GenBank-Updates@genbank.bio.net (03/05/91)
LOCUS HUMTS 1186 bp ds-DNA PRI 05-MAR-1991
DEFINITION Human thymidylate synthase gene, exon 1.
ACCESSION D00517
KEYWORDS thymidylate synthase.
SOURCE Human DNA from a genomic library of the mouse cell transformant CO,
clone lambda HTS-1.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1186)
AUTHORS Takeishi,K., Kaneda,S., Ayusawa,D., Shimizu,K., Gotoh,O. and
Seno,T.
TITLE Human thymidylate synthase gene: Isolation of phage clones which
cover a functionally active gene and structural analysis of the
region upstream from the translation initiation codon
JOURNAL J. Biochem. 106, 575-583 (1989)
STANDARD full staff_entry
COMMENT These data kindly submitted in computer readable form by:
Keiichi Takeishi
University of Shizuoka School of Food and Nutritional Sciences
395 Yada
Shizuoka-shi,
Shizuoka-ken 422
Japan
Phone: 0542-64-5540
Fax: 0542-64-5099
FEATURES Location/Qualifiers
misc_feature 115..400
/note="Alu sequence"
precursor_RNA 751..>1186
/note="thymidylate synthase mRNA and intron"
repeat_region 785..812
/note="inverted sequence to TTR"
repeat_region 827..916
/note="triple tandem repeat (TTR)"
CDS 924..>1128
/partial
/note="thymidylate synthase (EC 2.1.1.45), exon 1"
intron 1129..>1186
/note="thymidylate synthase intron 1"
BASE COUNT 224 a 386 c 347 g 229 t
ORIGIN Sau3AI site; Chromosome 18.
1 gatcgcgcca ctgcactcca gcctgggtga gagagcgaga ctctgtctca aaaaaaaaaa
61 aaaaagaccg ccagggctca aacaaaaaac ctcggaaaag ccctggcggt cttttttttt
121 tttttttttt tttttttttg ggacagtctt gctctgtcgc ccaggctgga gtacaatggt
181 cggatcttgg ctcactgcaa cctctgcctc ccaggttcaa gcaattcttc tgcctcagcc
241 tcccaagtag ccaccacgcc cagctaattt ttgtactttt agtagagacg ggggtttcac
301 catgttgtcc aggctggtct tgaactcctg acctcaggtg atccacccgc ctcggccccc
361 caaagtacta ggattacagg cgtgagccac cgcgtccagc gccctggcgg tttttaatca
421 agtagaaaag ctgcattata ccacttgctt cggttgcttc agtgagaacg aagaaatgga
481 aatgcaaatc ccttattagt tgtaggaaac agatctcaaa cagcagtttt gttgacaaga
541 ccgcaggaaa acgtgggaac tgtgctgctg gcttagagaa ggcgcggtcg accagacggt
601 tcccaaaggg cgcagtcctt cccagccacc gcacctgcat ccaggttccc gggtttccta
661 agactctcag ctgtggccct gggctccgtt ctgtgccaca cccgtggctc ctgcgtttcc
721 ccctggcgca cgctctctag agcgggggcc gccgcgaccc cgccgagcag gaagaggcgg
781 agcgcgggac ggccgcggga aaaggcgcgc ggaaggggtc ctgccaccgc gccacttggc
841 ctgcctccgt cccgccgcgc cacttggcct gcctccgtcc cgccgcgcca cttcgcctgc
901 ctccgtcccc cgcccgccgc gccatgcctg tggccggctc ggagctgccg cgccggccct
961 tgccccccgc cgcacaggag cgggacgccg agccgcgtcc gccgcacggg gagctgcagt
1021 acctggggca gatccaacac atcctccgct gcggcgtcag gaaggacgac cgcacgggca
1081 ccggcaccct gtcggtattc ggcatgcagg cgcgctacag cctgagaggt gacgccgcgg
1141 gcccctgcgg gacgggtggc gggaaggagg gaggcgcggc tgggga
//