GenBank-Updates@genbank.bio.net (02/15/91)
LOCUS HUMLAM1B 5613 bp ss-mRNA PRI 15-FEB-1991
DEFINITION Human laminin B1 chain mRNA, complete cds.
ACCESSION M61916 J02778
KEYWORDS laminin; membrane glycoprotein.
SOURCE Human placenta, cDNA to mRNA, clones HL-[40,42].
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 5613)
AUTHORS Pikkarainen,T., Eddy,R., Fukushima,Y., Byers,M., Shows,T.,
Pihlajaniemi,T., Saraste,M. and Tryggvason,K.
TITLE Human laminin B1 chain: A multidomain protein with gene (LAMB1)
locus in the q22 region of chromosome 7
JOURNAL J. Biol. Chem. 262, 10454-10462 (1987)
STANDARD full staff_entry
COMMENT Computer-readable copy of sequence in [J. Biol. Chem. 262,
10454-10462 (1987)] kindly provided by
K.Tryggvason, 03-JUN-1987. The location of this gene was mapped
to
chromosome 7, band q22. Three potential polyadenylation signals
(positions 5487-5592, 5555-5560, and 5604-5609), but no poly-A
tail, were found.
FEATURES Location/Qualifiers
CDS 118..5478
/note="lamini//hgml_locus_uid='LM0114W'"
/product="laminin B1"
/gene="LAMB1"
sig_peptide 118..180
/note="laminin B1 chain signal peptide"
mat_peptide 181..5475
/note="laminin B1 chain"
BASE COUNT 1556 a 1288 c 1488 g 1281 t
ORIGIN 505 bp upstream of EcoRI site; chromosome 7q31.
1 cccggagcag ggcgagagct cgcgtcgccg gaaaggaaga cgggaagaaa gggcaggcgg
61 ctcggcgggc gtcttctcca ctcctctgcc gcgtccccgt ggctgcaggg agccggcatg
121 gggcttctcc agttgctagc tttcagtttc ttagccctgt gcagagcccg agtgcgcgct
181 caggaacccg agttcagcta cggctgcgca gaaggcagct gctatcccgc cacgggcgac
241 cttctcatcg gccgagcaca gaagctttcg gtgacctcga cgtgcgggct gcacaagccc
301 gaaccctact gtatcgtcag ccacttgcag gaggacaaaa aatgcttcat atgcaattcc
361 caagatcctt atcatgagac cctgaatcct gacagccatc tcattgaaaa tgtggtcact
421 acatttgctc caaaccgcct taagatttgg tggcaatctg aaaatggtgt ggaaaatgta
481 actatccaac tggatttgga agcagaattc cattttactc atctcataat gactttcaag
541 acattccgtc cagctgctat gctgatagaa cgatcgtccg actttgggaa aacctggggt
601 gtgtatagat acttcgccta tgactgtgag gcctcgtttc caggcatttc aactggcccc
661 atgaaaaaag tcgatgacat aatttgtgat tctcgatatt ctgacattga accctcaact
721 gaaggagagg tgatatttcg tgctttagat cctgctttca aaatagaaga tccttatagc
781 ccaaggatac agaatttatt aaaaattacc aacttgagaa tcaagtttgt gaaactgcat
841 actttgggag ataaccttct ggattccagg atggaaatca gagaaaagta ttattatgca
901 gtttatgata tggtggttcg aggaaattgc ttctgctatg gtcatgccag cgaatgtgcc
961 cctgtggatg gattcaatga agaagtggaa ggaatggttc acggacactg catgtgcagg
1021 cataacacca agggcttaaa ctgtgaactc tgcatggatt tctaccatga tttaccttgg
1081 agacctgctg aaggccgaaa cagcaacgcc tgtaaaaaat gtaactgcaa tgaacattcc
1141 atctcttgtc actttgacat ggctgtttac ctggccacgg ggaacgtcag cggaggcgtg
