GenBank-Updates@genbank.bio.net (03/02/91)
LOCUS HUMMDR1A 2186 bp ds-DNA PRI 02-MAR-1991
DEFINITION Human multidrug-resistance (MDR1) gene, exon 1.
ACCESSION M57450 J05673
KEYWORDS multidrug-resistance.
SOURCE Human cancer multidrug-resistant cell line KB-C1 DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2186)
AUTHORS Kohno,K., Sato,S.-i., Uchiumi,T., Takano,H., Kato,S. and Kuwano,M.
TITLE Tissue-specific enhancer of the human multidrug-resistance (MDR1)
gene
JOURNAL J. Biol. Chem. 265, 19690-19696 (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
repeat_unit 623..627
/rpt_type=5' insertion target sequence
repeat_unit 628..950
/rpt_family="Alu repeat"
repeat_unit 951..955
/rpt_type=3' insertion target sequence
mRNA 2029..2158
/number=exon 1
/product="multidrug-resistance protein"
/gene="MDR1"
/partial
intron 2159..2186
/number=1
/gene="MDR1"
/partial
BASE COUNT 744 a 383 c 476 g 583 t
ORIGIN
1 aagcttaaca gaagtggtgg tggcacaaat gcaagactgg tgtctttcaa gaaaccaagg
61 actgttgaaa gtagcaagag ctagtttgtt ttaggtccat catgttttat attcacactt
121 tcatgtcagt ggagcaaaga aatggaatac aatataatag aatggtagaa tcttattttt
181 aaaatctgtg ttattctgat ctttaactta cttatatctt tgatagagat ctttacctga
241 tgctcaagat tgtagaaata gtataatcaa cataacagta tagcactgta tttatatcct
301 gcactgttta gggagggttt aaggccattc aaaaggatac ataaaataca acaagattac
361 ataaatgaaa ggtgagataa agcaacaaag caaaacaaaa gtgaaaacag agatcatagg
421 cacaaataag attaaaaacg catgtaatga agatgaaagc ttttacattt accccagatg
481 gaccacaggg ttgttgttaa gcctttaaac agtgaacaat gctgtacact tgcatatgca
541 attagaacat gtggaaaaaa tagtggcctg ttagaagcct aattaacaat ttgtgaaaaa
601 aaaaaaaaaa aaaaaaaaaa agaggccgag ctgtagctca cgcctgtaat ccctgcactt
661 tgggaggccg aggcgggcgg atcacgaggt caggagatca agaccatcct ggctaacaca
721 gtgaaaccca gtctctacga aaaatacaaa aaattagccg ggcgtggtgg cgggagcctg
781 tagtcccagc tacctgggag gctgaggcag gagaatggtg tgaacccggg aggcggagct
841 tgcagtgagc cgagatcctg ccactgcact ccagcctggg cgacaaagca agctccgtct
901 gcaaaaaaga aaaaagaaag aaaaacaaaa gaaaacttca ttgtattgta aggccaagaa
961 caaaatatat caagataagg aaaatttgta gtcaagaata gaaaaaaatt atggctttga
1021 agtatgagtt atttaaagaa agtggaaaca tcctcagact atgcagtaaa aaacaaagtg
1081 attttcttct tctaaactta tgcaataaac tgataggtaa tatgtgaaag tcatagaatg
1141 tagactagag gatacaacaa acctatttcc tctatgttca taagaagtaa gaaaagctct
1201 gatgtgagtt agcattgctt tacaattttg aattgtgcag attgccagta cttttcctca
1261 gtttgaagta aatagtggac aggaaaaaat attaaatgtt ggcagtaaat atggaaggaa
1321 attacaacta atgtaatatg ctaaaacatg ctatgtttat tttactaatt tgaattaaaa
1381 tgtaagaatt taaaatgccc tggaaaaaca cgggcattga tctgacgtct gaagttttaa
1441 aatattacac actttgaaat agcatttgta ccttgaaata cctgtctcta tatatttttt
1501 aaaacttcct ttttctttca ttccatttat catcaaataa aggatgaaca gatgtaactc
1561 agaaactgtc aagcatgctg aagaaagacc actgcagaaa aatttctcct agccttttca
1621 aaggtgttag gaagcagaaa ggtgatacag aattggagag gtcggagttt ttgtattaac
1681 tgtattaaat gcgaatcccg agaaaatttc ccttaactac gtcctgtagt tatatggata
1741 tgaagactta tgtgaacttt gaaagacgtg tctacataag ttgaaatgtc cccaatgatt
1801 cagctgatgc gcgtttctct acttgccctt tctagagagg tgcaacggaa gccagaacat
1861 tcctcctgga aattcaacct gtttcgcagt ttctcgagga atcagcattc agtcaatccg
1921 ggccgggagc agtcatctgt ggtgaggctg attggctggg caggaacagc gccggggcgt
1981 gggctgagca cagcgcttcg ctctctttgc cacaggaagc ctgagctcat tcgagtagcg
2041 gctcttccaa gctcaaagaa gcagaggccg ctgttcgttt cctttaggtc tttccactaa
2101 agtcggagta tcttcttcca agatttcacg tcttggtggc cgttccaagg agcgcgaggt
2161 aggggcacgc aaagctggga gctact
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