GenBank-Updates@genbank.bio.net (03/16/91)
LOCUS HUMTGFB3B 3303 bp ds-DNA PRI 16-MAR-1991
DEFINITION Human transforming growth factor beta-3 gene, 5' end.
ACCESSION M60556
KEYWORDS transforming growth factor beta-3.
SOURCE Human leukocyte DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3303)
AUTHORS Lafyatis,R., Lechleider,R., Kim,S.-J., Jakowlew,S., Roberts,A.B.
and Sporn,M.B.
TITLE Structural and functional characterization of the transforming
growth factor beta-3 promoter: A cAMP-responsive element regulates
basal and induced transcription
JOURNAL J. Biol. Chem. 265, 19128-19136 (1990)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
misc_feature 2152..2158
/standard_name="cAMP-responsive element"
TATA_signal 2170..2176
/gene="TGF-beta-3"
mRNA 2197..>3303
/note="major"
/gene="TGF-beta-3"
mRNA 2214..>3303
/note="minor"
/gene="TGF-beta-3"
mRNA 2219..>3303
/note="minor"
/gene="TGF-beta-3"
CDS 3301..>3303
/product="transforming growth factor beta-3"
/gene="TGF-beta-3"
/codon_start=3301
BASE COUNT 723 a 939 c 872 g 769 t
ORIGIN
1 cagtagtagc ttccagaact tgcttagcac ctgaatcacg tgtgaggttt gtaaagaaac
61 agagatgcca gggcctcagc tctggagact gattggtaga ggtggagtcc aaaaaagtat
121 aactttaata attttccttc ctatcttcaa ctgtctgctc aaaggccttc ccttatcacc
181 ctatttgaaa ctgcaacatc ccccaaccta ggcacacccc atcctccttc cctgcttgat
241 tttctgccac accacatttg tttgtttgct tgtctgtttg agacacggtc ttgctctgtc
301 gtccaggctg gagtgcagtg gtgcaatctt ggccccctgt aaactcgcct ccctggctca
361 agtgattatc ctgctcagcc tcccaagtag atgcgtgcgc caacatgccg ggctaatttt
421 tccatttttt tgtagagact gggtttcgcc gtgttgctgg ggctggtctc gaattcctga
481 gctcaagtaa tcctcctgca tgggcctccc caaatgctgg gattacaggc gtgagccact
541 gcacctggct cagcactttt taccgtacta catcatttac atatttattt agtttatcgc
601 ctcctccact gccccacccc tgcctctaaa taaaatttcc ctgagggcag gagttttgtt
661 tcgttcactg atattcttca cagagcctag aatagtgcct ggtatataga aacattaaac
721 tttttctgaa atttcagagg cagtatagca tagtaattaa gtccagaatc tggcaacgtc
781 ctgggtgcaa atcccaacag ctgacaccta ataactatgt gaccttgggc aagttacttt
841 taaagtttct acccctaggt ttcccattgg ttttgcaaat gaaagtaatg cctacccaag
901 ctagatagcc tgtgtaaata tcgcctccat cactcacaag cagtgtggtc tgtaaaaaaa
961 aaaacaaaaa actctatgcc tcagtttcct catccgtaaa agtgacccac cgctgtgctg
1021 ggatacagag aacagcccct tcagttagtg gcctggaagc cagcctctca gaaagggtcc
1081 aggaaggctg gagtgagatg gggtggagcg gcactcactc tcaggaaagt tcagttcaga
1141 ggcaagccct gtgttgcggg gtgcggggag ccacgtgccc taccctccct tggctgctcg
1201 tgggaaaagg cctagaggtt cgggccgaga agaggagcga aagcacagag ccgacttccc
1261 ctcacccatc tgggaaatgg ctcgggccaa ctgctgactt cgcgctcgct ggccgacgtc
1321 ctgcggagac ctcggcgggg agggaggctg aacatctgga tgacatttct gcgagagagc
1381 ggctccggag cggcggtcgg ggagggagag ctgctcgtgc gcacgtcggg ccgggaggga
1441 ggcgattcct cggggcctgg gtcttgtttt tctcgctctc taccgcagcc ccttctcccg
1501 cccctcagcc cccaccccgc agcccccagc ccccgagcct ccccggctcc cgaccagccg
1561 agctccttca ctggcggcct ccgctcgcca gagggcaccc tcgatcttcc ggaaaacgcc
1621 accatttttc actgcccctg gagcgtctcc aggcttctgc ccgcctcccg actccgatct
1681 tgtcaatgaa gaatcgggcc aggatcgccg cggagcggac gccgaccctc cgacccggct
1741 cgcaggctgg gagtcccctc tgcgaggctg gcatggccgc ccctaccggg tcccgcgccc
1801 tctgcggacc ctccccgggt tgggcctggc cgcgggcggc cccgggaccg ggggaccagg
1861 agggagagta gaccgggccg gacggcgcgg actgacagct ggcgagaggg cgccggggct
1921 gggggaaagg gagggagggg gctcatcgga gtaactttcc agaaaaacac caacgtgtgg
1981 caggagtgat tccaagaggg gaaaaaaagt tcagctacca cgtcgaacga gaggactcgc
2041 aaagtatttt tcaaaagggc tcggcttttc ctgtgcctgt ttaaaacatt aacatcgtgc
2101 agcaaaagag gctgcgtgcg ctggtccctc cctcccccac cccaggccag agacgtcatg
2161 ggagggaggt ataaaatttc agcagagaga aatagagaaa gcagtgtgtg tgcatgtgtg
2221 tgtgtgtgag agagagaggg agaggagcga gagggagagg gagagggaga gagagaaagg
2281 gagggaagca gagagtcaag tccaagggaa tgaccgagag aggcagagac aggggaagag
2341 gcgtgcgaga gaaggaataa cagcagcttt ccggagcagg cgtgccgtga actggcttct
2401 attttatttt atttttttct cctttttatt ttttaaagag aagcagggga cagaagcaat
2461 ggccgaggca gaagacaagc cgaggtgctg gtgaccctgg gcgtctgagt ggatgattgg
2521 ggctgctgcg ctcagaggcc tgcctccctg ccttccaatg catataaccc cacaccccag
2581 ccaatgaaga cgagaggcag ctgaaaaagt catttagaaa gcccccgagg aagtgtaaac
2641 aaaagagaaa gcatgaatgg agtgcctgag agacaagtgt gtcctgtact gccccacctt
2701 tagctgggcc agcaactgcc cggcccgctt ctccccacct actcactggt gatctttttt
2761 tttttacttt tttttccctt ttcttttcca ttctcttttc ttattttctt tcaaggcaag
2821 gcaaggattt tgattttggg acccagccat ggtccttctg cttcttcttt aaaataccca
2881 ctttctcccc atcgccaagc ggcgtttggc aatatcagat atccactcta tttattttta
2941 cctaaggaaa aactccagct cccttcccac tcccagctgc cttgccaccc ctcccagccc
3001 tctgcttgcc ctccacctgg cctgctggga gtcagagccc agcaaaacct gtttagacac
3061 atggacaaga atcccagcgc tacaaggcac acagtccgct tcttcgtcct cagggttgcc
3121 agcgcttcct ggaagtcctg aagctctcgc agtgcagtga gttcatgcac cttcttgcca
3181 agcctcagtc tttgggatct ggggaggccg cctggttttc ctccctcctt ctgcacgtct
3241 gctggggtct cttcctctcc aggccttgcc gtccccctgg cctctcttcc cagctcacac
3301 atg
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