GenBank-Updates@genbank.bio.net (12/01/90)
LOCUS HUMIGFIA 1758 bp ds-DNA PRI 01-DEC-1990
DEFINITION Human insulin-like growth factor I (IGF-I) gene, exon 1A.
ACCESSION M37483
KEYWORDS insulin-like growth factor I.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1758)
AUTHORS Tobin,G., Yee,D., Brunner,N. and Rotwein,P.
TITLE A novel human insulin-like growth factor messenger RNA is expressed
in normal and tumor cells
JOURNAL Unpublished (1990) Washington Univ Sch Med, 660 S. Euclid Ave., Box
8127, St. Louis, MO 63110
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [Unpublished (1990)
Washington Univ Sch Med, 660 S. Euclid Ave., Box8127, St. Lou]
kindly submitted by P.S.Rotwein, 03-AUG-1990.
FEATURES from to/span description
pept 1322 / 1336 insulin-like growth factor I precursor
sigp 1322 1336 insulin-like growth factor I signal peptide
pre-msg < 1 > 1758 IGF-I mRNA and introns
IVS 1337 1758 IGF-I intron A1
BASE COUNT 470 a 350 c 358 g 580 t
ORIGIN
1 aagcttttaa atatgatctt tggagctaag gtcccggaac tctgcactta tgcccagaga
61 gagtgttaaa gttagagtaa agtgtaattt ttcttccaaa aaagaactcc ttgacaactc
121 tctgaccttg catattttgt ataatttaaa caaatacata ctgtatatgg aaagcagaaa
181 ctttctaaga gctgcttgcc caacttttct gtttagaaga ggactttcat gggcaaagtt
241 tggacttggg gttctgtgtt ataaaactct gattttatat tcagtgtcgt gaagtccctt
301 taggtaaatc tggctgctgc tgtcagtgca ccgacttctc gtttccgatt gctggccgta
361 gttctagttt ccattctcag caaaattata tccttcaaga cttgtgtttt tttttcaatt
421 tgcaagcgct tttaagctgc tgtcactggc tccaccgatt caattgcctg agggctcaat
481 tcataagacg tctctgccac ttagtgcagc attcagttgc tgctttcaaa cacttcacca
541 ctacgacttt ccctagtcaa gtaagtggct ccaggagtta aagatacacc cttgtcaggc
601 acctgattct gctgttcctg agatgccaac acatgcaggc caccttgctt tcaaagaaat
661 gacgtcactg tgcatacata ctatgtgatc tagcagctgg agtttttgtc tccttactta
721 ggggatcata aaagaggctg tggagcgtta tctctgcatt aattacaagt taagaaaatt
781 gtttccaaat gcacttttca tgctgtgtat gctgaacact tcagaagtgg agctcttaat
841 aagttgttac ttttttctgt acttgaagca ggaagtggtt tgagggagct gcgtggtctt
901 tcacatgtaa ttcagtgggt aaaggtgtcc tgcccagagg cagagctcac cagcgtattg
961 tactctgact ctcaaggtat ttccaagtga gtgagtcggg ggaagggagt aagggagtgg
1021 actggagctt gggtcactat ctgggctgct acaataggca tacaatggaa ataggtggct
1081 tgactggggg gaaaagattg acttaaatcc cagctgtgca atttgttcat tgtttcaatg
1141 gacaaaaggc agtttaccca ggctcataat agcatacctg cctgggtgtc caaatgtaac
1201 tagatgcttt cacaaacccc acccacaaag cagcacatgt ttttaagact tcagttttct
1261 attcacatcg gcctcataat acccaccctg acctgctgta aaagacctgg aacaaacaaa
1321 aatgattaca cctacagtga gtattttctt atgacggttg ccctcaaatt ttacagggca
1381 ttttcattgt ggcccagaca tctggaatca attaatattc catttatcta agattaaaaa
1441 aaaaaagaac ttttaaaatt tgggtttgtg aatgattttt gagaaagtgt tttctgattt
1501 ttttttcttt ttttctcatg tctttctgat tcttcccttt tttttctatc atatctttcc
1561 tttctctcta ttgatttctt ttgtgtttgg caaaataaaa ggccaaggaa ataatgaaca
1621 tatgggacca cttgtttcac actttaaact cctaagcaag ttcggtattg ttttcatttg
1681 tgggaacata aaattctctg gttctctgtg ggtgtactgg actgttccta cactaaagga
1741 aaatgcacta gaggtctg
//GenBank-Updates@genbank.bio.net (12/01/90)
LOCUS HUMIGFIB 612 bp ss-mRNA PRI 01-DEC-1990
DEFINITION Human insulin-like growth factor I (IGF-I) mRNA, complete cds.
