GenBank-Updates@genbank.bio.net (03/05/91)
LOCUS CXB21CG 7401 bp ss-RNA VRL 05-MAR-1991
DEFINITION Coxsackievirus A21, complete viral genome.
ACCESSION D00538
KEYWORDS complete genome; polymerase; protease.
SOURCE Coxsackievirus (Coe strain), cDNA to viral RNA.
ORGANISM Coxsackievirus A21
Viridae; ss-RNA nonenveloped viruses; Isometric ss-RNA viruses;
Picornaviridae; Enterovirus.
REFERENCE 1 (bases 1 to 7401)
AUTHORS Hughes,P.J., North,C., Minor,P.D. and Stanway,G.
TITLE The complete nucleotide sequence of coxsackievirus A21
JOURNAL J. Gen. Virol. 70, 2943-2952 (1989)
STANDARD full staff_entry
COMMENT Protein boundaries are predicted by alignment with those of other
enteroviruses.
FEATURES Location/Qualifiers
CDS 712..7332
/note="polyprotein precursor"
mat_peptide 712..918
/note="VP4 protein"
mat_peptide 919..1734
/note="VP2 protein"
mat_peptide 1735..2454
/note="VP3 protein"
mat_peptide 2455..3348
/note="VP1 protein"
mat_peptide 3349..3795
/note="2A protein"
mat_peptide 3796..4086
/note="2B protein"
mat_peptide 4087..5070
/note="2C protein"
mat_peptide 5071..5331
/note="3A protein"
mat_peptide 5332..5397
/note="VPg (3B) protein"
mat_peptide 5398..5946
/note="protease (3C) protein"
mat_peptide 5947..7329
/note="polymerase (3D) protein"
BASE COUNT 2194 a 1647 c 1694 g 1866 t
ORIGIN 5' end of the viral RNA.
1 ttaaaacagc tctggggttg ctcccacccc agaggcccac gtggcggcta gtaatctggt
61 atcaggtacc tttgtacgcc tgttttatat cccttccccc gtaactttag aagcttatca
121 aaagttcaat agcaggggta caagccagta cctctacgaa caagcacttc tgtttccccg
181 gtgaaatcat atagactgta cccacggtca aaagtgattg atccgttatc cgcttgagta
241 cttcgagaag cctagtatcg ccttggaatc ttcgacgcgt tgcgctcaac actctgcccc
301 gagtgtagct taggctgatg agtctgggca ctccccaccg gcgacggtgg cccaggctgc
361 gttggcggcc tacccatggc tgatgccgtg ggacgctagt tgtgaacaag gtgtgaagag
421 cctattgagc tactcaagag tcctccggcc cctgaatgcg gctaatccta accacggagc
481 aatcgctcac gacccagtga gtaggttgtc gtaatgcgta agtctgtggc ggaaccgact
541 actttgggtg tccgtgtttc cctttatatt catactggct gcttatggtg acaatttacg
601 aattgttacc atatagctat tggattggcc acccagtgct gtgcaatata tttgagtgct
661 tctttcatag gtgttaccaa catcacattt aaaccacaat agtcagtgca aatgggggct
721 caagtttcaa cccaaaagac cggtgcacac gagaatcaaa acgtggcagc caatggatcc
781 accattaatt atactaccat caactactac aaagacagcg cgagtaactc cgctactaga
841 caagacctct cccaagatcc atcaaaattc acagaaccgg ttaaggactt aatgttgaaa
901 acagcaccag ctttaaactc gcccaacgtg gaagcatgtg ggtacagtga ccgtgtgagg
961 caaatcactt taggtaactc gaccattacc acacaggaag cagctaatgc tattgttgct
1021 tatggtgagt ggcccactta cataaatgac tcagaagcta atccggtaga tgcacccact
1081 gaaccagacg ttagtagcaa ccgtttttac accctggaat cggtgtcttg gaagaccact
1141 tcaaggggat ggtggtggaa gctaccagat tgtctaaaag atatgggaat gtttggtcag
1201 aatatgtact atcactactt aggacgctct ggttacacca ttcatgtcca gtgcaacgct
1261 tctaagtttc accaaggggc gttaggagtt ttcctgatac cagagtttgt catggcttgc
1321 aacactgaga gtaaaacatc atatgtttca tacatcaacg caaatcctgg tgaaaggggc
1381 ggtgagttca cgaacaccta caacccatca aacactgatg tcagtgaggg cagacagttc
1441 gcagcactgg attatctgct gggttctggt gtcctagcag gaaacgcttt cgtatacccg
1501 caccagatca tcaatttgcg caccaacaac agtgcaacaa ttgtggtacc atatgtgaac
1561 tcgctcgtga ttgattgtat ggcaaaacac aataactggg gtattgtcat attaccactg
1621 gcacccttgg cctttgccgc aacatcgtca ccacaggtgc ctattacagt gaccatcgca
1681 cccatgtgta cagaatttaa tgggttgaga aatattacca tcccagtaca tcaagggttg
