttttct cccatttctc 3541 tgtgtttact tttctgcctc tgactttggc ttacttctat ttttcctctc cctcctcctc 3601 ttcttccccc tttctctgtt ataatcttaa agtaccatta ctttcacatt tcccagtctc 3661 cgcagaaact gatctgttct attaagtctt ttttatatcc taaatatcca gagtcttatg 3721 caacttaaca ggcaaacccg ttcagtggta agtctctgta tatctagaaa ctcatatttc 3781 agaaagaaga taccaaattc ccagccccct gcatcctcat ttttaaggat atttatttag 3841 actttggtat caatgggtta agggtattgt ttaaaccact tgcctttgag aaaatccatt 3901 tttatgtgaa gtattaagta tagccctttc tagggactgg acaatctcat gaacttacta 3961 tgtttgttca gttaattaat tttaaaataa agttttacat caaaagaatt ttagaaaaga 4021 atcattttca taactcctgt tgtcagaaaa taaattttgc ctgttttcta tatgtcatta 4081 aatatacctg catttgttca aagcttataa aaggaaatct gaagcaaagt tatttactta 4141 tttcagtctt ttgtttcaat tacctagata ttttcattgt tttaaaattt aaattacatt 4201 aacaaccata aagattatgc ttctcactct tgtattcaca aattttctgt attagaggat 4261 ttgatttctt cacctccttt ttaagttttg aagaaaattc acttgctggc aaatattaat 4321 agaagcttct tattccaaaa tttatctgct gtgctcagga gagtggcaga aagaagaaaa 4381 gaagcttctt attccaaaat ttatctgctg tgctcaggag agtggcagaa agaagaaaac 4441 ttcggctttg atatcgtttc agttctctct ctgaactggc atcgtgccca gggtgagctg 4501 tcagctggag ctagtggttt ctgtggctgc caatttaaca caggttctta agaggctttc 4561 ggaaccctct tagaaacctg ccctagtaag cccagcagag caactgccct gtagttctct 4621 tgcctggaga aacctggctg tcttctggat ccttcttaat cctctttgac cctgttctca 4681 aacaggctct gaataaatca gagaagaagg ttctctggag acttctgtac agcacttaaa 4741 gtgtcttatt ttgcttgtct gaagacgtca tagcccttgg gaaattttag ctgaaaatgg 4801 ccactccctc cttcaacatc agagaaacta aaatatagag atatccacag caaggccaga 4861 gctagagaaa aacctcataa atcctaaatt cctgaaattt ctaataacca cactgctaaa 4921 tatattcttc atgtttttag actctttcct cttcttccat ccctgtattt aaactatcac 4981 agtgtctaaa ttgataaata ataacataat gaatcatgga taaatattga tataatgaat 5041 cttttttttt taatttcaga atcacatgaa agcatggaat cttatgaact tagtaagtga 5101 atatttaact tctttattca aatcccttgc attaaagaac ctcttcttat ttttaaataa 5161 acaagatgga aagatatata acagggaggg aaaagggggc ctcttttgga aaactaaagt 5221 aaatttttaa atctaatgac tataaaaatt gccaaaggag caatttttta agtttgaagt 5281 agtgcaatat gggatttaag ctacaggcga catatttaga agccataaaa tctcatttgg 5341 aaattttaaa ttggcaccac gtcaactgca cagatggaaa acgaggagta atgacaaatg 5401 gtaaagcaca gagctggacg ccaagtcagc tgggagacca caggcgccac gttaagctga 5461 gtgctgtttt ggtttttttg tgtttttctt tcttgttttt ttttttgaga cagtgtctca 5521 ctctgtcgcc caggctagag tgcagtggtg tgatctcggc tcgccgcaac ctccacctcc 5581 caggttcagg caattctcat gcctcagcct cctgagtagc tgggattaca ggcccatgac 5641 atcatgcctg gctaattttt gtatttttag tagagatggg gtttcaccat gttgtccagg 5701 ctggtctcga actcctggcc tcaagtgatc