GenBank-Updates@genbank.bio.net (03/05/91)
LOCUS CXB9CG 7452 bp ss-RNA VRL 05-MAR-1991
DEFINITION Coxsackievirus A9 complete viral genome.
ACCESSION D00627
KEYWORDS complete genome; polymerase; protease.
SOURCE Coxsackievirus A9 (Griggs strain) obtained from the American Type
Culture Collection, cDNA to viral RNA.
ORGANISM Coxsackievirus A
Viridae; ss-RNA nonenveloped viruses; Isometric ss-RNA viruses;
Picornaviridae; Enterovirus.
REFERENCE 1 (bases 1 to 7452)
AUTHORS Chang,K., Auvinen,P., Hyypia,T. and Stanway,G.
TITLE The nucleotide sequence of coxsackievirus A9; implications for
receptor binding and enterovirus classification
JOURNAL J. Gen. Virol. 70, 3269-3280 (1989)
STANDARD full staff_entry
COMMENT These data kindly submitted in computer readable form by:
Glyn Stanway
Biology Department,
Essex University
Wivenhoe Park
Colchester CO4 3SQ
Phone: 0206-873308
Fax: 0206-873598
FEATURES Location/Qualifiers
misc_feature 10..36
/note="stem-loop structure"
misc_feature 591..620
/note="stem-loop structure"
CDS 744..7349
/note="polyprotein precursor"
mat_peptide 747..950
/note="VP4 (1A) protein"
mat_peptide 951..1733
/note="VP2 (1B) protein"
mat_peptide 1734..2447
/note="VP3 (1C) protein"
mat_peptide 2448..3353
/note="VP1 (1D) protein (3' end put.)"
misc_feature 3315..3323
/note="RGD sequence"
mat_peptide 3354..3794
/note="2A protein (protease) (5' end put.)"
mat_peptide 3795..4091
/note="2B protein"
mat_peptide 4092..5078
/note="2C protein (helicase?)"
mat_peptide 5079..5345
/note="3A protein"
mat_peptide 5346..5411
/note="3B protein (VPg)"
mat_peptide 5412..5960
/note="3C protein (protease)"
mat_peptide 5961..7346
/note="3D protein (polymerase)"
BASE COUNT 2128 a 1708 c 1828 g 1788 t
ORIGIN 5' end of viral RNA.
1 tttaaaacag cctgtgggtt gttcccaccc acaggcgcca ccgggcgtta gcacactggt
61 atcacggtac ccttgtgcgc ctgttttata accccacccc gagtaaacct tagaagcaat
121 gcacctctgg tcaatagtag gtgtgacaca ccagtcacat cgtgaccaag cacttctgtc
181 tccccggact gagtatcaat aggctgctcg cgcggctgaa ggagaaagcg ttcgttaccc
241 ggccagctac ttcgagaagc ctagtaacac catgaaggtt gcagagtgtt tcgctcagca
301 cttcccctgt gtagatcagg ccgatgagtc accgcgttcc tcacgggcga ccgtggcggt
361 cgctgcgctg gtggcctgcc tatggggcaa cccataggac gctctaatgc tgacatggtg
421 cgaagagtct attgagctag ctggtagtcc tccggcccct gaatgcggct aatcccaact
481 gcggagcacg caccctcaaa ccagggggca gcgtgtcgta acgggcaact ctgcagcgga
541 accgactact ttgggtgtcc gtgtttcttt ttattcctat attggctgct tatggtgaca
601 attgagagat tgttaccata tagctattgg attggccatc cggtgagcaa cagagctatt
661 gtgtatctgt ttactggttt catacccctt aattacaaag aagtcaaaac ccttcacttg
721 atcttgttat tcaatacaac aaaatgggag ctcaagtgtc aacacagaaa actggagctc
