GenBank-Updates@genbank.bio.net (01/25/91)
LOCUS HUMEGFR 3888 bp ds-DNA PRI 25-JAN-1991
DEFINITION Human EGF receptor (EGFR) gene, 5' end.
ACCESSION M38425
KEYWORDS cell surface receptor.
SOURCE Human DNA, clone LIII.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3888)
AUTHORS Haley,J.D. and Waterfield,M.D.
TITLE ;
JOURNAL Unpublished (1990)
STANDARD simple staff_entry
COMMENT Draft entry and computer-readable sequence for [Unpublished (1990)]
kindly submitted
by J.D.Haley, 12-SEP-1990.
Oncogene Science Inc.
350 Community Drive
Manhasset, NY 11030
FEATURES Location/Qualifiers
CDS 1114..1201
/gene="EGFR"
/partial
BASE COUNT 762 a 1219 c 1101 g 806 t
ORIGIN Map position 7q12-14.
1 aagcttccgc gagtttccca ggcatttctc ctcgcgggac taccaggggt agtgggacac
61 ttagcctctc taaaagcacc tccacggctg tttgtgtcaa gcctttattc caagagcttc
121 acttttgcga agtaatgtgc ttcacacatt ggcttcaaag tacccatggc tggttgcaat
181 aaacattaag gaggcctgtc tctgcacccg gagttggtgc cctcatttca gatgatttcg
241 agggtgcttg acaagatctg aaggaccctc ggactttaga gcaccacctc ggaacgcctg
301 gcacccctgc cgcgcgggca cggcgacctc ctcagctgcc aggccagcct ctgatccccg
361 cgaggggtcc cgtagtgctg cagggggagg ctggggaccc gaataaagga gcagtttccc
421 cgtcggtgcc attatccgac gctggctcta aggctcggcc agtctgtcta aagctggtac
481 aagtttgctt tgtaaaacaa aagaagggaa agggggaagg ggaccctggc acagatttgg
541 ctcgacctgg acataggctg ggctgcaagt ccgcggggac cgggtccaga ggggcagtgc
601 tgggaacgcc cctctcggaa attaactcct cagggcaccg ctcccctccc atgcgccgcc
661 ccactcccgc cggagactag gtcccgcggg ggccaccgtg tccaccgcct cgcggccgct
721 ggccttgggt ccccgctgct ggttctcctc cctcctcctc gcattctcct cctcctctgc
781 tcctcccgat ccctcctccg ccgcctggtc cctcctcctc ccgccctgcc tcccgcgcct
841 cggcccgcgc gagctagacg tccgggcagc ccccggcgca gcgcggccgc agcagcctcc
901 tccccccgca cggtgtgagc gcccgccgcg ccgaggcggc cggagtcccg agctagcccc
961 gcggccgccg ccgcccagac cggacgacag gccacctcgt cgcgtccgcc cgagtccccg
1021 cctcgccgcc aacgccacaa ccaccgcgca cggccccctg actccgtcca gtattgatcg
1081 ggagagccgg agcgagctct tcggggagca gcgatgcgac cctccgggac ggccggggca
1141 gcgctcctgg cgctgctggc tgcgctctgc ccggcgagtc gggctctgga ggaaaagaaa
1201 ggtaagggcg tgtctcgcgg ctccccgccg cccccggatc gcgccccgga ccccgcagcc
1261 cgcccaaccg caccgcgcac cggcttcgcc cgcgcccccg cccgtccttt cctgtttcct
1321 tgagatcacg tgcgccgccg accgggaccg cgggaggaac gggacgtttc gttcttcggc
1381 cgggagagtc tggggcgggc ggaggaggag acgcgtggga caccgggctg caggccaggc
1441 ggggaacggc cgccgggacc tccggcgccc cgaaccgctc ccaactttct tccctcactt
1501 tccccgccca gctgcgcagg atcggcgtca gtgggcgaaa gccgggtgct ggtgggcgcc
1561 tggggccggg gtcccgcacg ggctccccgc gctgtcttcc cagggcgcga cggggtcctg
1621 gcgcgcaccc gagggccgct gcccacccgc cgagactgcc tgtttaggga agctgaggaa
1681 ggaacccaaa aatacagcct ccgctcggac cccgcgggac aggcggcttt ctgagaggac
