GenBank-Updates@genbank.bio.net (02/21/91)
LOCUS HUMCD46Q 2124 bp ss-mRNA PRI 21-FEB-1991
DEFINITION Human membrand cofactor protein [CD46 (MCP)] mRNA, complete cds.
ACCESSION M58050
KEYWORDS alternative splicing; complement; membrane cofactor protein.
SOURCE Human, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2124)
AUTHORS Purcell,D.F., Russell,S.M., Deacon,N.J., Brown,M.A., Hooker,D.J.
and McKenzie,I.F.
TITLE Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a
regulator of complement activation
JOURNAL Unpublished (1990)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
sig_peptide 35..136
/product="membrane cofactor protein"
/gene="CD46"
/codon_start=35
CDS 35..1168
/product="membrane cofactor protein"
/gene="CD46"
/codon_start=35
mat_peptide 137..1165
/product="membrane cofactor protein"
/gene="CD46"
/codon_start=137
exon 935..976
/note="alternatively spliced ser/thr/pro exon"
/product="membrane cofactor protein"
/gene="CD46"
exon 1115..1208
/note="alternatively spliced cytoplasmic exon"
/product="membrane cofactor protein"
/gene="CD46"
BASE COUNT 628 a 398 c 444 g 654 t
ORIGIN
1 gaattcgggg ataacagcgt cttccgcgcc gcgcatggag cctcccggcc gccgcgagtg
61 tccctttcct tcctggcgct ttcctgggtt gcttctggcg gccatggtgt tgctgctgta
121 ctccttctcc gatgcctgtg aggagccacc aacatttgaa gctatggagc tcattggtaa
181 accaaaaccc tactatgaga ttggtgaacg agtagattat aagtgtaaaa aaggatactt
241 ctatatacct cctcttgcca cccatactat ttgtgatcgg aatcatacat ggctacctgt
301 ctcagatgac gcctgttata gagaaacatg tccatatata cgggatcctt taaatggcca
361 agcagtccct gcaaatggga cttacgagtt tggttatcag atgcacttta tttgtaatga
421 gggttattac ttaattggtg aagaaattct atattgtgaa cttaaaggat cagtagcaat
481 ttggagcggt aagcccccaa tatgtgaaaa ggttttgtgt acaccacctc caaaaataaa
541 aaatggaaaa cacaccttta gtgaagtaga agtatttgag tatcttgatg cagtaactta
601 tagttgtgat cctgcacctg gaccagatcc attttcactt attggagaga gcacgattta
661 ttgtggtgac aattcagtgt ggagtcgtgc tgctccagag tgtaaagtgg tcaaatgtcg
721 atttccagta gtcgaaaatg gaaaacagat atcaggattt ggaaaaaaat tttactacaa
781 agcaacagtt atgtttgaat gcgataaggg tttttacctc gatggcagcg acacaattgt
841 ctgtgacagt aacagtactt gggatccccc agttccaaag tgtcttaaag tgtcgacttc
901 ttccactaca aaatctccag cgtccagtgc ctcaggtcct aggcctactt acaagcctcc
961 agtctcaaat tatccaggat atcctaaacc tgaggaagga atacttgaca gtttggatgt
1021 ttgggtcatt gctgtgattg ttattgccat agttgttgga gttgcagtaa tttgtgttgt
1081 cccgtacaga tatcttcaaa ggaggaagaa gaaaggcaca tacctaactg atgagaccca
1141 cagagaagta aaatttactt ctctctgaga aggagagatg agagaaaggt ttgcttttat
1201 cattaaaagg aaagcagatg gtggagctga atatgccact taccagacta aatcaaccac
1261 tccagcagag cagagaggct gaatagattc cacaacctgg tttgccagtt catcttttga
1321 ctctattaaa atcttcaata gttgttattc tgtagtttca ctctcatgag tgcaactgtg
1381 gcttagctaa tattgcaatg tggcttgaat gtaggtagca tcctttgatg cttctttgaa
1441 acttgtatga atttgggtat gaacagattg cctgctttcc cttaaataac acttagattt
1501 attggaccag tcagcacagc atgcctggtt gtattaaagc agggatatgc tgtattttat
1561 aaaattggca aaattagaga aatatagttc acaatgaaat tatattttct ttgtaaagaa
1621 agtggcttga aatctttttt gttcaaagat taatgccaac tcttaagatt attctttcac
1681 caactataga atgtatttta tatatcgttc attgtaaaaa gcccttaaaa atatgtgtat
1741 actactttgg ctcttgtgca taaaaacaag aacactgaaa attgggaata tgcacaaact
1801 tggcttcttt aaccaagaat attattggaa aattctctaa aagtaaaggg taaattctct
1861 attttttgta atgtgttcgg tgatttcaga aagctagaaa gtgtatgtgt ggcatttgtt
1921 ttcacttttt aaaacatccc taactgatcg aatatatcag taatttcaga atcagatgca
1981 tcctttcata agaagtgaga ggactctgac agccataaca ggagtgccac ttcatggtgc
2041 gaagtgaaca ctgtagtctt gttgttttcc caaagagaac tccgtatgtt ctcttaggtt
2101 gagtaaccca ctctgcccga attc
//