1741 ccaacaatga acacacctgg ttccaatcaa ttccttacat ctgatgactt ccagtcgccc
1801 tgtgccttac ctaattttga tgttactcca ccgatacaca tacccgggga agtgaagaat
1861 atgatggaac tagctgaaat tgacacactg atcccaatga acgcagtgga cgggaaggtg
1921 aacacaatgg aaatgtatca aataccattg aatgacaatt tgagcaaggc acctatattc
1981 tgtctatctt tatcacctgc ttctgacaaa cgactgagtc acaccatgtt gggtgaaatt
2041 ctaaattatt acactcattg gacggggtcc atcaggttca cctttctatt ttgtggtagt
2101 atgatggcca ctggtaaact gctcctcagc tattccccac caggagctaa accaccaacc
2161 aatcgcaagg atgcaatgct aggtacacac atcatctggg acctagggtt acaatccagt
2221 tgttccatgg ttgcaccgtg gatctctaac acagtgtaca ggcggtgtgc acgtgatgac
2281 ttcactgagg gcgggtttat aacttgcttt tatcaaacta gaattgttgt gcctgcttca
2341 acccccacca gtatgttcat gttaggcttt gttagtgcgt gtccagattt cagtgtcaga
2401 ctgcttaggg acacttccca tattagtcaa tcaaaactaa tagcacgcac acaaggcatt
2461 gaagacctca ttgacacagc gataaagaat gccttaagag tgtcccaacc acttcggccc
2521 agtcaactga agcaacccaa tggagtaaat agccaggagg tgccagctct aactgctgtg
2581 gaaacaggag catctggtca agcgatcccc agtgatgtgg tggaaactag acacgtgata
2641 aattacaaaa ccaggtctga atcgtgtctt gagtcattct ttgggagagc tgcgtgtgtc
2701 acaatcctat ctctgaccaa ctcttccaag agcggggagg agaagaagca tttcaacata
2761 tggaacatta catacaccga cactgttcag ttacgcagaa aattggagtt tttcacgtat
2821 tccaggtttg accttgaaat gacttttgtg ttcacagaga attaccctag tacagccagt
2881 ggggaagtgc gtaaccaatg tgaccagatc atgtacattc caccaggggc accccgtcca
2941 tcatcctggg atgactatac atggcaatcc tcctctaacc cttccatctt ttacatgtat
3001 ggaaatgcac ctccacggat gtcaattcct tacgtgggga ttgccaatgc ctattcacac
3061 ttctatgatg gctttgcacg ggtgccactt gagggtgaga ataccgatgc tggtgacacg
3121 ttttacggct tagtgtccat aaatgatttt ggagttttag cagttagagc ggtaaaccgc
3181 agtaacccac acactataca cacatctgtg agagtgtaca tgaaaccaaa acacattcgg
3241 tgttggtgcc ccagacctcc tcgggctgta ttatacaggg gagagggagt ggacatgata
3301 tccagtgcaa ttcaacctct gactaaagta gactcaatta ccacttttgg gtttggccac
3361 cagaacaagg cagtgtacgt tgccggttac aagatttgta actaccacct agcaacccca
3421 agtgatcact tgaatgcaat tagtgtgtta tgggacaggg atttaatggt ggtggaatct
3481 agagcccagg gaactgatac cattgccagg tgtagttgca ggtgtggagt ttactattgt
3541 gaatctagaa ggaagtacta ccttgtcact ttcactggcc caacgtttcg atttatggaa
3601 gcaaatgact actatccagc aagataccag tctcacatgc tgatagggtg cggatttgca
3661 gaacccgggg actgtggtgg gatattaagg tgcactcatg gggtgattgg tatcatcact
3721 gcagggggtg aagggatagt agcctttgct gacattagag acctttgggt gtatgaagag
3781 gaagccatgg aacagggaat aacaagttac atcgaatccc tcggtacagc ttttggtgca
3841 gggttcaccc acacaatcag tgagaaagtg actgagttga caacaatggt caccagtact
3901 atcacagaaa aattactgaa aaatttagtg aaaatagtat cggctctagt gattgttgtg
3961 agaaattatg aggacactac cacgatcctt gcaacactag cattacttgg gtgtgatata
4021 tctccttggc aatggttgaa gaagaaggca tgtgacttac tagagattcc tcatgtgatg
4081 cgccaaggtg atgggtggat gaagaaattc acagaggctt gcaatgcagc taaagggctt
4141 agatgggtca gcaataaaat ttccaagttt gtagattggt tgaagtgtaa aattatccca
4201 gaagctaagg acaaggtgga atttctcacc aagttgaaac agctagacat gctggaaaat
4261 caaattgcaa ccatccacca atcttgcccc agccaagaac aacaagagat ccttttcaac
4321 aacgtaagat ggctagcagt ccagtcccgt cggttcgcgc cattatatgc tgtggaggca
4381 cgccggatta gcaaaatgga gagcacaata aacaattata tacagttcaa gagcaaacac
4441 cgtattgagc cagtatgtat gctcgttcat gggtcaccag ggacgggtaa gggtatagct
4501 agctcattga taggtagagc aatagcagag agggaaacca catcggtcta ctcagtgcca
4561 ctggccccat ctcactttga tggctataaa caacaagggt atgatatgga cgacctaaac