ACCESSION M37484
KEYWORDS insulin-like growth factor I.
SOURCE Human transplantable breast tumor cell line 61, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 612)
AUTHORS Tobin,G., Yee,D., Brunner,N. and Rotwein,P.
TITLE A novel human insulin-like growth factor messenger RNA is expressed
in normal and tumor cells
JOURNAL Unpublished (1990) Washington Univ Sch Med, 660 S. Euclid Ave., Box
8127, St. Louis, MO 63110
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [Unpublished (1990)
Washington Univ Sch Med, 660 S. Euclid Ave., Box8127, St. Lou]
kindly submitted by P.S.Rotwein, 03-AUG-1990.
FEATURES from to/span description
pept 151 564 insulin-like growth factor precursor
sigp 151 246 insulin-like growth factor signal peptide
matp 247 561 insulin-like growth factor
BASE COUNT 155 a 173 c 155 g 129 t
ORIGIN
1 gcatacctgc ctgggtgtcc aaatgtaact agatgctttc acaaacccca cccacaaagc
61 agcacatgtt tttaagactt cagttttcta ttcacatcgg cctcataata cccaccctga
121 cctgctgtaa aagacctgga acaaacaaaa atgattacac ctacagtgaa gatgcacacc
181 atgtcctcct cgcatctctt ctacctggcg ctgtgcctgc tcaccttcac cagctctgcc
241 acggctggac cggagacgct ctgcggggct gagctggtgg atgctcttca gttcgtgtgt
301 ggagacaggg gcttttattt caacaagccc acagggtatg gctccagcag tcggagggcg
361 cctcagacag gcatcgtgga tgagtgctgc ttccggagct gtgatctaag gaggctggag
421 atgtattgcg cacccctcaa gcctgccaag tcagctcgct ctgtccgtgc ccagcgccac
481 accgacatgc ccaagaccca gaaggaagta catttgaaga acgcaagtag agggagtgca
541 ggaaacaaga actacaggat gtaggaagac cctcctgagg agtgaagagt gacatgccac
601 cgcaggatcc tt
//GenBank-Updates@genbank.bio.net (01/31/91)
LOCUS HUMIGFIA 1758 bp ds-DNA PRI 31-JAN-1991
DEFINITION Human insulin-like growth factor I (IGF-I) gene, exon 1A.
ACCESSION M37483
KEYWORDS insulin-like growth factor I.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1758)
AUTHORS Tobin,G., Yee,D., Brunner,N. and Rotwein,P.
TITLE A novel human insulin-like growth factor messenger RNA is expressed
in normal and tumor cells
JOURNAL Unpublished (1990) Washington Univ Sch Med, 660 S. Euclid Ave., Box
8127, St. Louis, MO 63110
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [Unpublished (1990)
Washington Univ Sch Med, 660 S. Euclid Ave., Box8127, St. Lou]
kindly submitted
by P.S.Rotwein, 03-AUG-1990.
