GenBank-Updates@genbank.bio.net (03/05/91)
LOCUS MUSAPE 4856 bp ds-DNA ROD 05-MAR-1991
DEFINITION Mouse apolipoprotein E gene.
ACCESSION D00466
KEYWORDS apolipoprotein E.
SOURCE Mus musculus (BALB/c) genomic DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (sites)
AUTHORS Rajavashisth,T.B., Kaptein,J.S., Reue,K.L. and Lusis,A.J.
TITLE Evolution of apolipoprotein E: Mouse sequence and evidence for an
11-nucleotide ancestral unit
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 8085-8089 (1985)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 4856)
AUTHORS Horiuchi,K., Tajima,S., Menju,M. and Yamamoto,A.
TITLE Structure and expression of mouse apolipoprotein E gene
JOURNAL J. Biochem. 106, 98-103 (1989)
STANDARD full staff_entry
COMMENT
[Proc. Natl. Acad. Sci. U.S.A. 82, 8085-8089 (1985)] sites.
Submitted in computer readable form by S. Tajima on 12-Sep-1989.
FEATURES Location/Qualifiers
CDS join(1821..1863,2403..2571,2949..3672)
/note="apolipoprotein"
misc_signal 926..931
/note="put. GC box"
misc_signal 946..951
/note="put. GC box"
misc_signal 965..971
/note="put. TATA box"
precursor_RNA 997..3781
/note="apolipoprotein mRNA and introns"
intron 1039..1797
/note="apolipoprotein intron"
exon 1821..1863
/note="apolipoprotein, exon 2"
exon 1821..1863
/note="apolipoprotein, exon 2"
exon 1821..1863
/note="apolipoprotein, exon 2"
exon 1821..1863
/note="apolipoprotein, exon 2"
intron 1864..2402
/note="apolipoprotein intron"
repeat_region 2162..2197
/note="CA repeat"
exon 2403..2571
/note="apolipoprotein, exon 3"
exon 2403..2571
/note="apolipoprotein, exon 3"
exon 2403..2571
/note="apolipoprotein, exon 3"
exon 2403..2571
/note="apolipoprotein, exon 3"
variation 2518..2518
/note="g in [J. Biochem. 106, 98-103 (1989)]; t in [Proc.
Natl. Acad. Sci. U.S.A. 82, 8085-8089 (1985)]"
intron 2572..2948
/note="apolipoprotein intron"
exon 2949..3672
/note="apolipoprotein, exon 4"
exon 2949..3672
/note="apolipoprotein, exon 4"
exon 2949..3672
/note="apolipoprotein, exon 4"
exon 2949..3672
/note="apolipoprotein, exon 4"
variation 3225..3225
/note="g in [J. Biochem. 106, 98-103 (1989)]; t in [Proc.
Natl. Acad. Sci. U.S.A. 82, 8085-8089 (1985)]"
misc_signal 3762..3767
/note="poly(A) signal"
repeat_region 4167..4376
/note="rodent repeat(B2)"
BASE COUNT 1108 a 1291 c 1267 g 1190 t
ORIGIN 5' end of Sau3AI site.
