GenBank-Updates@genbank.bio.net (02/07/91)
LOCUS HUMPAIA 17509 bp ds-DNA PRI 07-FEB-1991
DEFINITION Human, plasminogen activator inhibitor-1 gene, exons 2 to 9.
ACCESSION J03764 M55991
KEYWORDS plasminogen activator; serine protease.
SOURCE Human DNA, clones PAI-Cos 1 and PAI-Cos 2.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 17509)
AUTHORS Bosma,P.J., van den Berg,E.A., Kooistra,T., Siemieniak,D.R. and
Slightom,J.L.
TITLE Human plasminogen activator inhibitor-1 gene: Promoter and
structural gene nucleotide sequences
JOURNAL J. Biol. Chem. 263, 9129-9141 (1988)
STANDARD full staff_entry
REFERENCE 2 (bases 1 to 17509)
AUTHORS Bosma,P.J., Kooistra,T., Siemieniak,D.R. and Slightom,J.L.
TITLE Further characterization and functional analysis of the 5'-flanking
DNA of human plasminogen activator inhibitor-1 gene
JOURNAL Unpublished (1990)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence [J. Biol. Chem. 263,
9129-9141 (1988)] kindly submitted by
J.L.Slightom 12-APR-1988
FEATURES Location/Qualifiers
CDS join(4455..4725,6490..6723,
7947..8141,9747..9945,11538..11638,
11758..11844,13053..13136,13457..13494)
/note="plasminogen activator-1"
prim_transcript 3040..15199
/note="plasminogen activator-1 mRNA and introns"
intron 3307..4453
/note="PAI-1, intron A"
exon 4455..4725
/note="plasminogen activator-1, exon 2 (first coding exon)
/nomgen='PLANH1' /map='7q21.3-q22'
/hgml_locus_uid='LS0101Y'"
/codon_start=4455
intron 4726..6489
/note="PAI-1, intron B"
exon 6490..6723
/note="plasminogen activator-1, exon 3"
/codon_start=6490
intron 6724..7946
/note="PAI-1, intron C"
exon 7947..8141
/note="plasminogen activator-1, exon 4"
/codon_start=7947
intron 8142..9746
/note="PAI-1, intron D"
exon 9747..9945
/note="plasminogen activator-1, exon 5"
/codon_start=9747
intron 9946..11537
/note="PAI-1, intron E"
exon 11538..11638
/note="plasminogen activator-1, exon 6"
/codon_start=11538
intron 11639..11757
/note="PAI-1, intron F"
exon 11758..11844
/note="plasminogen activator-1, exon 7"
/codon_start=11758
intron 11845..13052
/note="PAI-1, intron G"
exon 13053..13136
/note="plasminogen activator-1, exon 8"
/codon_start=13053
intron 13137..13456
/note="PAI-1, intron H"
exon 13457..13494
/note="plasminogen activator-1, exon 9"
/codon_start=13457
BASE COUNT 4974 a 4406 c 4386 g 3743 t
ORIGIN 131 bp upstream of SacI site; chromosome 7q21.3-q22.
1 gggacatcta gctatgtcta gacccattga actttcaagt cttcgaggct tggtactgcc
61 tgatccctgt tcccctctga tccttaaggt cagagagcaa agccttgggg ggtacttttt
121 tttttttttt ttgagacaga ttcttgctct gtcacccagg ctggagtgca atagcatgat
181 ctcggctcac tgcaacctcc acctcccagg ttcaagcgat tctcctgcct cagcctccca
241 agcagctagg attacaggca cgcaccacca tgcctagctg atttttatat ttttagtaga
301 gatggggttt catcatattg gccgggctgg tcttgaactc ctggcctcaa gtgatccacc
361 tgccttggcc tcccgaagtg ctaggattac aggtgtgagc caccatgccc tgtcttgggg
421 tacttttgag gacaagagtt aagttcggga ctgggcatgt tggcttatac actttgggag