cacccaccac agcctcccaa agtgccggga 5761 ttacaggcat gagccaccac acccagccag ctgattgctg ttgaatagct ggatttataa 5821 agactgagca taggaggaaa tggcacatca ctctcatttt taatttattc attattttta 5881 tagtgtttaa actgttcatg tatcggcaat ctagttatgc ttcataaatc ctcaggacag 5941 agaatttctc ctcaaaagga atttaaaatc taccaagtag aaatacagaa attaagaaag 6001 gcaaagtgat cgtccaaact caaaaccaac aaagcctata tgacaagtct ctaagacaca 6061 tggattgatt actgatttca tttgatcagg aagttaatga aatctacttt atactctcct 6121 ttaatttttg ccaatctccg tttatatgag ttgcataagt taaggcactt tcaaatatat 6181 ttgtgtcaag gaatattcac ggaaatattt ccagctatgt gtcgctaaaa ctgcatttat 6241 ttattttctg ttctaagatc ccttcattaa caggagaaat gcaaatacct tcatatcccc 6301 tcagcagaga tggagagcta aagtccaaga gaggtcagta acaaaacttc atgaggagtg 6361 gtcatttttc ccagtgtaga tcacagatct gaattggagt gggaaacagc tttttcatca 6421 tatacattat ttctaattgt atctttaaaa tcaaaaaact taaaagcaat attcagaaaa 6481 caactgaatt attagaaaat tatttgggga aagatccgga aaggagaagg aaggaggaga 6541 gaaaggagga cagaaagaaa acttctattt tcattaaaaa aaaaaaaaaa atctcctgtt 6601 ctgccttccc tccctggttt tttttttggt tggttggttg gtttttctga gacagagtct 6661 cactctgttg cccagactgg attatagtgg cactatctcg tgcctcagcc tcccaagtag 6721 ctgggattat aggcacgtgc taccatgtcc agctattttt gcattttttg tagagacggg 6781 gttttgtcat gttggccagg ctagtcttga actcctgacc tcaagtgatc cacccacctc 6841 agcctcccaa agtgctggga ttacaggcct gagccaccgc acccagcctc tccctgttct 6901 ttaaatatct cttaatatag gggggcatgg agagaaagtc tctccaatat tttcttcttc 6961 ttttccattt ttgtattttt ccactttatc cttctcaatt ttggcctctt cttccacttt 7021 ctaggatccg agaacgctct aagcctgtcc acgagctcaa tagggaagcc tgtgatgact 7081 acagactttg cgaacgctac gccatggttt atggatacaa tgctgcctat aatcgctact 7141 tcaggaagcg ccgagggacc aaatgagact gagggaagaa aaaaaatctc tttttttctg 7201 gaggctggca cctgattttg tatccccctg tagcagcatt actgaaatac ataggcttat 7261 atacaatgct tctttcctgt atattctctt gtctggctgc accccttttt cccgccccca 7321 gattgataag taatgaaagt gcactgcagt gagggtcaaa ggagagtcaa catatgtgat 7381 tgttccataa taaacttctg gtgtgatact ttcatcttgt aaatctgctt tcttttggga 7441 agatattgag atatttaaat catggcccac cttacccaaa ataggagatt ctgttcatct 7501 catatctagt attaattaga aaaataacta cataaaaaga aggaagctaa gaaggcactc 7561 actcagccat aaattctcta aaccctctct accttggaat ccgtgaatgg aatctggtat 7621 gttttttgca ggattttcct attgtaaatt gtggcaaata cagggctccc ttcatttgct 7681 tttcatctct tatgcatcaa agtcaaaaac atttctgaat caagataatc taga //
GenBank-Updates@genbank.bio.net (01/31/91)