1741 ctccccgcct ccgcgctccg cgcaggtctc aaactgaagc cggcgcccgc cagcctggcc
1801 ccggcccctc tccaggtccc cgcgatcctc gttccccagt gtggagtcgc agcctcgacc
1861 tgggagctgg gagaactcgt ctaccaccac ctgcggctcc cggggagggg tggtgctggc
1921 ggcggttagt ttcctcgttg gcaaaaggca ggtggggtcc gacccgcccc ttgggcgcag
1981 accccggccg ctcgcctcgc ccggtgcgcc ctcgtcttgc ctatccaaga gtgcccccca
2041 ctcccgggac cccagctccc tccgcgcccg cgccgaaagc cccaggctct ccttcgatgg
2101 ccgcctcgcg gagacgtccg ggtctgctcc acctgcagcc cttcggtcgc gcctgggctt
2161 cgcggtggag cgggacgcgg ctgtccggcc actgcagggg gggatcgcgg gactcttgag
2221 cggaagcccc ggaagcagag ctcatcctgg ccaacaccat ggtgtttcaa aatggggctc
2281 acagcaaact tctcctcaaa acccggagac tttctttctt ggatgtctct ttttgctgtt
2341 tgaagaattt gagccaacca aaatattaaa cctgtcttac acacacacac acacacacac
2401 acacacacac accggattgc tgtccctggt tcaagtgtgc caagtgtgca gaagaacatg
2461 agcgagtctg gcttcgtgac taccgaccat aaacccactt gacaggggaa acatgccttg
2521 gaaggtttaa ttgcacaatt ccaaccttga ctgcgcgggt tccaagagcc aggcccgtac
2581 ttgctgttga tgtcattggc ttggggagtt ggggtttggt gcccagcgcg gtcgttgggg
2641 gaggggcgga aggcatagaa cagtggttcc ctgcgccctt ctgcacattg gaattacctg
2701 ggattaaaaa aaaaaaatca aaacaaaaac cagtgtctcg tcccgccccc agacattctg
2761 atttaattgg catggggcaa gacctggact tgggattttt tttaatgctc ttcatgtgat
2821 ctgttgggca gccagatttg gggatcacta gacggaagaa ggattgttaa agtctccgga
2881 gatgttactt gccaatgcta agagctcttt gagacatctg gaattgttac aatattgcca
2941 aatataggaa agagggaaaa ggtagagtgt gattccaata ataaaggatt ccgcttttca
3001 ttgaaggaac tggtggaaag gtttcttctc tgctagacct gcaggcccgt cctgcctgcc
3061 tggggcgccc gggagacgcg ggcctgctcc ggagactgct gactgccggt cctgttagtc
3121 aggtgtcagc cctgtctctg ccgaagagac tcttctcttt attttaaatt aaaccctcag
3181 agcaccacca aagcatcact tttctccctc cattggtgtt ctcattcttt gatgttactt
3241 gtttgaacac cactattagt agttggagat ttgttcctga gaaaaatata aataccactt
3301 aatttgcctg tttgtcccgc attcactcaa aacagaatgc tcctgaagac aagagagaga
3361 gtaggagaac agacgctatt ccattacagt aacataaaag actggatttt caggggcaaa
3421 ttattaaaat aggagatgag ctcttttaac agaaatttgt ttaaggcctg tgtctatcaa
3481 attcagtgga ttttattcaa gatgcacttt gtttagtggg agttttgttt ggttctggga
3541 catgctaact tctagacttg ctgctcttag aggtaatgac tgccagacac catttcatga
3601 gtcctaatcc ccacattaag cataagaggt gcacactctc ctcctatggg ggaaactgag
3661 gtacgaagaa ctaaagtgac tttcccacag ctggtgggag gcagacggga aattcacacc
3721 aggggcttcc aactccagat ccctctctca acttccaaac tccactgcct tgtccgagtt
3781 ctggtttcag gagatccaaa tcaggtgtgt gcaaatgtct aatgtcagag ctggcaaggg
3841 gaaagggccc agggagccgg ctcatgacga tgagcctgtc tgaagctt
//GenBank-Updates@genbank.bio.net (03/07/91)
LOCUS HUMEGFR 3888 bp ds-DNA PRI 07-MAR-1991
DEFINITION Human EGF receptor (EGFR) gene, 5' end.