481 gcaaaggtga gaggattgtt ccagcccagg aatttgagac cagcctggtc aacatagcaa
541 gactctgtct ctataagaaa aataataatt agctgggcgt ggtggtgctt gcctgtagtc
601 cccgatactt gcttgagccc aggagttcaa gtctgcagtg tgctatgatc acatgactgc
661 actccagcct tggtgacaga gtgagaccct gtctccaaaa aaaaaaaaaa aaagagatgg
721 gtttggggct ggacttgtct tcttccaaga ggtcagggca gttgcttctt cctcaccgct
781 aaccacactc tcagggactc caaaccacaa ctaagaaaag gaaaaagaca taaacaagag
841 gcagtttcac aggaagagtt ctcctaatgt gtctgtgagc ctaactttcc gactgtggtt
901 ctcctctctt tccctgccag ctgtgagaaa gcaaagccta aggcagatta aaaagcagga
961 gggctgctca gtgtggttgc ccttggtatc tgtttactga aaaaattcaa aacaaacatc
1021 cgacgcttcc acccactgaa acttcctgtg actctgctat cggctgttgc catggattct
1081 cccaactgaa ccccaccaca tacactaaac ccaacagtcc gtggacccca agtatgccat
1141 ctctccaata caggaccccc tgggcagcac cctggccacc cttccatcca caacatccag
1201 accacacggc caagggcacc tgaccctgtc aaaaccccaa atccagctgg gcgcggtggc
1261 tcatgcctgt aatcccagca tttgggaggc cgaggcagcc ggattcacga agtcaggagt
1321 tcgagaccag cctgaccaaa catggtgaac cccgtctcta ctaaaataca aaaattagcc
1381 gggcgtggtg gtgcacacct gtaatcccag ctactcggga ggctgaggca ggagaaccac
1441 ttgaacctgg gaggcggaga ttgcagtgag ccaagatagt gctactgcac tcagcctggg
1501 caacaaaata agactccgtc tcaaaacaga aaaacaaaaa aaacaaaaaa caacaacaac
1561 aacaaaatcc actagtctag ccctacatgc tcacccactg ctagccagtt tccaccctct
1621 acagcagagg tacccaacct ctgggccagg ggcccgtact ggtccatagc ctgttaggaa
1681 cccaggctgc ataaccagga ggtgagtggc aggtgagtga aatttcatct gtagttacag
1741 ccactcctca tcactcgcat taccaccaga gctccactcc ctgtcagatc agcggcggca
1801 ttagattctc ataggagctc gaaccctatt ctaaactgtt catgtgaggg atctaggttg
1861 caagctccct atgagaatct aatgcctgat gatctgtcac ggtctcccat cacccctaga
1921 tgggaccatc tagttgcagg aaaacaagct caggctccca ctgattctac acgatggtga
1981 attgtggaat tatttcatta tatatattac aatgtaataa taatagaaat aaagcacaca
2041 ataaatgtaa tgtgcttgaa tcatcccgaa accatcccac cctggtctgt gaaaaaattg
2101 tcttccatga aaccagtccc tggtgccaaa aacgttgagg accactgctc cacagaatct
2161 atcggtcact cttcctcccc tcaccccctt gccctaaaag cacaccctgc aaacctgcca
2221 tgaattgaca ctctgtttct atcccttttc cccttgtgtc tgtgtctgga ggaagaggat
2281 aaaggacaag ctgccccaag tcctagcggg cagctcgagg aagtgaaact tacacgttgg
2341 tctcctgttt ccttaccaag cttttaccat ggtaacccct ggtcccgttc agccaccacc
2401 accccaccca gcacacctcc aacctcagcc agacaaggtt gttgacacaa gagagccctc
2461 aggggcacag agagagtctg gacacgtggg ggagtcagcc gtgtatcatc ggaggcggcc
2521 gggcacatgg cagggatgag ggaaagacca agagtcctct gttgggccca agtcctagac
2581 agacaaaacc tagacaatca cgtggctggc tgcatgccct gtggctgttg ggctgggccc
2641 aggaggaggg aggggcgctc tttcctggag gtggtccaga gcaccgggtg gacagccctg
2701 ggggaaaact tccacgtttt gatggaggtt atctttgata actccacagt gacctggttc
2761 gccaaaggaa aagcaggcaa cgtgagctgt tttttttttc tccaagctga acactagggg
2821 tcctaggctt ttgggtcacc cggcatggca gacagtcaac ctggcaggac atccgggaga
2881 gacagacaca ggcagagggc agaaaggtca agggaggttc tcaggccaag gctattgggg
