GenBank-Updates@genbank.bio.net (02/20/91)
LOCUS HUMGHG 4452 bp ds-DNA PRI 20-FEB-1991
DEFINITION Homo sapiens granzyme H gene, complete cds.
ACCESSION M57888
KEYWORDS granzyme H; serine protease.
SOURCE Human DNA, clone lambda B34.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 4452)
AUTHORS Haddad,P., Jenne,D.E., Tschopp,J., Clement,M.-., Mathieu-Mahul,D.
and Sasportes,M.
TITLE Structure and evolutionary origin of the human granzyme H gene
JOURNAL Int. Immunol. (1990) In press
STANDARD simple staff_review
FEATURES Location/Qualifiers
mRNA join(512..688,1835..1982,2500..2635,2841..3098,
3501..>3769)
/product="granzyme H"
CDS join(634..688,1835..1982,2500..2635,2841..3098,
3501..3644)
/product="granzyme H"
/codon_start=634
exon 512..688
/number=1
/product="granzyme H"
exon 1835..1982
/number=2
/product="granzyme H"
exon 2500..2635
/number=3
/product="granzyme H"
exon 2841..3098
/number=4
/product="granzyme H"
exon 3501..>3769
/number=5
/product="granzyme H"
BASE COUNT 1109 a 1251 c 1008 g 1084 t
ORIGIN
1 gggattctaa atatcccaaa atatgaatct gagatagtgg taagatagga atgggttgcc
61 atttgcagta tttgttgggt gtgtgcaact ctgcatactg ctaaggcaag tccagcctcc
121 gtctcacacc aacaggcaga tttccccacc acggccctta ccatcttgtg ctctaacccc
181 agattttcag tctactcttg ctaaccatca attcttcaag gcaagagcca tgtctctcat
241 atccctggat ctggcttgct aaataattat tcatgatttt atctgagtag aaaaagagcc
301 aagaactgag aaaaggagac attcttggtt ctcagtcact gaggagcttc tgcagccaca
361 gcttcaacag ctccacctcc ttgttcttta ttcttgcttt caccttgtta ctcagcagca
421 ggggtgtaaa tgtgacagtg ccatgtcaac ttaaaccaaa ccagataatt ttaataaacc
481 accttctata atgacaccca tcaaaaccag aaggggacaa gtctaggagg tctctgaggt
541 tactgtaccc atccctcctt catctccctc cagcatttgt ttctggaagg agtcaacacc
601 aacagctctg acctgggcag ccttcctgag aaaatgcagc cattcctcct cctgttggcc
661 tttcttctga cccctggggc tgggacaggt aagtgactat ccctattcca gaggcctgaa
721 cccatcttat aagataccct gtacccatga gcactggtca ggaattttcc tcaatctgag
781 cccacctccc attccacacc cagacttata aatctgaggc tagatagaca ctcagcaaag
841 atcgaaaaat gaagggtgtt ccctaaaagg tttaatgggt gttagcctct ccctagacct
901 ctcctttatg acctggagtg tggattgttc ttagaaaggc atttggtagg gaatgtgaag
961 ctaaaaaaga taagtaatta ttactctaca ctccaaccca ggaaagagga gctcagacac
1021 caagttgcag tcataggagt tgttactgga ctcagcttaa gaaccactta ttcagtgccc
1081 ccacccagtc acccctgcca ggagggaagc ccatggtgca actgatctca gagatggcaa
1141 gatgactgtg tccatagctc tcccattacc ttggctccac ctgggctttg cgattcattt
1201 ttagttgatt tctccacttc cttctgcctt tgcaggccct cagctactcc actgacctgg
1261 tgataacccc ctctaacatc cctgaggtcc tgaatcccac cagcactacc cccactaaac
1321 ctcagccaaa ggctaattgg aggctattca tttatgcacc aaacaacact tactgagaac
1381 ctagaatgtg ttcagccctg gcacatgaga attttagaaa atccaactcc agaagctcat
1441 gggtagatca ttagaaaatg gcaccaatca ggaggacagc agaggctcag aggaatcaga
1501 gagactcact aaaaaggagg agcctgggaa gtcctgtcca ggatcctctg gggctctacc
1561 actgtgaaaa tagatctttc ttcctccatg tgtgtttctg cagtaggatg cagaagtcaa
1621 gcactgtcca ttctttctga gagaaggttc tgagacttaa agttcagaaa agcttgctct
1681 gcctgcaagg agtactgcct gcagagctca ggaggacccc tccctcactg tctgcagcac
1741 acaaaacact tcaccctcaa tcactgtcgt cctaagcctt ctctcctgac tgcagccatc