ACCESSION M38425
KEYWORDS cell surface receptor; epidermal growth factor receptor.
SOURCE Human DNA, clone LIII.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3888)
AUTHORS Haley,J.D. and Waterfield,M.D.
TITLE Contributory effects of de novo transcription and premature
transcript termination in the regulation of human epidermal growth
factor receptor proto-oncogene RNA synthesis
JOURNAL J. Biol. Chem. 266, 1746-1753 (1991)
STANDARD simple staff_entry
COMMENT Draft entry and computer-readable sequence for [Unpublished (1990)]
kindly submitted
by J.D.Haley, 12-SEP-1990.
Oncogene Science Inc.
350 Community Drive
Manhasset, NY 11030
FEATURES Location/Qualifiers
CDS 1114..1201
/product="epidermal growth factor receptor"
/gene="EGFR"
/codon_start=1114
/partial
intron 1202..3888
/number=1
/gene="EGFR"
/partial
BASE COUNT 762 a 1219 c 1101 g 806 t
ORIGIN Map position 7q12-14.
1 aagcttccgc gagtttccca ggcatttctc ctcgcgggac taccaggggt agtgggacac
61 ttagcctctc taaaagcacc tccacggctg tttgtgtcaa gcctttattc caagagcttc
121 acttttgcga agtaatgtgc ttcacacatt ggcttcaaag tacccatggc tggttgcaat
181 aaacattaag gaggcctgtc tctgcacccg gagttggtgc cctcatttca gatgatttcg
241 agggtgcttg acaagatctg aaggaccctc ggactttaga gcaccacctc ggaacgcctg
301 gcacccctgc cgcgcgggca cggcgacctc ctcagctgcc aggccagcct ctgatccccg
361 cgaggggtcc cgtagtgctg cagggggagg ctggggaccc gaataaagga gcagtttccc
421 cgtcggtgcc attatccgac gctggctcta aggctcggcc agtctgtcta aagctggtac
481 aagtttgctt tgtaaaacaa aagaagggaa agggggaagg ggaccctggc acagatttgg
541 ctcgacctgg acataggctg ggctgcaagt ccgcggggac cgggtccaga ggggcagtgc
601 tgggaacgcc cctctcggaa attaactcct cagggcaccg ctcccctccc atgcgccgcc
661 ccactcccgc cggagactag gtcccgcggg ggccaccgtg tccaccgcct cgcggccgct
721 ggccttgggt ccccgctgct ggttctcctc cctcctcctc gcattctcct cctcctctgc
781 tcctcccgat ccctcctccg ccgcctggtc cctcctcctc ccgccctgcc tcccgcgcct
841 cggcccgcgc gagctagacg tccgggcagc ccccggcgca gcgcggccgc agcagcctcc
901 tccccccgca cggtgtgagc gcccgccgcg ccgaggcggc cggagtcccg agctagcccc
961 gcggccgccg ccgcccagac cggacgacag gccacctcgt cgcgtccgcc cgagtccccg
1021 cctcgccgcc aacgccacaa ccaccgcgca cggccccctg actccgtcca gtattgatcg
1081 ggagagccgg agcgagctct tcggggagca gcgatgcgac cctccgggac ggccggggca
1141 gcgctcctgg cgctgctggc tgcgctctgc ccggcgagtc gggctctgga ggaaaagaaa
1201 ggtaagggcg tgtctcgcgg ctccccgccg cccccggatc gcgccccgga ccccgcagcc
1261 cgcccaaccg caccgcgcac cggcttcgcc cgcgcccccg cccgtccttt cctgtttcct
1321 tgagatcacg tgcgccgccg accgggaccg cgggaggaac gggacgtttc gttcttcggc
1381 cgggagagtc tggggcgggc ggaggaggag acgcgtggga caccgggctg caggccaggc
1441 ggggaacggc cgccgggacc tccggcgccc cgaaccgctc ccaactttct tccctcactt
1501 tccccgccca gctgcgcagg atcggcgtca gtgggcgaaa gccgggtgct ggtgggcgcc