2941 tttgctcaat tgttcctgaa tgctcttaca cacgtacaca cacagagcag cacacacaca
3001 cacacacaca tgcctcagca agtcccagag agggaggtgt cgagggggac ccgctggctg
3061 ttcagacgga ctcccagagc cagtgagtgg gtggggctgg aacatgagtt catctatttc
3121 ctgcccacat ctggtataaa aggaggcagt ggcccacaga ggagcacagc tgtgtttggc
3181 tgcagggcca agagcgctgt caagaagacc cacacgcccc cctccagcag ctgaattcct
3241 gcagctcagc agccgccgcc agagcaggac gaaccgccaa tcgcaaggca cctctgagaa
3301 cttcaggtag gagaaaagca aactccctcc aacctcttac ttcgggctta aggcagagaa
3361 ctcgcctccc cagaatctcc tccctccatg atcccccgct attcctctat tttcttttcc
3421 tcggacctgc agccttgggt cgaccctgcc ctaggggtga ctgcaggaga gcagggagga
3481 tggtcaggcg tcaccaacaa ccccatcacc cagtaacaag aaccttgact ctctcagtcc
3541 ctctgcatca agacacttac ccatttccca cctcatgcct gctaacttga atgaaacaat
3601 cgctgggaaa gcattaagag attaaggctg ggcactgtgg ctcatgcctg taatcccagc
3661 actttgtgag gctgaggcag gcagataact tgagcccagg agtttgagac cagcctgggc
3721 aacatggcaa aaccctgctc tcccaaaaaa atacaaaaat tagctgggcg tgctggtgtg
3781 cctgtattcc cagctacttg ggaggctgag gtgggaggat tgcttcagct ggggaggacg
3841 gaggctgcag ggagccaaga ctgagccatt gcacccagcc tgggtgacag agcaagaccc
3901 tgtctctaaa aatgaatgaa aggaaggaag aaagagagag aaagagagag aggaaagaag
3961 gaaggaagta aagaagaaag aaagaaagaa agaggaaaga ggaagaaaga aagaaaagaa
4021 agaaaagaaa agaaagcaaa tttaaagctt atgcaaatca aagatgttgt gataattgat
4081 aattgagtct gggctaaatt ccccctgggc tgcaaaggca gagagtggta atgactctca
4141 cctgcttttc ttctaaggct tttttacggg acacagaggg aagggagatg gactggattc
4201 caagattccc acagggcaag atgggcgaag actccctgcc actgcccggg gataagtcag
4261 tctgagtgag acggagtggg atgggcttag aacctgaaca tgtcatggtc tcttcctgca
4321 ccttgcccta gtgttcactt accacctgct tgcaggaaac aagaagagca gggcccacag
4381 ctggccagct cccctcccct cccgcctgtc ttccagaacg attccttcac cagccctctt
4441 tccattgctc taggatgcag atgtctccag ccctcacctg cctagtcctg ggcctggccc
4501 ttgtctttgg tgaagggtct gctgtgcacc atcccccatc ctacgtggcc cacctggcct
4561 cagacttcgg ggtgagggtg tttcagcagg tggcgcaggc ctccaaggac cgcaacgtgg
4621 ttttctcacc ctatggggtg gcctcggtgt tggccatgct ccagctgaca acaggaggag
4681 aaacccagca gcagattcaa gcagctatgg gattcaagat tgatggtgag ccacgggaca
4741 ccaggggagg tgggtggcat gcagaacaga cctaccagaa gccaaggaaa ggctggctct
4801 ggcttagccg agccaagccc catacagctg tgctgcaggg gccaccccat cttcttccca
4861 ctacactcca agtcactgga cccttgaatc tccaagggtg tctgaccagt agatttaccg
4921 cttattcacc accgtgtgat cttaacctcg ttaagtttgc ccatctacaa aatgaggatt
4981 atttgctgtc ctaaagaatt catgagccgg gcgcggtggc tcaaacgcct gtaatcccag
5041 cactttggga ggccaaggcg ggcggatcat gaggtcagga gatcaagacc atcctggcta
5101 acacagtgaa actccatctc tactaaaaat acaaaaaaaa ttagccaggc gtggtggcag
5161 gcgcctgtag tcccagctac tcgggaggct gaggcaggag aatggcatga acccaagagg
5221 cagagcttgc agtgagctga gatcgtgcca ctgcactcca gcctgggcga cagagagaga
5281 ctccgtctca aaaaaaaaaa ataaagaatt catggaatta cacttgtgaa atacttagca
5341 tagccatcac tataggaaaa aaatctaagg ccaggcacag tgcctcatgc ctgtaatctc