FEATURES Location/Qualifiers
exon <1..1336
/number=1A
/gene="IGF-I gene"
CDS 1322..>1336
/product="insulin-like growth factor I"
/gene="IGF-I gene"
/codon_start=1322
sig_peptide 1322..>1336
/product="insulin-like growth factor I"
/gene="IGF-I gene"
/codon_start=1322
intron 1337..>1758
/number=1A
/gene="IGF-I gene"
BASE COUNT 470 a 350 c 358 g 580 t
ORIGIN
1 aagcttttaa atatgatctt tggagctaag gtcccggaac tctgcactta tgcccagaga
61 gagtgttaaa gttagagtaa agtgtaattt ttcttccaaa aaagaactcc ttgacaactc
121 tctgaccttg catattttgt ataatttaaa caaatacata ctgtatatgg aaagcagaaa
181 ctttctaaga gctgcttgcc caacttttct gtttagaaga ggactttcat gggcaaagtt
241 tggacttggg gttctgtgtt ataaaactct gattttatat tcagtgtcgt gaagtccctt
301 taggtaaatc tggctgctgc tgtcagtgca ccgacttctc gtttccgatt gctggccgta
361 gttctagttt ccattctcag caaaattata tccttcaaga cttgtgtttt tttttcaatt
421 tgcaagcgct tttaagctgc tgtcactggc tccaccgatt caattgcctg agggctcaat
481 tcataagacg tctctgccac ttagtgcagc attcagttgc tgctttcaaa cacttcacca
541 ctacgacttt ccctagtcaa gtaagtggct ccaggagtta aagatacacc cttgtcaggc
601 acctgattct gctgttcctg agatgccaac acatgcaggc caccttgctt tcaaagaaat
661 gacgtcactg tgcatacata ctatgtgatc tagcagctgg agtttttgtc tccttactta
721 ggggatcata aaagaggctg tggagcgtta tctctgcatt aattacaagt taagaaaatt
781 gtttccaaat gcacttttca tgctgtgtat gctgaacact tcagaagtgg agctcttaat
841 aagttgttac ttttttctgt acttgaagca ggaagtggtt tgagggagct gcgtggtctt
901 tcacatgtaa ttcagtgggt aaaggtgtcc tgcccagagg cagagctcac cagcgtattg
961 tactctgact ctcaaggtat ttccaagtga gtgagtcggg ggaagggagt aagggagtgg
1021 actggagctt gggtcactat ctgggctgct acaataggca tacaatggaa ataggtggct
1081 tgactggggg gaaaagattg acttaaatcc cagctgtgca atttgttcat tgtttcaatg
1141 gacaaaaggc agtttaccca ggctcataat agcatacctg cctgggtgtc caaatgtaac
1201 tagatgcttt cacaaacccc acccacaaag cagcacatgt ttttaagact tcagttttct
1261 attcacatcg gcctcataat acccaccctg acctgctgta aaagacctgg aacaaacaaa
1321 aatgattaca cctacagtga gtattttctt atgacggttg ccctcaaatt ttacagggca
1381 ttttcattgt ggcccagaca tctggaatca attaatattc catttatcta agattaaaaa
1441 aaaaaagaac ttttaaaatt tgggtttgtg aatgattttt gagaaagtgt tttctgattt
1501 ttttttcttt ttttctcatg tctttctgat tcttcccttt tttttctatc atatctttcc
1561 tttctctcta ttgatttctt ttgtgtttgg caaaataaaa ggccaaggaa ataatgaaca
1621 tatgggacca cttgtttcac actttaaact cctaagcaag ttcggtattg ttttcatttg
1681 tgggaacata aaattctctg gttctctgtg ggtgtactgg actgttccta cactaaagga
1741 aaatgcacta gaggtctg
//GenBank-Updates@genbank.bio.net (01/31/91)
LOCUS HUMIGFIB 612 bp ss-mRNA PRI 31-JAN-1991
DEFINITION Human insulin-like growth factor I (IGF-I) mRNA, complete cds.
ACCESSION M37484
KEYWORDS insulin-like growth factor I.
SOURCE Human transplantable breast tumor cell line 61, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 612)
AUTHORS Tobin,G., Yee,D., Brunner,N. and Rotwein,P.
TITLE A novel human insulin-like growth factor messenger RNA is expressed
in normal and tumor cells
JOURNAL Unpublished (1990) Washington Univ Sch Med, 660 S. Euclid Ave., Box
8127, St. Louis, MO 63110
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [Unpublished (1990)
Washington Univ Sch Med, 660 S. Euclid Ave., Box8127, St. Lou]
kindly submitted
by P.S.Rotwein, 03-AUG-1990.
