GenBank-Updates@genbank.bio.net (02/20/91)
LOCUS MUSIGCD17 4095 bp ds-DNA ROD 20-FEB-1991 DEFINITION Mouse ig germline d-j-c region: igd tail exons. ACCESSION J00450 V00791 V00792 KEYWORDS alternate splicing; delta-immunoglobulin; immunoglobulin; immunoglobulin heavy chain; membrane bound immunoglobulin. SEGMENT 17 of 42 SOURCE mouse liver dna([Nature 296, 410-415 (1982)]), and cdna to myeloma tepc 1017 mrna([Science 209, 1353-1360 (1980)]). ORGANISM Mus musculus Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae. REFERENCE 1 (bases 259 to 464) AUTHORS Tucker,P.W., Liu,C.-., Mushinski,J.F. and Blattner,F.R. TITLE Mouse immunoglobulin D: Messenger RNA and genomic DNA sequences JOURNAL Science 209, 1353-1360 (1980) STANDARD full staff_review REFERENCE 2 (bases 1 to 4095) AUTHORS Cheng,H.-L., Blattner,F.R., Fitzmaurice,L., Mushinski,J.F. and Tucker,P.W. TITLE structure of genes for membrane and secreted murine igd heavy chains JOURNAL Nature 296, 410-415 (1982) STANDARD full staff_review COMMENT For an overview of the musigdjc loci see the first paragraph of 'comment' in musigdjc01. The secreted and membrane-bound tails of igd are encoded by a single mRNA transcript and are expressed by alternative mRNA processing pathways. Ivs c of the sites table may be terminated at any one of three locations. proceeding 5' to 3', the first termination point used is at exon delta-s (exon4s of the sites table), which is the secreted tail. The second splice point is putative and may code for a second secreted tail, delta-x (exon4x in the sites table). That this exon is expressed is suggested by dot blots of spleen rna ([Nature 296, 410-415 (1982)]). Ivs c's third possible splice point is for the first of the two exons encoding the membrane-bound tail, delta-m1 (exon 4m of the sites table). In addition to the alternative splicing for ivs c, there may also be alternative processing for the 3' untranslated region since two polyadenylation signals (aataaa) are found 3' to the termination of the membrane-bound tail. For the other c-delta exons see musigdjc14, musigdjc15 & musigdjc16. FEATURES Location/Qualifiers intron <1..258 /note="c-delta secreted form intron c" intron <1..744 /note="c-delta putative secreted x form intron c" intron <1..1982 /note="c-delta membrane bound form intron c" CDS join(J00447:584..865,J00448:17..121,J00449:17..337, 1983..2140,2361..2369) /partial /note="Ig delta chain" exon 259..326 /note="Ig delta chain, exon 4 of secreted c region" exon 745..812 /note="Ig delta chain, exon 4 of secreted x c region" exon 1983..>2140 /note="Ig delta chain, exon 4 of membrane bound c region" intron 2141..2360 /note="c-delta membrane bound form intron d" exon 2361..>2369 /note="Ig delta chain, exon 5 of membrane bound c region" BASE COUNT 1124 a 944 c 866 g 1161 t ORIGIN 141bp 5' to hinfi site about 3.7kb 3' to <musigcd16> 1 tcagtaatta caagatacaa atgattgata accaagacag agacagtaca tgggattaga 61 cctgaggtac gggaaaggtt gggaaagcat tcatagtgtc ccttgctaca agaagtccca 121 gagctttgca gggtgtgagc agattctaac ctcccccatt ggcaagtctt ctcaaggctg 181 cttctgctac tagagaaccc tctttcccag ccacctgcca ctatttatca cttatctgag 241 ttttccccat gattctagga tgctaccacc tcctgcctga gtcagacggt ccttctagga 301 gacctgatgg tcctgccctt gcctgagacc tttctaggct gaatggtcat catgtccacg 361 gtctggttag cttggttgcc tctgtgttaa gttgcttcat actacatgta gcaaggaaag 421 ttacctttcc acttctcagg acactgtaaa gaagcacttc tgtaaattat agtgagaaaa 481 cgatcaataa taaatgaaat gaacaaacat aaacctctct tatcactatc gggacattgc 541 cctaaggcct cttgtggacg cctgaaacct tgagttgttc ttaagccatg tgtcacttca 601 gtcattaacc tgtggctgag gtggatcctg actgacaaac agacaggcgt gtagacagct 661 tgaagcctgg acaaagagaa ggttgacgtt ccaggcaaag caagagccta tcacattgtt 721 ccaaagtgtg tgatttagaa tcagaagatt tcttgtttaa aatatactca aaaagttata 781 aaatatcagc caggactagt cataaagctt aaatctgaga gagagagaga gagagagaga 841 