781 atgaaaccag tttaagtgcg gcaggtaatt caattataca ttatacgaac atcaactact
841 ataaagatgc tgcgtctaat tcggctaatc ggcaagactt tacacaagac ccgagtaagt
901 ttacagagcc tgttaaagat gttatgatta agtctttacc tgccctcaac tcaccaacag
961 tagaagagtg cgggtacagc gatcgggtta ggtccatcac ccttggaaac tccacgataa
1021 ccacgcagga gtgtgctaac gtggtggtgg ggtatggtag atggcccact tacctcaggg
1081 acgacgaggc gactgccgag gatcaaccca cacagcctga cgtagcaaca tgccgctttt
1141 atactttaga ttcaatcaag tgggaaaagg gatcggtggg gtggtggtgg aagttcccag
1201 aagcgcttag tgatatggga ttattcggtc agaacatgca ataccactac ctgggtcgtg
1261 cagggtacac tattcaccta caatgtaacg cttccaagtt ccatcaaggg tgtttgctag
1321 tagtgtgtgt gcccgaggct gagatgggag gagctgtggt tggacaagca ttttccgcca
1381 ccgcgatggc aaatggtgat aaagcatatg agttcactag cgcaacccaa agtgatcaga
1441 caaaagttca aactgctata cacaatgcag ggatgggcgt aggtgtaggg aacctcacta
1501 tctacccgca ccagtggata aatttgcgca ccaacaacag tgccaccata gtgatgccat
1561 atattaatag tgtgcccatg gacaacatgt tcagacatta taattttacc ctgatggtga
1621 taccttttgt gaaactggac tatgccgaca ccgcatccac gtacgtgcca attacagtga
1681 cggtggcccc aatgtgtgcg gagtataacg gcttacgtct ggcacaagcg caaggtttgc
1741 caactatgaa cacaccagga agcacgcaat tcctaacatc agatgacttt caatcgccgt
1801 gcgctttgcc acaatttgat gtgacgccta gtatgaacat cccaggagaa gtgaagaacc
1861 taatggaaat agcagaagtg gactcggtcg tgcccgtgaa caatgtccaa gacaccactg
1921 accaaatgga gatgttcagg ataccagtga ccataaatgc ccctctacaa caacaggttt
1981 ttggcctcag attgcaacca ggcttagata gtgtgtttaa gcacactctg ttgggagaaa
2041 ttctaaacta ctatgcgcac tggtcaggca gcatgaagct gacatttgtg ttttgcgggt
2101 ctgcaatggc aacagggaaa tttttaatag catattcacc acctggggcc aaccccccga
2161 aaacacgaaa ggatgcaatg ctgggaacac atatcatatg ggacattggt ttacaatcta
2221 gctgtgtgtt gtgtgtgcca tggatcagtc aaacacatta taggcttgta cagcaggatg
2281 agtacaccag cgctggttac gtgacgtgtt ggtatcagac tggtatgatt gtcccaccag
2341 gaaccccaaa ttctagctct attatgtgct ttgcatcagc gtgcaacgac ttctcagtaa
2401 gaatgttgag ggacacacca ttcatatccc aggataataa gctgcaaggg gatgtggaag
2461 aagccattga gagggcacgt tgtacagttg ctgacaccat gcgtacgggg cctagcaatt
2521 ccgcgagcgt acctgcactc actgcagttg agacagggca cacctcgcaa gttactccaa
2581 gtgacactat gcagacaaga catgtgaaaa actatcattc gcgctctgag tcgactgtgg
2641 agaatttcct cggtcggtcg gcatgcgtgt acatggaaga gtacaagacc actgataagc
2701 atgttaacaa gaaattcgtc gcctggccaa tcaacacaaa acaaatggtt cagatgcgga
2761 ggaagctgga aatgttcact tatcttaggt ttgatatgga ggtaactttt gtgatcacaa
2821 gtcgacaaga ccccggaaca accctagctc aggacatgcc cgtgttgacg cgccaaatca
2881 tgtatgtgcc acctggcggt ccgattccag caaaagttga tgattatgcc tggcagacgt
2941 ctacaaaccc cagcattttc tggacggaag gaaacgcacc agcgcgcatg tccatcccat