5401 agcacttttg gagtttgagg caggaggatc acccaaggct aggagttcaa ggccagcctg
5461 ggcaatacgg tgaaaccccg tctctaataa aaatataaaa attagtctga tgaggtggtg
5521 cacctgtaat cccagctact caggaagctg agacacaaga atcactttaa cccgggaggt
5581 ggaggtggca gtgagctgag atcacaccat tgcactccag cctaggtgac agagtgagac
5641 ctgtcaaaaa aaaaaaaaga aagagagaga gagagagaag agagagaaag aaagaagaag
5701 aaagaaagaa agagagagag agaaagaaag aaagaaagaa agaaagaaac aaagaaacaa
5761 agaaagaaag gaaaagaaaa aaaaaactaa ggccaggcaa ggtggcttat gactgtaatt
5821 tcagcacttt ggaagattga ggcaggagga tcacttgagg ccagaagttc gagacaagac
5881 tgagcaacag ggagacccct gcctctacaa aaaaatttac aaattagcca gatgtggtga
5941 cacatacctg tagtcccaac tactcaggag gctgaggtgg gaggatggct tgagcccagg
6001 agctggaggc tgcagtgagc tatgattgta ccactgcact tcagcctggg caacaaaggg
6061 aagccctgtc tgaaaaaaaa aaaaaaagaa aaagaagaag aaagaaaata tttgggttca
6121 accaggaggc gaggttgcag taagctgaca tcgcgccatt gcactccagc ctgggagaca
6181 agagcaaaac tccaactcaa aaaaaaaaaa aaaaaaaaac aggaagaaaa tatttagggt
6241 tcataactta agaacagaga aaaatattct agcccaaaga aagggttggg atctgagact
6301 tttgaagaaa ggaaggagat acagaaaaga gatttcatcc tggaatgaaa tctccctcca
6361 gagagccctg ggaaagcacg gtagccccca tccatcagag tggagcccct tgtgggggaa
6421 gtgggctcgg ctgggaaccc tcaattcagc ataagcctca catgtcctct cctctctgtc
6481 ccggtgcaga caagggcatg gcccccgccc tccggcatct gtacaaggag ctcatggggc
6541 catggaacaa ggatgagatc agcaccacag acgcgatctt cgtccagcgg gatctgaagc
6601 tggtccaggg cttcatgccc cacttcttca ggctgttccg gagcacggtc aagcaagtgg
6661 acttttcaga ggtggagaga gccagattca tcatcaatga ctgggtgaag acacacacaa
6721 aaggtgagca ggcagggaaa ggaaacccat ttcctgggcc tcaagagaaa gggaatttgg
6781 aaataaatcc acatatccca gttgggtgca gtagttcaca cctgtaatcc cagcccaaca
6841 ctttgggagg tctaggcgag aggaaggctt gaggcctgga gtttgagacc agcctggcca
6901 acataacaag acctcatctc ttcaaaaaat ttaaaaacca gccgggcatg gtggtgcaca
6961 cctgtagtcc cagctacttg ggaggctgag gtgggaggat cacttgagtc cagcagttca
7021 aggctgcagt gagctatgtt tgcaccacca cactccagcc tgagtcacag aacaagacct
7081 catctctaaa aaacaaacaa aaaccaaatc cacatatcct aaaaaatgct ccttttcagc
7141 attctcttct ctatggacaa agggctggat gctttaagaa ccaaatctta ggctgggcac
7201 ggtggctcac gcctctaatc ctagcacttt gagaggccaa ggcgggcaga ttgcctgagc
7261 acaggagttc gagaccagcc tggccaacat ggtgaaaccc tgtttctgtc aaaaatacaa
7321 aaaattagcc aggtgtgttg gcgcgtgcct ataatcccag ctgctcggga ggatgaggtt
7381 caaagaatca cttgaacccg ggaggcagag gctgcagtga gctgagatca tgccactgca
7441 ctccagcctg ggtgacagag caagactttg tctccaaaaa aaggaactag acgggttcat
7501 ttaaacccct gactgcagcc ctttgacata catccaattg aggactgggg actccgggaa
7561 acatctaaaa ggcttaaaaa ctttgtctaa cttcagccgg gcatggtggc tcacacctgt
7621 aatcccagca ctttgggagg ctgaggcagg tggatcacaa ggtcaggagt ttgagacgag
7681 cctgaccaac atggtgaaac cccgtctcta ctaaaaatac aaaaattagc caggcatggt
7741 ggcaggcgcc tgtaatccca gctattcggg aggctgaggc aggagaattg cttgaacccc
