GenBank-Updates@genbank.bio.net (02/07/91)
LOCUS HUMTPOD 1046 bp ds-DNA PRI 07-FEB-1991
DEFINITION Human thyroperoxidase mRNA, 3' end, and the Graves' disease
mutation.
ACCESSION M55702
KEYWORDS thyroperoxidase.
SOURCE Human Graves' thyroid, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1046)
AUTHORS Zanelli,E., Henry,M., Charvet,B. and Malthiery,Y.
TITLE Evidence for an alternate splicing in the thyroperoxidase messenger
from patients with Graves' disease
JOURNAL Biochem. Biophys. Res. Commun. 170, 735-741 (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS join(1..611,742..913)
/note="Graves' disease mutated protein"
/gene="TPO"
/partial
/product="thyroperoxidase"
CDS 1..795
/gene="TPO"
/codon_start=1
/partial
/product="thyroperoxidase"
mutation 611..742
/note="g-130 bp-g in wt; gg in Graves' disease patients."
/gene="TPO"
polyA_site 1046..>
/gene="TPO"
BASE COUNT 236 a 281 c 307 g 222 t
ORIGIN
1 ttttggtggg agaacagcca cgtcttcacg gatgcacaga ggcgtgagct ggagaagcac
61 tccctgtctc gggtcatctg tgacaacact ggcctcacca gggtgcccat ggatgccttc
121 caagtcggca aattccccga agactttgag tcttgtgaca gcatcactgg catgaacctg
181 gaggcctgga gggaaacctt tcctcaagac gacaagtgtg gcttcccaga gagcgtggag
241 aatggggact ttgtgcactg tgaggagtct gggaggcgcg tgctggtgta ttcctgccgg
301 cacgggtatg agctccaagg ccgggagcag ctcacttgca cccaggaagg atgggatttc
361 cagcctcccc tctgcaaaga tgtgaacgag tgtgcagacg gtgcccaccc cccctgccac
421 gcctctgcga ggtgcagaaa caccaaaggc ggcttccagt gtctctgcgc ggacccctac
481 gagttaggag acgatgggag aacctgcgta gactccggga ggctccctcg ggtgacttgg
541 atctccatgt cgctggctgc tctgctgatc ggaggcttcg caggtctcac ctcgacggtg
601 atttgcaggt ggacacgcac tggcactaaa tccacactgc ccatctcgga gacaggcgga
661 ggaactcccg agctgagatg cggaaagcac caggccgtag ggacctcacc gcagcgggcc
721 gcagctcagg actcggagca ggagagtgct gggatggaag gccgggatac tcacaggctg
781 ccgagagccc tctgagggca aagtggcagg acactgcaga acagcttcat gttcccaaaa
841 tcaccgtacg actcttttcc aaacacaggc aaatcggaaa tcagcaggac gactgttttc
901 ccaacacggg taaatctagt accatgtcgt agttactctc aggcatggat gaataaatgt
961 tatagctgca tttgtctggc cttttcttgt aaacattgcc tgatttgttc cttctggggc
1021 tttgcattaa aatgtattta cagatt
//GenBank-Updates@genbank.bio.net (03/02/91)
LOCUS HUMTPOD 1046 bp ds-DNA PRI 02-MAR-1991
DEFINITION Human thyroperoxidase mRNA, 3' end, and the Graves' disease
mutation.
ACCESSION M55702
KEYWORDS thyroperoxidase.
SOURCE Human Graves' thyroid, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1046)
AUTHORS Zanelli,E., Henry,M., Charvet,B. and Malthiery,Y.
TITLE Evidence for an alternate splicing in the thyroperoxidase messenger
from patients with Graves' disease
JOURNAL Biochem. Biophys. Res. Commun. 170, 735-741 (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS join(1..611,742..913)
/note="Graves' disease mutated protein"
/product="thyroperoxidase"
/gene="TPO"
/codon_start=1
/partial
CDS 1..795
/product="thyroperoxidase"
/gene="TPO"
/codon_start=1
/partial
mutation 611..742
/note="g-130 bp-g in wt; gg in Graves' disease patients."
/gene="TPO"
polyA_site 1046..1046
/gene="TPO"
BASE COUNT 236 a 281 c 307 g 222 t
ORIGIN
1 ttttggtggg agaacagcca cgtcttcacg gatgcacaga ggcgtgagct ggagaagcac
61 tccctgtctc gggtcatctg tgacaacact ggcctcacca gggtgcccat ggatgccttc
121 caagtcggca aattccccga agactttgag tcttgtgaca gcatcactgg catgaacctg
181 gaggcctgga gggaaacctt tcctcaagac gacaagtgtg gcttcccaga gagcgtggag
241 aatggggact ttgtgcactg tgaggagtct gggaggcgcg tgctggtgta ttcctgccgg
301 cacgggtatg agctccaagg ccgggagcag ctcacttgca cccaggaagg atgggatttc
361 cagcctcccc tctgcaaaga tgtgaacgag tgtgcagacg gtgcccaccc cccctgccac
421 gcctctgcga ggtgcagaaa caccaaaggc ggcttccagt gtctctgcgc ggacccctac
481 gagttaggag acgatgggag aacctgcgta gactccggga ggctccctcg ggtgacttgg
541 atctccatgt cgctggctgc tctgctgatc ggaggcttcg caggtctcac ctcgacggtg
601 atttgcaggt ggacacgcac tggcactaaa tccacactgc ccatctcgga gacaggcgga
661 ggaactcccg agctgagatg cggaaagcac caggccgtag ggacctcacc gcagcgggcc
721 gcagctcagg actcggagca ggagagtgct gggatggaag gccgggatac tcacaggctg
781 ccgagagccc tctgagggca aagtggcagg acactgcaga acagcttcat gttcccaaaa
841 tcaccgtacg actcttttcc aaacacaggc aaatcggaaa tcagcaggac gactgttttc
901 ccaacacggg taaatctagt accatgtcgt agttactctc aggcatggat gaataaatgt
961 tatagctgca tttgtctggc cttttcttgt aaacattgcc tgatttgttc cttctggggc
1021 tttgcattaa aatgtattta cagatt
//