4621 caaaaccccg atggtatgga catgaaactg ttttgccaaa tggtatcaac agtggagttc
4681 attcctccaa tggcctcact agaggagaag ggtattttgt ttacatctga ttatgtcctg
4741 gcttctacca actctcactc aatagcacca cccacagtag ctcatagtga tgccttaacc
4801 agacgatttg catttgatgt ggaggtttac acgatgtctg aacattcagt caaaggcaaa
4861 ctaaacatgg ccacagccac tcagttgtgt aaggattgtc caacacctgc aaatttcaaa
4921 aagtgttgcc ctctcgtctg tggaaaggcc ttgcaattaa tggacaggta caccagacag
4981 aggttcactg tggatgagat taccacatta atcatgaatg agaaaaacag aagggccaac
5041 attggcaatt gtatggaagc cttgtttcaa ggaccactga ggtacaaaga tctgaagatt
5101 gatgtgaaga cagttccccc ccctgagtgc atcagtgatt tattacaagc agtggattct
5161 caagaggtta gggattactg tgagaagaaa ggctggatcg ttaacgttac tagccagata
5221 caattagaaa ggaacatcaa tagggccatg actatactcc aagctgttac cacatttgca
5281 gcagtcgcag gagtagtgta tgtaatgtac aaactcttcg ctggccagca gggtgcatac
5341 actggcttgc caaacaaaaa gcccaatgtc cctactatca gaattgctaa agtccagggg
5401 ccaggatttg actatgcagt ggcaatggca aaaagaaaca tagttactgc aaccaccact
5461 aagggtgaat ttaccatgtt aggggtgcat gataatgtag caatattgcc aacccatgcc
5521 gctccaggag aaactatcat tgttgatggg aaagaagtgg agatcctaga tgccagagcc
5581 ttagaagatc aagcgggaac caaccttgag attaccatta ttactctaaa aagaaatgag
5641 aaatttagag acatcagacc acatattccc acccaaatta ctgaaactaa cgatggagtg
5701 ttgatcgtga acactagtaa gtaccccaac atgtatgtcc cagttggtgc tgtgactgaa
5761 cagggatatc ttaatctcag tggacgccaa actgctcgta ctttaatgta caactttcca
5821 acacgagcag gccagtgcgg aggaatcatc acttgtactg gcaaagtcat tgggatgcac
5881 gttggcggga acggttcaca tgggtttgca gcagccctta agcgatcata cttcacccaa
5941 aatcagggcg aaattcaatg gatgaggtca tcaaaagaag tggggtaccc cattataaat
6001 gccccatcca agacaaagtt agaacccagt gcttttcact atgtttttga aggtgttaag
6061 gaaccagctg tgctcactaa aaatgacccc agactaaaaa cagattttga agaagccatc
6121 ttttcaaaat acgtggggaa caaaattact gaagtggacg aatacatgaa agaagcagtg
6181 gatcactatg caggacagtt aatgtcactg gatatcaaca cagaacagat gtgcctggag
6241 gatgccatgt acggtactga tggtcttgaa gctctggatc ttagcactag tgctggatac
6301 ccttatgttg caatggggaa aaagaaaaga gacattctag acaaacagac cagggatact
6361 aaagagatgc agagactttt ggacacctat ggaatcaacc taccattagt cacatacgtg
6421 aaagatgaac tcagatcaaa gactaaagtg gaacaaggaa agtcaaggtt gattgaagct
6481 tccagtctta atgattcagt tgcaatgaga atggcctttg gcaatcttta cgcagctttc
6541 cacaagaatc caggcgtggt gacaggatca gcagttggtt gtgacccaga tttgttttgg
6601 agcaagatac cagtgctaat ggaagaaaaa ctcttcgctt ttgactacac agggtatgat
6661 gcctcactca gccctgcttg gtttgaagct cttaaaatgg tgttagaaaa gattggattc
6721 ggcaatagag tagactacat agactacctg aaccactctc accaccttta taaaaacaaa
6781 acttattgtg tcaaaggtgg catgccatcc ggctgctctg gcacatcaat tttcaactca
6841 atgattaata acctgatcat taggacgctt ttactgagaa cctacaaggg catagacttg
6901 gaccacctaa aaatgattgc ctatggtgat gacgtgatag cttcctaccc ccatgaggtt
6961 gacgctagtc tcctagccca atcaggaaaa gactatggac tgaccatgac tccagcagat
7021 aaatcagcaa cctttgaaac agtcacatgg gagaatgtaa cattcctgaa aagatttttc
7081 agagcagatg agaagtatcc attcctggtg catccagtga tgccaatgaa agaaattcac
7141 gaatcaatca gatggaccaa ggaccctaga aacacacagg atcacgtacg ctcattgtgc
7201 ctattggctt ggcataacgg cgaagaagaa tataataaat ttttagctaa aatcagaagt
7261 gtgccaatcg gaagagcttt attgctccca gagtactcca cattgtaccg ccgatggctc
7321 gattcatttt agtaacccta cctcagtcgg attcggattg ggttatactg ttgtaggggt
7381 aaatttttct ttaattcgga g
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