7801 ggagacagag gttgcagcga gccgagatcg cgccactgca ctccagcctg gcaatagagt
7861 gagactccat ctcaaaacaa caacaacaac aacaacaaca aaatcgtcta acttcctgat
7921 cttcctgatc attgattttc ccataggtat gatcagcaac ttgcttggga aaggagccgt
7981 ggaccagctg acacggctgg tgctggtgaa tgccctctac ttcaacggcc agtggaagac
8041 tcccttcccc gactccagca cccaccgccg cctcttccac aaatcagacg gcagcactgt
8101 ctctgtgccc atgatggctc agaccaacaa gttcaactat agtaagtcca agagcccctt
8161 ccccacagcc cacagcaact gcatctcatt cctggggtct cccaaggaat acccaaaatg
8221 tcaccctctg agggaggaag accacaggga atgctcccct ttaagggagg agagacccta
8281 gaatatactc cagctttgac aaagatttcc caagcaggag acatcaggat aatgggaaca
8341 gaagacagga ggtttatccc atgaaggatg aagaagctga aatccagaga ttccctcagg
8401 gccacatttg tccacctgac tccagggtct catcttcgtg tgttgctagt gtgattacct
8461 ggggatgaga aatcctgctg ggggagttga ggttaagagg atgaggactc caggtgctgt
8521 ggctcacgcc tgtaatccca gcactttggg aggccaaggc aggtggatca ggagtttgag
8581 gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc ctgtctctac taaaaatgca
8641 aaaattagcc aggtgtggtg gcaggcgcct gtaatcccag ctactcggga ggctgaggca
8701 ggagaatcac ttgagcccgg gaggtggagg ttgcagtgag ccgaacgaaa ttgagccact
8761 tcaccccagc ctgggcgaaa gagtgaaatt ccattcaaaa aaaaaaggat gaggactggg
8821 atgaactggt ggctgggtgt ggggaaaatg gaagtgaagg aaggccaaaa gagacagaga
8881 aggcctggcg cggcgactca cgcctataat cccagcactt tgggaggctg agaaggggga
8941 ttgcttgagg ccagaagttg aataccagtc tgggcagcat agcaagaccc tgcctctaca
9001 aaaaaaaaat tttttttaat tagccaggct tggtgacatg catctgtagt ctactcaaga
9061 agctgaggtg aggccaggca tggtggctca cgcctgtatt cccagcactt tgggaggtca
9121 aggcgggtgg atgacctgag gtcaggagtt caagaccagc ctggccaaca tggtgaaacc
9181 ccatctgtat aaaaatacaa aaattagctg ggcatgatag caggtgcctg taattccagc
9241 tactcaggtg gctgaggtgg gagaatctat tgaacccggg agggggaggt tgcagtgagc
9301 cgagatcatg ccattgcact ccagcctggg cgacagagtg agactccttc tcaaaacaaa
9361 caaacaaaca aacaaaatac agaagctgag gcgggaggaa catttgaacc ggattcggag
9421 gctgcagtga gctatgattg caccactgcg ctccagtctg tgtgacagtg agaccctgtc
9481 tcttacacac acacacacac acacacacac gcacacacac agagagaaat tagaagatac
9541 tgaattggca gaagagaagg gaaatagaaa ttaaaatact gaatagggga gcagtgaaca
9601 ggggataccc aaaagccaag agcgagagag agcctggctt ccagaaatag tggagaagcc
9661 aggagaacta ggtgaaaacc cagtgctggg ttgccatcag caagagctgg agccatttcc
9721 aacgaaccat cttgtcgtct tcacagctga gttcaccacg cccgatggcc attactacga
9781 catcctggaa ctgccctacc acggggacac cctcagcatg ttcattgctg ccccttatga
9841 aaaagaggtg cctctctctg ccctcaccaa cattctgagt gcccagctca tcagccactg
9901 gaaaggcaac atgaccaggc tgccccgcct cctggttctg cccaagtaag ccaccccgct
9961 atctccccga cctaccaacc cctctctcct ggctccctaa agtcaccgcc cccaggttga
10021 atttcccaga tctgtgacgc ttgcaggaca tgcatgtgtg ggaggctgat gggaaactgt
10081 ggcctgggtt tgattatgag tcttgcaatc atccctcccc ctgtttctgc tggagggcag
10141 gggacagctc ttcctgacca cacccccaca ttgactatcc ccagaatacc cagcaaaagc
10201 ccccaaaagg agagtcagag aaatgaggga ggtgggggcc caatcagtcc acatctactt