FEATURES Location/Qualifiers
CDS 151..564
/product="insulin-like growth factor I"
/gene="IGF-I gene"
/codon_start=151
sig_peptide 151..246
/gene="IGF-I gene"
/codon_start=151
mat_peptide 247..561
/product="insulin-like growth factor I"
/gene="IGF-I gene"
/codon_start=247
BASE COUNT 155 a 173 c 155 g 129 t
ORIGIN
1 gcatacctgc ctgggtgtcc aaatgtaact agatgctttc acaaacccca cccacaaagc
61 agcacatgtt tttaagactt cagttttcta ttcacatcgg cctcataata cccaccctga
121 cctgctgtaa aagacctgga acaaacaaaa atgattacac ctacagtgaa gatgcacacc
181 atgtcctcct cgcatctctt ctacctggcg ctgtgcctgc tcaccttcac cagctctgcc
241 acggctggac cggagacgct ctgcggggct gagctggtgg atgctcttca gttcgtgtgt
301 ggagacaggg gcttttattt caacaagccc acagggtatg gctccagcag tcggagggcg
361 cctcagacag gcatcgtgga tgagtgctgc ttccggagct gtgatctaag gaggctggag
421 atgtattgcg cacccctcaa gcctgccaag tcagctcgct ctgtccgtgc ccagcgccac
481 accgacatgc ccaagaccca gaaggaagta catttgaaga acgcaagtag agggagtgca
541 ggaaacaaga actacaggat gtaggaagac cctcctgagg agtgaagagt gacatgccac
601 cgcaggatcc tt
//GenBank-Updates@genbank.bio.net (02/06/91)
LOCUS HUMIGFIA 1758 bp ds-DNA PRI 06-FEB-1991
DEFINITION Human insulin-like growth factor I (IGF-I) gene, exon 1A.
ACCESSION M37483
KEYWORDS insulin-like growth factor I.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1758)
AUTHORS Tobin,G., Yee,D., Bruenner,N. and Rotwein,P.
TITLE A novel human insulin-like growth factor I messenger RNA is
expressed in normal and tumor cells
JOURNAL Mol. Endocrinol. 4, 1914-1920 (1990)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [Unpublished (1990)
Washington Univ Sch Med, 660 S. Euclid Ave., Box8127, St. Lou]
kindly submitted
by P.S.Rotwein, 03-AUG-1990.
FEATURES Location/Qualifiers
exon <1..1336
/number=1A
/gene="IGF-I gene"
CDS 1322..>1336
/gene="IGF-I gene"
/codon_start=1322
/product="insulin-like growth factor I"
sig_peptide 1322..>1336
/gene="IGF-I gene"
/codon_start=1322
/product="insulin-like growth factor I"
intron 1337..>1758
/number=1A
/gene="IGF-I gene"
BASE COUNT 470 a 350 c 358 g 580 t
ORIGIN
1 aagcttttaa atatgatctt tggagctaag gtcccggaac tctgcactta tgcccagaga
61 gagtgttaaa gttagagtaa agtgtaattt ttcttccaaa aaagaactcc ttgacaactc
121 tctgaccttg catattttgt ataatttaaa caaatacata ctgtatatgg aaagcagaaa
181 ctttctaaga gctgcttgcc caacttttct gtttagaaga ggactttcat gggcaaagtt
241 tggacttggg gttctgtgtt ataaaactct gattttatat tcagtgtcgt gaagtccctt
301 taggtaaatc tggctgctgc tgtcagtgca ccgacttctc gtttccgatt gctggccgta
361 gttctagttt ccattctcag caaaattata tccttcaaga cttgtgtttt tttttcaatt
421 tgcaagcgct tttaagctgc tgtcactggc tccaccgatt caattgcctg agggctcaat
481 tcataagacg tctctgccac ttagtgcagc attcagttgc tgctttcaaa cacttcacca
541 ctacgacttt ccctagtcaa gtaagtggct ccaggagtta aagatacacc cttgtcaggc
601 acctgattct gctgttcctg agatgccaac acatgcaggc caccttgctt tcaaagaaat
661 gacgtcactg tgcatacata ctatgtgatc tagcagctgg agtttttgtc tccttactta
721 ggggatcata aaagaggctg tggagcgtta tctctgcatt aattacaagt taagaaaatt