3001 ttatcagcat aggaaatgca tacagcaatt tttatgacgg gtggtcaaat tttgatcaga
3061 ggggctcata cgggtacaat accctgaata acttaggtca catatatgtg agacacgtga
3121 gtggaagtag tcctcaccca atcacgagca ctattagagt gtatttcaag ccaaaacata
3181 ccagagcttg ggtgccgcgc cctccaaggc tatgccaata caagaaggca tttagcgtgg
3241 atttcacgcc aactcccatt acagacacca ggaaagacat caacactgta accaccgtgg
3301 cgcaaagtcg gcgtcggggt gacatgtcca cccttaacac gcatggtgcc ttcggacaac
3361 aatccggggc cgtctatgtg ggcaactaca gagtgatcaa cagacacctg gcaacacaca
3421 cggattggca aaattgcgtg tgggaggatt acaatagaga cctccttgtg agcacgacta
3481 cagcgcacgg gtgtgatgtc atagctagat gccagtgtac aaccggggtg tacttttgtg
3541 catccaagaa caagcactac cctgtttcat tcgaagggcc aggtttagtg gaagtccaag
3601 agagtgaata ctaccctaaa agatatcaat cccatgtact tctggcagca ggattttccg
3661 aaccagggga ctgtggtggc atcttaaggt gtgaacacgg tgtcataggc atcgtaacca
3721 tgggaggcga aggtgttgtg ggttttgctg acgtgcgcga cctcttatgg ttagaggatg
3781 acgctatgga gcagggtgtg aaggactacg tggagcaact tggaaatgca tttggttcag
3841 gcttcaccaa tcagatctgt gagcaagtta accttttaaa agaatcacta gtgggtcaag
3901 actccatctt agagaaatct ctaaaagccc tagtcaagat aatatcagcc ttagtgatcg
3961 tggtgaggaa ccacgatgac ctaattacag tgactgccat actagccctc atcggttgca
4021 cctcgtctcc atggcggtgg cttaaacaga aagtgtcaca gtattatggg atacccatgg
4081 ctgaacgcca aaatgatagc tggctcaaga aattcactga aatgacaaat gcctgcaaac
4141 gaatggagtg gatagccatc aaaattcaga agtttataga gtggctcaaa gttaaaattc
4201 taccagaggt aagggagaag catgagttcc tgaacagact taaacagctt cccctattag
4261 agagtcagat tgccaccatc gagcagagtg caccatccca aagcgaccaa gagcaattgt
4321 tttccaatgt ccagtacttt gcacactatt gcagaaagta tgcccccctc tacgcagcag
4381 aggcaaagag ggtgttctcc cttgagaaaa agatgagcaa ttacatacag ttcaagtcca
4441 aatgccgtat tgagcctgta tgtttgctcc tacatgggag tccaggtgcc ggcaagtcgg
4501 tggcaacaaa cctaattgga aggtcactcg ctgagaaatt aaacagttca gtgtactcat
4561 taccaccaga cccagatcac tttgatggct acaaacaaca ggccgtagtg attatggatg
4621 acctatgcca gaaccctgat ggaaaagatg tctccttgtt ttgccaaatg gtctctagtg
4681 tagattttgt gccgcccatg gctgccttgg aagagaaggg cattttgttc acctctccgt
4741 tcgttctggc atcgactaat gcaggatcca taaatgctcc aactgtgtca gacagcaggg
4801 ccttagcaag gaggtttcac ttcgatatga acattgaagt tatctccatg tatagtcaga
4861 acggcaaaat aaatatgccg atgtcagtga agacgtgtga tgaagagtgc tgtccagtca
4921 actttaagaa gtgttgccct ctagtatgtg gtaaagccat ccagttcata gacagaagaa
4981 cccaagttag atactccctt gacatgctgg taactgagat gtttagagag tataaccata
5041 ggcatagtgt cggggccacc cttgaggcat tattccaggg tccaccgata tatagagaaa
5101 ttaagatcag tgttgcgcca gagacaccac caccacctgt catcgctgat ctactcaagt
5161 cggtggacag tgaggatgtg agagagtact gcaaagaaaa gggatggttg atccctgagg
5221 taaactccac cctccaaatt gaaaaatacg tcagtcgggc tttcatttgc ttgcaggcaa