LOCUS HUMMGPA 7734 bp ds-DNA PRI 31-JAN-1991 DEFINITION Human matrix Gla protein (MGP) gene, complete cds. ACCESSION M55270 J05572 KEYWORDS matrix Gla protein; vitamin K-dependent protein. SOURCE Human leukocyte DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 7734) AUTHORS Cancela,L., Hsieh,C.-L., Francke,U. and Price,P.A. TITLE Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene JOURNAL J. Biol. Chem. 265, 15040-15048 (1990) STANDARD full staff_review FEATURES Location/Qualifiers mRNA join(3399..3515,5060..5092,6258..6333,7025..7166, 7167..>7734) /gene="MGP" mat_peptide join(3512..3515,5060..5092,6258..6333,7025..7163) /product="matrix Gla protein" /gene="MGP" CDS join(3455..3511,3512..3515,5060..5092,6258..6333, 7025..7166) /product="matrix Gla protein" /gene="MGP" CAAT_signal complement(2868..2872) /gene="MGP" CAAT_signal 3276..3280 /gene="MGP" TATA_signal 3358..3366 /gene="MGP" exon 3399..3515 /number=1 /gene="MGP" sig_peptide 3455..3511 /product="matrix Gla protein" /gene="MGP" /codon_start=3455 intron 3516..5059 /number=1 /gene="MGP" exon 5060..5092 /number=2 /gene="MGP" intron 5093..6257 /number=2 /gene="MGP" repeat_unit complement(5470..5788) /rpt_family="Alu" /gene="MGP" exon 6258..6333 /number=3 /gene="MGP" intron 6334..7024 /number=3 /gene="MGP" repeat_unit complement(6679..6888) /gene="MGP" exon 7025..7166 /number=4 /gene="MGP" polyA_signal 7389..7394 /gene="MGP" repeat_unit 7489..7678 /gene="MGP" BASE COUNT 2303 a 1580 c 1470 g 2381 t ORIGIN Chromosome 12 1 ccagtgagaa agctcatcac ttggtctcct ttaaggccag ttggctgcct aacaattttt 61 taaataagag gagccagtat taaatttttg ttcaaagagc acacttgatg catgagacag 121 ggcccatatc tgtatttttc tctactgtat ttccagccta gagttgacaa acagtagatg 181 ctcagtacat ttgttggcta gatagataac ttgatggatg gctggctggc tggctggctg 241 gctggatgga tggatggatg ggagaattat gaaatcatga agctccttct ggccctgaca 301 ggcatggtca ttcttctctt ttctgcctga gagtaggtgg aataggagat ctgtattact 361 ccatggcttc tcttgcttca gttcctacgt tgccaacctc acatgaggag aatcctacac 421 atgtttaaaa actggcaatc atatcactgt ctcatatttc tgttatcact tctgggagtt 481 tcttcaaata ttctctcctc tgaataacac ttcttttttg ttaagggaaa atgtctatat 541 aagtgtcttt cataattatc taaaatctaa ttagaattta gagtttcatg tggtctcgtc 601 ttgacaagat atcccaatta agaaaatgca aactagctgg caaaattaat ttgttcaaat 661 ttcaatattt tctgaaaatt ttcagacagt attctgcaat ctcaaacaat gctattccta 721 accaaagcaa cttttatttc tctgttccca tgtctcgctt ttaatatgtc tcaccttcta 781 caactgcctc cgtttttctc tgtcactcag tctctaccta aaactcaccc agcaaaccaa 841 attggtaagg ctcttctcat ttccccttct ccgttttttt ttttttccta cttccattct 901 tttcttctgt cttctctcag atgagtcaat cttggtcctt tctaatgcaa agctcccatc 961 cctgcttcat gcgttagtcc aagtcctcat cataaaaaca tatgactgga gttggcattc 1021 acaaagttgt ctttgaaatg gggagtaagg tgacagagga gaaaaagaag agctctggat 1081 tctcagacat gttaataatt tttacatatc