10261 agggtcgccc catcagcact tccatcccca accctttcaa gtcaacatcc aaacaaaaga
10321 aatcacttcc aaggacggag cagctcaaag cgcagctcta gctggggttc caagaaagca
10381 gatttttcga aatccttctg cagaaggaag caaagagatt ttttgaaatc tttctgcaga
10441 aggagaaggc tggagctggg gaactccaga attataggga agcctcccac cacgctcatc
10501 ccaaatttcc ggatgctata atgccaggct tggggaaaga ggagaattta gttggttagc
10561 tggtgcgtgc tctcacttgc atcctctctc ttcctctttt ttttttttct cctctctctc
10621 tggctcataa aaatggaggt aattagttgt gccctggtga gaagcagaga gtgcacaaag
10681 gccccctgct tgagtcctct tcagggttag ctctcagaaa cacaatctgc agaacagatt
10741 tttgttccaa catccttgca ggagaatttg cccttagctt cccccacccc agccaggctg
10801 aataaaatta tgctgaaact actgtcttat ttgaggaaag taattagtca taggtgggag
10861 ggggtgggga gattgcagaa gaatgttcat gaatattagg attttcagct ctaagggggg
10921 actttgtaaa cagctttaga agaagaacca ggccggctgg gtgtggtggc tcatgcctgt
10981 aatctcagca tttggggagg ccaaggcggg cggatcactt gaggtcagga gtttgagacc
11041 agcctggcca acatggtgaa accctgtctc tattaaaaat acaaaaatta gccggctgtg
11101 gtagcgagcg cctatgatcc cagctactcc ggaggctgag gccagagaat cacatgaacc
11161 tgggaggtgg aggctgcagt gagccgagat cacgccactg cactccagcc tgggggacag
11221 agcaagaatc tgtttcaaaa aaaaaaaaag aaaaatagga aggaaggaag gaaaggaaag
11281 gaaagaagag agagagaaag aaagagagag aaagaaagaa agaaagaaag aaagaaagaa
11341 agaaagaaag aaagaaagaa agaaagaaaa agaaaggaaa gaaagaacga acgaaccagg
11401 cctccctctc caaccttcac ctccgtccct attctggcca cttgattcgg gggacacctg
11461 gtaggggatg gggaaaggtg ggagctgcca gccagagggg gaccccggct tgagcagcct
11521 cttgctgcta tctgcaggtt ctccctggag actgaagtcg acctcaggaa gcccctagag
11581 aacctgggaa tgaccgacat gttcagacag tttcaggctg acttcacgag tctttcaggt
11641 aagaagactt tcctttgcat tttctcaccc cagtggactg cgggggcccc taagaggaaa
11701 aaggaacctc tccttgagag cggcagcgat ctaatcctgt atccacatct gtttcagacc
11761 aagagcctct ccacgtcgcg caggcgctgc agaaagtgaa gatcgaggtg aacgagagtg
11821 gcacggtggc ctcctcatcc acaggtgagt ctggctcagg tgaggctcca cgggtgtcgc
11881 ctccatcgcc cttcaggata actggtcccc agacccggaa aggaccccgc agccctctcg
11941 gcacagagca gctctgtctg tgctcagcca tcacccactc cccacctgtt tctcagcctg
12001 gaaaacgggc ttgggaccat ggaaccctgt ttcctcgcct gatggctcct aagttccctg
12061 actgtgaaaa ggcctcctaa agaaaaaccc aagttgttcc cacagtggga agtaaactta
12121 agaaacatgc ttatcaggct gggcatggtg gctcccacct gtaatcccag cgctttgggg
12181 gaccaaggca ggtgaatcac ttgaggtcag gaattcgaga ccagcctggg caacatggca
12241 aaaccctatc tctactaaaa atacaaaaat taggcaggcg tggtggcatg tgcctgtagt
12301 cccagctact tgggaggctg aggcaggaga atcacttgaa tccaggaggc agaggttgca
12361 gtgagccgag atcacgctgc tgcactccag cctgggcaat agagcatgac tctgaagaaa
12421 agaaagaaag aaagagagag agagagaaaa gaaagaaaga aagaaagaaa gaaagaaaga
12481 aagaaagaaa gaaagaaaga aagaaagaca aagaaagaga aagaaagaga agaaaagaaa
12541 agaaagagct tatcaataag cccttaaagg atttagataa atgtgtgtaa gggaagagct
12601 gatccattgc taccaagctc ctggaggaaa ccaggtctca gaggatgtcc ctaaactttt