1201 tgtgatgact gtcagcacaa caccatgggg cgcaactgtg agcagtgcaa gccgttttac
1261 taccagcacc cagagaggga catccgagat cctaatttct gtgaacgatg tacgtgtgac
1321 ccagctggct ctcaaaatga gggaatttgt gacagctata ctgatttttc tactggtctc
1381 attgctggcc agtgtcggtg taaattaaat gtggaaggag aacattgtga tgtttgcaaa
1441 gaaggcttct atgatttaag cagtgaagat ccatttggtt gtaaatcttg tgcttgcaat
1501 cctctgggaa caattcctgg agggaatcct tgtgattccg agacaggtca ctgctactgc
1561 aagcgtctgg tgacaggaca gcattgtgac cagtgcctgc cagagcactg gggcttaagc
1621 aatgatttgg atggatgtcg accatgtgac tgtgaccttg ggggagcctt aaacaacagt
1681 tgctttgcgg agtcaggcca gtgctcatgc cggcctcaca tgattggacg tcagtgcaac
1741 gaagtggaac ctggttacta ctttgccacc ctggatcact acctctatga agcggaggaa
1801 gccaacttgg ggcctggggt tagcatagtg gagcggcaat atatccagga ccggattccc
1861 tcctggactg gagccggctt cgtccgagtg cctgaagggg cttatttgga gtttttcatt
1921 gacaacatac catattccat ggagtacgac atcctaattc gctacgagcc acagctaccc
1981 gaccactggg aaaaagctgt catcacagtg cagcgacctg gaaggattcc aaccagcagc
2041 cgatgtggta ataccatccc cgatgatgac aaccaggtgg tgtcattatc accaggctca
2101 agatatgtcg tccttcctcg gccggtgtgc tttgagaagg gaacaaacta cacggtgagg
2161 ttggagctgc ctcagtacac ctcctctgat agcgacgtgg agagccccta cacgctgatc
2221 gattctcttg ttctcatgcc atactgtaaa tcactggaca tcttcaccgt gggaggttca
2281 ggagatgggg tggtcaccaa cagtgcctgg gaaacctttc agagataccg atgtctagag
2341 aacagcagaa gcgttgtgaa aacaccgatg acagatgttt gcagaaacat catctttagc
2401 atttctgccc tgttacacca gacaggcctg gcttgtgaat gcgaccctca gggttcgtta
2461 agttccgtgt gtgatcccaa cggaggccag tgccagtgcc ggcccaacgt ggttggaaga
2521 acctgcaaca gatgtgcacc tggaactttt ggctttggcc ccagtggatg caaaccttgt
2581 gagtgccatc tgcaaggatc tgtcaatgcc ttctgcaatc ccgtcactgg ccagtgccac
2641 tgtttccagg gagtgtatgc tcggcagtgt gatcggtgct tacctgggca ctggggcttt
2701 ccaagttgcc agccctgcca gtgcaatggc cacgccgatg actgcgaccc agtgactggg
2761 gagtgcttga actgccagga ctacaccatg ggtcataact gtgaaaggtg cttggctggt
2821 tactatggcg accccatcat tgggtcaggt gatcactgcc gcccttgccc ttgcccagat
2881 ggtcccgaca gtggacgcca gtttgccagg agctgctacc aagatcctgt tactttacag
2941 cttgcctgtg tttgtgatcc tggatacatt ggttccagat gtgacgactg tgcctcagga
3001 tactttggca atccatcaga agttgggggg tcgtgtcagc cttgccagtg tcacaacaac
3061 attgacacga cagacccaga agcctgtgac aaggagactg ggaggtgtct caagtgcctg
3121 taccacacgg aaggggaaca ctgtcagttc tgccggtttg gatactatgg tgatgccctc
3181 cggcaggact gtcgaaagtg tgtctgtaat tacctgggca ccgtgcaaga gcactgtaac
3241 ggctctgact gccagtgcga caaagccact ggtcagtgct tgtgtcttcc taatgtgatc
3301 gggcagaact gtgaccgctg tgcgcccaat acctggcagc tggccagtgg cactggctgt
3361 gacccatgca actgcaatgc tgctcattcc ttcgggccat cttgcaatga gttcacgggg