atatataaat gggattttgc agagaagaac 1141 cagaaataga tgggagagca atggacagga aaggcagatg agggaccgaa gagacacagc 1201 tcccaaaaga aagttagcct tacaaaaacc aagacgataa agagaaatgc ttaagtttag 1261 ggaatccagt ggaagcagtg atttaaggtg aacaaaaggt gaaccttaag ttgaaatgag 1321 aagtgtagga ttttcaagtt tagtttctgg gagtgtaaaa ataaaaaaac aattgtgatg 1381 tcagaggctg aaagattata gttgtcattt gaacttgggg ataaaggaga catctatgac 1441 ttggctggaa aagacagagc taatgtacat tgcaaagcac atatttatag caggaaaatg 1501 ggaagatttc tctttaattc tggagatgga gtggggatgg ggagagtaga ctactcattt 1561 taagggtgaa acattggaat tcaacttgtt tgatgttata ttaattggtg gttaattact 1621 aagctaagta cgtataaaac ttttatctat ggctagcttg tccccccaaa gtcatgcaat 1681 atagtgaact ggctttcgca ctttaaatta ttcattgatc atgtaatgat tcagatgatt 1741 catcttccaa gatggacact gaaactaaca ctcatagtag gttgtggttt aaagagtgga 1801 acaaccgcca gtctcattag tggaaattgt gatggttgaa tttatcaagg atgaacatac 1861 acggtcttct ttctgagatt ttctttaaga ttttcgcaca gataatctat ttcttaggtt 1921 ttggagagaa aacttgaatt ttattgatcc ctcagaactc aatctttcag atttcaaagg 1981 agctatttct tttaatgggg actctgttaa tatttataaa agctcttcac aggatggagg 2041 gtgggaggga aactccatcc caacaagaca aaaagaatga agcatgaggc tccacctagt 2101 tcatcactgc tccttgaaat acatcagtat tgaaagacac atccacccca cccccaaccc 2161 agccctattg ctgttccagc tcaagagtca gaggtcccga agctgtagct cttctacaat 2221 agtctccaaa aaatatggtt tatgatttga ttaaagaata ctgcctcgcc agaagctccc 2281 gagaggcaca tctggtagga cagattttgt gattgcaaaa gaagggggaa aaaaagaaag 2341 aaagaaaaga cctctctata caagataacc agaggcatca aactgaaatc ctcctgtgga 2401 aaataagcta gtacttctgg gcctgatggt gtagtgaaaa cctgtgcttg aggatacatt 2461 acagtgaaag agcaaagtga atagtaagta gctattactt acctccttag ggaggtgtgt 2521 tgtttgtctg tacatccccc acagcaccta gcacagtacc ttgcatctca cctgccactc 2581 actaaaaagt ctatcaagtt agttaattat cgagacaacg ccctcagaaa tgagagaaca 2641 gtaccctctt atccttgctg cactttccag cactgatacg ctgcctaaaa gaggactagg 2701 gcacaggttt gaattaatgt cacaaaactg gatgggcaag ttacaacggt gttgattaag 2761 gaaacagaac tcatggggca ccggatatct ccatcctgat gaacccttgg aaaaatgcca 2821 aagatgcata tccccaggca aatgcctgat tagtctggga ttgatagatt ggtctaggat 2881 tcagccctac tgggaagatg tctaaattat aatcagtgta gaaagcgaag ttctcctaga 2941 agaagaggca aaggttaaaa agaagaaaag aaaagaaagt gaagtccttt ctcccccaaa 3001 acctctcatc aatcaatcag ggtaacaaac agaacactag ggctctgtct gtggaccaaa 3061 cccaaaagcc ctgcggtcag ggccaggagg gtagatcatg tgtttgtggc aacttcctct 3121 gtgggctttt gcccaggtct gtccccaagc atacgatggc caaaacttct gcaccagagc 3181 agcatcctgt gtaacacagt caggtccagc agttagggaa aactgcccac tcagagtaga 3241 taatatctgg aaggaatgac tgtttgggaa aagttccaat gctagttcag tgccaaccct 3301 tccccacctt ctccagctct