GenBank-Updates@genbank.bio.net (03/19/91)
LOCUS HUMIGHAC1 550 bp ds-DNA PRI 19-MAR-1991
DEFINITION Human germline Ig alpha mutant chain gene V-J6 region.
ACCESSION M60323
KEYWORDS immunoglobulin; immunoglobulin heavy chain; joining exon;
variable region.
SEGMENT 1 of 4
SOURCE Human jejunal mucosa cell hybridoma DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 550)
AUTHORS Cogne,M. and Preud'Homme,J.-L.
TITLE Gene deletions force nonsecretory alpha-chain disease plasma cells
to produce membrane-form alpha-chain only
JOURNAL J. Immunol. 145, 2455-2458 (1990)
STANDARD simple staff_review
FEATURES Location/Qualifiers
intron 131..466
/gene="IgA mutant"
misc_feature 237..525
/note="inserted sequence"
/gene="IgA mutant"
misc_feature 467..550
/note="sequence with no homology to V-h-chiains"
/gene="IgA mutant"
BASE COUNT 119 a 136 c 152 g 143 t
ORIGIN chromosome 14
1 ctgcagctct gggagaggac ccccaggtct gagattccca ggtgtttccg gtcggtgacc
61 agcactgagc acagagaacg caccatggac tttggactga actggattgt ccttcttgca
121 attcttagag gtgacccatg ggtagattga catcttaaga gtgagcgaac acgtgtgagg
181 ggcacagtcg ccccgtgagc cagtgtctgt ccggaggtcc ccagtgtgac gtgcagtcat
241 caccagtcca tgtggccaga aagtcttatc taatcgttag agtgatgtgt caaaagtggg
301 gatttgtggt cgcccactgt tgcctcgagg gctcaaaaaa cttgtctttt tttttagtgg
361 gaggctcgtg acatttaacc agcacttaga gtgatgtgtc aaaagggggg atttatggtc
421 gcccactgtt gactcgcggg ctcaagaaac ttgtcttgtt ttttagtggc aacctctatg
481 tatttaagca ccggttcccc aatcgtcaca acgagtcgcg accctgggac caccagctcc
541 gtctcctccg
//