GenBank-Updates@genbank.bio.net (02/16/91)
LOCUS HUMTRH1 362 bp ds-DNA PRI 16-FEB-1991
DEFINITION Human thyrotropin releasing hormone (TRH) gene, exon 1.
ACCESSION M58042
KEYWORDS thyrotropin releasing hormone.
SEGMENT 1 of 3
SOURCE Human lung fibroblast DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 362)
AUTHORS Yamada,M., Radovick,S., Wondisford,F.E., Nakayama,Y.,
Weintraub,B.D. and Wilber,J.F.
TITLE Cloning and structure of human genomic DNA and hypothalamic cDNA
encoding human preprothyrotropin-releasing hormone
JOURNAL Mol. Cell. Endocrinol. 14, 551-556 (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
misc_feature 91..96
/note="gc box"
misc_feature 118..123
/note="gc box"
TATA_signal 214..218
/gene="TRH"
exon 243..346
/number=1
/gene="TRH"
BASE COUNT 48 a 156 c 113 g 45 t
ORIGIN
1 gatctccaga ggtggtgcag aaacgacccc gcgccggcgc cccatcctgc ggccagtgcc
61 tccgcgcccc ggctccggtc cccaccgtcc ccgccccaga tttccggagg agcaggcggg
121 cggggtcccg cggggccggc tgccgtcagc gccccttccc ggcggccgcg acccctcccc
181 gctgacctca ctcgagccgc cgcctggcgc agatataagc ggcggcccat ctgaagaggg
241 ctcggcaggc gcccggggtc ctcagcgctg cagactcctg acctgccgac tgcggatccc
301 gagtccccgg atcccggacc catcctgtgg agcccactcc tggcaggtaa ccgccccaac
361 cc
//GenBank-Updates@genbank.bio.net (02/16/91)
LOCUS HUMTRH2 250 bp ds-DNA PRI 16-FEB-1991
DEFINITION Human thyrotropin releasing hormone (TRH) gene, exon 2.
ACCESSION M58043
KEYWORDS thyrotropin releasing hormone.
SOURCE Human lung fibroblast DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 250)
AUTHORS Yamada,M., Radovick,S., Wondisford,F.E., Nakayama,Y.,
Weintraub,B.D. and Wilber,J.F.
TITLE Cloning and structure of human genomic DNA and hypothalamic cDNA
encoding human preprothyrotropin-releasing hormone
JOURNAL Mol. Cell. Endocrinol. 14, 551-556 (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
intron order(M58042:347..362,1..12)
/number=1
/note="1050 bp gap."
/gene="TRH"
exon 13..231
/number=2
/note="first expressed exon."
/gene="TRH"
sig_peptide 21..92
/gene="TRH"
/codon_start=21
BASE COUNT 37 a 85 c 86 g 42 t
ORIGIN
1 cccctaaccc agacgccgcg atgcccggcc cttggttgct gctcgctctg gctttgaccc
61 tgaacctgac cggtgtcccc ggcggccgtg ctcagccaga ggcggcccag caggaggcag
121 tgacggccgc ggagcatccg ggcctggatg acttcctgcg ccaggtggag cgcctcctct
181 tcctccggga aaacatccag cggctgcaag gggaccaggg tgagcactcc ggtgagtgga
241 tggggctgtt
//GenBank-Updates@genbank.bio.net (02/16/91)
LOCUS HUMTRH3 1359 bp ds-DNA PRI 16-FEB-1991
DEFINITION Human thyrotropin releasing hormone (TRH) gene, exon 3.
ACCESSION M58044
KEYWORDS thyrotropin releasing hormone.
SEGMENT 3 of 3
SOURCE Human lung fibroblast DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1359)
AUTHORS Yamada,M., Radovick,S., Wondisford,F.E., Nakayama,Y.,
Weintraub,B.D. and Wilber,J.F.
TITLE Cloning and structure of human genomic DNA and hypothalamic cDNA
encoding human preprothyrotropin-releasing hormone
JOURNAL Mol. Cell. Endocrinol. 14, 551-556 (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
intron order(M58043:232..250,1..13)
/number=2
/note="650 bp gap."
