GenBank-Updates@genbank.bio.net (03/19/91)
LOCUS HUMIGHAC2 985 bp ds-DNA PRI 19-MAR-1991
DEFINITION Human germline Ig alpha mutant chain gene CH2 region.
ACCESSION M60324
KEYWORDS constant region; immunoglobulin; immunoglobulin heavy chain;
switch region.
SEGMENT 2 of 4
SOURCE Human jejunal mucosa cell hybridoma DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 985)
AUTHORS Cogne,M. and Preud'Homme,J.-L.
TITLE Gene deletions force nonsecretory alpha-chain disease plasma cells
to produce membrane-form alpha-chain only
JOURNAL J. Immunol. 145, 2455-2458 (1990)
STANDARD simple staff_review
FEATURES Location/Qualifiers
intron 1..971
/gene="IgA mutant"
misc_feature 614..669
/note="insertion sequence"
/gene="IgA mutant"
misc_feature 670..880
/note="switch region"
/gene="IgA mutant"
misc_feature 881..971
/note="vestigial CH1-CH2 intron"
/gene="IgA"
BASE COUNT 218 a 230 c 300 g 237 t
ORIGIN chromosome 14
1 gagcaggaga ctcatttatg tgagtctttt gagtgaccat tgtctgggtc gctcccattt
61 aactttccct aaagcccatt tgacggagtg gtcgcacgag ctgctccaca acctctgaat
121 ggggatggct tgggtaatga tgcttgagag catgccaagc cccactggcg tcgcccttgt
181 ctaagtcatt gactgtaggt catcatcgca cccttgaaag cagcccatgc ctttcaaagc
241 gatttatggt ccctggcaga attttaagtg gcaaaatcag ataaaatgcc tttcttggtt
301 gtttccaatg atgactgtta tttagaggga atttaaaggc aggggtttac tgcagactca
361 gaagggaggt gatgctccgg gaaggtggag actctgagca tctcaatacc ctcctcttgg
421 tgcagaagat ctgctgccac ttctagacca aggggacctg ctcattttta tcacagcaca
481 gactcctaaa ttcttggtct cattctcaag atgtgtaaat gactttaaag cagtaaagaa
541 atattccacc caggtagtgg agggtgatga ttggaaatgc tttggaacca aaacccaggt
601 ggcgctgggg cagttcaact cagcccagtt cagctcaact cagcccagtt cagccttgtt
661 tagctgcttg ggctgggctg agttgggcta ggctgggctg agctgggctg agctaggctg
721 ggctggctgg gctgagcggg actgagcggg ctgacctgag ctaggctggg ctgagcgggg
781 ctgagctgag ctaggctgga ctgggctggg ctgagccaag gtgaaccggg ttgagcgtgc
841 tgtgatgggc tgagccaagg taggctgagc tgagccaagt cccaggaggt ggtggtggac
901 aggccaggag ggacgaggcg ggggcacggg gaagcatgtg ctgaccacct caggccatct
961 ctccactcca gttccctcaa ctcca
//