5281 taaccacatt cgtgtcagta gctgggatca tctacataat atataagctc tttgcaggct
5341 ttcagggtgc atatacagga atacccaatc agaaacctaa ggtacctacc ttaagacaag
5401 caaaagtgca gggtcccgca tttgaattcg ccgttgcaat gatgaagaga aactcaagca
5461 cggtgaagac tgagtatggc gaattcacca tgctgggcat ctatgacagg tgggccgtct
5521 taccacgcca cgctaagcct ggaccaacca tcctgatgaa tgaccaggaa gtgggcgtga
5581 tggatgctaa ggaattagtg gataaggatg gcacaaacct agaactgaca ttgcttaaat
5641 taaacaggaa tgagaagttc agagacatca gaggcttctt agctaaggag gagatggagg
5701 tcaacgaagc cgtgctagca attaatacca gtaaatttcc caacatgtac attccagtgg
5761 gacaagtcac ggactacggc ttcctaaacc tgggtggtac acccactaag agaatgctca
5821 tgtacaactt ccccacaaga gcaggtcagt gcggcggagt gctcatgtcc actggcaaag
5881 tcttgggaat ccatgttggt ggaaatggtc atcaaggttt ctcagcagca cttctcaagc
5941 actacttcaa tgatgaacaa ggagagatcg agttcattga gagttcaaag gatgcagggt
6001 tcccgattat caatacacct agtaagacca agctggagcc aagtgtcttc catcaagttt
6061 ttgaaggtgt caaagaacca gcggtcctca ggaatggtga tccacgcctc aaagctaatt
6121 ttgaggaagc catattttcc aagtacatcg gaaatgttaa cacgcacgtg gatgaataca
6181 tgctggaagc tgttgatcat tatgccggac aattggccac cctagatatt agcactgaac
6241 caatgaagtt ggaggatgct gtatacggta ctgaaggtct tgaggctctt gacctaacaa
6301 cgagtgcagg ttacccttat gttgctctgg gcatcaagaa gagggacatt ctctcaaaga
6361 agaccaggga cctgaccaag ctgaaggagt gcatggacaa gtatggccta aacttgccaa
6421 tgataaccta tgtgaaagat caactcagat ctgcagagaa ggtggcaaag ggaaagtcta
6481 ggctcattga ggcgtccagt ttgaatgact ccgtggcaat gagacagaca ttcggcaacc
6541 tatacaaaac ttttcaccta aacccaggga ttgtgactgg cagtgccgtc gggtgtgacc
6601 cggatctctt ttggagtaaa ataccagtaa tgttaaacgg tcacctcata gcctttgatt
6661 actctggata tgatgctagc ttgagtcctg tatggtttgc ttgtctaaaa ctactacttg
6721 agaaacttgg ttactcgcac aaggagacca attacattga ttacctgtgc aactcccatc
6781 acctgtacag ggacaagcat tatttcgtgc ggggtggcat gccatcagga tgttctggca
6841 cgagcatctt taactcaatg ataaacaaca tcataattag gacactcatg ttgaaggttt
6901 acaaagggat cgacttggat caattcagga tgattgctta tggtgacgat gtgatcgcat
6961 catacccgtg gcccatagat gcgtctttgc ttgctgaagc tggcaaggac tatggattaa
7021 tcatgacacc agcagacaaa ggggagtgct tcaatgaagt tacttggact aacgtcacat
7081 tcctaaagag gtattttaga gcagatgaac aatacccctt tttagtgcac cctgttatgc
7141 ctatgaaaga catacacgaa tcaatcagat ggaccaagga tccaaagaac acccaagacc
7201 acgtgcgctc gctatgctta ttagcttggc acaacgggga gcacgaatat gaggagttca
7261 ttcgcaaaat caggagcgtc ccagttggac gttgtttgac cctacctgcg ttctcaaccc
7321 tacgcaggaa gtggttggac tctttctaaa ttagagacaa tttgaactga tttgaattgg
7381 ctcaacccta ctgtactaac cgaactagat aacggtgcag taggggtaaa ttctccgcat
7441 tcggtgcgga gg
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