GenBank-Updates@genbank.bio.net (03/06/91)
LOCUS MUSMDR1B 723 bp ds-DNA ROD 06-MAR-1991
DEFINITION Mouse multidrug resistance P-glycoprotein (mdr1b) gene, exon 1.
ACCESSION M57524
KEYWORDS P-glycoprotein; integral membrane glycoprotein; multidrug
resistance.
SOURCE Mouse macrophage cell line J7.V1-1 DNA, clone lambda-4.1.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 723)
AUTHORS Cohen,D., Piekarz,R.L., Hsu,S.I.-H., DePinho,R.A., Carrasco,N. and
Horwitz,S.B.
TITLE Structural and functional analysis of the mouse mdr1b gene promoter
JOURNAL J. Biol. Chem. 266, 2239-2244 (1991)
STANDARD full staff_entry
FEATURES Location/Qualifiers
protein_bind 313..320
/note="AP-1 binding site."
CAAT_signal 492..496
/gene="mdr1b"
protein_bind 530..536
/note="SP-1 binding site."
TATA_signal 548..556
/gene="mdr1b"
exon 580..721
/number=1
/product="P-glycoprotein"
/gene="mdr1b"
intron 722..723
/gene="mdr1b"
/partial
BASE COUNT 221 a 165 c 144 g 193 t
ORIGIN
1 gaattccaga acatctaaga actataccct gggaaaaaac acagatattg attccagagt
61 tagaagttga aaatactatg tactttgaaa tatcatttct accttgaaat tgtataggac
121 tatcatccaa gccaagacca tatatatata tatatatata tatatatata tatatttcac
181 agaaaaattt ctaccagcct agaaagcaat gctgtcagaa aaaaaaaaaa aactttacag
241 aataagcaag gtccctggtt gctttattaa ttatattaga ttagctatgt cagggaaagt
301 gtctttttaa gtatgactca tcagagaacc aactgtgtac tatccaggta tatacacttc
361 tgtatggaca cttacctgaa cacgtaaaga caagtctatg taaatgtctg agggaaccag
421 cgcccttctc aaaaaaatca gggtaagcct ggaagtatct cctgtttcgc aaccgctcca
481 gctgcccatg cccaatccca cccaccaggc tgattggctg ccgggcctta gggcggccgc
541 tggcatctat tttaatccgg ggcccgagga agccctctgg ctccttcccg cagtggctct
601 tgaagccgta agaggctgag gccgctgctt ccatcttctg aggttccgct caactcagag
661 ctacttccaa attctacatc ttggctgact ttgcgaagga aacccggagg tggcacgtga
721 ggt
//