781 gtttccaaat gcacttttca tgctgtgtat gctgaacact tcagaagtgg agctcttaat
841 aagttgttac ttttttctgt acttgaagca ggaagtggtt tgagggagct gcgtggtctt
901 tcacatgtaa ttcagtgggt aaaggtgtcc tgcccagagg cagagctcac cagcgtattg
961 tactctgact ctcaaggtat ttccaagtga gtgagtcggg ggaagggagt aagggagtgg
1021 actggagctt gggtcactat ctgggctgct acaataggca tacaatggaa ataggtggct
1081 tgactggggg gaaaagattg acttaaatcc cagctgtgca atttgttcat tgtttcaatg
1141 gacaaaaggc agtttaccca ggctcataat agcatacctg cctgggtgtc caaatgtaac
1201 tagatgcttt cacaaacccc acccacaaag cagcacatgt ttttaagact tcagttttct
1261 attcacatcg gcctcataat acccaccctg acctgctgta aaagacctgg aacaaacaaa
1321 aatgattaca cctacagtga gtattttctt atgacggttg ccctcaaatt ttacagggca
1381 ttttcattgt ggcccagaca tctggaatca attaatattc catttatcta agattaaaaa
1441 aaaaaagaac ttttaaaatt tgggtttgtg aatgattttt gagaaagtgt tttctgattt
1501 ttttttcttt ttttctcatg tctttctgat tcttcccttt tttttctatc atatctttcc
1561 tttctctcta ttgatttctt ttgtgtttgg caaaataaaa ggccaaggaa ataatgaaca
1621 tatgggacca cttgtttcac actttaaact cctaagcaag ttcggtattg ttttcatttg
1681 tgggaacata aaattctctg gttctctgtg ggtgtactgg actgttccta cactaaagga
1741 aaatgcacta gaggtctg
//GenBank-Updates@genbank.bio.net (02/06/91)
LOCUS HUMIGFIB 612 bp ss-mRNA PRI 06-FEB-1991
DEFINITION Human insulin-like growth factor I (IGF-I) mRNA, complete cds.
ACCESSION M37484
KEYWORDS insulin-like growth factor I.
SOURCE Human transplantable breast tumor cell line 61, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 612)
AUTHORS Tobin,G., Yee,D., Bruenner,N. and Rotwein,P.
TITLE A novel human insulin-like growth factor I messenger RNA is
expressed in normal and tumor cells
JOURNAL Mol. Endocrinol. 4, 1914-1920 (1990)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [Unpublished (1990)
Washington Univ Sch Med, 660 S. Euclid Ave., Box8127, St. Lou]
kindly submitted
by P.S.Rotwein, 03-AUG-1990.
FEATURES Location/Qualifiers
CDS 151..564
/gene="IGF-I gene"
/codon_start=151
/product="insulin-like growth factor I"
sig_peptide 151..246
/gene="IGF-I gene"
/codon_start=151
mat_peptide 247..561
/gene="IGF-I gene"
/codon_start=247
/product="insulin-like growth factor I"
BASE COUNT 155 a 173 c 155 g 129 t
ORIGIN
1 gcatacctgc ctgggtgtcc aaatgtaact agatgctttc acaaacccca cccacaaagc
61 agcacatgtt tttaagactt cagttttcta ttcacatcgg cctcataata cccaccctga
121 cctgctgtaa aagacctgga acaaacaaaa atgattacac ctacagtgaa gatgcacacc
181 atgtcctcct cgcatctctt ctacctggcg ctgtgcctgc tcaccttcac cagctctgcc
241 acggctggac cggagacgct ctgcggggct gagctggtgg atgctcttca gttcgtgtgt
301 ggagacaggg gcttttattt caacaagccc acagggtatg gctccagcag tcggagggcg
361 cctcagacag gcatcgtgga tgagtgctgc ttccggagct gtgatctaag gaggctggag
421 atgtattgcg cacccctcaa gcctgccaag tcagctcgct ctgtccgtgc ccagcgccac
481 accgacatgc ccaagaccca gaaggaagta catttgaaga acgcaagtag agggagtgca
541 ggaaacaaga actacaggat gtaggaagac cctcctgagg agtgaagagt gacatgccac
601 cgcaggatcc tt
//