12661 aaggttcata ttcaggaaaa caaacaactt ccagctgggc ttagtggctc actcctgtaa
12721 tcccagcact ttgggaggcc gaggcaggag gatcgcttga gcccaggaat ttgagaccag
12781 cctgggcaat ataatgagac tgtgtctcta caaaaattag aaaaaaatta gccaggcatg
12841 gtggcatgca cctgtagccc cagttacttg ggagactgag gtgggaggat cacttgagcc
12901 catgagttca aggctgcagt gagccatgaa ggtgccactg cactcccgcc tggcgacaga
12961 gggagaccct gtctctaaga aaaacggcgg gggtgggggt ggtgccagtg ccagcatccc
13021 tctgttctaa gacattgtcc cttctcttgc agctgtcata gtctcagccc gcatggcccc
13081 cgaggagatc atcatggaca gacccttcct ctttgtggtc cggcacaacc ccacaggtga
13141 gcctggaacc catcacgttc cacatcctcc cacccattct ttctctcagg aactagtccc
13201 gacagatgca gacatccctc tatccctgag agggctctgg gcagggaacc cataacccta
13261 ccctgcttcc tgtcccaaga ggaggctacc ttctatcacc cacagacagt gccgggtccc
13321 cgctctgtga ctcaggcagc tgcgactcca gacagctcac tcatctgcct agatctcagt
13381 ccttccaccc acatccagcc tgatgagctg tcccactcct tctgcttctc aacccccatg
13441 gttcttccac cctcaggaac agtccttttc atgggccaag tgatggaacc ctgaccctgg
13501 ggaaagacgc cttcatctgg gacaaaactg gagatgcatc gggaaagaag aaactccgaa
13561 gaaaagaatt ttagtgttaa tgactctttc tgaaggaaga gaagacattt gccttttgtt
13621 aaaagatggt aaaccagatc tgtctccaag accttggcct ctccttggag gacctttagg
13681 tcaaactccc tagtctccac ctgagaccct gggagagaag tttgaagcac aactccctta
13741 aggtctccaa accagacggt gacgcctgcg ggaccatctg gggcacctgc ttccacccgt
13801 ctctctgccc actcgggtct gcagacctgg ttcccactga ggccctttgc aggacggaac
13861 tacggggctt acaggagctt ttgtgtgcct ggtagaaact atttctgttc cagtcacatt
13921 gccatcactc ttgtactgcc tgccaccgcg gaggaggctg gtgacaggcc aaaggccagt
13981 ggaagaaaca ccctttcatc tcagagtcca ctgtggcact ggccacccct ccccagtaca
14041 ggggtgctgc aggtggcaga gtgaatgtcc cccatcatgt ggcccaactc tcctggcctg
14101 gccatctccc tccccagaaa cagtgtgcat gggttatttt ggagtgtagg tgacttgttt
14161 actcattgaa gcagatttct gcttcctttt atttttatag gaatagagga agaaaggtca
14221 gatgcgtgcc cagctcttca ccccccaatc tcttggtggg gaggggtgta cctaaatatt
14281 tatcatatcc ttgcccttga gtgcttgtta gagagaaaga gaaccaccaa ggaaaataat
14341 attatttaaa ctcgctccta gtgtttcttt gtggtctgtg tcaccgtatc tcaggaagtc
14401 cagccacttg actggcacac acccctccgg acatccagcg tgacggagcc cacactgcca
14461 ccttgtggcc gcctgagacc ctcgcgcccc ccgcgccccc cgcgcccctc tttttcccct
14521 tgatggaaat tgaccataca atttcatcct ccttcagggg atcaaaagga cggagtgggg
14581 ggacagagac tcagatgagg acagagtggt ttccaatgtg ttcaatagat ttaggagcag
14641 aaatgcaagg ggctgcatga cctaccagga cagaactttc cccaattaca gggtgactca
14701 cagccgcatt ggtgactcac ttcaatgtgt catttccggc tgctgtgtgt gagcagtgga
14761 cacgtgaggg gggggtgggt gagagagaca ggcagctcgg attcaactac cttagataat
14821 atttctgaaa acctaccagc cagagggtag ggcacaaaga tggatgtaat gcactttggg
14881 aggccaaggc gggaggattg cttgagccca ggagttcaag accagcctgg gcaacatacc
14941 aagacccccg tctctttaaa aatatatata ttttaaatat acttaaatat atatttctaa
15001 tatctttaaa tatatatata tattttaaag accaatttat gggagaattg cacacagatg
15061 tgaaatgaat gtaatctaat agaagcctaa tcagcccacc atgttctcca ctgaaaaatc