1 gatcttcctg cctcagcttt gcatatggct agcactatag acccatgttc cagtgaatga
61 cttatggctt gtcttttttt tttttttttt ttttttttat gtgcattagt gttttgcctg
121 catgtatgcc ttcgtgaggg tagcagatct tggtgttaca gttgtgagct gctgtgtggg
181 tgctgcgatt ttgaacctag gtcctgtgaa atcgagtcag tgctcctaac ctctgagtca
241 tctctccagc tcctgctctt ctgcttttat gaggaaaaag aaaagagaag tggcttgaga
301 gtggaaaatg cacatgcagg ggtgcacacc tgcagtcccc agcatgctac agcagaggca
361 gaaggacctt tgtgggttag agggcagcct gagaatctta tctcaaaaca actttttaaa
421 atgtgctctg taggggtagc tcttccctcc caaggtgaca cattgcaatc gccagaaaca
481 gatcaggagc atcaacgctt ggtttcccag ggcttggctt aatgtatggc ttcaaaccca
541 tcgggagcca ccactgaaca gctcctgaag gaactggagc acgtcccagc cttggaatgg
601 aaagagttca cctgtggtgg aggaatcaac aacgagggat cccagaacaa cgatcttcac
661 cccagaagct gagcctctta gcccccaccc acccatttcc agtttaggct gaccagctct
721 tttctttaca atgcaccaga cccgcggaaa gggaaggagc ggttctcagt gcccagtacc
781 aaggcctgga ttattcaatg aggtgtccgc tccctttgtt ggcggggagg ggagcggggg
841 tcacaaggca tccaaactcc acctctttcc tctgccctgc tgtgaagggg gagagaacaa
901 cccgcctcgt gacagcgtgc acagcccgcc ctagccctga ggagggggcg gacaggggga
961 gtcctataat tggaccggtc tgggatccga tcccctgctc agaccctgga ggctaaggac
1021 ttgtttcgga aggagctggt aagacaagct gggctgggga ttcacccagg gaccttggta
1081 ggatgtgggc tgggaacctt gagatccccc ggagtccagg aaacaggcac aagaattgga
1141 aaagcaggca gcacgataga agtcttgggg gacaaactaa ggactcgagg taactagcct
1201 ttgccagagt cagagcaggt ggaggggtta cctccaggaa ggagtacggg actgtcggtg
1261 ccacggcgta ccggctcaac taggaaccag tcctatggcg aaaaaactcg ggatgagcct
1321 taggctgctt tttatataaa tacctactga tttccatcac agtccccaag taacccggac
1381 tggtttcaaa ctgtggctcc tcatggctga gctccctaag ttctgtagtt gtgggagggt
1441 accacttcgc agggatggag gacgattaaa aatcgtgtta aattaacaca aaatggaaag
1501 caggacttag ccgggaagaa agaggaatgt aagctggacc acccgctggc cctctgtgaa
1561 gtggaatttg aaccctagga gagggagctg gaatttttgg cagcggatcc acccggggtg
1621 ccgagatagc gaactcggca aggggaggta aacagacctt tgggaagagc gggtgctctg
1681 ttttggagat gtttgtgatg gctcacagat ctgagaaggg aagatggggt tctctgggtg
1741 gccggagtcc ctccaccccc gccccctggt gttcaaagac aatttttccc tccgcagact
1801 ggccaatcac aattgcgaag atgaaggctc tgtgggccgt gctgttggtc acattgctga
1861 caggtatgga gcaaggactt gctgtggtgc cgctttttct gctcctctgt ggactctatt
1921 ctagccctag atctcttctg ctggtgggtt gaggctgagg cggttctgag acctctctga
1981 gattcaatag ccctgagcag ctgttttata tactctttag gccttgattt cccctaacta
2041 taagaggatt gatggcttag tgggtaaagg tgcttatcat aaagcttgaa gacttaactc
2101 tgagaccaac atagtggaag gagagagcca attccctcta gaactctgac ctccaagggt
2161 acacacacac acacacacac acacacacac acacacaata aaaagttgat ttcttagttg
2221 ctcttaaaag tgggtataca ttttctaatt ccacacctgc ctagtctcgg ctctgaacta
2281 cataggatac aagacagtgc atgcttgtag tatctaaaca gactccacag cctccagacc
2341 cacttcaaag agacccaaaa agactgtagg tcctgaccca gccttaaact tactctacac
2401 aggatgccta gccgagggag agccggaggt gacagatcag ctcgagtggc aaagcaacca