gagagagagg tgttcatgta tatacatatg tgtgtgtgtg tatatatatg tatgtatatg 901 tatgtatatg tgtatattgg tgtttgggtg tcagattccc tggaattaaa gttataaaca 961 gttatgagct gcaaagtagg ctttccaatg tcttgttctc caccataggt aattgaaact 1021 ggaaactaca ggtaaaggag gctgccaagt gtttcttatt atgctaagat tcagtgttct 1081 acaatattca catgatttca ctttgatatg gtgaaatgcc tttaggccaa cgcatccaca 1141 gacttcacag tgaccccagc tgagcttaca tataatgtca aacagcactt gttgaataga 1201 tacccaagca gccctgtgac ccatggtgtt ttccttaatt cttcccatct gccttggact 1261 ttcacacctt gagttgagat gtgctttctg tagaaatgta tttccctagg tctgtacatc 1321 agccaccacc ctttctgatc ttggaccgta cttcagtctc cagctgggat attcatatgc 1381 atgcttagat atggcataac catcgttaac gtcttccgtt acctttagga ttaagttacc 1441 gtagctagga tgctttccaa tctctccctc catttgcaaa ggctcagggt tccttctgac 1501 tctggagtag tactctttcc caatgagtgc accatgacca ctattcttcc ttagaatgtt 1561 actccccttt ctctgccttt ttcatggcac atctttctga gaaaacctac ctggtctagc 1621 tgctctttct gggtcttctt aagtagtaac ctaactctgc accatccgtg tggcagtgac 1681 atagatccac atcaggtttg gattcagata ttccaatccc atgcagacca atctatgtgt 1741 gagattccag gatccagcag gctggggcat gggttgaggg gtaggattct ttggggcaaa 1801 gtggttagta ggcacttggg actgaaagtg ataagtatta gcgggaggag ggcatatgat 1861 caaaacattg ctgctggatg tgaaagctgt accttcaggt tcagtgttca ggagaccagg 1921 ttaataagaa ataatctttc tgtagggtgg agaccttctc atgagcacta gttcttccct 1981 aggcatagtc aacaccatcc aacactcgtg tatcatggat gagcaaagtg acagctacat 2041 ggacttagag gaggagaacg gcctgtggcc cacaatgtgc accttcgtgg ccctcttcct 2101 gctcacactg ctctacagtg gcttcgtcac cttcatcaag gtaggcctcc taccacctcc 2161 ttctgaaccc ttcctgggca catgtaagat acccttccag gggcattttg aaacccatcg 2221 gtacttctgg agtggctagg gaatgcacaa gtaattggga ggccatggtc actgttcagc 2281 ttctgggccc tatgtagctc cacggacttt ccctgtttct cagacaacag cctctgtatg 2341 acttcacggc tctctggcag gtgaagtaga ccaggacagc agaatcctgc aactacagag 2401 aaaagtgctt tccctcaaca tgaagccaac taagaagata ccttctatgc agagagaaat 2461 gccaaggccc tcctctcaat acctgctctc cacctagact cccagactca aaatgcctag 2521 tatccttggc tataggcaaa gcaggtgttc tgctgctcca gccctactca tcgatgtccc 2581 ctgcctcccc ccaagccctc atcattccat aagcatgctg tggtctaccc cacctgcctc 2641 ctggtaattt gtttgtttgt ttgtttgttt ctgtgatcta aataaactca aaccacatga 2701 gatctgagga aaacagtgga gaagccacta gggaggggta tcagagtcac actgaagaaa 2761 attgttcagt gaactaagaa actctcctcc caccttaaac tctcagttga cttctcacat 2821 acacataagc atatacacat gcacatgtgc acatcacagt cacatgcatg ataacacagg 2881 cagacgtgca tgagtgcaca tgcataccta ctcagatgca cataaattta cagcagagcc 2941 ttaggtgaca ggaatgggga ctgtggtcat ttgaataaga accccatagg ctcatatagt 3001 tgaatgctta gtcaccaggg agtggaactc tttaacagga tcagaaagat tcagaggcaa 3061 gtccttgttg taggaagtgt gtgtcactgg agcacgggta ggctttcagg tttcaaaagt 3121 tcatgtcagg actagagtct ctctgtcact ctgtgtctct atatctcttc tgaattctag 3181 gtaatttctc cagcactatg tccactggca taccaccatg ctccctacca tgatgtaaat 3241 gaactaaccc ctgaaactgt tagcaagcct caattaaatg ctttctttta taagaattgt 3301 tgtggccatg gtgtctcttc atagcaatgg aacagtgact aagactagga atattccaca 3361 tgcaaatttc tagtttgttt tggctcctaa tcttactacc tatacaagac cctgagtacc 3421 tgtatttcca cttcctccat cacagacatt gacagtacac acctacctaa actgagatgg 3481 gtcaatgaaa ggaacacagt aaatacgttg gtactaggca acatgtggtg acaccctcct 3541 gttacctgct gtgggttggg tatatccccc aaattcatgc tgatatcttt atatcaatgt 3601 atcagaagat aaggagatca caaagagtcc tcataattgg gattagtgtt cctagttaaa 3661 caagctagaa agatcccttc acccagacac tatgaaacag agctgtccat agatgtgtaa 3721 atgagtcctg tagggtatgg aaactactag aatctttgtc ttagaccttc agactcagaa 3781 tgatgaaaag tacatttctg atattatgat tcacttggtt caaggataat ttttgtaggc 3841 acccaagtag accaaggcat cggtcaacat cctttagtat gatagagtca aaacaagacc 3901 cagattcatg ttgtacatca acagatgata acacaggggt gatgggaagg atctcaatgt 3961 cagttcgatt ctcttgctcc cttactctat cctctactgt gtggagagca ggagggagga 4021 tacattagga gataacatct tcccttcacc attctggcta ttcctctcac tattcccctt 4081 gatgaacttg gatcc //