ctcccactgg ttcctcccct ctcaactgct ctggttctta 3361 taaaaacctc acagccttcc actaacatcc cataggagcc tctctcccta ctgctgctac 3421 acaagaccct gagactgacc tgcaggacga aaccatgaag agcctgatcc ttcttgccat 3481 cctggccgcc ttagcggtag taactttgtg ttatggtgag aaacttttct cccatttctc 3541 tgtgtttact tttctgcctc tgactttggc ttacttctat ttttcctctc cctcctcctc 3601 ttcttccccc tttctctgtt ataatcttaa agtaccatta ctttcacatt tcccagtctc 3661 cgcagaaact gatctgttct attaagtctt ttttatatcc taaatatcca gagtcttatg 3721 caacttaaca ggcaaacccg ttcagtggta agtctctgta tatctagaaa ctcatatttc 3781 agaaagaaga taccaaattc ccagccccct gcatcctcat ttttaaggat atttatttag 3841 actttggtat caatgggtta agggtattgt ttaaaccact tgcctttgag aaaatccatt 3901 tttatgtgaa gtattaagta tagccctttc tagggactgg acaatctcat gaacttacta 3961 tgtttgttca gttaattaat tttaaaataa agttttacat caaaagaatt ttagaaaaga 4021 atcattttca taactcctgt tgtcagaaaa taaattttgc ctgttttcta tatgtcatta 4081 aatatacctg catttgttca aagcttataa aaggaaatct gaagcaaagt tatttactta 4141 tttcagtctt ttgtttcaat tacctagata ttttcattgt tttaaaattt aaattacatt 4201 aacaaccata aagattatgc ttctcactct tgtattcaca aattttctgt attagaggat 4261 ttgatttctt cacctccttt ttaagttttg aagaaaattc acttgctggc aaatattaat 4321 agaagcttct tattccaaaa tttatctgct gtgctcagga gagtggcaga aagaagaaaa 4381 gaagcttctt attccaaaat ttatctgctg tgctcaggag agtggcagaa agaagaaaac 4441 ttcggctttg atatcgtttc agttctctct ctgaactggc atcgtgccca gggtgagctg 4501 tcagctggag ctagtggttt ctgtggctgc caatttaaca caggttctta agaggctttc 4561 ggaaccctct tagaaacctg ccctagtaag cccagcagag caactgccct gtagttctct 4621 tgcctggaga aacctggctg tcttctggat ccttcttaat cctctttgac cctgttctca 4681 aacaggctct gaataaatca gagaagaagg ttctctggag acttctgtac agcacttaaa 4741 gtgtcttatt ttgcttgtct gaagacgtca tagcccttgg gaaattttag ctgaaaatgg 4801 ccactccctc cttcaacatc agagaaacta aaatatagag atatccacag caaggccaga 4861 gctagagaaa aacctcataa atcctaaatt cctgaaattt ctaataacca cactgctaaa 4921 tatattcttc atgtttttag actctttcct cttcttccat ccctgtattt aaactatcac 4981 agtgtctaaa ttgataaata ataacataat gaatcatgga taaatattga tataatgaat 5041 cttttttttt taatttcaga atcacatgaa agcatggaat cttatgaact tagtaagtga 5101 atatttaact tctttattca aatcccttgc attaaagaac ctcttcttat ttttaaataa 5161 acaagatgga aagatatata acagggaggg aaaagggggc ctcttttgga aaactaaagt 5221 aaatttttaa atctaatgac tataaaaatt gccaaaggag caatttttta agtttgaagt 5281 agtgcaatat gggatttaag ctacaggcga catatttaga agccataaaa tctcatttgg 5341 aaattttaaa ttggcaccac gtcaactgca cagatggaaa acgaggagta atgacaaatg 5401 gtaaagcaca gagctggacg ccaagtcagc tgggagacca caggcgccac gttaagctga 5461 gtgctgtttt ggtttttttg tgtttttctt tcttgttttt ttttttgaga cagtgtctca 5521 ctctgtcgcc