/gene="TRH"
CDS join(M58043:21..231,14..531)
/product="thyrotropin releasing hormone"
/gene="TRH"
/codon_start=21
mRNA join(M58042:243..346,M58043:13..231,14..1251)
/product="thyrotropin releasing hormone"
/gene="TRH"
mRNA join(M58042:243..346,M58043:13..231,14..1359)
/product="thyrotropin releasing hormone"
/gene="TRH"
exon 14..1251
/number=3
/gene="TRH"
exon 14..1359
/number=3
/gene="TRH"
/partial
mat_peptide 46..69
/product="thyrotropin releasing hormone"
/gene="TRH"
/codon_start=46
mat_peptide 136..159
/product="thyrotropin releasing hormone"
/gene="TRH"
/codon_start=136
mat_peptide 199..222
/product="thyrotropin releasing hormone"
/gene="TRH"
/codon_start=199
mat_peptide 250..273
/product="thyrotropin releasing hormone"
/gene="TRH"
/codon_start=250
mat_peptide 352..375
/product="thyrotropin releasing hormone"
/gene="TRH"
/codon_start=352
mat_peptide 475..498
/product="thyrotropin releasing hormone"
/gene="TRH"
/codon_start=475
polyA_signal 1228..1233
/gene="TRH"
BASE COUNT 304 a 375 c 392 g 288 t
ORIGIN
1 tttccttcct cagcgtccca gatctttcaa tctgactggc tctccaaacg tcagcatcca
61 ggcaaaagag aggaggagga ggaagaggga gttgaagaag aggaagagga agaagggggg
121 gctgtgggac cccacaaacg gcagcaccct ggccgacgag aagatgaggc ttcatggtca
181 gtcgatgtaa cccagcacaa gcggcagcat cctggccggc gctccccctg gcttgcatat
241 gctgtcccga agcggcagca cccaggcaga aggctggcag atcccaaggc tcaaaggagc
301 tgggaagaag aggaggagga ggaagagaga gaggaagacc tgatgcctga aaaacgccag
361 catccgggca agagggccct gggaggcccc tgtgggcccc agggagccta tggtcaagcg
421 ggcctcctgc tggggctcct ggatgacctg agtaggagcc agggagctga ggaaaagcgg
481 cagcaccctg gtcggcgggc agcctgggtc agggagcccc tggaggagtg aacccagttt
541 tccctgaagt cgagtttgtg gtctaaggat gtcttgagcc ctgtgtgccc caccattcat
601 gacctctgta ttctctagtt agatccctga ccataagcct gagcccctcc ctcccagccc
661 catattcaca cacatcccag cccctggcct tgccctcttc ctttaggcat gtgagaaaat
721 cagcctagca gtttaaaccc cactttcctc cacttagcac cataggcaag ggggcagatc
781 ccagagcccc tctcaccccc cccaccacag gcctgctcct tccttagcct tggctaagat
841 ggtccttctg tgtcttgcaa agactcccca agtggacagg gagcccctgg gagggcagcc
901 agtgagggtg gggtgggact gaagcgttgt gtgcaaatcc agcttccatc ccctccccaa
961 cctggcagga ttctccatgt gtaaacttca cccccaggac ccaggatctt ctcctttctg
1021 ggcatccctt tgtgggtggg cagagccctg acccacagct gtgttactgc ttggagaagc
1081 atatgtaggg gcataccctg tggtgttgtg ctgtgtctgg ctgtgggata aatgtgtgtg
1141 ggaatattga aacatcgcct aggaattgtg gtttgtatat aaccctctaa gcccctatcc
1201 cttgtcgatg acagtcatcc taatgataat aaaacctgca tccagataat cacggagctc
1261 tgtggttgct gttctgtcgc agctggcatg ggattcttct ttcgcattga gagggatatt
1321 taaaagggga tgggactaga gttctcagct ctgctgcag
//