2461 accctgggag caggccctga accgcttctg ggattacctg cgctgggtgc agacgctgtc
2521 tgaccaggtc caggaagagc tgcagagctc ccaagtcaca caagaactga cgtgagtgtc
2581 cagctctttc accctcggca ggcaccagct gatccagggt tgcctcctat ctgggtcccc
2641 agccccttct tgtttccttt ctcaattagt gtgtagccca ggttggcctt gaatcctcct
2701 gccttcttta gccttctgga tgctgggagg aacagacatt tattacttgc ttggtcgatt
2761 ggcttttggc ttcttgagac aggatcccat tctgtaactc aagctggctt cgaaggctct
2821 gcaattctta tgccgcagct tctcaacttc tgggaacaca agcgagtacc atcacctctt
2881 gcctctgtgg tttctggccc cttctgtcct gccttcatct ccttcctgtg tttcctctgg
2941 gcctgcaggg cactgatgga ggacactatg acggaagtaa aggcttacaa aaaggagctg
3001 gaggaacagc tgggtccagt ggcggaggag acacgggcca ggctgggcaa agaggtgcag
3061 gcggcacagg cccgactcgg agccgacatg gaggatctac gcaaccgact cgggcagtac
3121 cgcaacgagg tgcacaccat gctgggccag agcacagagg agatacgggc gcggctctcc
3181 acacacctgc gcaagatgcg caagcgcttg atgcgggatg ccgaggatct gcagaagcgc
3241 ctagctgtgt acaaggcagg ggcacgcgag ggcgccgagc gcggtgtgag tgccatccgt
3301 gagcgcctgg ggcctctggt ggagcaaggt cgccagcgca ctgccaacct aggcgctggg
3361 gccgcccagc ctctgcgcga tcgcgcccag gcttttggtg accgcatccg agggcggctg
3421 gaggaagtgg gcaaccaggc ccgtgaccgc ctagaggagg tgcgtgagca catggaggag
3481 gtgcgctcca agatggagga acagacccag caaatacgcc tgcaggcgga gatcttccag
3541 gcccgcctca agggctggtt cgagccaata gtggaagaca tgcatcgcca gtgggcaaac
3601 ctgatggaga agatacaggc ctctgtggct accaacccca tcatcacccc agtggcccag
3661 gagaatcaat gagtatcctt ctcctgtcct gcaacaacat ccatatccag ccaggtggcc
3721 ctgtctcaag cacctctctg gccctctggt ggcccttgct taataaagat tctccgagca
3781 cattctgagt ctctgtgagt gattccaatc agcttcagcc tcagtttatt gttttttgcc
3841 ttacctagca cacattccat ggccctgtca ctatctgtag agggaggtgg ttttgcagca
3901 atagaaatga agcctaggac ctagcaacat aaaagaacaa gtgatctacc actgagccac
3961 gcccacagcc tcactggggg attctaggca ggggctctac cactgagcca cccgcagccc
4021 tcactgggga atcatatcta ccactgagtc acgcccctcc agcccctcac tacggaattc
4081 tagtcagtag ctctaccact gagccacacc cacagcctct ggggctcttc accgccccct
4141 acccctggat tctaggcatg ggcatcattt tatttattta tttatttaag atttgtttat
4201 cttatgtata aggtacactg cagctgtctt caggcgtcag gtcccattac agatggttgt
4261 gagccaccat gtggttgctg ggaattgaac tcaggactta tagaagagta gtcagtgctc
4321 ttaactgctg agccatctct ccagcaccca gtacaggctc ttctatttag ctatatccac
4381 ccttcttttt agtctgaaat aggatctcaa ctgatttcct tgcactcctc tagcctagtt
4441 ggtcttgaat attgaatctt gtttcaatca atctctacag gaactgagaa aggcatgtac
4501 acttcatgtg ggtcagttgg gctacttttc ccaacttccc aagcacccac tcgacagcta
4561 tgccttgaat caatcaacat gtaagagacc agggtcgcca ggacggagat ttacttttct
4621 ggttgtctta tctctcctcc tccgctctag tcttatctga ccaccctctc cttgccttgt
4681 ctctcctctt tttcccttct aggcttcctt ttctggcttc ctgttttcct gatcctctgt
4741 tatctcaccc tcccgcggtt tcttttgctc tgggcctttg gttggcggtt tctacggttt
4801 ctacgtggct tttggaacct cagcctttct cccttgctct gaagttagct ggatcc
//