1561 tggggccggg gtcccgcacg ggctccccgc gctgtcttcc cagggcgcga cggggtcctg
1621 gcgcgcaccc gagggccgct gcccacccgc cgagactgcc tgtttaggga agctgaggaa
1681 ggaacccaaa aatacagcct ccgctcggac cccgcgggac aggcggcttt ctgagaggac
1741 ctccccgcct ccgcgctccg cgcaggtctc aaactgaagc cggcgcccgc cagcctggcc
1801 ccggcccctc tccaggtccc cgcgatcctc gttccccagt gtggagtcgc agcctcgacc
1861 tgggagctgg gagaactcgt ctaccaccac ctgcggctcc cggggagggg tggtgctggc
1921 ggcggttagt ttcctcgttg gcaaaaggca ggtggggtcc gacccgcccc ttgggcgcag
1981 accccggccg ctcgcctcgc ccggtgcgcc ctcgtcttgc ctatccaaga gtgcccccca
2041 ctcccgggac cccagctccc tccgcgcccg cgccgaaagc cccaggctct ccttcgatgg
2101 ccgcctcgcg gagacgtccg ggtctgctcc acctgcagcc cttcggtcgc gcctgggctt
2161 cgcggtggag cgggacgcgg ctgtccggcc actgcagggg gggatcgcgg gactcttgag
2221 cggaagcccc ggaagcagag ctcatcctgg ccaacaccat ggtgtttcaa aatggggctc
2281 acagcaaact tctcctcaaa acccggagac tttctttctt ggatgtctct ttttgctgtt
2341 tgaagaattt gagccaacca aaatattaaa cctgtcttac acacacacac acacacacac
2401 acacacacac accggattgc tgtccctggt tcaagtgtgc caagtgtgca gaagaacatg
2461 agcgagtctg gcttcgtgac taccgaccat aaacccactt gacaggggaa acatgccttg
2521 gaaggtttaa ttgcacaatt ccaaccttga ctgcgcgggt tccaagagcc aggcccgtac
2581 ttgctgttga tgtcattggc ttggggagtt ggggtttggt gcccagcgcg gtcgttgggg
2641 gaggggcgga aggcatagaa cagtggttcc ctgcgccctt ctgcacattg gaattacctg
2701 ggattaaaaa aaaaaaatca aaacaaaaac cagtgtctcg tcccgccccc agacattctg
2761 atttaattgg catggggcaa gacctggact tgggattttt tttaatgctc ttcatgtgat
2821 ctgttgggca gccagatttg gggatcacta gacggaagaa ggattgttaa agtctccgga
2881 gatgttactt gccaatgcta agagctcttt gagacatctg gaattgttac aatattgcca
2941 aatataggaa agagggaaaa ggtagagtgt gattccaata ataaaggatt ccgcttttca
3001 ttgaaggaac tggtggaaag gtttcttctc tgctagacct gcaggcccgt cctgcctgcc
3061 tggggcgccc gggagacgcg ggcctgctcc ggagactgct gactgccggt cctgttagtc
3121 aggtgtcagc cctgtctctg ccgaagagac tcttctcttt attttaaatt aaaccctcag
3181 agcaccacca aagcatcact tttctccctc cattggtgtt ctcattcttt gatgttactt
3241 gtttgaacac cactattagt agttggagat ttgttcctga gaaaaatata aataccactt
3301 aatttgcctg tttgtcccgc attcactcaa aacagaatgc tcctgaagac aagagagaga
3361 gtaggagaac agacgctatt ccattacagt aacataaaag actggatttt caggggcaaa
3421 ttattaaaat aggagatgag ctcttttaac agaaatttgt ttaaggcctg tgtctatcaa
3481 attcagtgga ttttattcaa gatgcacttt gtttagtggg agttttgttt ggttctggga
3541 catgctaact tctagacttg ctgctcttag aggtaatgac tgccagacac catttcatga
3601 gtcctaatcc ccacattaag cataagaggt gcacactctc ctcctatggg ggaaactgag
3661 gtacgaagaa ctaaagtgac tttcccacag ctggtgggag gcagacggga aattcacacc
3721 aggggcttcc aactccagat ccctctctca acttccaaac tccactgcct tgtccgagtt
3781 ctggtttcag gagatccaaa tcaggtgtgt gcaaatgtct aatgtcagag ctggcaaggg
3841 gaaagggccc agggagccgg ctcatgacga tgagcctgtc tgaagctt
//