15121 ctctttcttt ggggtttttc tttctttctt ttttgatttt gcactggacg gtgacgtcag
15181 ccatgtacag gatccacagg ggtggtgtca aatgctattg aaattgtgtt gaattgtatg
15241 ctttttcact tttgataaat aaacatgtaa aaatgtttca aaaaaataat aaaataaata
15301 aatacgaaga atatgtcagg acagtcactg ccttcacctt ctccatttca caccggtggt
15361 acaagaaatc agaagcctag gccaggtgtg gtggttcatg cctgtaatcc cagcactttg
15421 ggaagccgag gtgggtggat cacctaaggt caggagtttg agaccagcct ggacaacatg
15481 gtgaaacccc gtctctacta aaaatacaaa aattagccgg gcgcggtggc tggcgcctgt
15541 aatcccagct actcgggagg ctgaggcagg agaatcactt gaagccagga ggcagaggtt
15601 gcagtgagct gagattgcac cactgaactc caggctgggt ggcagagcga gactccctct
15661 caaaaaacaa caactacaaa gacaacaaca aacccagaat caaaatcctg ttggtccata
15721 gacctcatgg gtggaagaga ccttcctaca tccaggttgg cccaacatgg gggagtccat
15781 gaaatggtca cctcagctct gccacaagcc ccaaggataa gttgattctg cccctgggaa
15841 tcatcctcaa aaaggaaaaa aatgttcccc tgccataaac tttccactta tgcagatggg
15901 cctgctcgta agtcactgtc actgtgggtt cccaactctg ttcatgacac ttccttccag
15961 caccaaatgc ttcccacccc tctactccca ctccccattc ttcaaaccca gctcaagttc
16021 cagttcctcc acctaggact tcccatggat ccggccaata tcactctcag gtccagcgca
16081 gtggcccacg cctgtaatct cagcactttg ggaggccggg gcaggaagat tgcttgaggc
16141 caggagtttc agaccagcct ggacaacata gtgagactct tcctctaaga aaagaaagag
16201 agaaagagag agagaaagac agaggaaaga gagagaaaaa taaagaaaga gaaagagaga
16261 aagaaagaaa gaaaaagaaa aagaacgaaa gaaagaaaga aagagaaaga aagaaagaaa
16321 gaaaaagaaa ggaaggaagg aaggaaagaa aggagggagg gagggaggga aggaaggaag
16381 gaaggaagga aggggatcaa aacatcatca ctctcaactc gacactgact gagttttctt
16441 ctccctggtc tgtaacagtg cttggattct cgagtgttct ttagctttgt gtgtgtgtgt
16501 cttaccctcc ccaagcccat caaggtatca ggtttcttga aaacaaggct ctcttgttat
16561 atatactcta gcatcttctt gaaaatggct tcctgaaaag tcttttatta tctttctcca
16621 gcatctcgaa ggcttttggc agagggcaca cttccctcca ttagtttctg ttcaaatatt
16681 caaaaataat tttttaaact gaaaaaagac caataaccat ctgttgaact tgtatactgt
16741 ctaactccag aaccctgaag ataggattca gagatgcagc cccctgaaca cccgactcat
16801 ttctattgct ttttaaacaa ttttttgtag aacggggttg caccatgttt tgaacttttg
16861 ggctcaaaca atcctcctgc ctcggcctcc caaattgctg ggattacagt tgtgagccac
16921 catgcccagc ttggctcagg tgtacctttc aacctcctta taccctgaaa gtatgactaa
16981 ttcaggccca ggctagtggc tgaaaagtta cctgtctcta acagatttgc ttggaaagct
17041 aaacagcctc tttttgcaca aaatgcttca aaaagcagaa caaattagcc ctaactctgc
17101 agtatacagt tcaaaaactg ctcatccatg ctgagatggc tctagaggaa aaagagtcct
17161 tcaaaaagcc cccttaccac agaggaggct tgttccagga aatccccaat ttacaagctc
17221 tcaagctatt gtgaggcaaa aaatgatgta gactcagcaa gcacgagacc tgcccagccc
17281 tgtttagctt tgcctagccc tgtcccttgc ctgttctaag tttgtcttcc cttctctatt
17341 tttttttttc ttttaagaca gggtctcgct ttgttgctga ggcaaaagtg cagtagcaca
17401 atcttagctt attacagcct ccatctccta ggcccaaagc catcctcgca cctcagcctc
17461 ccgagtagct gggaccacag gtgtgcgccg ccaagccctg ctaatattt
//