3421 cagtgccagt gcatgcctgg gtttggaggc cgcacctgca gcgagtgcca ggaactcttc
3481 tggggagacc ccgacgtgga gtgccgagcc tgtgactgtg accccagggg cattgagacg
3541 ccacagtgtg accagtccac gggccagtgt gtctgcgttg agggtgttga gggtccacgc
3601 tgtgacaagt gcacgcgagg gtactcgggg gtcttccctg actgcacacc ctgccaccag
3661 tgctttgctc tctgggatgt gatcattgcc gagctgacca acaggacaca cagattcctg
3721 gagaaagcca aggccttgaa gatcagtggt gtgatcgggc cttaccgtga gactgtggac
3781 tcggtggaga ggaaagtcag cgagataaaa gacatcctgg cgcagagccc cgcagcagag
3841 ccactgaaaa acattgggaa tctctttgag gaagcagaga aactgattaa agatgttaca
3901 gaaatgatgg ctcaagtaga agtgaaatta tctgacacaa cttcccaaag caacagcaca
3961 gccaaagaac tggattctct acagacagaa gccgaaagcc tagacaacac tgtgaaagaa
4021 cttgctgaac aactggaatt tatcaaaaac tcagatattc ggggtgcctt ggatagcatt
4081 accaagtatt tccagatgtc tcttgaggca gaggagaggg tgaatgcctc caccacagaa
4141 cccaacagca ctgtggagca gtcagccctc atgagagaca gagtagaaga cgtgatgatg
4201 gagcgagaat cccagttcaa ggaaaaacaa gaggagcagg ctcgcctcct tgatgaactg
4261 gcaggcaagc tacaaagcct agacctttca gccgctgccg aaatgacctg tggaacaccc
4321 ccaggggcct cctgttccga gactgaatgt ggcgggccaa actgcagaac tgacgaagga
4381 gagaggaagt gtggggggcc tggctgtggt ggtctggtta ctgttgcaca caacgcctgg
4441 cagaaagcca tggacttgga ccaagatgtc ctgagtgccc tggctgaagt ggaacagctc
4501 tccaagatgg tctctgaagc aaaactgagg gcagatgagg caaaacaaag tgctgaagac
4561 attctgttga agacaaatgc taccaaagaa aaaatggaca agagcaatga ggagctgaga
4621 aatctaatca agcaaatcag aaactttttg acccaggata gtgctgattt ggacagcatt
4681 gaagcagttg ctaatgaagt attgaaaatg gagatgccta gcaccccaca gcagttacag
4741 aacttgacag aagatatacg tgaacgagtt gaaagccttt ctcaagtaga ggttattctt
4801 cagcatagtg ctgctgacat tgccagagct gagatgttgt tagaagaagc taaaagagca
4861 agcaaaagtg caacagatgt taaagtcact gcagatatgg taaaggaagc tctggaagaa
4921 gcagaaaagg cccaggtcgc agcagagaag gcaattaaac aagcagatga agacattcaa
4981 ggaacccaga acctgttaac ttcgattgag tctgaaacag cagcttctga ggaaaccttg
5041 ttcaacgcgt cccagcgcat cagcgagtta gagaggaatg tggaagaact taagcggaaa
5101 gctgcccaaa actccgggga ggcagaatat attgaaaaag tagtatatac tgtgaagcaa
5161 agtgcagaag atgttaagaa gactttagat ggtgaacttg atgaaaagta taaaaaagta
5221 gaaaatttaa ttgccaaaaa aactgaagag tcagctgatg ccagaaggaa agccgaaatg
5281 ctacaaaatg aagcaaaaac tcttttagct caagcaaata gcaagctgca actgctcaaa
5341 gatttagaaa gaaaatatga agacaatcaa agatacttag aagataaagc tcaagaatta
5401 gcaagactgg aaggagaagt ccgttcactc ctaaaggata taagccagaa agttgctgtg
5461 tatagcacat gcttgtaaca gaggagaata aaaaatggct gaggtgaaca aggtaaaaca
5521 actacatttt aaaaactgac ttaatgctct tcaaaataaa acatcaccta tttaatgttt
5581 ttaatcacat tttgtatgag ttaaataaag ccc
//