caggctagag tgcagtggtg tgatctcggc tcgccgcaac ctccacctcc 5581 caggttcagg caattctcat gcctcagcct cctgagtagc tgggattaca ggcccatgac 5641 atcatgcctg gctaattttt gtatttttag tagagatggg gtttcaccat gttgtccagg 5701 ctggtctcga actcctggcc tcaagtgatc cacccaccac agcctcccaa agtgccggga 5761 ttacaggcat gagccaccac acccagccag ctgattgctg ttgaatagct ggatttataa 5821 agactgagca taggaggaaa tggcacatca ctctcatttt taatttattc attattttta 5881 tagtgtttaa actgttcatg tatcggcaat ctagttatgc ttcataaatc ctcaggacag 5941 agaatttctc ctcaaaagga atttaaaatc taccaagtag aaatacagaa attaagaaag 6001 gcaaagtgat cgtccaaact caaaaccaac aaagcctata tgacaagtct ctaagacaca 6061 tggattgatt actgatttca tttgatcagg aagttaatga aatctacttt atactctcct 6121 ttaatttttg ccaatctccg tttatatgag ttgcataagt taaggcactt tcaaatatat 6181 ttgtgtcaag gaatattcac ggaaatattt ccagctatgt gtcgctaaaa ctgcatttat 6241 ttattttctg ttctaagatc ccttcattaa caggagaaat gcaaatacct tcatatcccc 6301 tcagcagaga tggagagcta aagtccaaga gaggtcagta acaaaacttc atgaggagtg 6361 gtcatttttc ccagtgtaga tcacagatct gaattggagt gggaaacagc tttttcatca 6421 tatacattat ttctaattgt atctttaaaa tcaaaaaact taaaagcaat attcagaaaa 6481 caactgaatt attagaaaat tatttgggga aagatccgga aaggagaagg aaggaggaga 6541 gaaaggagga cagaaagaaa acttctattt tcattaaaaa aaaaaaaaaa atctcctgtt 6601 ctgccttccc tccctggttt tttttttggt tggttggttg gtttttctga gacagagtct 6661 cactctgttg cccagactgg attatagtgg cactatctcg tgcctcagcc tcccaagtag 6721 ctgggattat aggcacgtgc taccatgtcc agctattttt gcattttttg tagagacggg 6781 gttttgtcat gttggccagg ctagtcttga actcctgacc tcaagtgatc cacccacctc 6841 agcctcccaa agtgctggga ttacaggcct gagccaccgc acccagcctc tccctgttct 6901 ttaaatatct cttaatatag gggggcatgg agagaaagtc tctccaatat tttcttcttc 6961 ttttccattt ttgtattttt ccactttatc cttctcaatt ttggcctctt cttccacttt 7021 ctaggatccg agaacgctct aagcctgtcc acgagctcaa tagggaagcc tgtgatgact 7081 acagactttg cgaacgctac gccatggttt atggatacaa tgctgcctat aatcgctact 7141 tcaggaagcg ccgagggacc aaatgagact gagggaagaa aaaaaatctc tttttttctg 7201 gaggctggca cctgattttg tatccccctg tagcagcatt actgaaatac ataggcttat 7261 atacaatgct tctttcctgt atattctctt gtctggctgc accccttttt cccgccccca 7321 gattgataag taatgaaagt gcactgcagt gagggtcaaa ggagagtcaa catatgtgat 7381 tgttccataa taaacttctg gtgtgatact ttcatcttgt aaatctgctt tcttttggga 7441 agatattgag atatttaaat catggcccac cttacccaaa ataggagatt ctgttcatct 7501 catatctagt attaattaga aaaataacta cataaaaaga aggaagctaa gaaggcactc 7561 actcagccat aaattctcta aaccctctct accttggaat ccgtgaatgg aatctggtat 7621 gttttttgca ggattttcct attgtaaatt gtggcaaata cagggctccc ttcatttgct 7681 tttcatctct tatgcatcaa agtcaaaaac atttctgaat caagataatc taga //