GenBank-Updates@genbank.bio.net (02/28/91)
LOCUS HUMAPOAIB 878 bp ss-mRNA PRI 28-FEB-1991
DEFINITION Human apolipoprotein A-I mRNA, complete cds.
ACCESSION M27875
KEYWORDS apolipoprotein; apolipoprotein A-I.
SOURCE Human liver DNA, clone PNIV 1602.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Moguilevsky,N., Roobol,C., Loriau,R., Guillaume,J.P., Jacobs,P.,
Cravador,A., Herzog,A., Brouwers,L., Scarso,A., Gilles,P.,
Holmquist,L., Carlson,L.A. and Bollen,A.
TITLE Production of human recombinant proapolipoprotein A-I in
Escherichia coli purification and biomedical characterization
JOURNAL DNA 8, 429-436 (1989)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Funke,H., von Eckardstein,A., Pritchard,P.H., Karas,M., Albers,J.J.
and Assmann,G.
TITLE A frameshift mutation in the human apolipoprotein A-1 gene causes
high density lipoprotein dificiency, partial lecithin:
Cholesterol-acyltransferase dificiency, and corneal opacities
JOURNAL J. Clin. Invest. 87, 371-376 (1991)
STANDARD full staff_review
COMMENT
[DNA 8, 429-436 (1989)] sites; for [Unpublished (1989) Rue de
L'Industrie 24, B1400 Nivelles, Belgium].
Draft entry and computer-readable sequence for [Unpublished (1989)
Rue de L'Industrie 24, B1400 Nivelles, Belgium] kindly submitted
by N.Moguilevsky, 13-OCT-1989.
FEATURES Location/Qualifiers
CDS 20..823
/note="proapolipoprotein /nomgen='APOA1' /map='11q23-q24'
/hgml_locus_uid='LE0096N'"
/codon_start=20
sig_peptide 20..73
/note="apolipoprotein signal peptide"
/codon_start=20
mat_peptide 92..820
/note="apolipoprotein"
/codon_start=92
mutation 696..698
/note="cgc in wt; cc in mutation causing high density
lipoprotein deficiency."
/gene="APOA1"
/citation=J. Clin. Invest. 87, 371-376 (1991)
BASE COUNT 196 a 273 c 282 g 127 t
ORIGIN
1 tcccccacgg cccttcagga tgaaagctgc ggtgctgacc ttggccgtgc tcttcctgac
61 ggggagccag gctcggcatt tctggcagca agatgaaccc ccccagagcc cctgggatcg
121 agtgaaggac ctggccactg tgtacgtgga tgtgctcaaa gacagcggca gagactatgt
181 gtcccagttt gaaggctccg ccttgggaaa acagctaaac ctaaagctcc ttgacaactg
241 ggacagcgtg acctccacct tcagcaagct gcgcgaacag ctcggccctg tgacccagga
301 gttctgggat aacctggaaa aggagacaga gggcctgagg caggagatga gcaaggatct
361 ggaggaggtg aaggccaagg tgcagcccta cctggacgac ttccagaaga agtggcagga
421 ggagatggag ctctaccgcc agaaggtgga gccgctgcgc gcagagctcc aagagggcgc
481 gcgccagaag ctgcacgagc tgcaagagaa gctgagccca ctgggcgagg agatgcgcga
541 ccgcgcgcgc gcccatgtgg acgcgctgcg cacgcatctg gccccctaca gcgacgagct
601 gcgccagcgc ttggccgcgc gccttgaggc tctcaaggag aacggcggcg ccagactggc
661 cgagtaccac gccaaggcca ccgagcatct gagcacgctc agcgagaagg ccaagcccgc
721 gctcgaggac ctccgccaag gcctgctgcc cgtgctggag agcttcaagg tcagcttcct
781 gagcgctctc gaggagtaca ctaagaagct caacacccag tgaggcgccc gccgccgccc
841 cccttcccgg tgctcagaat aaacgtttcc aaagtggg
//