1801 cccagctact ttatcttcca gtctttcctt tcagaggaga tcatcggggg ccatgaggcc
1861 aagccccact cccgccccta catggccttt gttcagtttc tgcaagagaa gagtcggaag
1921 aggtgtggcg gcatcctagt gagaaaggac tttgtgctga cagctgctca ctgccaggga
1981 aggtaaggag cagcaccagc tcacctcctg agttccccct acagggaccc ttgttttctc
2041 ctggggactg cagcccaggg gagcttccag agttcctggt aacacaagcc catgaaagct
2101 catcggagca gccacctggg aataggacta agatgatgaa aggctgagaa ataggacagg
2161 gtcagagggt cagagggtca gaggtcagag caagtggcat ggtttcacac actggcccaa
2221 taaggcagta gtaaaggttg aatccatgca ttaaggatca aaatgcaaac tcgagcaatt
2281 tcatgatatt tcctgaaggc aagagagagc ccccagaagc cctactcttc atgtctttgt
2341 gaagtagagg gcacagtcac tcagccctgg agccctcctg tcccttcaac ttcccctcag
2401 ctgcagccct accctgccac agctgtcatc tgctcttcac tgctcctggg ctctatcccc
2461 tgtgactcca cccccatcct cactctgctc tctgtgcagc tccataaatg tcaccttggg
2521 ggcccacaat atcaaggaac aggagcggac ccagcagttt atccctgtga aaagacccat
2581 cccccatcca gcctataatc ctaagaactt ctccaacgac atcatgctac tgcaggtgag
2641 gcacactcct gccactcttg ctcttcttgg tccagttggt tccactccca ctgggatgcc
2701 ggccctttcc tcctttccat cctgacctct tggtcagttc ctgtgcctta gaggagaggg
2761 aagattgtgc agccccatca ctgtgtcggg gcccagaagg ccattgcctg acctggactt
2821 tcttgcttct tccccaccag ctggagagaa aggccaagtg gaccacagct gtgcggcctc
2881 tcaggctacc tagcagcaag gcccaggtga agccagggca gctgtgcagt gtggctggct
2941 ggggttatgt ctcaatgagc actttagcaa ccacactgca ggaagtgttg ctgacagtgc
3001 agaaggactg ccagtgtgaa cgtctcttcc atggcaatta cagcagagcc actgagattt
3061 gtgtggggga tccaaagaag acacagaccg gtttcaaggt tgggtttcca gcctctaccc
3121 agaaagacca cagggagaga ggaacttgag ggagttctgg ggtatgacag tggccagatc
3181 tttatgctct cagcccagag cttgggcagc ctgtgtcccc ctggaatcta gtctttagtc
3241 cactccttgg gtggactggg gtggctggag gggaaggatc tgtcatccga cagtcactta
3301 tcaccaaagt gtccgtgaga attgcagaga aaggcttggt ctggggagag ccagaaagca
3361 cagccagggc catgctggag acccaggact gagggaggtg agtgacaagg cctgcctggc
3421 actgatgtca cacaaaatcc ataacagaga ccacccatcc cagggaacac tagctcagtc
3481 tttcctctct ctgttcacag ggggactccg gggggcccct cgtgtgtaag gacgtagccc
3541 aaggtattct ctcctatgga aacaaaaaag ggacacctcc aggagtctac atcaaggtct
3601 cacacttcct gccctggata aagagaacaa tgaagcgcct ctaacagcag gcatgagact
3661 aaccttcctc tgggcctgac catctctggg acagaggcaa gaatcccaag gggtgggcag
3721 tcggggttgc aggactgtaa taaatggatc tctggtgtaa atatgactga agtcttattt
3781 attcactgaa ccatcttcaa tatgcaacaa cactgctcca ggcagccgtc tgctgtcagt
3841 tctggctttt gcttcttcct ttctccccca gccctccctc ctccctaaac cccatgctgt
3901 acagtttttt cactaatttc tcaatcacat gtctttgata ctgaaccctc tgttagagct
3961 ggtttgaact ccattataaa caaacaatct tcacccctct cccttcacaa aaaaaaataa
4021 acctctctgg acgttaggaa tttcttatcg tctctaaacc aactacctac tcccctaaca
4081 acgtagcaga gaatggagca gggcagtgga aaggaaataa ctccagggac tcagaaggcc
4141 agggccatgc catgagtact cagtttccat tttcagggcc tgtccctcca atgggggcag
4201 gcttctccca cagccaggtc tgcctgcagc ttaggaggtt gagatgctcc tctgcaccta
4261 ggtccctctt ccctgccctg gcccagccct gagctcagtc aaccttcttc cttcctggcc
4321 ggccttccca gctcccaaga gtttttcacc caagtgccct ggctaccagt ttctttccct
4381 tctagatcac cctgttctga agccagcctc tctctcatgt ccctaacaga gttcccagct
4441 ctgtgtgaat tc
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